CN105943795A - Traditional Chinese medicine composition for treating eczema and neurodermatitis, external preparation as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating eczema and neurodermatitis, external preparation as well as preparation method and application thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention relates to a traditional Chinese medicine composition for treating eczema and neurodermatitis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 0.5-1.5 parts of pseudo-ginsengs, 2-3 parts of sophora flavescens, 2-3 parts of coptis chinensis, 2-3 parts of rhizoma paridis, 1.5-2.5 parts of rhizoma atractylodi, 1-2 parts of cortex dictamni, 1-2 parts of Chinese prickly ash and 2-3 parts of liquorice roots. The invention further provides an external preparation containing the traditional Chinese medicine composition. According to the traditional Chinese medicine composition provided by the invention, all the components are reasonably matched and express the synergistic effect; the product has anti-inflammation and itching-stopping effect and particularly has good treatment effect on the eczema and the neurodermatitis; compared with common glucocorticoid type medicines for treating the eczema, the eczema and the neurodermatitis are not easy to recur or side effects including drug resistance and the like are not easy to generate, and the medicine is safe to use. The external preparation containing the traditional Chinese medicine composition has uniform texture and stable properties; the external preparation is convenient to use in daily life and has a good clinical popularization value.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to that one has antiinflammatory, itching-relieving action can be used for
The Chinese medicine for external application of the treatment dermatosis such as eczema and neurodermatitis.
Background technology
Eczema be a kind of immunology skin diseases be to occur one IV type on skin abnormal anti-
Should, it is the cellular immunization mediated by T cell.Chronic eczema can be sent out repeatedly because of acute, subacute
Make more not transfer chronic eczema to, also can the most i.e. present chronic inflammatory disease.Show as affected part skin
Skin thickens, infiltrates, brownish red or band agouti pigmentation calm, rough surface, coated with a little pityrosporum
Sample squama, or form a scab because scratching, there is individually lichenification in various degree, have limitation,
Edge is clearer, and periphery also can have pimple, papulovesicle to be dispersed in.
Eczema is dermatology common disease, and China's population prevalence is about 7.5%, and the U.S. is
10.7%.The cause of disease of eczema and morbidity substrate are still not clear at present.On Zhi Liao with control symptom,
Reduce recurrence, raising patients ' life quality is target.Main with glucocorticoid in the market
Class medicine is main.
Neurodermatitis is also known as lichen chronicus simplex.It is with paroxysmal skin pruritus and skin tongue
Moss turns to the chronic dermatosis of feature.For common skin diseases, being more common in adult, child is general
Do not fall ill.It is now recognized that Nervous and Mental Factors is the main inducing that primary disease occurs, anxious state of mind, spirit
Hypertonicity, anxious, living environment change suddenly etc. all can aggravate disease and repeatedly.
Gastrointestinal dysfunction, hormonal system dysfunction, internal chronic lesion infection etc.,
Paathogenic factor can be become.The friction that local excitation such as collar is really up to the mark and causes, chemical substance stimulation,
Sting, sunlight irradiate, scratch, and all can induce the generation of primary disease.
The purpose of neurodermatitis treatment is the most antipruritic, it is to avoid patient scratches because of pruritus, from
And increasing the weight of the state of an illness further, glucocorticoid ointment, cream or solution are generally selected in local treatment
External.
From taking into account short term effect and late result, the particularly the medical treatment safe problem in treatment is examined
Considering, there is easily bounce-back in glucocorticoid medicine treatment, easily recurs, easy drug resistance, and side effect is big
Etc. outstanding problem.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine for external application with antiinflammatory, itching-relieving action,
Can be used for treating the dermatosis such as eczema and neurodermatitis, and glucocorticoids medicine can be avoided
The defect of thing.
Specifically, the Chinese medicine composition that the present invention provides is by the raw material system including following weight portion
For forming: Radix Notoginseng 0.5～1.5 parts, Radix Sophorae Flavescentis 2～3 parts, Rhizoma Coptidis 2～3 parts, Rhizoma Paridis 2～3 parts,
Rhizoma Atractylodis 1.5～2.5 parts, Cortex Dictamni 1～2 parts, Pericarpium Zanthoxyli 1～2 parts, Radix Glycyrrhizae 2～3 parts.
