CN107050229B - Medicine composition for treating carbuncle-abscess scrofula and preparation method thereof - Google Patents
Medicine composition for treating carbuncle-abscess scrofula and preparation method thereof Download PDFInfo
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- CN107050229B CN107050229B CN201710289729.9A CN201710289729A CN107050229B CN 107050229 B CN107050229 B CN 107050229B CN 201710289729 A CN201710289729 A CN 201710289729A CN 107050229 B CN107050229 B CN 107050229B
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- scrofula
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- rhizoma
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a pharmaceutical composition for treating carbuncle-abscess scrofula and a preparation method thereof, which effectively solve the problems that western medicines for treating the carbuncle-abscess scrofula cannot eradicate the scrofula, are easy to relapse, have large side effects and high cost, and traditional Chinese medicines for treating the carbuncle-abscess scrofula have single effect, long treatment period, low cure rate and poor treatment effect, and are prepared from the following components in parts by weight: 2-8 g of rhizoma typhonii, 2-10 g of arisaema cum bile, 12-30 g of stringy stonecrop herb, 4-15 g of moutan bark, 6-12 g of figwort root, 2-12 g of houttuynia cordata, 2-12 g of blackberrylily rhizome, 2-8 g of subprostrate sophora, 8-30 g of astragalus, 4-15 g of lucid ganoderma, 4-12 g of verbena, 4-10 g of rhizoma paridis and 12-30 g of cactus are taken as raw material medicines to prepare the medicine; respectively slicing and mixing, adding water and decocting twice, filtering, combining the two decoction liquids, boiling with strong fire, and decocting with slow fire to obtain the traditional Chinese medicine composition.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating carbuncle scrofula and a preparation method thereof.
Background
Carbuncle and deep carbuncle are diseases in surgery of traditional Chinese medicine, are sores, are often called carbuncles widely and deep carbuncles, are explained as suppurative inflammation caused by bacterial infection of hair follicles and sebaceous glands of skin by modern medicine, and are common diseases and frequently encountered diseases in surgery of traditional Chinese medicine, wherein pathogenic bacteria are staphylococcus. Carbuncle is a local suppurative disease caused by infection of toxin and obstruction of qi and blood. Rapid onset of disease, easy pus discharge, easy ulceration and easy astringency. At the beginning, the local part is soft and headless, the skin is quickly caked, the skin is red-burning, swollen, painful, gradually enlarged, swollen and hard, and the skin feels scorching. Deep-rooted carbuncle is a suppurative disease caused by pathogenic factors, and is characterized in that the deep-rooted carbuncle is like chestnut in the beginning, does not generate heat and swell pain and is easy to expand to the periphery. After ulceration, it appears as a honeycomb and develops between muscles, where the skin is thick and tough, but often in the back of the neck and back. Scrofula is also called as sore, an infectious surgical disease of neck. The neck skin and flesh are connected in series with other masses of different sizes, with the smaller being called scrofula and the larger being called scrofula, collectively called scrofula and commonly called joke neck. It is commonly seen in teenagers and original tuberculosis patients, and it is usually seen in the neck, behind the ears, and also around the neck, in the supraclavicular fossa, chest and under the armpit. The tuberculosis is equivalent to the lymphoid tuberculosis in modern medicine, is mostly caused by specific infection caused by invasion of tubercle bacillus into the neck, and can break pus discharge in severe cases. The disease has no obvious symptoms in the early stage, and can have general symptoms such as fatigue, inappetence, emaciation, low fever and the like after the disease develops, and also has local symptoms of pathological organs.
At present, western medicines, ointments and other methods are mainly adopted for treating the carbuncle-abscess scrofula, and the treatment method has the advantages that although certain treatment is performed on the carbuncle-abscess scrofula, the scrofula cannot be eradicated, the scrofula is easy to relapse and is not beneficial to body health, and the western medicines, the ointments and the ointments contain more hormones, are easy to cause medicine dependence, have large side effects and are expensive; although there are also traditional Chinese medicines for treating superficial infection scrofula, the treatment is single, only superficial infection or scrofula can be treated, but two symptoms cannot be treated simultaneously, and the existing traditional Chinese medicines for treating superficial infection scrofula have long treatment period, low cure rate and poor curative effect.
