ES2442919T3 - Firma/marcadores de proteínas para la detección de adenocarcinoma - Google Patents
Firma/marcadores de proteínas para la detección de adenocarcinoma Download PDFInfo
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- ES2442919T3 ES2442919T3 ES08718919.7T ES08718919T ES2442919T3 ES 2442919 T3 ES2442919 T3 ES 2442919T3 ES 08718919 T ES08718919 T ES 08718919T ES 2442919 T3 ES2442919 T3 ES 2442919T3
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Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3169789D1 (en) | 1980-05-02 | 1985-05-15 | Edward P Davis | Leg aid device |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| CA1202235A (en) * | 1983-08-30 | 1986-03-25 | Paul S. Satoh | Immunoassay for complement fragments |
| US5856090A (en) | 1994-09-09 | 1999-01-05 | The Scripps Research Institute | DNA-methylase linking reaction |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| GB9704444D0 (en) * | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| US6355623B2 (en) * | 1998-09-24 | 2002-03-12 | Hopital-Sainte-Justine | Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage |
| WO2001002866A1 (en) | 1999-02-19 | 2001-01-11 | University Of Iowa Research Foundation | Diagnostics and therapeutics for arterial wall disruptive disorders |
| MXPA03010804A (es) | 2001-06-01 | 2004-11-22 | Cornell Res Foundation Inc | Anticuerpos modificados para antigeno de membrana especifico de la prostata y usos de los mismos. |
| DE60325628D1 (de) | 2002-09-30 | 2009-02-12 | Oncotherapy Science Inc | Gene und polypeptide in verbindung mit menschlichen pankreaskarzinomen |
| US20050260639A1 (en) * | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Method for diagnosing pancreatic cancer |
| DE60325541D1 (de) | 2002-10-31 | 2009-02-12 | Hoffmann La Roche | Verfahren/Präparat zur Erkennung von Pankreaskrebs |
| US20040219572A1 (en) * | 2002-12-17 | 2004-11-04 | Jie Chen | Specific markers for pancreatic cancer |
| JP3857241B2 (ja) * | 2003-02-17 | 2006-12-13 | スパンション インク | 昇圧電源の振幅を小さくしたチャージポンプ回路 |
| JP4194080B2 (ja) * | 2003-02-19 | 2008-12-10 | 茂 森村 | 膵癌検出用マーカー |
| KR20110094361A (ko) | 2003-04-11 | 2011-08-23 | 메디뮨 엘엘씨 | 재조합 ｉｌ９ 항체 및 그의 용도 |
| US20040248205A1 (en) * | 2003-04-16 | 2004-12-09 | Stern Lawrence J. | Major histocompatibility complex (MHC)-peptide arrays |
| US20050095611A1 (en) | 2003-05-02 | 2005-05-05 | Chan Daniel W. | Identification of biomarkers for detecting pancreatic cancer |
| AU2004255216B2 (en) | 2003-07-01 | 2010-08-19 | Immunomedics, Inc. | Multivalent carriers of bi-specific antibodies |
| EP1644732B1 (en) * | 2003-07-10 | 2010-02-24 | Central Institute For Experimental Animals | Animal model for the analysis of tumor metastasis |
| US20050277137A1 (en) | 2003-08-15 | 2005-12-15 | University Of Pittsburgh | Diagnostic multimarker serological profiling |
| DE602004022191D1 (de) * | 2003-12-24 | 2009-09-03 | Merck Serono Sa Coinsins | Cc-chemokin-bindende zeckenproteine |
| US20060106119A1 (en) * | 2004-01-12 | 2006-05-18 | Chang-Jie Guo | Novel integration for CO and H2 recovery in gas to liquid processes |
| CN102344493B (zh) | 2004-05-28 | 2014-09-03 | 艾更斯司股份有限公司 | 结合于psca蛋白的用于癌症诊断的抗体 |
| US8383357B2 (en) | 2005-03-16 | 2013-02-26 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors |
| JP2008535857A (ja) * | 2005-04-07 | 2008-09-04 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | 癌の診断、検出および処置におけるｃａｃｎａ１ｅ |
| WO2006110585A2 (en) | 2005-04-07 | 2006-10-19 | Novartis Vaccines And Diagnostics Inc. | Cancer-related genes (prlr) |
| US8632983B2 (en) | 2005-04-15 | 2014-01-21 | Van Andel Research Institute | Biomarkers for pancreatic cancer and diagnostic methods |
| CN1851455B (zh) | 2005-04-22 | 2010-11-10 | 复旦大学附属中山医院 | 一种肿瘤标志物-血清蛋白指纹图谱的检测方法 |
