CN114099623A - Dehumidifying and itching-relieving ointment and preparation method thereof - Google Patents

Dehumidifying and itching-relieving ointment and preparation method thereof Download PDF

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CN114099623A
CN114099623A CN202111197790.3A CN202111197790A CN114099623A CN 114099623 A CN114099623 A CN 114099623A CN 202111197790 A CN202111197790 A CN 202111197790A CN 114099623 A CN114099623 A CN 114099623A
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parts
weight
ointment
itching
fructus
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李记泉
李思佳
戴俭宇
金颖
王巍
马铁明
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Liaoning University of Traditional Chinese Medicine
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Liaoning University of Traditional Chinese Medicine
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Abstract

The invention belongs to the technical field of traditional Chinese medicine external preparations, and particularly relates to a dehumidifying and itching-relieving ointment and a preparation method thereof. The dehumidifying and itching-relieving ointment is prepared from the following medicinal materials in parts by mass: rhizoma Atractylodis, cortex Phellodendri, Coptidis rhizoma, radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae, cortex pseudolaricis, radix Angelicae sinensis, Kochiae fructus, fructus Cnidii, fructus Zanthoxyli, and calcined calamine micropowder; the auxiliary material comprises borneol, sesame oil and white vaseline, has reasonable design, has the effects of clearing away heat and toxic materials, removing dampness and relieving itching, and promoting granulation and healing sores, and has obvious curative effects on eczema, urticaria, acute dermatitis, herpes zoster acute stage, acne, mosquito bite and other erythra and pruritus skin diseases.

Description

Dehumidifying and itching-relieving ointment and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine external preparations, in particular to a dehumidifying and itching-relieving ointment and a preparation method thereof.
Background
Being the largest organ of the human body, the skin is the main barrier against the outside world. Skin diseases are often life threatening, and thus attention and money are often invested in diseases that are considered more serious, however, the psychosocial and occupational impact of skin diseases is often comparable to other chronic diseases. Five european countries report a lifetime epidemic of skin diseases including eczema (14.2%), atopic dermatitis (7.9%), psoriasis (5.2%) and albinism (1.9%). The pathogenesis of the skin disease is complex, and the skin disease is usually the result of the interaction of internal factors and external factors, wherein the internal factors comprise chronic digestive system diseases, mental stress, insomnia, overfatigue, mood changes, endocrine dyscrasia, infection, metabolic disorder and the like, and the external factors comprise living environment, climate changes, food or drug allergy and the like which can influence the occurrence of eczema. In recent years, the incidence of skin diseases such as eczema, urticaria and herpes zoster has been increasing year by year with changes in environmental climate, eating habits, work and rest laws, living habits, contact with articles and the like. Global disease burden studies have investigated the disability and mortality caused by global skin diseases and have shown that skin and subcutaneous diseases are the fourth leading cause of disability worldwide. Skin diseases have become a global public health problem and often have physiological, psychological and social effects. Many skin disorders have a chronic and repetitive process that requires us to treat the disease and help patients to adapt positively.
In international pharmaceutical research, transdermal absorption preparations have become a hot topic of formulation research after oral preparations and injection preparations. The ointment is a main preparation form of an external administration route for treating the skin diseases, and the unique advantage of not passing through the first pass effect of the liver and the damage of the gastrointestinal tract is the key reason of attracting people to use the ointment, so that the toxicity and the side effect of the medicine are greatly reduced, and the clinical curative effect is improved. The ointment is a semisolid external preparation with proper consistency prepared by uniformly mixing the medicine and a proper matrix, can be attached, adhered or spread on an application part for a long time after application, and can even enter blood circulation to play a role in systemic treatment after being absorbed through skin, thereby improving the utilization rate of transdermal absorption of the medicine. The external preparation is directly acted on the skin and locally absorbed through the epidermis, thereby achieving the effects of resisting infection, protecting the skin, reducing swelling, detoxifying, clearing heat, relieving itching and the like. The current market tends to be humanized more and more, and skin disease ointment products with various styles and different curative effects are produced according to the needs of people. Most of the existing itching relieving ointments can control short-term clinical symptoms in different degrees, but the long-term effect needs to be improved, and many ointments have large irritation to skin and relatively low patient compliance. Therefore, based on research results of years on external ointment for preventing and treating skin diseases such as eczema, urticaria, herpes zoster and the like, the dehumidifying and itching-relieving ointment which is remarkable in curative effect, simple and convenient to use and free of toxic and side effects and the preparation method thereof are prepared, and the problems are solved.