Disclosure of Invention
In view of the above situation, the present invention aims to provide a pharmaceutical composition for treating carbuncle-abscess scrofula and a preparation method thereof, which can effectively solve the problems that western medicines for treating the carbuncle-abscess scrofula cannot be eradicated, are easy to cause repeated attack, have large side effects and high cost, and traditional Chinese medicines for treating the carbuncle-abscess scrofula have single efficacy, long treatment period, low cure rate and poor curative effect.
The technical scheme of the invention is that the material is prepared from the following components by weight: 2-8 g of rhizoma typhonii, 2-10 g of arisaema cum bile, 12-30 g of stringy stonecrop herb, 4-15 g of moutan bark, 6-12 g of figwort root, 2-12 g of houttuynia cordata, 2-12 g of blackberrylily rhizome, 2-8 g of subprostrate sophora, 8-30 g of astragalus, 4-15 g of lucid ganoderma, 4-12 g of verbena, 4-10 g of rhizoma paridis and 12-30 g of cactus are taken as raw material medicines to prepare the medicine; the preparation method comprises the following steps:
(1) respectively slicing and mixing the raw materials, adding water, decocting twice, adding water 8 times of the total weight of the raw materials for the first time, decocting with strong fire for boiling for 10 minutes, decocting with slow fire for 30 minutes, and filtering to obtain a first decoction and dregs;
(2) adding 6 times of water into the medicine residues, decocting with strong fire until boiling, decocting with slow fire for 25 minutes, and filtering to obtain a second decoction;
(3) and mixing the two decoctions, boiling with strong fire, and decocting with slow fire for 15 min.
The invention can treat both carbuncle and deep-rooted carbuncle and scrofula, and has the advantages of high cure rate, good curative effect, short period and no recurrence.
Detailed description of the preferred embodiments
The following describes in further detail embodiments of the present invention with reference to examples.
Example 1
The invention is characterized by comprising the following components by weight: 5g of prepared rhizoma typhonii, 6g of prepared rhizoma arisaematis, 20g of stringy stonecrop herb, 10g of moutan bark, 8g of figwort root, 8g of houttuynia cordata, 8g of blackberrylily rhizome, 6g of subprostrate sophora, 15g of astragalus mongholicus, 8g of lucid ganoderma, 8g of verbena, 6g of rhizoma paridis and 15g of cactus as raw material medicines; the preparation method comprises the following steps:
(1) respectively slicing and mixing the raw materials, adding water, decocting twice, adding water 8 times of the total weight of the raw materials for the first time, decocting with strong fire for boiling for 10 minutes, decocting with slow fire for 30 minutes, and filtering to obtain a first decoction and dregs;
(2) adding 6 times of water into the medicine residues, decocting with strong fire until boiling, decocting with slow fire for 25 minutes, and filtering to obtain a second decoction;
(3) and mixing the two decoctions, boiling with strong fire, and decocting with slow fire for 15 min.
Example 2
The invention is characterized by comprising the following components by weight: 2g of prepared rhizoma typhonii, 2g of prepared rhizoma arisaematis, 12g of stringy stonecrop herb, 4g of moutan bark, 6g of figwort root, 2g of houttuynia cordata, 2g of blackberrylily rhizome, 2g of subprostrate sophora, 8g of astragalus mongholicus, 4g of lucid ganoderma, 4g of verbena, 4g of rhizoma paridis and 12g of cactus as raw material medicines; the preparation method comprises the following steps:
(1) respectively slicing and mixing the raw materials, adding water, decocting twice, adding water 8 times of the total weight of the raw materials for the first time, decocting with strong fire for boiling for 10 minutes, decocting with slow fire for 30 minutes, and filtering to obtain a first decoction and dregs;
(2) adding 6 times of water into the medicine residues, decocting with strong fire until boiling, decocting with slow fire for 25 minutes, and filtering to obtain a second decoction;
(3) and mixing the two decoctions, boiling with strong fire, and decocting with slow fire for 15 min.
