CN107108613B - 布罗莫结构域抑制剂及其用途 - Google Patents

布罗莫结构域抑制剂及其用途 Download PDF

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Publication number
CN107108613B
CN107108613B CN201580072351.6A CN201580072351A CN107108613B CN 107108613 B CN107108613 B CN 107108613B CN 201580072351 A CN201580072351 A CN 201580072351A CN 107108613 B CN107108613 B CN 107108613B
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alkyl
cancer
carbocyclyl
heterocyclyl
compound
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Expired - Fee Related
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CN201580072351.6A
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Chinese (zh)
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CN107108613A (zh
Inventor
B·K·阿尔布雷克特
S·F·贝隆
D·J·伯迪克
A·科特
T·克劳福德
L·A·戴金
V·萧魏徐
M·C·休伊特
Y·勒布朗
S·R·马格努森
C·G·纳斯维斯查克
F·A·罗梅罗
Y·唐
A·M·泰勒
S·王
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Genentech Inc
Constellation Pharmaceuticals Inc
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Genentech Inc
Constellation Pharmaceuticals Inc
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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CN201580072351.6A 2014-11-10 2015-11-10 布罗莫结构域抑制剂及其用途 Expired - Fee Related CN107108613B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077711P 2014-11-10 2014-11-10
US62/077,711 2014-11-10
PCT/US2015/059997 WO2016077375A1 (en) 2014-11-10 2015-11-10 Bromodomain inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
CN107108613A CN107108613A (zh) 2017-08-29
CN107108613B true CN107108613B (zh) 2020-02-25

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US (1) US10258603B2 (enExample)
EP (1) EP3218376B1 (enExample)
JP (1) JP6639497B2 (enExample)
CN (1) CN107108613B (enExample)
WO (1) WO2016077375A1 (enExample)

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MA40943A (fr) * 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
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WO2019201291A1 (zh) * 2018-04-20 2019-10-24 中国科学院上海药物研究所 组蛋白乙酰转移酶(hat)抑制剂及其用途
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CN117377668A (zh) * 2020-10-15 2024-01-09 迈欧伏特治疗公司 Pgdh抑制剂的吸入制剂及其使用方法
TW202237095A (zh) 2020-12-03 2022-10-01 德商艾斯巴赫生物有限公司 Ａｌｃ１抑制劑及與ｐａｒｐｉ之協同性
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CN107108613A (zh) 2017-08-29
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