Preferably, the raw material including following weight portion it is prepared from: Radix Notoginseng 1 part, Radix Sophorae Flavescentis 2～3
Part, Rhizoma Coptidis 2～3 parts, Rhizoma Paridis 2～3 parts, Rhizoma Atractylodis 1.5～2.5 parts, Cortex Dictamni 1～2 parts, flower
Green pepper 1～2 parts, Radix Glycyrrhizae 2～3 parts.
It is highly preferred that be prepared from by the raw material including following weight portion: Radix Notoginseng 0.9～1.1 parts,
Radix Sophorae Flavescentis 2.15～2.35 parts, Rhizoma Coptidis 2.4～2.6 parts, Rhizoma Paridis 2～2.2 parts, Rhizoma Atractylodis 1.65～1.85
Part, Cortex Dictamni 1.4～1.6 parts, Pericarpium Zanthoxyli 1.4～1.6 parts, Radix Glycyrrhizae 2.4～2.6 parts.
As the one most preferably scheme of the present invention, described Chinese medicine composition is by including following weight
The raw material of part is prepared from: Radix Notoginseng 1 part, Radix Sophorae Flavescentis 2.25 parts, Rhizoma Coptidis 2.5 parts, Rhizoma Paridis 2
Part, Rhizoma Atractylodis 1.75 parts, Cortex Dictamni 1.5 parts, 1.5 parts of Pericarpium Zanthoxyli, 2.5 parts of Radix Glycyrrhizae.
The present invention provide Chinese medicine composition be prepared from by kinds of traditional Chinese medicines compatibility, have antiinflammatory,
Itching-relieving action, especially has good therapeutical effect to eczema and neurodermatitis.
Prepared by the Traditional Chinese medicine extraction method that Chinese medicine composition of the present invention can use this area conventional
Obtain.Be fully extracted in order to ensure effective ingredient, present invention preferably employs water extraction normal pressure,
Extract under the conditions of 60～100 DEG C.
As a preferred embodiment of the present invention, described preparation method comprises the following steps: take former
Material, adds and accounts for raw material gross weight 6～the water of 8 times, at normal pressure, extracts 2～5 under the conditions of 60～100 DEG C
Secondary, each 3～6 hours, united extraction liquid, being condensed into proportion (heat is surveyed) is 1.30～1.33,
Obtain.
Present invention also offers the external preparation comprising the Chinese medicine composition that the present invention provides, as outward
Use ointment.
Specifically, described external preparation comprises the composition of following weight portion: described Chinese medicine composition
Thing 0.8～1.2 parts, Calamina 0.2～0.5 part, Borneolum Syntheticum 0.1～0.2 part, aqueous matrix adjuvant 1.5～3
Part, water 5～8.5 parts.
Wherein, described aqueous matrix adjuvant includes stearic acid, liquid paraffin, triethanolamine, sweet
One or more in oil, stearyl alcohol.As the preferred version of the present invention, described aqueous matrix
Adjuvant includes stearic acid, liquid paraffin, triethanolamine, glycerol and stearyl alcohol.Described in order to make
Aqueous matrix adjuvant gives full play to emulsifying effect, improve further gained preparation homogenizing,
Stability, the further preferred described stearic acid of the present invention, liquid paraffin, triethanolamine, glycerol
It is 1:0.4～0.55:0.05～0.1:0.4～0.55:0.1～0.2 with the weight ratio of stearyl alcohol.
The external preparation that the present invention provides will add appropriate Calamina, ice in Chinese medicine composition
Sheet, aqueous matrix adjuvant and water, make synergism between each component, it is ensured that gained external preparation
Uniformity and stability, beneficially patient are daily smears use.
The external preparation preparation method that external preparation of the present invention can use this area conventional obtains
Arrive.Present invention preferably employs emulsifying method to be prepared from.Specifically, comprise the steps:
Take Chinese medicine composition, Calamina, aqueous matrix adjuvant and water, after mixing, carry out emulsifying,
Add Borneolum Syntheticum after cooling, continue homogenizing, be cooled to room temperature,.
Wherein, in order to make the abundant homogenizing of each component and play synergism, add after described cooling
Temperature during Borneolum Syntheticum is preferably 42～45 DEG C.