Example 3
The invention is characterized by comprising the following components by weight: 8g of prepared rhizoma typhonii, 10g of prepared rhizoma arisaematis, 30g of stringy stonecrop herb, 15g of moutan bark, 12g of figwort root, 12g of houttuynia cordata, 12g of blackberrylily rhizome, 8g of subprostrate sophora, 30g of astragalus mongholicus, 15g of lucid ganoderma, 12g of verbena, 10g of rhizoma paridis and 30g of cactus as raw material medicines; the preparation method comprises the following steps:
(1) respectively slicing and mixing the raw materials, adding water, decocting twice, adding water 8 times of the total weight of the raw materials for the first time, decocting with strong fire for boiling for 10 minutes, decocting with slow fire for 30 minutes, and filtering to obtain a first decoction and dregs;
(2) adding 6 times of water into the medicine residues, decocting with strong fire until boiling, decocting with slow fire for 25 minutes, and filtering to obtain a second decoction;
(3) and mixing the two decoctions, boiling with strong fire, and decocting with slow fire for 15 min.
Example 4
The invention is characterized by comprising the following components by weight: 5g of prepared rhizoma typhonii, 6g of prepared rhizoma arisaematis, 21g of stringy stonecrop herb, 9g of moutan bark, 9g of figwort root, 7g of houttuynia cordata, 7g of blackberrylily rhizome, 5g of subprostrate sophora, 19g of astragalus mongholicus, 10g of lucid ganoderma, 8g of verbena, 7g of rhizoma paridis and 21g of cactus as raw material medicines; the preparation method comprises the following steps:
(1) respectively slicing and mixing the raw materials, adding water, decocting twice, adding water 8 times of the total weight of the raw materials for the first time, decocting with strong fire for boiling for 10 minutes, decocting with slow fire for 30 minutes, and filtering to obtain a first decoction and dregs;
(2) adding 6 times of water into the medicine residues, decocting with strong fire until boiling, decocting with slow fire for 25 minutes, and filtering to obtain a second decoction;
(3) and mixing the two decoctions, boiling with strong fire, and decocting with slow fire for 15 min.
In the above-mentioned pharmaceutical composition,
preparing giant typhonium rhizome: soaking clean rhizoma typhonii, changing water for 2-3 times every day, changing water if the rhizoma typhonii is sticky after several days, adding alum (2 kg of alum for every 100kg of rhizoma typhonii) after changing water, changing water after soaking for 1 day until the rhizoma typhonii tastes slightly, taking out, adding a proper amount of water into the ginger slices and the alum powder in a pot, boiling, pouring the rhizoma typhonii into the pot, boiling until no white heart exists, fishing out, removing the ginger slices, airing till six seven thousand, slicing into thick slices, and drying. (12.5 kg of ginger and alum are respectively used for every 100kg of rhizoma typhonii); has effects in expelling pathogenic wind, removing phlegm, arresting convulsion, removing toxic materials, dispersing pathogen accumulation, and relieving pain. Can be used for treating apoplexy, phlegm accumulation, facial palsy, dysphasia, infantile convulsion, epilepsy, tetanus, phlegm syncope, headache, scrofula, subcutaneous nodule, and venomous snake bite.
Preparing rhizoma arisaematis: soaking clean rhizoma arisaematis in water, changing water for 2-3 times every day, adding Alumen (2 kg for every 100kg rhizoma arisaematis) after changing water if foaming, soaking for one day, changing water again, and taking out when the cut opening tastes light numb tongue. Boiling rhizoma Zingiberis recens slice and Alumen in water, adding rhizoma arisaematis, decocting until there is no dry heart, removing rhizoma Zingiberis recens slice, air drying until four to six turns dry, slicing, and drying (12.5 kg of rhizoma Zingiberis recens and Alumen are used per 100kg of rhizoma arisaematis); has the effects of eliminating dampness and phlegm, dispelling pathogenic wind and relieving spasm, and resolving hard mass and swelling. Can be used for treating intractable phlegm cough, wind paralysis, vertigo, apoplexy, phlegm accumulation, wry eye and mouth, hemiplegia, epilepsy, infantile convulsion, tetanus, carbuncle swelling, and snake and insect bite.
