CN107088179A - Skin care oil for preventing and alleviating senile skin chap and its production and use - Google Patents
Skin care oil for preventing and alleviating senile skin chap and its production and use Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of skin care oil for being used to preventing and alleviating senile skin chap and its production and use, belong to daily cosmetics studying technological domain.The present invention is directed to the elderly's skin characteristic, propose a kind of skin care oil containing Chinese herbal medicine extract, the present invention utilizes advanced biotechnology, with reference to the theory of traditional Chinese medical science of Chinese tradition, by teasel root, the bark of eucommia, gumbo, sealwort and the extract of the bark of official magnolia have prepared the skin care oil with preventing and treating chap effect as active component.Raw material of the present invention select natural plants, non-stimulated to skin safe.Experiment proves that the skin care oil of the present invention not only has mitigation to chapped skin, also with anti-inflammation, moisturizing profit flesh, the effects such as Shu Min is antipruritic, and can repair skin barrier, the problems such as fundamentally treating senile skin chap, itch.In addition, raw material of the present invention obtain easy, preparation method simplicity, green safety, therefore, with good application prospect and market prospects.
Description
Technical field
The present invention relates to a kind of skin care formulation prepared by Chinese medical extract, more particularly to one kind is by Chinese medical extract
Prepare, with the skin care oil for preventing and alleviating chapped skin effect, further relate to the preparation method and purposes of the skin care oil.
The invention belongs to daily cosmetics studying technological domain.
Background technology
Fissura, also known as rhagadia manus et pedis, refer to that the dry skin and wire of hand, pedal skin caused by a variety of causes are split
A kind of disease of gap.Modern medicine believes that, when epidermal keratinocyte dehydration is more than 10%, it is possible to occur chapped skin.Chap
It is a kind of common skin symptom.The elderly is because of organ aging, and subcutaneous sweat gland secretion is reduced, and dry skin, skin keratin is thickened, and loses
Elasticity and extensibility are gone, the stimulation of mechanicalness or chemical substance is more susceptible to, winter climate is cold in addition, therefore when extremity movement
It is more easy to chap than young man.
Skin care item on the market are generally young man's design at present, have ignored the skin demand of the elderly.The elderly can only select
Select the skin care item that young man is applicable.And the skin of the elderly and the skin properties of young man have dramatically different, nursing care mode
There is difference.The cosmetics that the elderly is applicable using young man, it is impossible to reach obvious skin effect.
Therefore, be badly in need of at present it is a kind of can for the elderly design, safely and effectively can prevent and alleviate the elderly
The skin care formulation of chapped skin.
The content of the invention
An object of the present invention is to provide a kind of skin care oil for having and preventing and alleviating the elderly's chapped skin effect.
The second object of the present invention is to provide a kind of method for preparing above-mentioned skin care oil.
The third object of the present invention be to provide above-mentioned skin care oil preventing and treating chapped skin, repair skin barrier, anti-inflammatory with
And it is antipruritic in purposes.
To realize the purpose of the present invention, present invention employs following technical scheme：
The present invention utilizes advanced biotechnology, with reference to the theory of traditional Chinese medical science of Chinese tradition, by teasel root, the bark of eucommia, gumbo, Huang
Essence, the bark of official magnolia are effectively combined in together, and decide its consumption, so that compound preparation is formed, in addition, the present invention makees its extract
For active component, add in the preparation of preventing and treating chapped skin, make it have protection and repair skin barrier, anti-inflammatory, antipruritic
Effect, and it is safe and non-stimulating, so as to effectively prevention and alleviation senile skin chap, senile skin vigor is improved, recovers old
Year skin health.
Wherein, teasel root, Chinese medicine name.For Dipsacaceae herbaceos perennial teasel (Dipsacus asperoides
C.Y.Cheng et T.M.Ai) root, there is hemostatic analgesia.
The bark of eucommia (Eucommia ulmoides), is the dry bark of the Eucommiaceae plant bark of eucommia, is Chinese rare tonic
Material.Its is sweet, warm-natured.Contain gutta-percha, glucoside, alkaloid, pectin, fat, resin, organic acid and the life of a variety of dimensions in bark
Element and the necessary trace element of human body.