As a preferred embodiment of the present invention, described preparation method comprises the following steps: take hard
Fat acid, liquid paraffin, glycerol and stearyl alcohol, put in homogeneous emulsifying machine oil phase pot, be heated to melting
Melt, and continue to be heated to 70～80 DEG C, obtain mixed accessories；In emulsifying pot, add water, heat,
Separately take Chinese medicine composition, triethanolamine and Calamina, add in emulsifying pot, stir, continue
Continue and be heated to 70～80 DEG C；Add the adjuvant of the mixing of gained in oil phase pot, stop heating, enter
Row emulsifying and homogenizing；When pot temperature to be emulsified is down to 42～45 DEG C, add Borneolum Syntheticum, continue homogenizing,
Naturally cool to room temperature, to obtain final product.
The external preparation that described method is prepared from is preferably externally-applied ointment, can be filled into plastics,
Plastic-aluminum, aluminum flexible pipe, or loading plastics, vial preserve.
The present invention protects described Chinese medicine composition or described external preparation in preparation treatment further
Application in eczema or neurodermatitis medicine.Described eczema more preferably chronic eczema.
In the inflammation-resisting itch-stopping Chinese medicine composition that the present invention provides, between each component, carry out Reasonable
5, and play synergism, there is antiinflammatory, itching-relieving action, especially to eczema and nerve
Dermatitis has good therapeutical effect；The glucocorticoid medicine phase conventional with treatment eczema
Ratio, is difficult to bounce-back, recurs or produce the side effect such as drug resistance, drug safety.Comprise described in
The external preparation of drug composition is homogeneous, stable in properties, and routine use is convenient, has good
Clinical generalization value.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Present embodiments provide a kind of Chinese medicine composition for treating eczema and neurodermatitis,
Used water extraction to extract by following raw material to obtain: Radix Notoginseng 12kg, Radix Sophorae Flavescentis 27kg, Rhizoma Coptidis 30kg,
Rhizoma Paridis 24kg, Rhizoma Atractylodis 21kg, Cortex Dictamni 18kg, Pericarpium Zanthoxyli 18kg, Radix Glycyrrhizae 30kg.
Embodiment 2
Present embodiments provide a kind of Chinese medicine composition for treating eczema and neurodermatitis,
Used water extraction to extract by following raw material to obtain: Radix Notoginseng 12kg, Radix Sophorae Flavescentis 24kg, Rhizoma Coptidis 24kg,
Rhizoma Paridis 24kg, Rhizoma Atractylodis 18kg, Cortex Dictamni 12kg, Pericarpium Zanthoxyli 12kg, Radix Glycyrrhizae 24kg.
Embodiment 3
Present embodiments provide a kind of Chinese medicine composition for treating eczema and neurodermatitis,
Used water extraction to extract by following raw material to obtain: Radix Notoginseng 12kg, Radix Sophorae Flavescentis 36kg, Rhizoma Coptidis 36kg,
Rhizoma Paridis 36kg, Rhizoma Atractylodis 30kg, Cortex Dictamni 24kg, Pericarpium Zanthoxyli 24kg, Radix Glycyrrhizae 36kg.
Embodiment 4
Present embodiments providing the extracting method of a kind of Chinese medicine composition, embodiment 1～3 provides
Chinese medicine composition all can use following methods extraction to obtain:
Take each raw material, add the water accounting for raw material gross weight 7 times, carry at normal pressure, under the conditions of 100 DEG C
Taking 3 times, each 5 hours, united extraction liquid, being condensed into proportion (heat is surveyed) is 1.315, i.e.
?.
Embodiment 5
Present embodiments provide a kind of external preparation for treating eczema and neurodermatitis, adopt
Form through emulsifying by following component: the Chinese medicine composition 9kg that embodiment 1 provides, Calamina
2.5kg, Borneolum Syntheticum 1.5kg, stearic acid 8.32kg, liquid paraffin 4.17kg, triethanolamine 0.68kg,
Glycerol 4.58kg, stearyl alcohol 1.25kg, water 68kg.
Embodiment 6
Compared with Example 5, differing only in, described Chinese medicine composition is provided by embodiment 2.
Embodiment 7
Compared with Example 5, differing only in, described Chinese medicine composition is provided by embodiment 3.
Embodiment 8
A kind of external preparation for treating eczema and neurodermatitis, uses following component through all
Matter emulsifying forms: the Chinese medicine composition 0.8kg that embodiment 1 provides, Calamina 0.2kg, Borneolum Syntheticum
0.1kg, stearic acid 8.32kg, liquid paraffin 3.33kg, triethanolamine 0.42kg, glycerol 3.33kg,
Stearyl alcohol 0.84kg, water 5kg.