Sedum sarmentosum bunge: removing impurities and cutting into segments. Has the effects of promoting diuresis, eliminating jaundice, clearing away heat and toxic materials. Can be used for treating damp-heat jaundice, dysuria, carbuncle, swelling, and pyocutaneous disease.
Moutan bark: quickly cleaning, moistening, slicing, and drying in sunlight. Has the functions of clearing heat, cooling blood, promoting blood circulation and removing blood stasis. Can be used for treating heat entering nutrient-blood, warm toxic and macula, hematemesis and epistaxis, night fever and early coolness, no sweating and bone steaming, amenorrhea and dysmenorrhea, traumatic injury and pain, carbuncle, swelling and sore.
Figwort root: cleaning, moistening, slicing, and drying. Has effects in clearing away heat, cooling blood, nourishing yin, purging pathogenic fire, removing toxic materials, and dispersing pathogen accumulation. Can be used for treating heat entering nutrient-blood, toxic heat macula, yin impairment due to fever, crimson tongue with dipsosis, constipation due to body fluid injury, bone steaming, cough, conjunctival congestion, pharyngalgia, diphtheria, lymphoid tuberculosis, carbuncle, and skin ulcer.
Houttuynia cordata: removing impurities, quickly cleaning, cutting, and drying. Has the effects of clearing away heat and toxic materials, eliminating carbuncle, expelling pus, promoting urination, and treating stranguria. Can be used for treating lung abscess with purulent vomiting, phlegm heat, cough and asthma, dysentery, pyretic stranguria, carbuncle, swelling, and sore.
Shooting: removing impurities, cleaning, moistening, slicing, and drying. Has the effects of clearing away heat and toxic materials, eliminating phlegm, and relieving sore throat. Can be used for treating heat-toxin phlegm-water stagnation, sore throat, phlegm, saliva and carbuncle. Cough and asthma.
Subprostrate sophora root: removing residual stem and impurities, soaking, cleaning, moistening, slicing, and drying. Has the functions of clearing away heat and toxic material, eliminating swelling and relieving sore throat. Can be used for treating fire toxin accumulation, tonsillitis, sore throat, gingival swelling and pain, and aphtha of the mouth and tongue.
Astragalus root: removing impurities, cleaning, moistening, slicing, and drying. Has the effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, expelling pus, healing sore, and promoting granulation. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, spontaneous perspiration due to exterior deficiency, edema due to qi deficiency, internal heat, diabetes, blood deficiency, hemiplegia, arthralgia, numbness, carbuncle, cellulitis, and intractable ulcer.
Ganoderma lucidum: removing impurities, and drying in the shade. Has the effects of invigorating qi, tranquilizing mind, and relieving cough and asthma. Can be used for treating restlessness, insomnia, palpitation, cough and asthma due to pulmonary tuberculosis, asthenia, short breath, and anorexia.
Verbena: removing residual root and impurities, cleaning, moistening, cutting, and drying. Has the functions of promoting blood circulation to disperse blood clots, detoxicating, inducing diuresis, eliminating jaundice and preventing malaria. Can be used for treating abdominal mass, dysmenorrhea, amenorrhea, sore throat, carbuncle, edema, jaundice, and malaria.
The grass river vehicle: cleaning, slicing and drying. Has the functions of clearing away heat and toxic material, eliminating swelling, arresting convulsion and stopping bleeding. Can be used for treating febrile convulsion, enteritis, dysentery, carbuncle, cellulitis, hemoptysis, epistaxis, and snake and insect bite.
Cactus: cleaning, slicing and drying. Has the effects of promoting qi circulation, promoting blood circulation, clearing away heat and toxic materials. Can be used for treating cardialgia, gastralgia, abdominal mass, dysentery, hemorrhoid, hemorrhage, cough, laryngalgia, pulmonary abscess, acute mastitis, furuncle, scald, burn, and snake wound.
