CN107108649B - 用于制备噻吩并嘧啶化合物的新型方法及其中使用的中间体 - Google Patents

用于制备噻吩并嘧啶化合物的新型方法及其中使用的中间体 Download PDF

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Publication number
CN107108649B
CN107108649B CN201580071280.8A CN201580071280A CN107108649B CN 107108649 B CN107108649 B CN 107108649B CN 201580071280 A CN201580071280 A CN 201580071280A CN 107108649 B CN107108649 B CN 107108649B
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China
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formula
compound
salt
group
organic solvent
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CN201580071280.8A
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English (en)
Chinese (zh)
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CN107108649A (zh
Inventor
白种旭
郑载赫
金镐硕
河泰曦
徐贵贤
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Hanmi Pharmaceutical Co Ltd
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Hanmi Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201580071280.8A 2014-12-30 2015-12-30 用于制备噻吩并嘧啶化合物的新型方法及其中使用的中间体 Expired - Fee Related CN107108649B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20140192918 2014-12-30
KR10-2014-0192918 2014-12-30
PCT/KR2015/014491 WO2016108623A1 (en) 2014-12-30 2015-12-30 Novel method for preparing thienopyrimidine compound and intermediates used therein

Publications (2)

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CN107108649A CN107108649A (zh) 2017-08-29
CN107108649B true CN107108649B (zh) 2019-08-09

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CN201580071280.8A Expired - Fee Related CN107108649B (zh) 2014-12-30 2015-12-30 用于制备噻吩并嘧啶化合物的新型方法及其中使用的中间体

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US (2) US10040801B2 (enExample)
EP (1) EP3224257B1 (enExample)
JP (1) JP2018502081A (enExample)
KR (1) KR101803499B1 (enExample)
CN (1) CN107108649B (enExample)
ES (1) ES2759795T3 (enExample)
WO (1) WO2016108623A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170050453A (ko) * 2015-10-30 2017-05-11 한미약품 주식회사 싸이에노피리미딘 화합물의 신규 제조방법 및 이에 사용되는 중간체
EP3380482A4 (en) * 2015-12-31 2019-05-15 Hanmi Pharm. Co., Ltd. CRYSTALLINE FORMS OF A THIENOPYRIMIDINE COMPOUND
KR20180075228A (ko) * 2016-12-26 2018-07-04 한미약품 주식회사 싸이에노피리미딘 화합물의 신규 제조방법 및 중간체

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245759B1 (en) * 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2011162515A2 (en) * 2010-06-23 2011-12-29 Hanmi Holdings Co. , Ltd. Novel fused pyrimidine derivatives for inhd3ition of tyrosine kinase activity
US20120065233A1 (en) * 2008-03-19 2012-03-15 Vlad Edward Gregor Tyrosine kinase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101817833B (zh) * 2009-02-26 2013-03-06 中国科学院广州生物医药与健康研究院 Dpp-iv抑制剂

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245759B1 (en) * 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
US20120065233A1 (en) * 2008-03-19 2012-03-15 Vlad Edward Gregor Tyrosine kinase inhibitors
WO2011162515A2 (en) * 2010-06-23 2011-12-29 Hanmi Holdings Co. , Ltd. Novel fused pyrimidine derivatives for inhd3ition of tyrosine kinase activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors;Yusuke Endo et al.;《Bioorganic & Medicinal Chemistry Letters》;20141206;第25卷;第649-653页 *
Microwave-based synthesis of novel thienopyrimidine bioisosteres of gefitinib;Manisha S. Phoujdar et al.;《Tetrahedron Letters》;20071226;第49卷;第1269-1273页 *

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Publication number Publication date
EP3224257B1 (en) 2019-10-16
EP3224257A1 (en) 2017-10-04
JP2018502081A (ja) 2018-01-25
ES2759795T3 (es) 2020-05-12
CN107108649A (zh) 2017-08-29
US20170369504A1 (en) 2017-12-28
EP3224257A4 (en) 2018-07-04
KR101803499B1 (ko) 2017-11-30
KR20160082479A (ko) 2016-07-08
US10040801B2 (en) 2018-08-07
WO2016108623A1 (en) 2016-07-07
US10160770B2 (en) 2018-12-25
US20180312521A1 (en) 2018-11-01

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