Embodiment 9
A kind of external preparation for treating eczema and neurodermatitis, uses following component through all
Matter emulsifying forms: the Chinese medicine composition 1.2kg that embodiment 1 provides, Calamina 0.5kg, Borneolum Syntheticum
0.2kg, stearic acid 8.32kg, liquid paraffin 4.58kg, triethanolamine 0.84kg, glycerol 4.58kg,
Stearyl alcohol 1.67kg, water 8.5kg.
The external preparation that embodiment 5～9 is provided by the present invention carries out uniformity detection, each embodiment
The external preparation provided is the most uniform, it is simple to smear.After long storage time, embodiment
5～the 7 external preparation matter uniformities provided and stability are superior to embodiment 8～9.
Embodiment 10
Present embodiments provide the preparation method of external preparation, the Chinese drug-treated group that embodiment 5～9 provides
Compound all can use following methods extraction to obtain:
Take stearic acid, liquid paraffin, glycerol and stearyl alcohol, put in homogeneous emulsifying machine oil phase pot,
It is heated to melting, and continues to be heated to 75 DEG C, obtain mixed accessories；
In emulsifying pot, add water, heating, separately take Chinese medicine composition, triethanolamine and Calamina,
Add in emulsifying pot, stir, continue to be heated to 75 DEG C；In addition oil phase pot, gained is mixed
The adjuvant closed, stops heating, carries out emulsifying and homogenizing；When pot temperature to be emulsified is down to 45 DEG C,
Add Borneolum Syntheticum, continue homogenizing, naturally cool to room temperature, to obtain final product.
External preparation (hereinafter referred to as Chinese medicine eczema to the embodiment of the present invention 5 gained inflammation-resisting itch-stopping
Cream, referred to as eczema ointment), carry out antiinflammatory, the antipruritic and detection of rat Eczema Model.
Experimental example 1: antiinflammatory action detects
Material:
Reagent: (1) Chinese medicine eczema ointment, is configured to 30% and 15% (W/W) with aqueous matrix
Two concentration.(2) dimethylbenzene.(3) Oleum Tiglii, is configured to 2% concentration (4) acetic acid fluorine light
Pine, 0.025%.
Animal: Kunming mouse, medicine inspecting institute of Yunnan Province provides, body weight 18-20g, male and female half and half,
Routine feeding.
Method and result:
Mice 40, is randomly divided into 4 groups: Matrix controls group, fluocinolone acetonide matched group, eczema
Cream high concentration group and eczema ointment low concentration group, often group 10.Each group is all applied in dimethylbenzene
Two sides before and after the left ear of mice, every 0.03ml.It is right to smear at each group of left ear of mice after 30 minutes
Answer medicine, every about 5mg, be spaced to repeat for 30 minutes and smear once.Smear for the last time
After 30 minutes, be coated with medicine on the gauze left ear of wiped clean mice, take off neck and put to death mice,
Lay garden auricle with the card punch of diameter 7mm in the same area of mice two ear, use torsion sky
Put down and weigh.Using the difference of the weight of every Mus left and right auricle as swelling.The inspection of result t is carried out
Statistical procedures, is shown in Table 1
Table 1: the impact of eczema ointment xylol induced mice auricle edema
*: each group compares with Matrix controls group, the most similar
From table 1, high concentration eczema ointment and fluocinolone acetonide ointment equal xylol induced mice ear
Wide swelling has the inhibitory action (P < 0.01) of highly significant, and eczema ointment low concentration group effect is notable
(P<0.05).Result shows, the eczema ointment of high-concentration and low-concentration is respectively provided with significant antiinflammatory action.
Experimental example 2: itching-relieving action detects
1 material
1.1 Cavia porcelluss 200～300g, male and female dual-purpose, blood station, center, Kunming provide.
((1) Chinese medicine eczema ointment, is configured to 30% He with aqueous matrix for 1.2 medicines and reagent
15% (W/W) two concentration.(2) histamine phosphate (3) essential balm.