From the above, the invention fundamentally eliminates the damp toxin in the body of a patient according to the dialectical therapy of the traditional Chinese medicine, and has good curative effect, short treatment course, quick response and difficult relapse through clinical experiments, and the clinical data are as follows:
first, select the case
The patients in outpatients or hospitalizations have symptoms of abscess, cyst, lipoma, acne tumor on the skin, or chestnut-like pus head on the skin, swelling and pain due to inflammation, redness and swelling, rapid expansion to the periphery and deep part, successive increase of pus heads, and lotus seedpod and honeycomb shape after bursting, which cause general pyogenic infection, or swelling of cervical lymph nodes, pain, local redness and the like, and all the people are taken as the subjects of selected cases.
II, diagnosis standard
The main symptoms are: swelling and pain of lymph nodes, redness, skin abscess and cyst, chestnut-like pus head, red swelling and pain, and a lotus seedpod-like or cellular shape after burst, and general pyogenic infection.
The secondary symptoms are as follows: lipoma, acne tumor, painless enlargement of lymph nodes, no adhesion, local red, swelling, heat and pain.
The disease can be diagnosed by the main symptoms of 2 items and the secondary symptoms of 3 items.
Exclusion criteria:
1. aversion to cold, fever, localized edema and erythema.
2. Pregnant women, children, the elderly and the infirm.
3. The spleen and stomach are weak.
4. Hypertension, heart disease, renal insufficiency, epilepsy, tetanus and hyperthyroidism.
Third, treatment scheme
A patient orally takes a dose (200 ml) of the pharmaceutical composition every day, warmly takes the pharmaceutical composition twice, takes the pharmaceutical composition after half an hour of breakfast and supper respectively, takes seven days as a course of treatment, performs curative effect examination after taking one course of treatment, and sets a control group for comparison treatment. The pharmaceutical composition of the invention is group A. The XIHUANG pill is administered orally in group B, 1 bottle (3g) at a time, 2 times per day, seven days as a treatment course, and the treatment effect is checked and compared after administration of one treatment course.
Evaluation criteria of four syndrome therapeutic effects
1. The clinical cure is as follows: the symptoms and physical signs disappear or basically disappear, and the syndrome score is reduced by more than or equal to 95 percent.
2. The effect is shown: the symptoms and physical signs are obviously improved, and the syndrome integral is reduced by more than or equal to 70 percent.
3. The method has the following advantages: the symptoms and physical signs are improved, and the syndrome integral is reduced by more than or equal to 30 percent.
4. The symptoms and signs are not obviously improved or even aggravated, the syndrome integral is reduced by less than 30%, and the calculation formula (nimodipine method) is represented by (integration before treatment-integration after treatment) ÷ integration before treatment) × 100%.
Fifth, statistical treatment
93 superficial infection scrofula patients are treated by contrast and divided into two groups randomly, wherein 48 persons in the group A and 45 persons in the group B are examined after being taken for one week according to a treatment scheme, and the curative effect results are as follows after statistics:
clinical efficacy comparison of group A and group B
Medicine | Cases of disease | Recovery method | Show effect | Is effective | Invalidation | Total effective rate (%) |
A | 48 | 19 | 15 | 12 | 2 | 95.8% |
B | 45 | 8 | 11 | 13 | 13 | 71.1% |
The clinical curative effect of the A group is obviously superior to that of the B group (P is less than 0.01)
The curative effect of the A and B groups on the main clinical symptoms is compared
Group A also outperformed group B in terms of efficacy of major clinical symptoms.
Sixth, conclusion
From the above situation, the pharmaceutical composition of the invention is superior to Xihuang pill in clinical curative effect, has simple preparation process, can be taken only by simple extraction and concentration, has wide market prospect, and has great economic and social benefits.