Sealwort (Polygonatum sibiricum) is the plant of Liliaceae Polygonatum.Rhizome can be used as medicine.Sealwort rhizome contains
Nicotinic acid, mucilaginous substance, quinones.And the first, second containing Siberian solomonseal rhizome polysaccharide, third (being combined into by glucose, mannose, galacturonic acid),
Polygonatum rhizome oligosaccharide first, second, third (being combined into by glucose and fructose).In addition, separately containing 11 kinds of amino acid such as lysines.
Gumbo (Abelmoschus esculentus) is also known as okra, Abelmoschus esculentus, popular name swordweed, purling eggplant, gumbo
Fruit is containing pectin, cow's milk glycan etc., with helping digest, the effect of treat gastritis and gastric ulcer, protect skin and stomach lining.
The bark of official magnolia is the Magnoliacea plant bark of official magnolia (Magnolia officinalis Rehd.et Wils) or Magnolia bilola
The drying dry hide of (Magnolia officinalis Rehd.et Wils.var.biloba Rehd.et Wils.), root skin and
Branch skin.Magnolia bark contains Neolignans, and Neolignans, alkaloid, volatilization drop in monoterpene Neolignans
Oil etc., has effects that promoting the circulation of qi dampness elimination, warm in pain.
Specifically, a kind of of the present invention is used to prevent and alleviate in the skin care oil that senile skin is chapped to contain caprylic/capric
Triglycerides, Nexbase 2004, dimethyl silicone polymer, grape-kernel oil, tocopherol acetate and Chinese herbal medicine extract；
Wherein, carried in described Chinese herbal medicine extract containing Radix Dipsaci extract, eucommia ulmoides extracts, gumbo extract, sealwort
Take thing and Magnolia cortex P.E.
In the present invention, it is preferred to, the weight/mass percentage composition of each raw material is：Nexbase 2004 30-40wt%, Chinese herbal medicine is carried
Take thing 3.0-10.0wt%, dimethyl silicone polymer 5-15wt%, grape-kernel oil 1-10wt%, VE acetate 1-5wt%, surplus
For caprylic/capric triglyceride.It is furthermore preferred that the weight/mass percentage composition of each raw material is：Nexbase 2004 35wt%, Chinese herbal medicine is carried
Take thing 7wt%, dimethyl silicone polymer 15wt%, grape-kernel oil 10wt%, VE acetate 5wt%, caprylic/capric triglyceride
28wt%.
In the present invention, it is preferred to, described Chinese herbal medicine extract is extracted by the following method to be obtained：
(1) after each bulk drug is crushed, each bulk drug is weighed according to following parts by weight, mixes, obtains the mixing of each bulk drug
Thing；
The parts by weight of teasel root 20~40, bark of eucommia 15-30 parts by weight, the parts by weight of gumbo 15~30, the parts by weight of sealwort 10~20 with
And the parts by weight of the bark of official magnolia 10~20；
(2) the mixture concentration of volume percent for each bulk drug that step (1) is obtained is 50%~90% (v/v) ethanol
Extract, the mass volume ratio of bulk drug mixture and ethanol is 1:10~1:50(g：ML), 55 DEG C~85 DEG C 1~4h of extraction, are obtained
To extract solution；
(3) extract solution for obtaining step (2) is cooled to 20 DEG C~30 DEG C, and 100~200 mesh filter-cloth filterings obtain filtrate；
(4) added in the filtrate obtained to step (3) mixed with ethanol volume identical butanediol in step (2) or propane diols
It is molten uniform, the ethanol in solution is rotated out, is filtered by vacuum, filtrate is collected, produces.
Wherein, it is preferred that the parts by weight of each bulk drug are：The parts by weight of teasel root 40, the parts by weight of the bark of eucommia 30, the weight of gumbo 20
Part, the parts by weight of sealwort 15 and the parts by weight of the bark of official magnolia 15.
Wherein, it is preferred that the concentration of volume percent of ethanol is 75% (v/v), bulk drug mixture and second in step (2)
The mass volume ratio of alcohol is 1：20(g：mL).
Wherein, it is preferred that the condition of vacuum filtration is that 1.2 μm of filter plates are spread in Buchner funnel in step (4), carries out vacuum
Suction filtration.