Disclosure of Invention
This section is for the purpose of summarizing some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. In this section, as well as in the abstract and the title of the invention of this application, simplifications or omissions may be made to avoid obscuring the purpose of the section, the abstract and the title, and such simplifications or omissions are not intended to limit the scope of the invention.
In order to solve the problems in the prior art, the invention provides the dehumidifying and itching-relieving ointment and the preparation method thereof, the ointment has the functions of clearing away heat and toxic materials, dehumidifying and relieving itching, promoting tissue regeneration and healing sores, and can provide a whole set of prevention and treatment methods for treating erythra and pruritus skin diseases such as eczema, urticaria, acute dermatitis, herpes zoster (acute stage), acne, mosquito bite and the like, and related diseases such as burn, scald and the like.
To solve the above technical problem, according to an aspect of the present invention, the present invention provides the following technical solutions:
the dehumidifying and itching-relieving ointment is prepared from the following medicinal materials in parts by mass: rhizoma Atractylodis, cortex Phellodendri, Coptidis rhizoma, radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae, cortex pseudolaricis, radix Angelicae sinensis, Kochiae fructus, fructus Cnidii, fructus Zanthoxyli, and calcined calamine micropowder; the additional materials comprise Borneolum Syntheticum, oleum Sesami, and white vaseline. The invention has the functions of clearing away heat and toxic material, eliminating dampness and relieving itching, and promoting tissue regeneration and healing sore, and provides a whole set of prevention and treatment methods for treating erythra and pruritus skin diseases such as eczema, urticaria, acute dermatitis, herpes zoster (acute stage), acne, mosquito bite and the like, and related diseases such as burn, scald and the like.
As a preferable scheme of the dehumidifying and itching-relieving ointment and the preparation method thereof, the dehumidifying and itching-relieving ointment comprises the following components in parts by weight: the Chinese medicinal composition comprises the following components in parts by weight: 5-10 parts of rhizoma atractylodis, 5-10 parts of phellodendron, 5-10 parts of coptis chinensis, 5-10 parts of radix sophorae flavescentis, 5-10 parts of dittany bark, 5-10 parts of radix stemonae, 5-10 parts of cortex pseudolaricis, 5-10 parts of angelica sinensis, 5-10 parts of fructus kochiae, 5-10 parts of fructus cnidii, 2-3 parts of pepper and 5-10 parts of calcined calamine ultrafine powder.
As a preferable scheme of the dehumidifying and itching-relieving ointment and the preparation method thereof, the dehumidifying and itching-relieving ointment comprises the following components in parts by weight: the additional materials comprise 6 to 8 weight parts of borneol, 80 to 100 weight parts of sesame oil and 120 weight parts of white vaseline.
As a preferable scheme of the dehumidifying and itching-relieving ointment and the preparation method thereof, the dehumidifying and itching-relieving ointment comprises the following components in parts by weight: the method comprises the following steps:
step 1: soaking the medicinal materials in sesame oil: firstly, weighing 5-10 parts by weight of rhizoma atractylodis, 5-10 parts by weight of phellodendron, 5-10 parts by weight of coptis, 5-10 parts by weight of radix sophorae flavescentis, 5-10 parts by weight of dittany bark, 5-10 parts by weight of radix stemonae, 5-10 parts by weight of golden larch bark, 5-10 parts by weight of angelica, 5-10 parts by weight of fructus kochiae, 5-10 parts by weight of fructus cnidii, 2-3 parts by weight of pepper and 80-100 parts by weight of sesame oil; adding 1/3 weight parts of sesame oil into 5-10 weight parts of fructus Kochiae, 5-10 weight parts of fructus Cnidii and 2-3 weight parts of fructus Zanthoxyli, mixing, and soaking for 12-24 hr; taking 2/3 parts of sesame oil, adding 5-10 parts of rhizoma atractylodis, 5-10 parts of phellodendron, 5-10 parts of coptis, 5-10 parts of radix sophorae flavescentis, 5-10 parts of dittany bark, 5-10 parts of radix stemonae, 5-10 parts of golden larch bark and 5-10 parts of angelica, uniformly mixing, and soaking for 12-24 hours;
step 2: heating and soaking a sesame oil mixture containing 5-10 parts by weight of fructus kochiae, 5-10 parts by weight of fructus cnidii and 2-3 parts by weight of pepper on a small fire, repeatedly stirring until slight smoking, removing residues and leaving oil; pouring a sesame oil mixture which is soaked with 5-10 parts by weight of rhizoma atractylodis, 5-10 parts by weight of phellodendron, 5-10 parts by weight of coptis, 5-10 parts by weight of radix sophorae flavescentis, 5-10 parts by weight of dittany bark, 5-10 parts by weight of radix stemonae, 5-10 parts by weight of golden larch bark and 5-10 parts by weight of angelica, repeatedly stirring until slight smoking, removing residues and leaving oil;
and step 3: turning off the fire source, putting the smashed 6-8 parts by weight of borneol into the sesame oil mixture obtained in the step (2) while the mixture is hot, and repeatedly stirring until the borneol is completely melted;
and 4, step 4: adding 120 parts by weight of white vaseline into 100-120 parts by weight of the mixture while the mixture is hot, and repeatedly stirring until the white vaseline is completely melted;
and 5: adding 5-10 parts by weight of calcined calamine ultra-fine powder while the mixture is hot, and continuously and uniformly stirring until the calcined calamine ultra-fine powder is uniformly mixed;
step 6: and (3) uniformly stirring the mixture obtained in the step (5), cooling to a proper temperature (about 50-60 ℃), subpackaging into small packaging boxes, and storing at normal temperature in a dark place for later use.
