JP6773645B2 - 聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法 - Google Patents

聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法 Download PDF

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JP6773645B2
JP6773645B2 JP2017512289A JP2017512289A JP6773645B2 JP 6773645 B2 JP6773645 B2 JP 6773645B2 JP 2017512289 A JP2017512289 A JP 2017512289A JP 2017512289 A JP2017512289 A JP 2017512289A JP 6773645 B2 JP6773645 B2 JP 6773645B2
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cells
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cell
pharmaceutically acceptable
lgr5
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JP2017527285A5 (enExample
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カープ，ジェフリー，エム．
ランガー，ロバート，エス．
イン，シアオレイ
ジョシ，ニティン
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Massachusetts Institute of Technology
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JP2017512289A 2014-09-03 2015-09-03 聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法 Expired - Fee Related JP6773645B2 (ja)

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US201462045506P 2014-09-03 2014-09-03
US62/045,506 2014-09-03
US201462051003P 2014-09-16 2014-09-16
US62/051,003 2014-09-16
PCT/US2015/048442 WO2016037016A1 (en) 2014-09-03 2015-09-03 Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss

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JP2017527285A5 JP2017527285A5 (enExample) 2018-10-11
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JP2020123204A Active JP7237044B2 (ja) 2014-09-03 2020-07-17 聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法
JP2022174501A Withdrawn JP2023002795A (ja) 2014-09-03 2022-10-31 聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法

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JP2022174501A Withdrawn JP2023002795A (ja) 2014-09-03 2022-10-31 聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法

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CA2669693C (en) 2006-11-15 2018-06-12 Massachusetts Eye & Ear Infirmary Generation of inner ear cells
CA2905842C (en) 2013-03-14 2023-02-21 The Brigham And Women's Hospital, Inc. Compositions and methods for epithelial stem cell expansion comprising a wnt agonist and a histone deacetylase inhibitor
US20170314027A1 (en) 2014-08-06 2017-11-02 Massachusetts Eye And Ear Infirmary Increasing atoh1 life to drive sensorineural hair cell differentiantion
WO2016037016A1 (en) 2014-09-03 2016-03-10 The Brigham And Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
US11185536B2 (en) 2015-12-04 2021-11-30 Massachusetts Eye And Ear Infirmary Treatment of hearing loss by inhibition of casein kinase 1
US11021687B2 (en) 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
CN109219439B (zh) * 2016-01-29 2022-09-20 马萨诸塞眼科耳科诊所 内耳支持细胞的扩增和分化及其使用方法
US20170252339A1 (en) * 2016-03-02 2017-09-07 Frequency Therapeutics, Inc. Methods for controlled proliferation of stem cells / generating inner ear hair cells using 2-pyrimidinylaminoethylamino-2-pyridyl based compounds
AU2017227846A1 (en) * 2016-03-02 2018-08-30 Frequency Therapeutics, Inc. Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using WNT and TGF-beta inhibition
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
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