Further, the invention also provides a kind of method for preparing described skin care oil, it comprises the following steps：
(1) each raw material is weighed respectively；
(2) successively by caprylic/capric triglyceride, Nexbase 2004, Chinese herbal medicine extract, dimethyl silicone polymer, Portugal
Grape seed oil, VE acetates are added in container, heated while stirring, stir speed (S.S.) 150-450r/min, are heated to 60-85 DEG C, guarantor
It is warm 20-60 minutes；
(3) after cooling, produce.
Further, the invention also provides described skin care oil is being prevented and alleviated chapped skin, repairing skin screen
Barrier, anti-inflammatory and it is antipruritic in purposes.
Wherein, it is preferred that the crowd that is applicable of described skin care oil is 50 crowd more than one full year of life.
Skin care oil of the present invention recommends method：After daily morning and evening warm water cleaning, affected part is coated on, symptom of chapping
Severe patient can increase on demand.
The beneficial outcomes of the present invention：
Raw material of the present invention select natural plant composition, non-stimulated to skin safe.Ground for the elderly's skin characteristic
The Chinese herbal medicine extract of hair not only has mitigation to chap in itself, also with anti-inflammation, moisturizing profit flesh, and Shu Min is antipruritic etc.
Effect, and skin barrier can be repaired, fundamentally treat the skin problems such as old chap, itch.Meanwhile, the present invention is to old
Year application on human skin has protective effect, the generation that the elderly can be prevented to chap.Easy, preparation method letter that raw material of the present invention are obtained
Just, green safety, alleviates and prevention chap effect is good, with good application prospect and market prospects.
Brief description of the drawings
Fig. 1 is the erythrocyte hemolysis result of the test for the Chinese herbal medicine extract that embodiment 1 is prepared；
Fig. 2 is the lost situation of change of moisture of skin after the skin care oil prepared using embodiment 5.
Embodiment
The invention will now be further described with reference to specific embodiments, advantages of the present invention and feature will be with description and
It is apparent.But embodiment is only exemplary, does not constitute any limitation to the scope of the present invention.Those skilled in the art should
It should be appreciated that, the details and form of technical solution of the present invention can be repaiied without departing from the spirit and scope of the invention
Change or replace, but these modifications and replacement are each fallen within protection scope of the present invention.
Medicinal material used in the present embodiment can be commercially available from China Medicament Group Corp., meet People's Republic of China's medicine
2010 editions standards of allusion quotation.Other preparation raw materials source of the invention is shown in Table 1：
Table 1
| Material name | Standard Chinese title | Supplier |
| GTCC | Caprylic/capric triglyceride | BDCom's ippon |
| Nexbase 2004 | Nexbase 2004 | IMCD |
| PMX200(5cs) | Dimethyl silicone polymer | Gram of emblem |
| Grape-kernel oil | Grape fruit (CITRUS PARADISI) seed oil | Luxuriant woods is safe |
| VE acetates | Tocopherol acetate | Member of Imperial Academy's chemical industry |
The preparation of the Chinese herbal medicine extract of the present invention of embodiment 1
(1) after each bulk drug is crushed, each bulk drug is weighed respectively according to following weight proportioning, is well mixed：
Teasel root 20g, bark of eucommia 25g, gumbo 15g, sealwort 10g, bark of official magnolia 10g；
(2) extracted with concentration of volume percent for 50% (v/v) ethanol, the mass volume ratio between bulk drug and ethanol is
1:40 (g/mL), 85 DEG C of extraction 4h；
(3) extract solution for obtaining step (2) is cooled to 30 DEG C, and 100 mesh filter-cloth filterings obtain filtrate；
(4) added in the filtrate obtained to step (3) it is miscible uniform with ethanol volume identical butanediol in step (2),
The ethanol in solution is rotated out, vacuum decompression suction filtration collects filtrate, produces Chinese herbal medicine extract A.
Vacuum filtration condition is that 1.2 μm of filter plates are spread in Buchner funnel in the step (4), is filtered by vacuum.