As a preferable scheme of the dehumidifying and itching-relieving ointment and the preparation method thereof, the dehumidifying and itching-relieving ointment comprises the following components in parts by weight: the method comprises the steps of putting herbs into a sequence, respectively soaking the medicinal materials of rhizome and grass seed, and respectively heating and extracting the effective ingredients of the medicinal materials, so as to avoid the condition that the medicinal effective ingredients are not completely extracted due to excessive heating of grass seed medicines and uniform non-heating of the rhizome medicines when different medicines are mixed for soaking and heating.
As a preferable scheme of the dehumidifying and itching-relieving ointment and the preparation method thereof, the dehumidifying and itching-relieving ointment comprises the following components in parts by weight: the calcined calamine powder is ultrafine powder, the dosage is not more than 10 parts by weight, otherwise, precipitates are easily formed in the cooling process, and the calcined calamine powder is unevenly distributed when the ointment is subpackaged; the Borneolum has effects of refreshing, relieving exterior syndrome, dispersing pathogen, and relieving itching, and its dosage can be adjusted according to the severity of disease.
Compared with the prior art, the invention has the beneficial effects that: rhizoma atractylodis, phellodendron bark and coptis chinensis: clearing heat and removing toxicity, and eliminating dampness; radix sophorae flavescentis, dittany bark, fructus kochiae, fructus cnidii, radix stemonae, golden larch bark and pepper: the drug for the team to clear away heat and toxic material, remove dampness and relieve itching; borneol: the transdermal itching relieving effect is increased; chinese angelica: nourishing blood, promoting blood circulation, and promoting recovery of skin injury; calcined calamine powder: astringe dampness and heal wound, remove toxicity and relieve itching, which is a common herb for astringing dampness and healing wound in dermatology; and (3) sesame oil: as an extractant, can moisten skin and promote tissue regeneration; vaseline oil: as an excipient, the skin-moistening and tissue-regenerating ointment has the effects of clearing away heat and toxic materials, removing dampness, relieving itching, promoting tissue regeneration and healing sores, and has obvious curative effects on eczema, urticaria, acute dermatitis, herpes zoster in an acute stage, acne, mosquito bites and other erythra and pruritus skin diseases.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the present invention will be described in detail with reference to the accompanying drawings and detailed embodiments, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise. Wherein:
FIG. 1 is a flow chart of the preparation process of the dehumidifying itching-relieving ointment of the invention;
FIG. 2 is a schematic view of an experimental process in example 1 of the present invention;
FIG. 3 is a comparative graph in the test case of example 1 of the present invention (A: diluted anti-ovalbumin serum after dorsal intradermal injection, B: after modeling of blank rat PCA, C: after modeling of model rat PCA);
FIG. 4 shows the number of scratching changes in example 1 of the present invention;
FIG. 5 shows the change in the diameter of the wheal of the Lanzhou sky in example 1 of the present invention;
FIG. 6 shows the variation of the amount of Evans blue exuded in example 1 of the present invention;
FIG. 7 shows the change in the expression of IgE and histamine in the skin in example 1 of the present invention.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described herein, and it will be apparent to those of ordinary skill in the art that the present invention may be practiced without departing from the spirit and scope of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
Next, the present invention will be described in detail with reference to the drawings, wherein for convenience of illustration, the cross-sectional view of the device structure is not enlarged partially according to the general scale, and the drawings are only examples, which should not limit the scope of the present invention. In addition, the three-dimensional dimensions of length, width and depth should be included in the actual fabrication.
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.
