CN107073042A - 用于产生内耳毛细胞来治疗听力损失的组合物、系统和方法 - Google Patents

用于产生内耳毛细胞来治疗听力损失的组合物、系统和方法 Download PDF

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CN107073042A
CN107073042A CN201580059582.3A CN201580059582A CN107073042A CN 107073042 A CN107073042 A CN 107073042A CN 201580059582 A CN201580059582 A CN 201580059582A CN 107073042 A CN107073042 A CN 107073042A
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cells
cell
lgr5
differentiation
final
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Chinese (zh)
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J·M·卡普
R·S·兰格
尹晓磊
N·乔希
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Brigham and Womens Hospital Inc
Massachusetts Institute of Technology
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Brigham and Womens Hospital Inc
Massachusetts Institute of Technology
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CN201580059582.3A 2014-09-03 2015-09-03 用于产生内耳毛细胞来治疗听力损失的组合物、系统和方法 Pending CN107073042A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462045506P 2014-09-03 2014-09-03
US62/045,506 2014-09-03
US201462051003P 2014-09-16 2014-09-16
US62/051,003 2014-09-16
PCT/US2015/048442 WO2016037016A1 (en) 2014-09-03 2015-09-03 Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss

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Publication Number Publication Date
CN107073042A true CN107073042A (zh) 2017-08-18

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US (3) US10568883B2 (enExample)
EP (1) EP3189134A1 (enExample)
JP (3) JP6773645B2 (enExample)
KR (2) KR102493376B1 (enExample)
CN (1) CN107073042A (enExample)
AU (1) AU2015311816B2 (enExample)
CA (1) CA2959404A1 (enExample)
IL (2) IL299964A (enExample)
WO (1) WO2016037016A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108085296A (zh) * 2018-01-29 2018-05-29 清华大学 培养基及其用途
CN109689052A (zh) * 2016-03-02 2019-04-26 频率治疗公司 使用GSK-3-α抑制剂的受控增殖干细胞/产生内耳毛细胞的方法
CN112870383A (zh) * 2021-02-20 2021-06-01 东南大学 Hippo调控内耳干细胞增殖分化方法及在毛细胞再生中的应用
CN113164381A (zh) * 2018-10-02 2021-07-23 频率医疗公司 有关耳用治疗剂的药物组合物及方法
CN113195707A (zh) * 2018-08-17 2021-07-30 频率治疗公司 用于通过上调jag-1来生成毛细胞的组合物和方法
US11617745B2 (en) 2018-08-17 2023-04-04 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating FOXO

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007334260A1 (en) 2006-11-15 2008-06-26 Massachusetts Eye & Ear Infirmary Generation of inner ear cells
CN105358677B (zh) 2013-03-14 2018-06-15 布里格海姆妇女医院公司 用于上皮干细胞扩增和培养的组合物和方法
WO2016022776A2 (en) 2014-08-06 2016-02-11 Massachusetts Eye And Ear Infirmary Increasing atoh1 life to drive sensorineural hair cell differentiantion
KR102493376B1 (ko) 2014-09-03 2023-01-27 더 브리검 앤드 우먼즈 하스피털, 인크. 청력 손실의 치료를 위해 내이 털세포를 생성하기 위한 조성물, 시스템, 및 방법
US11185536B2 (en) 2015-12-04 2021-11-30 Massachusetts Eye And Ear Infirmary Treatment of hearing loss by inhibition of casein kinase 1
CA3010610A1 (en) 2016-01-08 2017-07-13 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
US11466252B2 (en) 2016-01-29 2022-10-11 Massachusetts Eye And Ear Infirmary Expansion and differentiation of inner ear supporting cells and methods of use thereof
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US20170252339A1 (en) * 2016-03-02 2017-09-07 Frequency Therapeutics, Inc. Methods for controlled proliferation of stem cells / generating inner ear hair cells using 2-pyrimidinylaminoethylamino-2-pyridyl based compounds
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US20190060371A1 (en) * 2016-03-02 2019-02-28 Frequency Therapeutics, Inc. Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using wnt and tgfbeta-inhibition
CN115814097A (zh) * 2016-06-03 2023-03-21 霍夫耳科研究所 用于内耳感觉毛细胞再生/替换的联合疗法
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