The preparation of the Chinese herbal medicine extract of the present invention of embodiment 2
(1) after each bulk drug is crushed, each bulk drug is weighed respectively according to following weight proportioning, is well mixed：
Teasel root 40g, bark of eucommia 30g, gumbo 20g, sealwort 15g, bark of official magnolia 15g；
(2) extracted with concentration of volume percent for 75% (v/v) ethanol, the mass volume ratio between bulk drug and ethanol is
1:20 (g/mL), 70 DEG C of extraction 2h；
(3) extract solution for obtaining step (2) is cooled to 20 DEG C, and 200 mesh filter-cloth filterings obtain filtrate；
(4) added in the filtrate obtained to step (3) it is miscible uniform with ethanol volume identical butanediol in step (2),
The ethanol in solution is rotated out, vacuum decompression suction filtration collects filtrate, produces Chinese herbal medicine extract B.
Vacuum filtration condition is that 1.2 μm of filter plates are spread in Buchner funnel in the step (4), is filtered by vacuum.
The preparation of the extract of the present invention of embodiment 3
(1) after each bulk drug is crushed, each bulk drug is weighed respectively according to following weight proportioning, is well mixed：
Teasel root 30g, bark of eucommia 15g, gumbo 30g, sealwort 20g, bark of official magnolia 20g.；
(2) extracted with concentration of volume percent for 90% (v/v) ethanol, the mass volume ratio between bulk drug and ethanol is
1:50 (g/mL), 55 DEG C of extraction 1h；
(3) extract solution for obtaining step (2) is cooled to 25 DEG C, and 150 mesh filter-cloth filterings obtain filtrate；
(4) added in the filtrate obtained to step (3) it is miscible uniform with ethanol volume identical propane diols in step (2),
The ethanol in solution is rotated out, vacuum decompression suction filtration collects filtrate, produces Chinese herbal medicine extract C.
Vacuum filtration condition is that 1.2 μm of filter plates are spread in Buchner funnel in the step (4), is filtered by vacuum.
The preparation of the skin care oil of the present invention of embodiment 4
1st, raw material and proportioning (mass percent)
It is shown in Table 2：
Table 2
2nd, the preparation method of skin care oil：
(1) each raw material is weighed respectively according to weight percentage；
(2) raw material in formula is sequentially added by numeric order, heated while stirring, stir speed (S.S.) 300r/min, heating
To 70 DEG C, 40 minutes are incubated, is produced after cooling.
The preparation of the skin care oil of the present invention of embodiment 5
1st, raw material and proportioning (mass percent)
It is shown in Table 3：
Table 3
2nd, the preparation method of skin care oil：
(1) each raw material is weighed respectively according to weight percentage；
(2) raw material in formula is sequentially added in order, is heated while stirring, stir speed (S.S.) 150r/min is heated to 85
DEG C, 20 minutes are incubated, is produced after cooling.
The preparation of the skin care oil of the present invention of embodiment 6
1st, raw material and proportioning (mass percent)
It is shown in Table 4：
Table 4
2nd, the preparation method of skin care oil：
(1) each raw material is weighed respectively according to weight percentage；
(2) raw material in formula is sequentially added in order, is heated while stirring, stir speed (S.S.) 450r/min is heated to 60
DEG C, 60 minutes are incubated, is produced after cooling.
The Efficacy experiments of the product of the present invention of embodiment 7
First, the safety experiment of Chinese herbal medicine extract A, Chinese herbal medicine extract B, Chinese herbal medicine extract C and its skin care oil
In order to assess whether the invention has adverse reaction to human body, the safety evaluation experiment of system has been carried out：It is red
The multiple Skin Irritation Test of cell hemolytic test, mouse and human closed formula patch test.
(1) erythrocyte hemolysis is tested
Erythrocyte hemolysis test method is with reference to Red Blood Cell Test System, in European alternative certification
The heart (European Centre for the Validation of Alternative Methods, ECVAM), European Union authority
Method validation center provide.Research shows that erythrocyte hemolysis rate to a certain extent can be with the excitant of response sample, haemolysis
Rate is higher, shows that the potential excitant of sample is bigger.The red blood cell that embodiment 1 prepares various concentrations Chinese herbal medicine extract sample is molten
Blood experimental result is as shown in Figure 1.
Fig. 1 results show that in the concentration range of tested concentration 1%~10% (v/v), embodiment 1 prepares Chinese herbal medicine and carried
Take thing to show extremely low erythrocyte hemolysis rate, show to exist that potential excitant possibility is extremely low, security is good.Hair
A person of good sense prepares Chinese herbal medicine extract with embodiment 2, embodiment 3 and repeats erythrocyte hemolysis experiment, obtains identical effect.