The invention provides a dehumidifying and itching-relieving ointment which is prepared from the following medicinal materials in parts by mass: 5-10 parts of rhizoma atractylodis, 5-10 parts of phellodendron, 5-10 parts of coptis chinensis, 5-10 parts of radix sophorae flavescentis, 5-10 parts of dittany bark, 5-10 parts of radix stemonae, 5-10 parts of cortex pseudolaricis, 5-10 parts of angelica sinensis, 5-10 parts of fructus kochiae, 5-10 parts of fructus cnidii, 2-3 parts of pepper and 5-10 parts of calcined calamine ultrafine powder. Wherein the additional material comprises 6 to 8 weight parts of borneol, 80 to 100 weight parts of sesame oil and 120 weight parts of white vaseline.
Based on the research of the inventor on skin diseases for many years, the skin diseases are located in skin striae, damp-heat stasis and qi and blood are the most common pathological mechanism of the heat syndrome of the skin diseases, red swelling and pruritus are the most common clinical symptoms of the skin diseases, and deficiency-excess mixed syndromes of heat toxin stagnation and skin malnutrition are complex syndromes that the skin diseases cannot be cured for a long time. The invention is specially designed for damp-heat syndrome dermatosis, including eczema, urticaria, acute dermatitis, herpes zoster (acute stage), acne, erythra and pruritus dermatosis such as mosquito bite and the like, and related diseases such as burn, scald and the like.
The monarch drug of the invention is radix sophorae flavescentis, dittany bark, rhizoma atractylodis and cortex phellodendri: the sophora flavescens clears heat and dries dampness, kills parasites and relieves itching, is a first-choice medicine for treating eczema, skin itch and mange leprosy; cang Zhu can dry dampness and dispel wind to relieve itching; phellodendron bark, cortex Phellodendri has effects of clearing heat, eliminating dampness, removing toxic substance, and treating sore, eczema and eczema; cortex Dictamni Radicis has effects of dispelling pathogenic wind, eliminating dampness, clearing heat and detoxicating, and can be used for treating wind-heat sore, scabies, tinea, and skin prurigo. The ministerial drugs are coptis chinensis, radix stemonae, golden larch bark, angelica, fructus kochiae and fructus cnidii: coptis root, rhizoma Coptidis clears heat and dampness, purges fire and removes toxicity, and can clear heat and toxicity of skin; killing insects and lice on the sessile stemona root and treating pruritus; cortex pseudolaricis has effects of killing parasite, treating tinea, and relieving itching, and can be used for treating scabies, tinea and pruritus; the angelica sinensis can nourish blood and blood, nourish skin, the belvedere fruit can clear heat, promote diuresis, dispel wind and relieve itching, and treat rubella, eczema and skin pruritus, and the common cnidium fruit can eliminate dampness, dispel wind, kill parasites and relieve itching, and is mainly used for treating eczema pruritus. The adjuvant drugs are pepper, calcined calamine powder and borneol: the Chinese prickly ash can kill parasites and relieve itching, and can be used for treating eczema and pruritus by external application; calcined calamine powder has the effects of astringing dampness, relieving itching and healing sore, and can be used for treating eczema and pruritus; borneol has the functions of clearing away heat and toxic material, preventing corrosion and promoting granulation, and can be used for treating sore and ulcer with swelling and pain, and unhealing after ulceration. The guiding drugs are sesame oil and white vaseline: the two components can nourish skin and improve skin dryness, while the white vaseline can be used as excipient to fix the liquid medicine to form ointment. Therefore, the monarch, minister, assistant and guide medicines are precise and appropriate in compatibility, have the effects of clearing heat and removing toxicity, removing dampness and relieving itching, and promoting granulation and healing sores, and can treat erythra and pruritus skin diseases such as eczema, urticaria, acute dermatitis, herpes zoster (acute stage), acne, mosquito bites and the like, and damp-heat syndrome skin diseases such as burns, scalds and the like.
