CN107074944B - 藉由针对cd4之单克隆抗体介导竞争型hiv进入抑制之hiv感染的治疗和功能性治愈 - Google Patents

藉由针对cd4之单克隆抗体介导竞争型hiv进入抑制之hiv感染的治疗和功能性治愈

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Publication number
CN107074944B
CN107074944B CN201480081992.3A CN201480081992A CN107074944B CN 107074944 B CN107074944 B CN 107074944B CN 201480081992 A CN201480081992 A CN 201480081992A CN 107074944 B CN107074944 B CN 107074944B
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China
Prior art keywords
antibody
hiv
administered
subject
cells
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CN201480081992.3A
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Chinese (zh)
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CN107074944A (zh
Inventor
王长怡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yangzhou Shizhiyuan Biotechnology Co ltd
Original Assignee
Yangzhou Shizhiyuan Biotechnology Co ltd
United Biomedical Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480081992.3A 2014-09-16 2014-11-11 藉由针对cd4之单克隆抗体介导竞争型hiv进入抑制之hiv感染的治疗和功能性治愈 Active CN107074944B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051200P 2014-09-16 2014-09-16
US62/051,200 2014-09-16
PCT/US2014/065048 WO2016043788A1 (en) 2014-09-16 2014-11-11 Treatment and functional cure of hiv infection by monoclonal antibodies to cd4 mediating competitive hiv entry inhibition

Publications (2)

Publication Number Publication Date
CN107074944A CN107074944A (zh) 2017-08-18
CN107074944B true CN107074944B (zh) 2025-12-05

Family

ID=55533661

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480081992.3A Active CN107074944B (zh) 2014-09-16 2014-11-11 藉由针对cd4之单克隆抗体介导竞争型hiv进入抑制之hiv感染的治疗和功能性治愈

Country Status (14)

Country Link
US (1) US11180555B2 (enExample)
EP (1) EP3194442A4 (enExample)
JP (2) JP6716544B2 (enExample)
KR (1) KR20170054478A (enExample)
CN (1) CN107074944B (enExample)
AU (2) AU2014406462A1 (enExample)
BR (1) BR112017005134A2 (enExample)
CA (1) CA2961464A1 (enExample)
MX (1) MX2017003546A (enExample)
RU (1) RU2762315C2 (enExample)
SG (1) SG11201702056YA (enExample)
TW (1) TWI695720B (enExample)
WO (1) WO2016043788A1 (enExample)
ZA (1) ZA201701856B (enExample)

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MX2017003546A (es) * 2014-09-16 2017-08-14 Ubi Ip Holdings Tratamiento y curacion fucional de la infeccion por vih por anticuerpos monoclonales para cd4, que median la inhibicion competitiva de la entrada de vih.
SG10202100268RA (en) * 2016-08-13 2021-02-25 United Biopharma Inc Treatment and sustained virologic remission of hiv infection by antibodies to cd4 in haart stabilized patients
SG11202007815TA (en) * 2018-03-05 2020-09-29 Oncoimmune Inc Methods of use of soluble cd24 for treating acquired immune deficiency syndrome (hiv/aids)
WO2021146272A1 (en) * 2020-01-13 2021-07-22 The Regents Of The University Of California Methods for treating viral infections
CN116063506A (zh) * 2022-09-02 2023-05-05 华道(上海)生物医药有限公司 一种分离的抗体及其用途

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US4381295A (en) 1979-04-26 1983-04-26 Ortho Pharmaceutical Corporation Monoclonal antibody to human helper T cells and methods of preparing same
DE3828582A1 (de) 1988-08-23 1990-03-01 Max Planck Gesellschaft Monoklonaler antikoerper zur inhibierung der infektion von zellen durch hiv-viren
EP0365209A3 (en) 1988-10-17 1990-07-25 Becton, Dickinson and Company Anti-leu 3a amino acid sequence
JPH0725794B2 (ja) 1990-03-23 1995-03-22 呉羽化学工業株式会社 新規なペプチド
ATE153536T1 (de) 1990-11-27 1997-06-15 Biogen Inc Hiv-induzierte synzytien blockierender anti-cd-4- antikörper
CA2124967C (en) 1991-12-17 2008-04-08 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
JPH06125783A (ja) 1991-12-28 1994-05-10 Chemo Sero Therapeut Res Inst 組換え抗ｈｉｖ抗体およびその調製方法
DE69535002T2 (de) 1994-03-08 2006-12-07 Memorial Sloan-Kettering Cancer Center Rekombinante humanisierte antikörper gegen fb5
US5961976A (en) 1996-06-03 1999-10-05 United Biomedical, Inc. Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV
US5962319A (en) 1997-05-19 1999-10-05 Bml, Inc. Human-Th1-specific protein, gene encoding the protein, transformants, recombinant vectors, and antibodies related to the gene
JP3231262B2 (ja) 1996-06-05 2001-11-19 株式会社ビー・エム・エル ヒトＴｈ１特異的タンパク質及びこれをコードする遺伝子、並びにこれに関連する形質転換体、組換えベクター及び抗体
JPH10155489A (ja) 1996-11-27 1998-06-16 Asahi Chem Ind Co Ltd 組換え抗体及びそれをコードする核酸
ES2258817T3 (es) 1997-05-21 2006-09-01 Biovation Limited Metodo para la produccion de proteinas no inmunogenas.
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WO1999061629A1 (fr) 1998-05-25 1999-12-02 Asahi Kasei Kogyo Kabushiki Kaisha Dispositif pour la separation cellulaire et procede de separation
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JP2003327536A (ja) 2002-03-07 2003-11-19 Kitasato Inst:The ヒト免疫不全症候群ウイルスの感染、増殖抑制剤
US20030211470A1 (en) 2002-03-15 2003-11-13 Olson William C. CD4-IgG2-based salvage therapy of HIV-1 infection
US7501494B2 (en) * 2003-01-15 2009-03-10 United Biomedical, Inc. Designed deimmunized monoclonal antibodies for protection against HIV exposure and treatment of HIV infection
KR100633856B1 (ko) * 2005-07-08 2006-10-13 조통래 산소와 오존을 함유한 미세기포가 녹아 있는 작물의병해충방제제
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Also Published As

Publication number Publication date
RU2762315C2 (ru) 2021-12-17
RU2017112967A (ru) 2018-10-17
JP6716544B2 (ja) 2020-07-01
JP2017529355A (ja) 2017-10-05
TWI695720B (zh) 2020-06-11
ZA201701856B (en) 2020-08-26
CN107074944A (zh) 2017-08-18
JP2020097569A (ja) 2020-06-25
US20170369576A1 (en) 2017-12-28
TW201611845A (en) 2016-04-01
US11180555B2 (en) 2021-11-23
MX2017003546A (es) 2017-08-14
SG11201702056YA (en) 2017-04-27
EP3194442A4 (en) 2018-05-23
KR20170054478A (ko) 2017-05-17
CA2961464A1 (en) 2016-03-24
BR112017005134A2 (pt) 2017-12-12
RU2017112967A3 (enExample) 2018-10-17
AU2021203071A1 (en) 2021-06-17
AU2021203071B2 (en) 2024-11-21
WO2016043788A1 (en) 2016-03-24
AU2014406462A1 (en) 2017-04-06
EP3194442A1 (en) 2017-07-26

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