(2) the multiple Skin Irritation Test of mouse
By the multiple Skin Irritation Test of mouse, it is determined that and evaluate Chinese herbal medicine extract it is local to mammal skin whether
There are stimulation or corrosiveness and its degree.
Test method skin irritation/corrosion test method with reference to as defined in 2007 editions cosmetics health specifications.Will be by
Once (or multiple) is coated on the skin of animal subject examination thing, and in predetermined time interval, observation animal skin is locally pierced
Swash the degree of effect and scored.Using own control, to evaluate stimulation of the tested material to skin.Acute skin irritation
The property experimental observation time limit should be enough to evaluate the invertibity or irreversibility of the effect.
Experimental result shows that 14 days given the test agent of continuous smearing (add embodiment 1 and prepare extracts of Chinese herbal medicine 5% respectively
And 10%), mouse skin does not occur erythema and oedema phenomenon.Inventor prepares Chinese herbal medicine with embodiment 2, embodiment 3 and extracted
Thing repeats erythrocyte hemolysis experiment, obtains identical effect.
The present invention prepares Chinese herbal medicine extract security well, nonirritant.
(3) human closed formula patch test
Human body patch test method reference《Cosmetics health specification (2007 editions)》, embodiment 4, embodiment 5, embodiment 6
Skin care oil difference counter sample 1, sample 2, the sample 3 prepared, carries out closed patch, investigates sample and human body is made respectively
Into the possibility of adverse reaction.Bare substrate 1-3 is same with discrete phase used in sample 1-3, but the corresponding Chinese herbal medicine of water consumption substitution is carried
Take thing that bare substrate is made.Skin adverse reaction classification is as shown in table 5.
The skin adverse reaction of table 5 is classified
According to table 5, dermoreaction situation of the subject in 30 minutes, 24h and 48h is observed using spot examination device is removed.Examination
Result is tested as shown in table 6-8.
Table 6 removes 30 minutes observation results of spot examination device
Table 7 removes spot examination device 24h observation results
| Sample number into spectrum | 0 grade | 1 grade | 2 grades | 3 grades | 4 grades |
| Blank | 30 | 0 | 0 | 0 | 0 |
| Sample 1 | 30 | 0 | 0 | 0 | 0 |
| Sample 2 | 30 | 0 | 0 | 0 | 0 |
| Sample 3 | 30 | 0 | 0 | 0 | 0 |
| Bare substrate 1 | 30 | 0 | 0 | 0 | 0 |
| Bare substrate 2 | 30 | 0 | 0 | 0 | 0 |
| Bare substrate 3 | 30 | 0 | 0 | 0 | 0 |
Table 8 removes spot examination device 48h observation results
| Sample number into spectrum | 0 grade | 1 grade | 2 grades | 3 grades | 4 grades |
| Blank | 30 | 0 | 0 | 0 | 0 |
| Sample 1 | 30 | 0 | 0 | 0 | 0 |
| Sample 2 | 30 | 0 | 0 | 0 | 0 |
| Sample 3 | 30 | 0 | 0 | 0 | 0 |
| Bare substrate 1 | 30 | 0 | 0 | 0 | 0 |
| Bare substrate 2 | 30 | 0 | 0 | 0 | 0 |
| Bare substrate 3 | 30 | 0 | 0 | 0 | 0 |
According to 2007《Cosmetics health specification》Requirement, judge prepared by the corresponding embodiment 4-6 of sample 1, sample 2, sample 3
Obtained skin care oil has no adverse reaction to human body skin.Result of the test shows, skin care oil of the invention is to human body skin without bad
Reaction occurs, and security is good.
2nd, the Ku812 cells IL- that Chinese herbal medicine extract A, Chinese herbal medicine extract B, Chinese herbal medicine extract C are induced PAMCI
8, IL-6 influence
(1) experimental principle
IL-6 is that the mononuclear macrophage activated in a kind of multifunctional cytokine, blood is its main source.It is also
Start systemic inflammatory reaction most strong cell factor.IL-8 is the cell factor secreted by Th1 cells, main mediated cell poison
Generated with the immune response auxiliary antibody of local inflammation-related, these effects can cause body local inflammation reaction.