As shown in fig. 1, the preparation process of the present invention comprises the following steps:
step 1: soaking the medicinal materials in sesame oil: firstly, weighing 5-10 parts by weight of rhizoma atractylodis, 5-10 parts by weight of phellodendron, 5-10 parts by weight of coptis, 5-10 parts by weight of radix sophorae flavescentis, 5-10 parts by weight of dittany bark, 5-10 parts by weight of radix stemonae, 5-10 parts by weight of golden larch bark, 5-10 parts by weight of angelica, 5-10 parts by weight of fructus kochiae, 5-10 parts by weight of fructus cnidii, 2-3 parts by weight of pepper and 80-100 parts by weight of sesame oil; adding 1/3 weight parts of sesame oil into 5-10 weight parts of fructus Kochiae, 5-10 weight parts of fructus Cnidii and 2-3 weight parts of fructus Zanthoxyli, mixing, and soaking for 12-24 hr; taking 2/3 parts of sesame oil, adding 5-10 parts of rhizoma atractylodis, 5-10 parts of phellodendron, 5-10 parts of coptis, 5-10 parts of radix sophorae flavescentis, 5-10 parts of dittany bark, 5-10 parts of radix stemonae, 5-10 parts of golden larch bark and 5-10 parts of angelica, uniformly mixing, and soaking for 12-24 hours;
step 2: heating and soaking a sesame oil mixture containing 5-10 parts by weight of fructus kochiae, 5-10 parts by weight of fructus cnidii and 2-3 parts by weight of pepper on a small fire, repeatedly stirring until slight smoking, removing residues and leaving oil; pouring a sesame oil mixture which is soaked with 5-10 parts by weight of rhizoma atractylodis, 5-10 parts by weight of phellodendron, 5-10 parts by weight of coptis, 5-10 parts by weight of radix sophorae flavescentis, 5-10 parts by weight of dittany bark, 5-10 parts by weight of radix stemonae, 5-10 parts by weight of golden larch bark and 5-10 parts by weight of angelica, repeatedly stirring until slight smoking, removing residues and leaving oil;
and step 3: turning off the fire source, putting the smashed 6-8 parts by weight of borneol into the sesame oil mixture obtained in the step (2) while the mixture is hot, and repeatedly stirring until the borneol is completely melted;
and 4, step 4: adding 120 parts by weight of white vaseline into 100-120 parts by weight of the mixture while the mixture is hot, and repeatedly stirring until the white vaseline is completely melted;
and 5: adding 5-10 parts by weight of calcined calamine ultra-fine powder while the mixture is hot, and continuously and uniformly stirring until the calcined calamine ultra-fine powder is uniformly mixed;
step 6: and (3) uniformly stirring the mixture obtained in the step (5), cooling to a proper temperature (about 50-60 ℃), subpackaging into small packaging boxes, and storing at normal temperature in a dark place for later use.
The following is a preferred embodiment 1 of the present invention
(1) Dispensing: weighing 50 g of rhizoma atractylodis, 50 g of phellodendron, 50 g of coptis, 50 g of radix sophorae flavescentis, 50 g of dittany bark, 50 g of radix stemonae, 50 g of golden larch bark, 50 g of angelica, 50 g of fructus kochiae, 50 g of fructus cnidii, 20 g of pepper, 50 g of calcined calamine powder, 60 g of borneol, 1000 g of sesame oil and 1200 g of white vaseline
(2) Soaking the medicinal materials in sesame oil: respectively soaking 50 g of rhizoma atractylodis, 50 g of phellodendron, 50 g of coptis, 50 g of radix sophorae flavescentis, 50 g of dittany bark, 50 g of radix stemonae, 50 g of golden larch bark, 50 g of angelica, 50 g of fructus kochiae, 50 g of fructus cnidii and 20 g of pepper in 1200 g of sesame oil in the step (1);
(3) heating: heating and soaking a sesame oil mixture of 50 g of fructus kochiae, 50 g of fructus cnidii and 20 g of pepper by using small fire, repeatedly stirring until the smoke is slightly emitted, and removing residues to leave oil; adding sesame oil mixture of 50 g of soaked rhizoma atractylodis, 50 g of phellodendron, 50 g of coptis chinensis, 50 g of sophora flavescens, 50 g of dittany bark, 50 g of radix stemonae, 50 g of golden larch bark and 50 g of angelica sinensis, repeatedly stirring until slight smoking, removing residues and leaving oil;
(4) melting the borneol: turning off a fire source, putting 60 g of smashed borneol into the sesame oil mixture obtained in the step (3) while the mixture is hot, and repeatedly stirring until the borneol is completely melted;
(5) melting Vaseline: 1200 g of white vaseline is added while the mixture is hot, and the mixture is repeatedly stirred until the white vaseline is completely melted;
(6) uniformly mixing the calamine ultrafine powder: adding 50 g of calcined calamine ultrafine powder while the raw materials are hot, and continuously stirring the raw materials uniformly until the calcined calamine ultrafine powder is uniformly mixed;
(7) cooling, packaging and storing: and (4) uniformly stirring the mixture obtained in the step (6), cooling to a proper temperature (about 50-60 ℃), subpackaging into small packaging boxes, and storing at normal temperature in a dark place for later use.
