CN107102142A - 检测腺癌的蛋白标志/标记 - Google Patents

检测腺癌的蛋白标志/标记 Download PDF

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Publication number
CN107102142A
CN107102142A CN201710115906.1A CN201710115906A CN107102142A CN 107102142 A CN107102142 A CN 107102142A CN 201710115906 A CN201710115906 A CN 201710115906A CN 107102142 A CN107102142 A CN 107102142A
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CN
China
Prior art keywords
cancer
antibody
individual
array
albumen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710115906.1A
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English (en)
Chinese (zh)
Inventor
C·A·K·博雷贝克
L·B·C·温格伦
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Immunovia AB
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Immunovia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0705876A external-priority patent/GB0705876D0/en
Priority claimed from GB0712181A external-priority patent/GB0712181D0/en
Application filed by Immunovia AB filed Critical Immunovia AB
Publication of CN107102142A publication Critical patent/CN107102142A/zh
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57438Specifically defined cancers of liver, pancreas or kidney
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN201710115906.1A 2007-03-27 2008-03-25 检测腺癌的蛋白标志/标记 Pending CN107102142A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0705876.1 2007-03-27
GB0705876A GB0705876D0 (en) 2007-03-27 2007-03-27 Method, array and use thereof
GB0712181A GB0712181D0 (en) 2007-06-25 2007-06-25 Method, array and use thereof
GB0712181.7 2007-06-25
CN200880013776A CN101680896A (zh) 2007-03-27 2008-03-25 检测腺癌的蛋白标志/标记

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880013776A Division CN101680896A (zh) 2007-03-27 2008-03-25 检测腺癌的蛋白标志/标记

Publications (1)

Publication Number Publication Date
CN107102142A true CN107102142A (zh) 2017-08-29

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710115906.1A Pending CN107102142A (zh) 2007-03-27 2008-03-25 检测腺癌的蛋白标志/标记
CN200880013776A Pending CN101680896A (zh) 2007-03-27 2008-03-25 检测腺癌的蛋白标志/标记

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200880013776A Pending CN101680896A (zh) 2007-03-27 2008-03-25 检测腺癌的蛋白标志/标记

Country Status (10)