Suppression to inflammatory factor IL-6 and IL-8 shows that Chinese herbal medicine extract has suppression scytitis, such as general red, scabies
Itch chap etc..
(2) experimental method：
With DMSO or distilled water prepare positive drug and embodiment 1, embodiment 2, the gained Chinese herbal medicine extract A of embodiment 3, B,
C, the used time, basic, normal, high concentration was 25mg/mL, 50mg/mL, 100mg/mL to be diluted containing 10% hyclone culture medium.
Ku812 cell densities are adjusted to 2.2 × 10 with the IMDM culture mediums containing 10% hyclone6Individual/mL cell
Suspension, is inoculated in 96 orifice plates, per the μ L of hole 200.If cell blank control group, model group, positive drug group and test medicine group, often
Group sets 3 parallel holes, 37 DEG C, 5%CO2Incubator culture stands 10min, positive drug and test medicine group add positive drug and by
Reagent thing, final concentration of 50 μ g/mL put pre-temperature in incubator and incubated, after 15min in addition to cell blank group, and each group cell adds thorn
Swashing agent PMA, A12387 makes final concentration be respectively 5nm, 1 μm, the cell blank group addition same volume culture mediums of DMSO containing isoconcentration.2h
Centrifugal separating cell, collects cell supernatant afterwards, determines IL-8, IL-6 content in supernatant.
(3) experimental result
Calculate the basic, normal, high concentration of extract A is respectively to IL-6 inhibiting rates：8.1%th, 13.7%, 28.1%；To IL-8
Inhibiting rate is respectively：5.1%th, 17.7%, 27.0%；The basic, normal, high concentration of extract B is respectively to IL-6 inhibiting rates：9.7%th,
16.4%th, 28.9%；It is respectively to IL-8 inhibiting rates：9.2%th, 18.1%, 30.1%；Extract C is distinguished IL-6 inhibiting rates
For：7.9%th, 20.6%, 23.4%；It is respectively to IL-8 inhibiting rates：6.1%th, 19.9%, 29.8%.Show embodiment 1, reality
Apply example 2, embodiment 3 gained Chinese herbal medicine extract A, B, C can by suppress IL-6, IL-8 play alleviate chap, it is Shu Min, antipruritic
Effect.
3rd, the effect of embodiment 4, embodiment 5, the preparation-obtained skin care oil of embodiment 6 in chapped skin is alleviated
Test population：The volunteer with chapped skin symptom of 20 50-70 Sui, wherein, male 10, women 10
Example.
Amount of samples：Volunteer is chapped after position is soaked 15 minutes with warm water daily and dried, by skin care oil (embodiment 5
Prepare) uniformly it is applied at chap, sooner or later twice daily, use 4 weeks.Cure criterion：Surface skin is flat, no scar, nothing
Sufferings, elasticity are good, skin color is normal.Effectively：Partly there is hyperplastic scar close to criterion of cure in treatment face 80%
Slightly higher than surface, flush is congested, the slightly hard person of matter；It is effective：Treatment face 60% is close to criterion of cure, and part appearance and normal skin are slightly
There is difference, flushed substantially with surrounding skin, color is slightly red or slightly white；It is invalid：It is grand that obvious hyperplastic scar occurs in treatment face 80%
Starting point sheet, it is in irregular shape, it is uneven, or skin is in patch pattern change, flush is congested, matter is hard, obfuscation, there is cusalgia and scabies
Gargalesthesia person.
As a result：1 month cure rate 20% (4), effective percentage is 40% (8), and obvious effective rate is 25% (5), total effective
Rate is up to 85%.Embodiment 4,6 skin care oils repeat the experimental result be the same as Example 5 of above-mentioned experiment.
4th, effect of the skin care oil that embodiment 5 is prepared in skin barrier reparation
1st, cuticula moisture loss is tested
Test sample is the gained skin care oil of embodiment 5, and water consumption substitution Chinese herbal medicine extract is made blank oil matrix, is used as sky
White control.
Test before through the trained health volunteer 30 of professional (each 15 of men and women), the age at 50~55 years old, institute
There is subject without skin or systemic disease history, recipient site is without exception, and tested period does not smear any unrelated with experiment
Medicine or cosmetics.
Test site room temperature (25 ± 1) DEG C, relative humidity (40 ± 5) %, subject should keep body to be stabilization before test
State.Using 35 DEG C or so clear water wipe subject's both arms after, in start after the 30min that sat quietly under test environment test.