The dehumidifying and itching-relieving ointment prepared by the invention has the effects of clearing heat, eliminating dampness, dispelling wind and relieving itching, and is suitable for the auxiliary treatment of eczema, urticaria, acute dermatitis, herpes zoster (acute stage), acne, mosquito bites and other erythra and pruritus skin diseases, and burns, scalds and other related diseases. The ointment can be automatically absorbed by skin, and applied to affected part 3-4 times a day.
(first) Experimental protocol
1. Experimental animals:
healthy male SD rats (SPF grade) 35 with body weight of 200 + -15 g and 6-8 weeks old are from Liaoning Biotechnology GmbH, Inc., license number SCXK (Liao) 2020-one 0001. The animal experiment conforms to the ethical committee standard of experimental animals of Liaoning traditional Chinese medicine university, and the animal ethical examination number is 21000042020047. All rats had free water and food intake at constant temperature of 23 + -3 deg.C and humidity of 40% -70%, and were subjected to adaptive feeding for 1 week before experiments were performed.
2. Drugs and reagents
BX51 model general optical microscope (olympus, japan); dW-HL388 type ultra-low temperature refrigerator (Mitsubishi of Chinese family); model CM1850-1-1 cryomicrotomes (Leica, Germany); disposable Huatuo brand acupuncture needle (Suzhou medical supplies Co., Ltd.) of 0.20mm × 25 mm; an SDZ-II type Huatuo brand electronic acupuncture instrument (Suzhou medical supplies Co., Ltd.); model Fresco 17 high speed refrigerated centrifuge (Thermo Scientific, usa); model BI-2000 medical image analysis system (dongtai alliance software limited); an electronic balance of the XPR5003S type (METTLER, switzerland); computer full-automatic dyeing machine model LST 94 (Histo-line, italy); ATP 700 type computer full automatic dehydrator (Histo-line, italy); YD-6L type biological tissue embedding machine (Leica, Germany); model RM2235 paraffin wax microtomes (Leica, germany); YD-a type biological tissue slide machine (yidi medical treatment); YD-B type biological tissue roasting machine (yidi medical treatment); YD-6L type biological tissue embedding machine (yidi medical treatment); YD-6L type biological tissue freezing station (yidi medical); f3 micropipette (siemer flyer, usa); model S10-2 constant temperature magnetic stirrer (selement instrument); anti-shedding slides (Saimer air, USA).
Gold-standard grade egg white albumin (source leaf organism, S12015), bacillus calmette-guerin vaccine for injection (shanghai biologicals institute, 201908082), evans blue (shanghai bamman organism, C0044), HE staining kit (beijing etae organism, YT8681), phosphate buffer (U.S. Caisson Labs, PBL06), paraformaldehyde (U.S. Sigma-Aldrich, P6148), toluidine blue (chinese Baomanbio, C0052), loratadine (U.S. med chem Express, HY-17043), chloral hydrate (shanghai ge to biochemistry, C11360), Hanks buffer (bosd organism, 15J10a80), TWEEN-20 (shanghai bi yutian, ST825), TRIS (U.S. ananbis, 6003), MAKER (shanghai bi yunnan, P0075), BCA protein quantification (shanghai yunnan biyunnan S), ECL (shanghai biyunnan, P0012), ECL (shanghai biyunnan P0288), bayunnan biyunnan (P466), pike P0285), and pike.
3. Preparation of anti-ovalbumin serum
After the experiment was started, 3 rats were randomly selected and sensitized with egg albumin and bcg vaccine by joint injection for 3 times every other day, 1 time every other day. 10 days after the last sensitization, taking abdominal aorta blood, centrifuging and taking serum to prepare allogeneic rat anti-chicken ovalbumin serum, diluting with physiological saline, and storing at-20 ℃ for later use.
4. Animal model establishment and intervention measures
The remaining 32 rats were randomly divided into a blank group, a model group, a ointment group and a western medicine group, 8 per group. The experiment adopts a pretreatment intervention method, and the time nodes implemented by the intervention methods of all groups of rats start 7 days before antigen attack (material drawing). 7 days before material taking, after adopting chloral hydrate to perform intraperitoneal injection for shallow anesthesia, cutting off mouse hairs in a region with a distance of 3cm on two sides of a back spine, selecting 3 points with a distance of 1cm on two sides of the spine in the region, and marking by a marker pen to be used as an injection-planned site. The experimental intervention method comprises the following steps: the ointment group is smeared with dehumidifying and itching relieving ointment on the back of a rat, the western medicine group adopts loratadine diluent for intragastric administration, and the model group and the blank group of rats are not interfered for 1 time/day for 7 consecutive days. The blank group is injected with physiological saline (0.1 ml/point) in the skin of the injection site before drawing materials for 2 days, and the rats of the model group, the ointment group and the western medicine group are injected with diluted anti-ovalbumin serum (0.1 ml/point) in the skin of the injection site on the back. After 48h, each group of rats was subjected to antigen challenge by tail vein injection of ovalbumin diluent and physiological saline of evans blue (1ml/100g), thereby establishing a rat model of urticaria. FIG. 2 is a schematic diagram of the experimental procedure.