2 methods and result
Take Cavia porcellus 40, be randomly divided into 5 groups, i.e. model group, Matrix controls group, essential balm
Matched group, eczema ointment high concentration group and eczema ointment low concentration group, often group 8.Give each before experiment
Shaving is carried on the back on the group Cavia porcellus right side fully, at sand paper scratch shaving, till slight oozing of blood occurs, and scratch
Area about 1cm2.Each group is coated with substrate, essential balm matched group, high concentration at wound surface respectively
Eczema ointment and low concentration eczema ointment 5mg/ are only.After coating 10 minutes, at wound surface, drip 0.01%
Histamine phosphate 25 μ l/ is only.Later every 10 minutes according to 0.01% progressive concentration, at wound surface
Only drip histamine phosphate 25 μ l/, until Cavia porcellus later licks metapedes.After occurring licking with every Cavia porcellus
The histamine phosphate's total amount given during foot is itch-threshold, records and compares.The results are shown in Table 2.
Table 2: eczema ointment causes, on histamine phosphate, the impact reacted of itching
Factor data is skewness, and heterogeneity of variance, uses rank test to carry out data process.By table
2 results show, the eczema ointment of high-concentration and low-concentration all can significantly improve the itch-threshold of Cavia porcellus, with model
Group and Matrix controls group compare, and have highly significant difference (P < 0.01).High concentration eczema ointment with
Essential balm group compares, difference nonsignificance (P > 0.05).Prompting eczema ointment the most only has
Itch effect.
Experimental example 3: the impact on rat back DNCB model of chronic eczema
1 instrument and material
1.1 laboratory animal
Normal SPF level SD rat, 180～220g, male and female half and half, Yunnan Province's medicine grind
Study carefully and provided.
1.2 medicine
((1) Chinese medicine eczema ointment is configured to 30% and 15% (W/W) two with aqueous matrix
Individual concentration.(2) hydrocortisone butyrate ointment (commercial, Tianjin Pharmaceutical Group Corp., Ltd).
1.3 reagent
DNFB (DNCB) (Chengdu Gracia chemical technology company limited)；
Paraformaldehyde (analytical pure, Tianjin great Mao chemical reagent factory).
1.4 instrument
CUT6062 full-automatic rotary paraffin slicing machine；BN-802A biological tissue wraps automatically
Bury machine；DYS-327 optical microscope；Stick microscope slide；Coverslip；10～100 μ l move liquid
Rifle；CP225D type electronic balance；Constant Temp. Oven.
2 experimental techniques
The foundation of 2.1 rat Eczema Model and medication
SD rat is randomly divided into 6 groups, it may be assumed that 1. eczema ointment high concentration group；2. eczema ointment is low
Concentration group；3. positive controls (hydrocortisone butyrate ointment group)；4. Matrix controls group；
5. blank group, often group 12, male and female half and half；6. normal group 6, male and female half and half.
All rat adaptabilities raise 7d.Sensitization the previous day, rat back electric shaver
Shaving, chooses 2cm × 2cm scope standby.1st day, before administration, take matched group 6 big
Mus, male and female half and half, put to death, take sensitization area skin about 1cm2, immerse the paraformaldehyde of 4%
Solution fixes 24h.It is molten that remaining respectively organizes DNFB (DNCB) acetone with 5%
Liquid 30 μ l in depilation position sensitization, after 7d with 0.2% DNCB acetone soln 50 μ l back
Excite, excite 1 time every 3d, continuous agitation 5 times.Back the previous day is excited in the 4th
It is administered 1g, every day 1 time, successive administration 1 week.And excite rear 0h, 72h in the 5th,
Dead 6 rats in every component other places, sampling, the paraformaldehyde solution immersing 4% fixes 24h.
2.2 degree of inflammation dynamic classifications
Respectively before rat is administered, the 5th excite after 0h and the 5th excite after 72h, see
Examine and excite area skin to react, and according to erythema classification of severity: substantially erythema, edema and
Ooze out, or substantially keratinization incrustation note 3 points；Slight erythema, edema, ooze out inconspicuous, or
Moderate keratinization remembers 2 points；Erythema, edema and ooze out the most inconspicuous, or slight keratinization remembers 1 point；
Skin normally remembers 0 point.
2.3 tissue pathological slice inspections
Sample, after paraformaldehyde fixes 24h, takes out, and carries out tissue dewatering, transparent, leaching
Wax, embedding, tissue is carried out longitudinal section parallel slices, slice thickness is 4 μm.Bake for 60 DEG C
Case bakes sheet 2h, 4 DEG C of Refrigerator stores.After HE dyeing, carry out histological observation and analysis.Meter
Calculate inflammatory cell quantity in each group of skin.