| EP1877796A2 (en) * | 2005-05-05 | 2008-01-16 | Philadelphia Health & Education Corporation d/b/a | Diagnosis of liver pathology through assessment of protein glycosylation |
| EP1736780A1 (en) * | 2005-06-24 | 2006-12-27 | Eppendorf Array Technologies S.A. | Method and means for detecting and/or quantifying hierarchical molecular change of a cell in response to an external stimulus |
| JP2007051880A (ja) * | 2005-08-15 | 2007-03-01 | Tokyo Univ Of Science | 膵臓癌の検出方法、膵臓癌の診断キット |
| NZ593224A (en) | 2006-01-11 | 2012-10-26 | Genomic Health Inc | Gene expression markers (fap) for colorectal cancer prognosis |
| WO2007107774A2 (en) | 2006-03-22 | 2007-09-27 | Cartela R & D Ab | Integrin alpha-10 subunit as therapeutic target and diagnostic/prognostic marker for cancer |
| CA2650699A1 (en) | 2006-04-18 | 2007-11-01 | Perseus Proteomics Inc. | Diagnostic agent and therapeutic agent for pancreatic cancer |
| US20080038301A1 (en) | 2006-08-08 | 2008-02-14 | The Procter & Gamble Company | Personal care product comprising collapsible water-containing capsules |
| KR100819122B1 (ko) | 2006-09-30 | 2008-04-04 | 남명진 | 췌장암 진단용 키트 |
| US9353415B2 (en) * | 2006-12-19 | 2016-05-31 | Thomson Reuters (Scientific) Llc | Methods for functional analysis of high-throughput experimental data and gene groups identified therefrom |
| CN101246176B (zh) | 2007-02-13 | 2013-06-05 | 许洋 | 鳞状细胞癌抗原阴性宫颈癌血清蛋白质检测的质谱试剂及其制备方法 |
| ES2442919T3 (es) | 2007-03-27 | 2014-02-14 | Immunovia Ab | Firma/marcadores de proteínas para la detección de adenocarcinoma |
| GB0709092D0 (en) | 2007-05-11 | 2007-06-20 | Borrebaeck Carl | Diagnosis and method of disease |
| NZ555363A (en) | 2007-05-24 | 2009-11-27 | Pacific Edge Biotechnology Ltd | Prognosis prediction for melanoma cancer |
| KR20120087885A (ko) | 2007-06-29 | 2012-08-07 | 안국약품 주식회사 | 난소암의 예측 마커 |
| EP2217625B1 (en) | 2007-11-08 | 2021-08-04 | Precision Biologics, Inc. | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers |
| GB0723179D0 (en) | 2007-11-27 | 2008-01-02 | Immunovia Ab | Diagnostic methods and arrays for use in the same |
| JP2011516826A (ja) | 2008-03-07 | 2011-05-26 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 間葉系様腫瘍細胞またはこの形成を阻害する作用剤の同定のための方法 |
| GB0815846D0 (en) | 2008-09-01 | 2008-10-08 | Immunovia Ab | diagnosis, prognosis and imaging of disease |
| CN101676300B (zh) | 2008-09-16 | 2012-05-02 | 中国科学院生物物理研究所 | 一种抑制人结肠肿瘤生长的新型抗体及其在制备用于早期诊断结直肠癌、子宫内膜癌以及胰腺癌的诊断剂中的应用 |
| CN101451975B (zh) | 2008-12-29 | 2012-01-25 | 浙江大学 | 一种检测胃癌预后与分期血清蛋白质的方法 |
| WO2010102195A2 (en) | 2009-03-06 | 2010-09-10 | The Johns Hopkins University | Annexin a11 and associated genes as biomarkers for cancer |
| CN104535765A (zh) | 2009-03-12 | 2015-04-22 | 癌症预防和治疗有限公司 | 鉴定、评估、预防以及治疗肺疾病的方法及试剂盒 |
| CN101880707A (zh) | 2009-05-05 | 2010-11-10 | 中国人民解放军第二军医大学 | microRNA-21在鉴别胰腺癌中的应用 |
| CN101613748A (zh) | 2009-06-09 | 2009-12-30 | 中国人民解放军第二军医大学 | 一种检测胰腺癌血清标志物的方法 |
| RU2421149C2 (ru) | 2009-07-16 | 2011-06-20 | Ольга Васильевна Кокуева | Способ дифференциальной диагностики рака поджелудочной железы и хронического панкреатита |
| SG168431A1 (en) | 2009-07-23 | 2011-02-28 | Univ Singapore | Cancer biomarker and the use thereof |
| US20120264634A1 (en) | 2009-09-29 | 2012-10-18 | Protagen Aktiengesellschaft | Marker Sequences for Pancreatic Cancer Diseases, Pancreatic Carcinoma and Use Thereof |
| CN102279264A (zh) | 2010-06-09 | 2011-12-14 | 李彬 | 48种恶性肿瘤标志物抗体芯片的制备方法 |
| WO2012021407A2 (en) | 2010-08-13 | 2012-02-16 | Morehouse School Of Medicine | Biomarkers for stroke |
| US9255142B2 (en) | 2010-09-09 | 2016-02-09 | Beijing Cotimes Biotech Co., Ltd. | Blood markers for diagnosing epithelium derived cancers and monoclonal antibodies thereof |