5. Index of material drawing and detection
After the model is established, the frequency of scratching the sensitized parts on the back of the rat is recorded, and the material is taken after half an hour. The ruler measures the area of the blue spot wheal of the skin of the sensitization part on the back of the rat, the toluidine blue staining method observes the degranulation shape and the number of the MCs of the subcutaneous loose connective tissue, the HE staining method detects the pathological change of the skin tissue of the sensitization part on the back, and the ELISA method detects the content of the IgE and the histamine of the skin tissue of the sensitization part on the back. During the course of the experiment, the general state of each group of rats was observed and recorded.
(II) results of the experiment
1. Variation of number of scratching
The blank group showed no significant back scratching behavior; compared with the blank group, the scratching times of the model group are obviously increased (P < 0.01); compared with the model group, the scratching times of the ointment group and the western medicine group are obviously reduced (P is less than 0.05, and P is less than 0.01); compared with the ointment group, the scratching times of the western medicine group have no obvious change, and the difference has no statistical significance (P is more than 0.05).
2. Skin blue spot wheal diameter variation
The rats in the blank group do not have the wheal; compared with the blank group, the skin at the sensitization part of the model group has obvious bluish spot wheal (P is less than 0.01); compared with the model group, the diameters of the whelk patches of the ointment group and the western medicine group are obviously reduced (P <0.01), the diameters of the whelk patches of the western medicine group are slightly reduced, but the difference is not statistically significant (P > 0.05). FIG. 3 shows the change of the blue spot on the back of a rat.
3. Variation in the amount of Evensky blue exuded from the skin
The infiltration amount of the blank group of Evans blue is less; compared with a blank group, the evans blue exudation amount of the model group is obviously increased (P < 0.01); compared with the model group, the evans blue seepage amount of the ointment group and the western medicine group is obviously reduced (P is less than 0.01); compared with the ointment group, the evans blue seepage amount of the western medicine group is slightly reduced, but the difference is not statistically significant (P > 0.05).
4. Change in skin IgE, Histamine expression
Compared with a blank group, the expression of IgE and histamine of the skin tissue of the model group is obviously increased (P < 0.01); compared with the model group, the skin tissue IgE and histamine expression of the ointment group and the western medicine group are obviously reduced (P is less than 0.05, and P is less than 0.01); compared with the ointment group, the skin tissue histamine expression of the western medicine group is obviously reduced (P <0.05), the IgE expression is slightly reduced, but the difference is not statistically significant (P > 0.05).
While the invention has been described above with reference to an embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, the various features of the disclosed embodiments of the invention may be used in any combination, provided that no structural conflict exists, and the combinations are not exhaustively described in this specification merely for the sake of brevity and resource conservation. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims (6)

1. The dehumidifying and itching-relieving ointment is characterized in that: is prepared from the following medicinal materials in percentage by mass: rhizoma Atractylodis, cortex Phellodendri, Coptidis rhizoma, radix Sophorae Flavescentis, cortex Dictamni Radicis, radix Stemonae, cortex pseudolaricis, radix Angelicae sinensis, Kochiae fructus, fructus Cnidii, fructus Zanthoxyli, and calcined calamine micropowder; the additional materials comprise Borneolum Syntheticum, oleum Sesami, and white vaseline. The invention has the functions of clearing away heat and toxic material, eliminating dampness and relieving itching, and promoting tissue regeneration and healing sore, and provides a whole set of prevention and treatment methods for treating erythra and pruritus skin diseases such as eczema, urticaria, acute dermatitis, herpes zoster (acute stage), acne, mosquito bite and the like, and related diseases such as burn, scald and the like.
2. The ointment of claim 1, which is characterized in that: the Chinese medicinal composition comprises the following components in parts by weight: 5-10 parts of rhizoma atractylodis, 5-10 parts of phellodendron, 5-10 parts of coptis chinensis, 5-10 parts of radix sophorae flavescentis, 5-10 parts of dittany bark, 5-10 parts of radix stemonae, 5-10 parts of cortex pseudolaricis, 5-10 parts of angelica sinensis, 5-10 parts of fructus kochiae, 5-10 parts of fructus cnidii, 2-3 parts of pepper and 5-10 parts of calcined calamine ultrafine powder.