At subject's inboard arm is away from palm base portion 5cm, tested region (4cm × 4cm) is marked, same arm can be simultaneously
Mark multiple regions (interval 1cm), the equal random distribution of test sample.The blank value of each test zone is first measured, then test specimens
By (2.0 ± 0.1) mg/cm2Consumption carry out single application, after coating use Multi-functional skin moisture tester and moisture of skin
Lost instrument measures the moisture loss value in the tested region of 0.5h, 1h, 2h and 4h and blank control region respectively.
Test and the data that 5 times measure in subject's smearing same sample region are averaged, using SPSS statistical softwares
Carry out t check analyses.
2nd, experimental result
Moisture of skin, which scatters and disappears, to be changed
Moisture of skin windage (Transepidermal water loss, TEWL) is reflected in test period, test block
Domain moisture loss changes with time rule, and it can be with the skin barrier maintenance function of characterization test sample, its smaller, moisture of value
Scatter and disappear fewer, skin repair ability is stronger；Conversely, skin repair ability is weaker.
Percentage of water loss (%)=(sample sets water loss amount-starting moisture windage)/starting moisture windage × 100
Moisture loss result is shown in Fig. 2.As a result show：In 4h, the gained skin care oil of embodiment 5 has skin repair ability effect
Really, maintenance most pronounced effects, with skin barrier protective effect, can effectively prevent the generation of chap.Embodiment 4,6 skin care oils
Repeat the experimental result be the same as Example 5 of above-mentioned experiment.
5th, the itching-relieving efficacies clinical verification for the skin care oil that embodiment 5 is prepared
(1) experimental method：
Patient source is Chinese department of traditional Chinese medicine institute acupuncture hospital dermatology department out-patient.This group totally 30, man 14, female 16
Example, it is the oldest 58 years old, minimum 50 years old.The course of disease is most long 1 year, most short 2 months.
Clinic has discomfort when being mainly shown as face, hand, lower limb, pedal skin, itches, furfur, especially using cosmetics after,
There is a series of symptom, it is repeatedly refractory.
Only for the crowd based on face of sensitive group, cosmetics can be with user.Exclude severe allergy, whole body mistake
Quick and other patients with medical sign disease.
(2) methods of clinical observation and criterion of therapeutical effect：
1st, sample application method：
After daily mildy wash face cleaning, the skin care oil for applying embodiment 5 in face and sensitive part is appropriate, once in the morning and once at night.1
Week, 2 weeks, 3 weeks, 4 weeks (1 month) are respectively counted once.
2nd, curative effect determinate standard
(1) cure：Clinical symptom disappearance, condition susceptible disappear；
(2) effectively：Clinical symptom relief, condition susceptible disappear or disappeared, and reduce or reduce；
(3) it is invalid：Clinical symptoms, condition susceptible do not improve.
(3) clinical observation result and conclusion
1st, result
The total situation of the skin care oil clinical observation of 1 month and subject's Symptoms prepared using embodiment 5 is with treating
The situation of effect refers to table 9.
The total situation of clinical observation for the skin care oil that the embodiment 5 of table 9 is prepared
2nd, clinical effectiveness is analyzed
(1) (itch, erythema, dry furfur situation use implementation for skin of face sensitive group skin of face cardinal symptom
The skin care oil 1 month of example 5 is to efficient up to 90% (27), and the cure rate of 1 month is 77% (23).
(2) overall assessment of the trier to the skin care oil of Application Example 5：
A, " feeling very good, be worth application " account for 67% (20)；
B, " feeling fine, can apply " account for 17% (5)；
C, " feel general, can with can be without " account for 13% (4)；
D, " feeling bad, be unworthy applying " account for 3% (1).
(3) as long as adhering to using notable to sensitive skin crowd therapeutic effect.
The skin care oil that inventor is prepared with embodiment 4,6 repeats above-mentioned experiment, as a result ibid.
Claims (10)
1. a kind of skin care oil for being used to preventing and alleviating senile skin chap, it is characterised in that containing pungent in described skin care oil
Acid/Triglyceride DDD, Nexbase 2004, dimethyl silicone polymer, grape-kernel oil, tocopherol acetate and Chinese herbal medicine are extracted
Thing；
Wherein, Radix Dipsaci extract, eucommia ulmoides extracts, gumbo extract, Rhizoma Polygonati extract are contained in described Chinese herbal medicine extract
And Magnolia cortex P.E.
