CN107108672B - 稠合的五环咪唑衍生物 - Google Patents

稠合的五环咪唑衍生物 Download PDF

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CN107108672B
CN107108672B CN201580053711.8A CN201580053711A CN107108672B CN 107108672 B CN107108672 B CN 107108672B CN 201580053711 A CN201580053711 A CN 201580053711A CN 107108672 B CN107108672 B CN 107108672B
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alkyl
group
formula
radical
represents hydrogen
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CN107108672A (zh
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T·德哈罗加西亚
M·德利尼
J·P·希尔
J·R·昆西
宣梦阳
朱昭宁
D·C·布鲁金斯
M·D·卡尔米亚诺
Y·埃夫拉尔
M·C·哈钦斯
J·A·约翰逊
S·雅多
J·凯阿尔特斯
M·麦科斯
M·D·塞尔比
M·A·肖
D·L·L·斯温嫩
L·斯基奥
Y·福里谢
B·菲洛什-罗梅
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Match Norfin Inc
UCB SA
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Match Norfin Inc
UCB SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A—HUMAN NECESSITIES
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
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  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580053711.8A 2014-10-03 2015-10-02 稠合的五环咪唑衍生物 Active CN107108672B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP14290299 2014-10-03
EP14290299.8 2014-10-03
EP15162641.3 2015-04-07
EP15162641 2015-04-07
EP15171036 2015-06-08
EP15171036.5 2015-06-08
PCT/EP2015/072868 WO2016050975A1 (en) 2014-10-03 2015-10-02 Fused pentacyclic imidazole derivatives

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CN107108672A CN107108672A (zh) 2017-08-29
CN107108672B true CN107108672B (zh) 2019-11-08

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US (3) US10202405B2 (OSRAM)
EP (1) EP3201196B1 (OSRAM)
JP (1) JP6629847B2 (OSRAM)
KR (1) KR102442235B1 (OSRAM)
CN (1) CN107108672B (OSRAM)
AP (1) AP2017009809A0 (OSRAM)
AU (1) AU2015326798B2 (OSRAM)
BR (1) BR112017006669B1 (OSRAM)
CA (1) CA2962826C (OSRAM)
CL (1) CL2017000787A1 (OSRAM)
CO (1) CO2017003331A2 (OSRAM)
CR (1) CR20170167A (OSRAM)
DK (1) DK3201196T3 (OSRAM)
EA (1) EA032839B1 (OSRAM)
EC (1) ECSP17027306A (OSRAM)
ES (1) ES2885432T3 (OSRAM)
GT (1) GT201700044A (OSRAM)
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HU (1) HUE056133T2 (OSRAM)
IL (1) IL251147B (OSRAM)
LT (1) LT3201196T (OSRAM)
MA (1) MA40770B1 (OSRAM)
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ES2951837T3 (es) * 2018-10-24 2023-10-25 UCB Biopharma SRL Derivados de imidazol pentacíclicos condensados como moduladores de la actividad de TNF
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TW202513567A (zh) * 2023-06-09 2025-04-01 大陸商上海翰森生物醫藥科技有限公司 五環類衍生物抑制劑、其製備方法與應用
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WO2025201449A1 (zh) * 2024-03-27 2025-10-02 海思科医药集团股份有限公司 一种杂环衍生物及其在医药上的应用
WO2025212627A1 (en) * 2024-04-03 2025-10-09 Forward Therapeutics, Inc. Modulators of tnf-alpha activity
WO2025218735A1 (zh) * 2024-04-17 2025-10-23 上海翰森生物医药科技有限公司 五环类衍生物抑制剂、其制备方法和应用
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