3. The ointment of claim 2, which is characterized in that: the additional materials comprise 6 to 8 weight parts of borneol, 80 to 100 weight parts of sesame oil and 120 weight parts of white vaseline.
4. The method for preparing the ointment for removing dampness and relieving itching according to any one of claims 1 to 3, wherein the ointment comprises the following components: the method comprises the following steps:
step 1: soaking the medicinal materials in sesame oil: firstly, weighing 5-10 parts by weight of rhizoma atractylodis, 5-10 parts by weight of phellodendron, 5-10 parts by weight of coptis, 5-10 parts by weight of radix sophorae flavescentis, 5-10 parts by weight of dittany bark, 5-10 parts by weight of radix stemonae, 5-10 parts by weight of golden larch bark, 5-10 parts by weight of angelica, 5-10 parts by weight of fructus kochiae, 5-10 parts by weight of fructus cnidii, 2-3 parts by weight of pepper and 80-100 parts by weight of sesame oil; adding 1/3 weight parts of sesame oil into 5-10 weight parts of fructus Kochiae, 5-10 weight parts of fructus Cnidii and 2-3 weight parts of fructus Zanthoxyli, mixing, and soaking for 12-24 hr; taking 2/3 parts of sesame oil, adding 5-10 parts of rhizoma atractylodis, 5-10 parts of phellodendron, 5-10 parts of coptis, 5-10 parts of radix sophorae flavescentis, 5-10 parts of dittany bark, 5-10 parts of radix stemonae, 5-10 parts of golden larch bark and 5-10 parts of angelica, uniformly mixing, and soaking for 12-24 hours;
step 2: heating and soaking a sesame oil mixture containing 5-10 parts by weight of fructus kochiae, 5-10 parts by weight of fructus cnidii and 2-3 parts by weight of pepper on a small fire, repeatedly stirring until slight smoking, removing residues and leaving oil; pouring a sesame oil mixture which is soaked with 5-10 parts by weight of rhizoma atractylodis, 5-10 parts by weight of phellodendron, 5-10 parts by weight of coptis, 5-10 parts by weight of radix sophorae flavescentis, 5-10 parts by weight of dittany bark, 5-10 parts by weight of radix stemonae, 5-10 parts by weight of golden larch bark and 5-10 parts by weight of angelica, repeatedly stirring until slight smoking, removing residues and leaving oil;
and step 3: turning off the fire source, putting the smashed 6-8 parts by weight of borneol into the sesame oil mixture obtained in the step (2) while the mixture is hot, and repeatedly stirring until the borneol is completely melted;
and 4, step 4: adding 120 parts by weight of white vaseline into 100-120 parts by weight of the mixture while the mixture is hot, and repeatedly stirring until the white vaseline is completely melted;
and 5: adding 5-10 parts by weight of calcined calamine ultra-fine powder while the mixture is hot, and continuously and uniformly stirring until the calcined calamine ultra-fine powder is uniformly mixed;
step 6: and (3) uniformly stirring the mixture obtained in the step (5), cooling to a proper temperature (about 50-60 ℃), subpackaging into small packaging boxes, and storing at normal temperature in a dark place for later use.
5. The preparation method of the ointment for removing dampness and relieving itching as claimed in claim 3, wherein the ointment comprises the following components: the method comprises the steps of putting herbs into a sequence, respectively soaking the medicinal materials of rhizome and grass seed, and respectively heating and extracting the effective ingredients of the medicinal materials, so as to avoid the condition that the medicinal effective ingredients are not completely extracted due to excessive heating of grass seed medicines and uniform non-heating of the rhizome medicines when different medicines are mixed for soaking and heating.
6. The preparation method of the ointment for removing dampness and relieving itching as claimed in claim 3, wherein the ointment comprises the following components: the calcined calamine powder is ultrafine powder, the dosage is not more than 10 parts by weight, otherwise, precipitates are easily formed in the cooling process, and the calcined calamine powder is unevenly distributed when the ointment is subpackaged; the Borneolum has effects of refreshing, relieving exterior syndrome, dispersing pathogen, and relieving itching, and its dosage can be adjusted according to the severity of disease.
CN202111197790.3A 2021-10-14 2021-10-14 Dehumidifying and itching-relieving ointment and preparation method thereof Pending CN114099623A (en)

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Application publication date: 20220301