3 experimental results
3.1 degree of inflammations compare
There is erythema, light to moderate water in negative group, blank ointment group back compared with normal group
Swollen, ooze out substantially.Bare substrate group compared with normal group, back occur light to moderate erythema,
Edema, oozes out substantially.The most it is not obviously improved after being administered 1 week.
High-concentration and low-concentration eczema ointment group, positive controls the 5th excite rear 0h compared with negative group,
Erythema, edema all alleviate.After 72h, skin surface does not has obvious erythema, edema.Therefore,
Eczema ointment can play good therapeutical effect for eczema.Each group rat back skin lesion situation is commented
Divide and be shown in Table 3.
Table 3: rat back skin lesion situation scoring (n=6, x ± s)
Can be drawn by table 3, high-concentration and low-concentration eczema ointment group, positive controls and negative control group
Compare and all there is significant difference (P value is respectively 0.004,0.002 and 0.021), show
Three groups of medicines all have therapeutic effect to eczema.And high-concentration and low-concentration eczema ointment group and Matrix controls group it
Between all there is significant difference (P=0.003,0.007), high concentration eczema ointment group and the positive are right
According to there is no significant difference (P=0.736) between group, show high concentration eczema ointment group and the positive
Matched group is suitable to the therapeutic effect of eczema, and the therapeutic effect that low concentration eczema ointment group is to eczema
The poorest.
3.2 tissue pathological slice inspections
The tissue slice that HE dyes is placed under optical microscope and carries out histological examination, amplify
Multiple is 400 times, normal skin and be administered before matched group and packet modeling be administered after 0,72
The histological indications of h rat skin section is visible: compare with normal group, negative control group
And bare substrate treated animal epidermis thickens, hyperkeratosis or focal parakeratosis and the incrustation of shallow table,
The situations such as trochanterellus prolongation thickens, and acantholysis cell edema is plump, granular layer is plump；Dermal vascular
Dilatation and congestion, endotheliocytic swelling, intercellular edema, inflammatory cell infiltration (lymphocyte,
Oxyphil cell, mastocyte) etc..Compare with negative control group and bare substrate group, medication
Rear high-concentration and low-concentration eczema ointment and positive controls rat above dermatosis situation are to some extent
Alleviating or suppress the slight keratinization of epidermis, parakeratosis is collections, and the most accidental, and epidermis slightly increases
Thick or thicken inconspicuous, edema cell is accidental；Intradermal minority inflammatory cell infiltration, accidental addicted to
Property granulocyte, vascular endothelial cell has no or only mild swelling.To the inflammation in each group of skin corium
Cell quantity counts, and the results are shown in Table 4.
Table 4: rat dorsum skin inflammatory cell quantity
Can be drawn by table 4, high-concentration and low-concentration eczema ointment group, positive controls and negative control
Group, bare substrate group are compared and all be there is significant difference (P=0.000), show three groups of medicines
Eczema is all had therapeutic effect.
The external preparation therapeutic effect that embodiment 5～7 is provided by the present invention carries out Parallel testing, its
In, the antiinflammatory of embodiment 5 gained external preparation, antipruritic effect and for rat Eczema Model
Therapeutic effect optimal.
Although, used general explanation, detailed description of the invention and test, to this
Bright make detailed description, but on the basis of the present invention, it can have been made some modifications or improvements,
This will be apparent to those skilled in the art.Therefore, without departing from present invention spirit
On the basis of these modifications or improvements, belong to the scope of protection of present invention.
Claims (10)
1. the Chinese medicine composition being used for treating eczema and neurodermatitis, it is characterized in that, it is prepared from by the raw material including following weight portion: Radix Notoginseng 0.5～1.5 parts, Radix Sophorae Flavescentis 2～3 parts, Rhizoma Coptidis 2～3 parts, Rhizoma Paridis 2～3 parts, Rhizoma Atractylodis 1.5～2.5 parts, Cortex Dictamni 1～2 parts, Pericarpium Zanthoxyli 1～2 parts, Radix Glycyrrhizae 2～3 parts.
Chinese medicine composition the most according to claim 1, it is characterised in that be prepared from by the raw material including following weight portion: Radix Notoginseng 1 part, Radix Sophorae Flavescentis 2～3 parts, Rhizoma Coptidis 2～3 parts, Rhizoma Paridis 2～3 parts, Rhizoma Atractylodis 1.5～2.5 parts, Cortex Dictamni 1～2 parts, Pericarpium Zanthoxyli 1～2 parts, Radix Glycyrrhizae 2～3 parts.