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US (3) US20100105571A1 (enExample)
EP (3) EP2140269B1 (enExample)
JP (3) JP6115801B2 (enExample)
CN (2) CN107102142A (enExample)
AU (3) AU2008231575A1 (enExample)
CA (1) CA2681899C (enExample)
DK (1) DK2140269T3 (enExample)
ES (1) ES2442919T3 (enExample)
PL (1) PL2140269T3 (enExample)
WO (1) WO2008117067A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008117067A2 (en) 2007-03-27 2008-10-02 Carl Arne Krister Borrebaeck Protein signature/markers for the detection of adenocarcinoma
GB0723179D0 (en) * 2007-11-27 2008-01-02 Immunovia Ab Diagnostic methods and arrays for use in the same
US10359425B2 (en) 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
EP2415877A3 (en) * 2010-02-17 2012-02-15 Deutsches Krebsforschungszentrum Means and methods for diagnosing pancreatic cancer
GB201009798D0 (en) 2010-06-11 2010-07-21 Immunovia Ab Method,array and use thereof
MX355020B (es) 2010-07-09 2018-04-02 Somalogic Inc Biomarcadores de cancer de pulmon y usos de los mismos.
JP5931874B2 (ja) * 2010-08-13 2016-06-08 ソマロジック・インコーポレーテッド 膵癌バイオマーカーおよびその使用
GB201103726D0 (en) * 2011-03-04 2011-04-20 Immunovia Ab Method, array and use thereof
GB201319878D0 (en) * 2013-11-11 2013-12-25 Immunovia Ab Method, Array and use thereof
KR20150129932A (ko) 2014-05-12 2015-11-23 연세대학교 산학협력단 보체인자 b 단백질에 특이적으로 결합하는 항체를 포함하는 췌장암 진단용 키트
GB201516801D0 (en) * 2015-09-22 2015-11-04 Immunovia Ab Method, array and use thereof
RU2627448C1 (ru) * 2016-04-05 2017-08-08 федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный аграрный университет" Способ иммуногистохимического выявления антигенов в препаратах органов продуктивных и непродуктивных животных длительного хранения в фиксаторах
GB201608192D0 (en) * 2016-05-10 2016-06-22 Immunovia Ab Method, array and use thereof
GB201701572D0 (en) 2017-01-31 2017-03-15 Immunovia Ab Methods, arrays and uses thereof
GB202010970D0 (en) 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0039578B1 (en) 1980-05-02 1985-04-10 Edward P. Davis Leg aid device
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
CA1202235A (en) * 1983-08-30 1986-03-25 Paul S. Satoh Immunoassay for complement fragments
US5856090A (en) 1994-09-09 1999-01-05 The Scripps Research Institute DNA-methylase linking reaction
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
GB9704444D0 (en) * 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6355623B2 (en) * 1998-09-24 2002-03-12 Hopital-Sainte-Justine Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage
WO2001006262A1 (en) 1999-02-19 2001-01-25 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration
JP4619651B2 (ja) 2001-06-01 2011-01-26 コーネル・リサーチ・ファンデーション・インコーポレイテッド 前立腺特異的膜抗原に対する修飾抗体およびその使用
WO2004031411A2 (en) 2002-09-30 2004-04-15 Oncotherapy Science, Inc. Genes and polypeptides relating to human pancreatic cancers
US20050260639A1 (en) * 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Method for diagnosing pancreatic cancer
ATE419533T1 (de) 2002-10-31 2009-01-15 Hoffmann La Roche Verfahren/präparat zur erkennung von pankreaskrebs
WO2004055519A2 (en) * 2002-12-17 2004-07-01 Sinogenomax Co. Ltd. Specific markers for pancreatic cancer
JP3857241B2 (ja) * 2003-02-17 2006-12-13 スパンション インク 昇圧電源の振幅を小さくしたチャージポンプ回路
JP4194080B2 (ja) * 2003-02-19 2008-12-10 茂 森村 膵癌検出用マーカー
AU2004229501B2 (en) 2003-04-11 2011-08-18 Medimmune, Llc Recombinant IL-9 antibodies and uses thereof
US20040248205A1 (en) * 2003-04-16 2004-12-09 Stern Lawrence J. Major histocompatibility complex (MHC)-peptide arrays
WO2004099432A2 (en) 2003-05-02 2004-11-18 The Johns Hopkins University Identification of biomarkers for detecting pancreatic cancer
KR20060041205A (ko) 2003-07-01 2006-05-11 이뮤노메딕스, 인코오포레이티드 양특이성 항체들의 다가 담체들
DE602004025706D1 (enExample) * 2003-07-10 2010-04-08 Central Inst Exper Animals
US20050277137A1 (en) * 2003-08-15 2005-12-15 University Of Pittsburgh Diagnostic multimarker serological profiling
WO2005063812A2 (en) * 2003-12-24 2005-07-14 Applied Research Systems Ars Holding N.V. Cc-chemokine-binding tick proteins
US20060106119A1 (en) * 2004-01-12 2006-05-18 Chang-Jie Guo Novel integration for CO and H2 recovery in gas to liquid processes
BRPI0520902B1 (pt) 2004-05-28 2021-11-30 Agensys, Inc Anticorpo monoclonal ou fragmento de ligação ao antígeno do mesmo que se liga a proteínas psca para diagnóstico de câncer, método para produção dos mesmos, hibridoma, polinucleotídeo, vetor, composição, ensaio para detectar a presença de uma proteína psca e método de detecção de uma proteína psca
US8383357B2 (en) 2005-03-16 2013-02-26 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
JP2008535853A (ja) 2005-04-07 2008-09-04 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド 癌関連遺伝子
JP2008535857A (ja) * 2005-04-07 2008-09-04 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド 癌の診断、検出および処置におけるcacna1e
US8632983B2 (en) 2005-04-15 2014-01-21 Van Andel Research Institute Biomarkers for pancreatic cancer and diagnostic methods
CN1851455B (zh) 2005-04-22 2010-11-10 复旦大学附属中山医院 一种肿瘤标志物-血清蛋白指纹图谱的检测方法
EP1877796A2 (en) * 2005-05-05 2008-01-16 Philadelphia Health & Education Corporation d/b/a Diagnosis of liver pathology through assessment of protein glycosylation
EP1736780A1 (en) * 2005-06-24 2006-12-27 Eppendorf Array Technologies S.A. Method and means for detecting and/or quantifying hierarchical molecular change of a cell in response to an external stimulus