2. skin care oil as claimed in claim 1, it is characterised in that the weight/mass percentage composition of each raw material is：Nexbase 2004 30-
40wt%, Chinese herbal medicine extract 3.0-10.0wt%, dimethyl silicone polymer 5-15wt%, grape-kernel oil 1-10wt%, VE vinegar
Acid esters 1-5wt%, surplus is caprylic/capric triglyceride.
3. skin care oil as claimed in claim 2, it is characterised in that the weight/mass percentage composition of each raw material is：Nexbase 2004
35wt%, Chinese herbal medicine extract 7wt%, dimethyl silicone polymer 15wt%, grape-kernel oil 10wt%, VE acetate 5wt% are pungent
Acid/Triglyceride DDD 28wt%.
4. skin care oil as claimed in claim 1, it is characterised in that described Chinese herbal medicine extract is extracted by the following method
Arrive：
(1) after each bulk drug is crushed, each bulk drug is weighed according to following parts by weight, mixes, obtains the mixture of each bulk drug；
The parts by weight of teasel root 20~40, bark of eucommia 15-30 parts by weight, the parts by weight of gumbo 15~30, the parts by weight of sealwort 10~20 and thickness
Plain 10~20 parts by weight；
(2) mixture for each bulk drug that step (1) is obtained is that 50%~90% (v/v) ethanol is carried with concentration of volume percent
Take, the mass volume ratio of bulk drug mixture and ethanol is 1:10~1:50(g：ML), 55 DEG C~85 DEG C 1~4h of extraction, are obtained
Extract solution；
(3) extract solution for obtaining step (2) is cooled to 20 DEG C~30 DEG C, and 100~200 mesh filter-cloth filterings obtain filtrate；
(4) added in the filtrate obtained to step (3) miscible with ethanol volume identical butanediol in step (2) or propane diols
It is even, the ethanol in solution is rotated out, is filtered by vacuum, filtrate is collected, produces.
5. skin care oil as claimed in claim 3, it is characterised in that the parts by weight of each bulk drug are：The parts by weight of teasel root 40, Du
Secondary 30 parts by weight, the parts by weight of gumbo 20, the parts by weight of sealwort 15 and the parts by weight of the bark of official magnolia 15.
6. skin care oil as claimed in claim 3, it is characterised in that the concentration of volume percent of ethanol is 75% in step (2)
(v/v), the mass volume ratio of bulk drug mixture and ethanol is 1：20(g：mL).
7. skin care oil as claimed in claim 3, it is characterised in that the condition of vacuum filtration is in Buchner funnel in step (4)
1.2 μm of filter plates are spread, are filtered by vacuum.
8. a kind of method for preparing the skin care oil described in claim any one of 1-7, it is characterised in that comprise the following steps：
(1) each raw material is weighed respectively；
(2) successively by caprylic/capric triglyceride, Nexbase 2004, Chinese herbal medicine extract, dimethyl silicone polymer, grape pip
Oil, VE acetates are added in container, are heated while stirring, stir speed (S.S.) 150-450r/min, are heated to 60-85 DEG C, are incubated 20-
60 minutes；
(3) after cooling, produce.
9. skin care oil described in claim any one of 1-7 prevent and alleviate chapped skin, repair skin barrier, anti-inflammatory and
Purposes in antipruritic.
10. purposes as claimed in claim 9, it is characterised in that the applicable crowd of described skin care oil is 50 more than one full year of life
Crowd.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610410741.6A CN107088179A (en) | 2016-06-13 | 2016-06-13 | Skin care oil for preventing and alleviating senile skin chap and its production and use |
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|---|---|---|---|
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271860A (en) * | 2013-06-18 | 2013-09-04 | 菏泽尧舜牡丹生物科技有限公司 | Skin care oil containing peony oil and preparation method thereof |
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2016
- 2016-06-13 CN CN201610410741.6A patent/CN107088179A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271860A (en) * | 2013-06-18 | 2013-09-04 | 菏泽尧舜牡丹生物科技有限公司 | Skin care oil containing peony oil and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
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