CN107074817B - 用于成像亨廷顿蛋白的探针 - Google Patents

用于成像亨廷顿蛋白的探针 Download PDF

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Publication number
CN107074817B
CN107074817B CN201580058254.1A CN201580058254A CN107074817B CN 107074817 B CN107074817 B CN 107074817B CN 201580058254 A CN201580058254 A CN 201580058254A CN 107074817 B CN107074817 B CN 107074817B
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alkyl
group
imaging
pyridine
pet
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CN107074817A (zh
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C·多敏古兹
J·维恰克
J·巴德
C·J·布朗
T·M·克吕尔
D·克拉克-弗鲁
S·海耶斯
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CHDI Foundation Inc
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CHDI Foundation Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN201580058254.1A 2014-08-29 2015-08-28 用于成像亨廷顿蛋白的探针 Active CN107074817B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311625463.2A CN118005611A (zh) 2014-08-29 2015-08-28 用于成像亨廷顿蛋白的探针

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462043644P 2014-08-29 2014-08-29
US62/043,644 2014-08-29
PCT/US2015/047396 WO2016033436A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Related Child Applications (1)

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CN107074817A CN107074817A (zh) 2017-08-18
CN107074817B true CN107074817B (zh) 2023-12-15

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CN202311625463.2A Pending CN118005611A (zh) 2014-08-29 2015-08-28 用于成像亨廷顿蛋白的探针

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Country Status (20)

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US (2) US11071793B2 (OSRAM)
EP (1) EP3186241B1 (OSRAM)
JP (3) JP2017527559A (OSRAM)
KR (1) KR102410760B1 (OSRAM)
CN (2) CN107074817B (OSRAM)
AU (1) AU2015308765B2 (OSRAM)
BR (1) BR112017004136B1 (OSRAM)
CA (1) CA2959531C (OSRAM)
DK (1) DK3186241T3 (OSRAM)
EA (1) EA037275B1 (OSRAM)
ES (1) ES2841746T3 (OSRAM)
HR (1) HRP20202032T1 (OSRAM)
HU (1) HUE052892T2 (OSRAM)
IL (1) IL250805B (OSRAM)
MX (2) MX383202B (OSRAM)
PL (1) PL3186241T3 (OSRAM)
PT (1) PT3186241T (OSRAM)
SG (1) SG11201701578YA (OSRAM)
SI (1) SI3186241T1 (OSRAM)
WO (1) WO2016033436A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3186233T3 (pl) 2014-08-29 2022-02-28 Chdi Foundation, Inc. Sondy do obrazowania białka huntingtyny
ES2818107T3 (es) 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina
WO2016033440A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
ES2841746T3 (es) 2014-08-29 2021-07-09 Chdi Foundation Inc Sondas para la imagen de la proteína de Huntington
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
US10865201B2 (en) 2016-09-12 2020-12-15 Valo Health, Inc. Bicyclic compounds useful as GPR120 modulators
CA3041033A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Monocyclic compounds useful as gpr120 modulators
JP7619952B2 (ja) 2019-02-25 2025-01-22 シーエイチディーアイ ファウンデーション，インコーポレーテッド 変異型ハンチンチンタンパク質を標的とするための化合物及びその使用
JP7720847B2 (ja) * 2019-12-18 2025-08-08 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチンチンタンパク質をイメージングするための化合物及びプローブ
BR112022025238A2 (pt) * 2020-06-11 2023-02-14 Chdi Foundation Inc Compostos heterocíclicos e agentes de imageamento para formar imagem da proteína huntingtina
BR112023020857A2 (pt) * 2021-04-08 2023-12-12 Chdi Foundation Inc Compostos de isoindolinona e agentes de imaginologia para imaginologia da proteína huntingtina

Citations (4)

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WO2000076969A1 (en) * 1999-06-10 2000-12-21 Warner-Lambert Company Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives
WO2009042907A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
CN101500995A (zh) * 2006-03-17 2009-08-05 美国政府卫生与公共服务部 用于治疗脊髓型肌萎缩和其它用途的1-氧代-异吲哚啉化合物
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도

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US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
US20050148650A1 (en) * 2002-03-01 2005-07-07 Shigenori Ohkawa Antidepressant
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
JP5632612B2 (ja) * 2007-12-05 2014-11-26 あすか製薬株式会社 ラクタム化合物又はその塩及びｐｐａｒ活性化剤
TWI577677B (zh) 2012-04-25 2017-04-11 拉夸里亞創藥股份有限公司 作爲ｔｔｘ－ｓ阻斷劑之吡咯並吡啶酮衍生物
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PL3186233T3 (pl) 2014-08-29 2022-02-28 Chdi Foundation, Inc. Sondy do obrazowania białka huntingtyny
ES2818107T3 (es) 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina
WO2016033440A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
ES2841746T3 (es) 2014-08-29 2021-07-09 Chdi Foundation Inc Sondas para la imagen de la proteína de Huntington
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina

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WO2000076969A1 (en) * 1999-06-10 2000-12-21 Warner-Lambert Company Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives
CN101500995A (zh) * 2006-03-17 2009-08-05 美国政府卫生与公共服务部 用于治疗脊髓型肌萎缩和其它用途的1-氧代-异吲哚啉化合物
WO2009042907A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도

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Publication number Publication date
EP3186241A1 (en) 2017-07-05
HRP20202032T1 (hr) 2021-02-19
JP7042940B2 (ja) 2022-03-28
CA2959531A1 (en) 2016-03-03
US20210379211A1 (en) 2021-12-09
CN107074817A (zh) 2017-08-18
US11071793B2 (en) 2021-07-27
EP3186241B1 (en) 2020-10-07
JP6843282B2 (ja) 2021-03-17
IL250805B (en) 2020-08-31
EA037275B1 (ru) 2021-03-03
PL3186241T3 (pl) 2021-05-17
JP2021088584A (ja) 2021-06-10
IL250805A0 (en) 2017-04-30
PT3186241T (pt) 2021-01-08
MX383202B (es) 2025-03-13
JP2020079272A (ja) 2020-05-28
ES2841746T3 (es) 2021-07-09
WO2016033436A1 (en) 2016-03-03
AU2015308765A1 (en) 2017-03-23
BR112017004136B1 (pt) 2022-05-03
EA201790432A1 (ru) 2017-09-29
MX2017002704A (es) 2017-10-23
US20170281804A1 (en) 2017-10-05
JP2017527559A (ja) 2017-09-21
CN118005611A (zh) 2024-05-10
BR112017004136A2 (pt) 2017-12-12
SG11201701578YA (en) 2017-03-30
US12036291B2 (en) 2024-07-16
KR20170047348A (ko) 2017-05-04
DK3186241T3 (da) 2021-01-11
AU2015308765B2 (en) 2020-06-04
MX2021005891A (es) 2021-06-23
SI3186241T1 (sl) 2021-03-31
KR102410760B1 (ko) 2022-06-20
HUE052892T2 (hu) 2021-05-28
EP3186241A4 (en) 2018-04-18
CA2959531C (en) 2023-01-10

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