JP2007051880A (ja) * 2005-08-15 2007-03-01 Tokyo Univ Of Science 膵臓癌の検出方法、膵臓癌の診断キット
KR20090003178A (ko) 2006-01-11 2009-01-09 게노믹 헬쓰, 인코포레이티드 직장결장암 예후에 대한 유전자 발현 마커
WO2007107774A2 (en) 2006-03-22 2007-09-27 Cartela R & D Ab Integrin alpha-10 subunit as therapeutic target and diagnostic/prognostic marker for cancer
ATE487139T1 (de) 2006-04-18 2010-11-15 Perseus Proteomics Inc Diagnostikum und therapeutikum gegen bauchspeicheldrüsenkrebs
US20080038301A1 (en) 2006-08-08 2008-02-14 The Procter & Gamble Company Personal care product comprising collapsible water-containing capsules
KR100819122B1 (ko) 2006-09-30 2008-04-04 남명진 췌장암 진단용 키트
RU2473555C2 (ru) * 2006-12-19 2013-01-27 ДжинГоу, Инк. Новые способы функционального анализа большого количества экспериментальных данных и групп генов, идентифицированных из указанных данных
CN101246176B (zh) 2007-02-13 2013-06-05 许洋 鳞状细胞癌抗原阴性宫颈癌血清蛋白质检测的质谱试剂及其制备方法
WO2008117067A2 (en) 2007-03-27 2008-10-02 Carl Arne Krister Borrebaeck Protein signature/markers for the detection of adenocarcinoma
GB0709092D0 (en) 2007-05-11 2007-06-20 Borrebaeck Carl Diagnosis and method of disease
NZ555363A (en) 2007-05-24 2009-11-27 Pacific Edge Biotechnology Ltd Prognosis prediction for melanoma cancer
EP2637020A3 (en) 2007-06-29 2014-01-08 Correlogic Systems Inc. Predictive markers for ovarian cancer
EP2217625B1 (en) 2007-11-08 2021-08-04 Precision Biologics, Inc. Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
GB0723179D0 (en) 2007-11-27 2008-01-02 Immunovia Ab Diagnostic methods and arrays for use in the same
WO2009111067A2 (en) 2008-03-07 2009-09-11 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal -like tumor cells or their formation
GB0815846D0 (en) 2008-09-01 2008-10-08 Immunovia Ab diagnosis, prognosis and imaging of disease
CN101676300B (zh) 2008-09-16 2012-05-02 中国科学院生物物理研究所 一种抑制人结肠肿瘤生长的新型抗体及其在制备用于早期诊断结直肠癌、子宫内膜癌以及胰腺癌的诊断剂中的应用
CN101451975B (zh) 2008-12-29 2012-01-25 浙江大学 一种检测胃癌预后与分期血清蛋白质的方法
US20120004289A1 (en) 2009-03-06 2012-01-05 The Johns Hopkins University Annexin a11 and associated genes as biomarkers for cancer
EP3444359A1 (en) 2009-03-12 2019-02-20 Cancer Prevention And Cure, Ltd. Methods of identification of non-small cell lung cancer
CN101880707A (zh) 2009-05-05 2010-11-10 中国人民解放军第二军医大学 microRNA-21在鉴别胰腺癌中的应用
CN101613748A (zh) 2009-06-09 2009-12-30 中国人民解放军第二军医大学 一种检测胰腺癌血清标志物的方法
RU2421149C2 (ru) 2009-07-16 2011-06-20 Ольга Васильевна Кокуева Способ дифференциальной диагностики рака поджелудочной железы и хронического панкреатита
SG168431A1 (en) 2009-07-23 2011-02-28 Univ Singapore Cancer biomarker and the use thereof
EP2483690A1 (de) 2009-09-29 2012-08-08 Protagen AG Markersequenzen für pankreaskrebserkrankungen, pankreaskarzinom und deren verwendung
CN102279264A (zh) 2010-06-09 2011-12-14 李彬 48种恶性肿瘤标志物抗体芯片的制备方法
CN106011233A (zh) 2010-08-13 2016-10-12 莫尔豪斯医学院 中风的生物标记
WO2012031374A1 (zh) 2010-09-09 2012-03-15 北京同为时代生物技术有限公司 用于诊断上皮源性癌症的血液标志物及其单克隆抗体
GB201103726D0 (en) 2011-03-04 2011-04-20 Immunovia Ab Method, array and use thereof
CN102201038B (zh) 2011-04-27 2013-06-05 浙江大学 脑瘤p53蛋白表达检测方法
CN102286464B (zh) 2011-06-30 2013-07-17 眭维国 尿毒症长链非编码核糖核酸差异性表达图谱模型及其构建方法
WO2013052480A1 (en) 2011-10-03 2013-04-11 The Board Of Regents Of The University Of Texas System Marker-based prognostic risk score in colon cancer
WO2013106844A2 (en) 2012-01-13 2013-07-18 Oncocyte Corporation Methods and compositions for the treatment and diaginosis of pancreatic cancer
EP2929350A4 (en) 2012-12-04 2016-11-16 Caris Mpi Inc MOLECULAR PROFILING OF CANCER
TWI658049B (zh) 2013-03-12 2019-05-01 腫瘤療法 科學股份有限公司 Kntc2胜肽及含此胜肽之疫苗
CA2902841A1 (en) 2013-03-13 2014-10-02 Creatics Llc Methods and compositions for detecting pancreatic cancer
WO2014151079A2 (en) 2013-03-15 2014-09-25 The United States Of America, As Represented By The Sec. Dept. Of Health And Human Services Ratio based biomarkers and methods of use thereof
JP6683986B2 (ja) 2013-07-10 2020-04-22 国立大学法人 東京大学 がん幹細胞分子マーカー
GB201319878D0 (en) * 2013-11-11 2013-12-25 Immunovia Ab Method, Array and use thereof
WO2015112429A1 (en) 2014-01-23 2015-07-30 Newomics Inc Methods and systems for diagnosing diseases
WO2015157557A1 (en) 2014-04-09 2015-10-15 Myriad Rbm, Inc. Methods of diagnosing pancreatic cancer and methods related thereto
WO2015171736A2 (en) 2014-05-07 2015-11-12 University Of Utah Research Foundation Biomarkers and methods for diagnosis of early stage pancreatic ductal adenocarcinoma
KR20150129932A (ko) 2014-05-12 2015-11-23 연세대학교 산학협력단 보체인자 b 단백질에 특이적으로 결합하는 항체를 포함하는 췌장암 진단용 키트
GB201501930D0 (en) 2015-02-05 2015-03-25 Univ London Queen Mary Biomarkers for pancreatic cancer
CN105092845A (zh) 2015-07-10 2015-11-25 深圳市贝沃德克生物技术研究院有限公司 胰腺癌蛋白生物标记物、用途及其检测芯片和检测装置
CN105092844A (zh) 2015-07-10 2015-11-25 深圳市贝沃德克生物技术研究院有限公司 胰腺癌蛋白生物标记物的检测试剂盒及检测系统
GB201516801D0 (en) 2015-09-22 2015-11-04 Immunovia Ab Method, array and use thereof
GB201608192D0 (en) * 2016-05-10 2016-06-22 Immunovia Ab Method, array and use thereof
GB201701572D0 (en) 2017-01-31 2017-03-15 Immunovia Ab Methods, arrays and uses thereof
US12416636B2 (en) 2018-05-31 2025-09-16 University Of Florida Research Foundation, Inc. Personalized treatment of pancreatic cancer
CN111171053B (zh) 2020-01-06 2021-03-05 丽水市中心医院 一种化合物在制备治疗胰腺癌药物中的应用
GB202010970D0 (en) * 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof

Also Published As

Publication number Publication date
EP3851856A3 (en) 2021-11-03
JP2017067792A (ja) 2017-04-06
EP2140269A2 (en) 2010-01-06
CN101680896A (zh) 2010-03-24
JP2010522875A (ja) 2010-07-08
JP6115801B2 (ja) 2017-04-19
WO2008117067A3 (en) 2008-11-20
CA2681899C (en) 2018-06-19
AU2014204510A1 (en) 2014-08-07
EP2140269B1 (en) 2013-11-20
ES2442919T3 (es) 2014-02-14
WO2008117067A2 (en) 2008-10-02
EP3851856A2 (en) 2021-07-21
CA2681899A1 (en) 2008-10-02
AU2008231575A1 (en) 2008-10-02
AU2014204510B2 (en) 2016-10-27
WO2008117067A9 (en) 2008-12-31
AU2016238939A1 (en) 2016-11-03
US20200018760A1 (en) 2020-01-16
AU2014204510C1 (en) 2017-01-19
PL2140269T3 (pl) 2014-07-31
JP6465902B2 (ja) 2019-02-06
AU2016238939B2 (en) 2018-08-02
DK2140269T3 (da) 2013-12-16
WO2008117067A8 (en) 2009-04-16
EP2490025A2 (en) 2012-08-22
EP2490025A3 (en) 2012-11-28
US20170307620A1 (en) 2017-10-26
US20100105571A1 (en) 2010-04-29
JP2015187611A (ja) 2015-10-29
US11525832B2 (en) 2022-12-13

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Application publication date: 20170829