Claims (5)
1. The medicine composition for treating carbuncle-abscess scrofula is characterized by comprising the following components in parts by weight: the traditional Chinese medicine composition is prepared from 2-8 g of rhizoma typhonii, 2-10 g of arisaema cum bile, 12-30 g of stringy stonecrop herb, 4-15 g of moutan bark, 6-12 g of figwort root, 2-12 g of houttuynia cordata, 2-12 g of blackberrylily rhizome, 2-8 g of subprostrate sophora, 8-30 g of astragalus, 4-15 g of lucid ganoderma, 4-12 g of verbena, 4-10 g of rhizoma paridis and 12-30 g of cactus, and the preparation method comprises the following steps:
(1) respectively slicing and mixing the raw materials, adding water, decocting twice, adding water 8 times of the total weight of the raw materials for the first time, decocting with strong fire for boiling for 10 minutes, decocting with slow fire for 30 minutes, and filtering to obtain a first decoction and dregs;
(2) adding 6 times of water into the medicine residues, decocting with strong fire until boiling, decocting with slow fire for 25 minutes, and filtering to obtain a second decoction;
(3) and mixing the two decoctions, boiling with strong fire, and decocting with slow fire for 15 min.
2. The pharmaceutical composition for treating superficial infection scrofula according to claim 1, wherein the composition is prepared from the following raw materials by weight: 5g of prepared rhizoma typhonii, 6g of prepared rhizoma arisaematis, 20g of stringy stonecrop herb, 10g of moutan bark, 8g of figwort root, 8g of houttuynia cordata, 8g of blackberrylily rhizome, 6g of subprostrate sophora, 15g of astragalus mongholicus, 8g of lucid ganoderma, 8g of verbena, 6g of rhizoma paridis and 15g of cactus.
3. The pharmaceutical composition for treating superficial infection scrofula according to claim 1, wherein the composition is prepared from the following raw materials by weight: 2g of prepared rhizoma typhonii, 2g of prepared rhizoma arisaematis, 12g of stringy stonecrop herb, 4g of moutan bark, 6g of figwort root, 2g of heartleaf houttuynia herb, 2g of blackberry lily, 2g of subprostrate sophora, 8g of astragalus, 4g of lucid ganoderma, 4g of verbena, 4g of rhizoma paridis and 12g of cactus.
4. The pharmaceutical composition for treating superficial infection scrofula according to claim 1, wherein the composition is prepared from the following raw materials by weight: 8g of prepared rhizoma typhonii, 10g of prepared rhizoma arisaematis, 30g of stringy stonecrop herb, 15g of moutan bark, 12g of figwort root, 12g of houttuynia cordata, 12g of blackberrylily rhizome, 8g of subprostrate sophora, 30g of astragalus mongholicus, 15g of lucid ganoderma, 12g of verbena, 10g of rhizoma paridis and 30g of cactus.
5. The pharmaceutical composition for treating superficial infection scrofula according to claim 1, wherein the composition is prepared from the following raw materials by weight: 5g of prepared rhizoma typhonii, 6g of prepared rhizoma arisaematis, 21g of stringy stonecrop herb, 9g of moutan bark, 9g of figwort root, 7g of houttuynia cordata, 7g of blackberrylily rhizome, 5g of subprostrate sophora, 19g of astragalus mongholicus, 10g of lucid ganoderma, 8g of verbena, 7g of rhizoma paridis and 21g of cactus.
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WO2011160684A1 (en) * | 2010-06-22 | 2011-12-29 | Parabolic Biologicals Sprl | Use of uleine for the prevention and/or the treatment of infectious diseases |
CN103463519A (en) * | 2013-10-08 | 2013-12-25 | 潘健 | Traditional Chinese medicine for treating blood stasis vein disease type scrofula |
CN105878868A (en) * | 2014-06-27 | 2016-08-24 | 黎秋萍 | Medicine capable of clearing away heat and toxic materials, eliminating carbuncles and removing stasis |
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WO2011160684A1 (en) * | 2010-06-22 | 2011-12-29 | Parabolic Biologicals Sprl | Use of uleine for the prevention and/or the treatment of infectious diseases |
CN103463519A (en) * | 2013-10-08 | 2013-12-25 | 潘健 | Traditional Chinese medicine for treating blood stasis vein disease type scrofula |
CN105878868A (en) * | 2014-06-27 | 2016-08-24 | 黎秋萍 | Medicine capable of clearing away heat and toxic materials, eliminating carbuncles and removing stasis |
CN105998727A (en) * | 2014-06-27 | 2016-10-12 | 黎秋萍 | Medicine for clearing heat, removing toxicity, eliminating carbuncle and removing stasis |
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