| GB201103726D0 (en) | 2011-03-04 | 2011-04-20 | Immunovia Ab | Method, array and use thereof |
| CN102201038B (zh) | 2011-04-27 | 2013-06-05 | 浙江大学 | 脑瘤p53蛋白表达检测方法 |
| CN102286464B (zh) | 2011-06-30 | 2013-07-17 | 眭维国 | 尿毒症长链非编码核糖核酸差异性表达图谱模型及其构建方法 |
| WO2013052480A1 (en) | 2011-10-03 | 2013-04-11 | The Board Of Regents Of The University Of Texas System | Marker-based prognostic risk score in colon cancer |
| US20150018235A1 (en) | 2012-01-13 | 2015-01-15 | Oncocyte Corporation | Methods and Compositions for the Treatment and Diagnosis of Pancreatic Cancer |
| AU2013355260B2 (en) | 2012-12-04 | 2019-07-25 | Caris Mpi, Inc. | Molecular profiling for cancer |
| TWI658049B (zh) | 2013-03-12 | 2019-05-01 | 腫瘤療法 科學股份有限公司 | Ｋｎｔｃ２胜肽及含此胜肽之疫苗 |
| CA2902841A1 (en) | 2013-03-13 | 2014-10-02 | Creatics Llc | Methods and compositions for detecting pancreatic cancer |
| CA2904973A1 (en) | 2013-03-15 | 2014-09-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Ratio based biomarkers and methods of use thereof |
| JP6683986B2 (ja) | 2013-07-10 | 2020-04-22 | 国立大学法人 東京大学 | がん幹細胞分子マーカー |
| GB201319878D0 (en) * | 2013-11-11 | 2013-12-25 | Immunovia Ab | Method, Array and use thereof |
| WO2015112429A1 (en) | 2014-01-23 | 2015-07-30 | Newomics Inc | Methods and systems for diagnosing diseases |
| WO2015157557A1 (en) | 2014-04-09 | 2015-10-15 | Myriad Rbm, Inc. | Methods of diagnosing pancreatic cancer and methods related thereto |
| US10451628B2 (en) | 2014-05-07 | 2019-10-22 | University Of Utah Research Foundation | Biomarkers and methods for diagnosis of early stage pancreatic ductal adenocarcinoma |
| KR20150129932A (ko) | 2014-05-12 | 2015-11-23 | 연세대학교 산학협력단 | 보체인자 b 단백질에 특이적으로 결합하는 항체를 포함하는 췌장암 진단용 키트 |
| GB201501930D0 (en) | 2015-02-05 | 2015-03-25 | Univ London Queen Mary | Biomarkers for pancreatic cancer |
| CN105092845A (zh) | 2015-07-10 | 2015-11-25 | 深圳市贝沃德克生物技术研究院有限公司 | 胰腺癌蛋白生物标记物、用途及其检测芯片和检测装置 |
| CN105092844A (zh) | 2015-07-10 | 2015-11-25 | 深圳市贝沃德克生物技术研究院有限公司 | 胰腺癌蛋白生物标记物的检测试剂盒及检测系统 |
| GB201516801D0 (en) | 2015-09-22 | 2015-11-04 | Immunovia Ab | Method, array and use thereof |
| GB201608192D0 (en) * | 2016-05-10 | 2016-06-22 | Immunovia Ab | Method, array and use thereof |
| GB201701572D0 (en) | 2017-01-31 | 2017-03-15 | Immunovia Ab | Methods, arrays and uses thereof |
| WO2019232361A1 (en) | 2018-05-31 | 2019-12-05 | University Of Florida Research Foundation | Personalized treatment of pancreatic cancer |
| CN111171053B (zh) | 2020-01-06 | 2021-03-05 | 丽水市中心医院 | 一种化合物在制备治疗胰腺癌药物中的应用 |
| GB202010970D0 (en) * | 2020-07-16 | 2020-09-02 | Immunovia Ab | Methods, arrays and uses thereof |
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| WO2008117067A2 (en) | 2008-10-02 |
| JP2015187611A (ja) | 2015-10-29 |
| JP6465902B2 (ja) | 2019-02-06 |
| EP3851856A3 (en) | 2021-11-03 |
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| EP2490025A3 (en) | 2012-11-28 |
| US11525832B2 (en) | 2022-12-13 |
| CA2681899C (en) | 2018-06-19 |
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| EP2140269B1 (en) | 2013-11-20 |
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| WO2008117067A8 (en) | 2009-04-16 |
| JP2017067792A (ja) | 2017-04-06 |
| AU2014204510A1 (en) | 2014-08-07 |
| WO2008117067A9 (en) | 2008-12-31 |
| WO2008117067A3 (en) | 2008-11-20 |
| US20170307620A1 (en) | 2017-10-26 |
| PL2140269T3 (pl) | 2014-07-31 |
| AU2008231575A1 (en) | 2008-10-02 |
| US20100105571A1 (en) | 2010-04-29 |
| CN107102142A (zh) | 2017-08-29 |
| EP3851856A2 (en) | 2021-07-21 |
| DK2140269T3 (da) | 2013-12-16 |
| AU2014204510B2 (en) | 2016-10-27 |
| EP2140269A2 (en) | 2010-01-06 |
| AU2016238939A1 (en) | 2016-11-03 |
| JP6115801B2 (ja) | 2017-04-19 |
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