Chinese medicine composition the most according to claim 1, it is characterized in that, it is prepared from by the raw material including following weight portion: Radix Notoginseng 0.9～1.1 parts, Radix Sophorae Flavescentis 2.15～2.35 parts, Rhizoma Coptidis 2.4～2.6 parts, Rhizoma Paridis 2～2.2 parts, Rhizoma Atractylodis 1.65～1.85 parts, Cortex Dictamni 1.4～1.6 parts, Pericarpium Zanthoxyli 1.4～1.6 parts, Radix Glycyrrhizae 2.4～2.6 parts；
Preferably, the raw material including following weight portion it is prepared from: Radix Notoginseng 1 part, Radix Sophorae Flavescentis 2.25 parts, Rhizoma Coptidis 2.5 parts, Rhizoma Paridis 2 parts, Rhizoma Atractylodis 1.75 parts, Cortex Dictamni 1.5 parts, 1.5 parts of Pericarpium Zanthoxyli, 2.5 parts of Radix Glycyrrhizae.
4., according to the Chinese medicine composition described in claims 1 to 3 any one, it is characterised in that described Chinese medicine composition uses water extraction, it is prepared at normal pressure, under the conditions of 60～100 DEG C；
Preferably employ the method comprised the steps to be prepared: take raw material, add and account for raw material gross weight 6～the water of 8 times, at normal pressure, extract 2～5 times under the conditions of 60～100 DEG C, each 3～6 hours, united extraction liquid, it is condensed into proportion 1.30～1.33, to obtain final product.
5. the external preparation being used for treating eczema and neurodermatitis, it is characterised in that comprise the Chinese medicine composition described in Claims 1 to 4 any one.
External preparation the most according to claim 5, it is characterised in that comprise the composition of following weight portion: described Chinese medicine composition 0.8～1.2 parts, Calamina 0.2～0.5 part, Borneolum Syntheticum 0.1～0.2 part, aqueous matrix adjuvant 1.5～3 parts, water 5～8.5 parts.
External preparation the most according to claim 6, it is characterised in that described aqueous matrix adjuvant includes one or more in stearic acid, liquid paraffin, triethanolamine, glycerol, stearyl alcohol；
Preferably it is made up of stearic acid, liquid paraffin, triethanolamine, glycerol and stearyl alcohol.
External preparation the most according to claim 7, it is characterised in that described aqueous matrix adjuvant is made up of with weight ratio 1:0.4～0.55:0.05～0.1:0.4～0.55:0.1～0.2 stearic acid, liquid paraffin, triethanolamine, glycerol and stearyl alcohol.
9. the preparation method of external preparation described in claim 5～8 any one, it is characterised in that comprise the steps: to take Chinese medicine composition, Calamina, aqueous matrix adjuvant and water, carry out emulsifying after mixing, add Borneolum Syntheticum after cooling, continue homogenizing, it is cooled to room temperature,.
10. the application in preparation treatment eczema or neurodermatitis medicine of the external preparation described in Chinese medicine composition described in Claims 1 to 4 any one or claim 5～8 any one；It is preferably the application in preparation treatment chronic eczema or neurodermatitis medicine.
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| CN106266876A (en) * | 2016-09-27 | 2017-01-04 | 泰山医学院 | A kind of for compound ointment treating eczema and preparation method thereof |
| CN106362049A (en) * | 2016-10-14 | 2017-02-01 | 柳州环山科技有限公司 | Pure traditional Chinese medicine composition for eczema treatment and preparation method thereof |
| CN107050136A (en) * | 2017-03-13 | 2017-08-18 | 南通蛇类治疗研究所 | Treat the nanometer emulsifiable paste of neurodermatitis |
| CN107551116A (en) * | 2017-10-25 | 2018-01-09 | 杨莉 | A kind of medicine for treating neurodermatitis and preparation method thereof |
| CN115300574A (en) * | 2022-06-24 | 2022-11-08 | 朱明浩 | Application of eczema ointment containing seven kinds of ginseng and coptis in preparation of medicine for treating neurodermatitis |
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| CN115300574A (en) * | 2022-06-24 | 2022-11-08 | 朱明浩 | Application of eczema ointment containing seven kinds of ginseng and coptis in preparation of medicine for treating neurodermatitis |
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