CN107050229A - A kind of pharmaceutical composition for treating ulcer scrofula and preparation method thereof - Google Patents
A kind of pharmaceutical composition for treating ulcer scrofula and preparation method thereof Download PDFInfo
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- CN107050229A CN107050229A CN201710289729.9A CN201710289729A CN107050229A CN 107050229 A CN107050229 A CN 107050229A CN 201710289729 A CN201710289729 A CN 201710289729A CN 107050229 A CN107050229 A CN 107050229A
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- scrofula
- radix
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- ulcer
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Abstract
The present invention relates to pharmaceutical composition for the treatment of ulcer scrofula and preparation method thereof, effectively solving western medicine ulcer scrofula can not eradicate, easy recurrent exerbation, side effect is big, cost is high and treatment by Chinese herbs ulcer scrofula effect is single, treatment cycle is long, cure rate is low, the problem of weak curative effect, is by following weight meter:2~8g of processed rhizoma typhonii or radix aconiti corean, 2~10g of Rhizoma Arisaematis (processed), 12~30g of stringy stonecrop, 4~15g of moutan bark, 6~12g of radix scrophulariae, 2~12g of cordate houttuynia, 2~12g of blackberry lily, 2~8g of subprostrate sophora, 8~30g of the Radix Astragali, 4~15g of ganoderma lucidum, 4~12g of Verbena officinalis, careless river 4~10g of car and 12~30g of cactus are made as bulk drug;Cut into slices, mix respectively, add water to cook twice, filtering merges decoction liquor twice, boiled by intense fire, then with being cooked by slow fire, produces, and the present invention can both treat ulcer or treat scrofula, and cure rate is high, and good effect, the cycle is short, no recurrence.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of pharmaceutical composition for treating ulcer scrofula and preparation method thereof.
Background technology
Ulcer and scrofula are the diseases of TCM surgery, and ulcer is a kind of carbuncle, and more wide is carbuncle, and deep is subcutaneous ulcer, so
Carbuncle the hair follicle and sebaceous glands of skin are construed in groups by the purulent inflammation caused by bacterium infection, pathogen by modern medicine
It is the common disease and frequently-occurring disease of TCM surgery for staphylococcus.Carbuncle is the local suppuration infected poison heresy, qi and blood obstruction and caused
Property disease.Morbidity is rapid, easy purulence, easily bursts, easily holds back.It is soft without a head from the beginning of local light, lump quickly, Biao Pi inflammation rednesses are swollen, pain, by
The big height of flaring is swollen and hard, and that touches is scorching hot.Subcutaneous ulcer is the purulent disease of malicious evil retardance and cause, it is characterized in that from the beginning of Ru Li, not generating heat
Distending pain, easily expands to surrounding.After festering, shape such as honeycomb is sent out between muscle, and all skin is thick and tough and tensile place can all be sent out
It is raw, but be mainly in after neck and back.Scrofula is also known as scrofula, is born in a kind of infectious surgical disease of neck.In neck skin and flesh
Between the core block that can lay one's hand on and differ in size, series winding mutually, its medium and small person claims scrofula, and big person claims scrofula, is referred to as scrofula, is commonly called as scrofula.
Be more common in teenager and original tuberculosis patient, be apt to occur in after neck, ear, the winding neck also having, extend to supraclavicular fossa, chest and
Oxter.It is due to the specific infection caused by tubercle bacillus intrusion neck, seriously equivalent to the scrofula of modern medicine more
When can diabrosis suppurate.Disease early stage and non-evident sympton, can have that constitutional symptom is for example tired after disease development, lose the appetite, become thin,
The local symptom of low-heat etc., also diseased organ.
At present for the treatment of ulcer scrofula, mainly using methods such as Western medicine and ointment, this treatment method, although right
Ulcer scrofula plays certain treatment, but can not eradicate, easy recurrent exerbation, is unfavorable for healthy, and contains Western medicine ointment more
Hormone is also easy to produce drug dependence, and side effect is big, expensive;Though also there is the Chinese medicine for the treatment of ulcer scrofula, treat single, only
Ulcer or scrofula can be treated, and two kinds of symptoms can not be treated simultaneously, and the Chinese medicine of existing treatment ulcer scrofula, treatment cycle
Long, cure rate is low, weak curative effect.
The content of the invention
For above-mentioned situation, to overcome prior art defect, ulcer scrofula is treated it is an object of the invention to provide one kind
Pharmaceutical composition and preparation method thereof, can effectively solve western medicine ulcer scrofula can not eradicate, easy recurrent exerbation, side effect
Greatly, cost is high and treatment by Chinese herbs ulcer scrofula effect is single, and treatment cycle is long, and cure rate is low, the problem of weak curative effect.
The technical scheme is that by following weight meter:2~8g of processed rhizoma typhonii or radix aconiti corean, 2~10g of Rhizoma Arisaematis (processed), stringy stonecrop
12~30g, 4~15g of moutan bark, 6~12g of radix scrophulariae, 2~12g of cordate houttuynia, 2~12g of blackberry lily, 2~8g of subprostrate sophora, the Radix Astragali 8~
30g, 4~15g of ganoderma lucidum, 4~12g of Verbena officinalis, careless river 4~10g of car and 12~30g of cactus are made as bulk drug;Preparation method
It is:
(1), above-mentioned raw materials medicine cut into slices respectively, is mixed, add water to cook twice, for the first time plus bulk drug gross weight 8
Amount water, high heat decoction boiling 10 minutes, then with being cooked by slow fire 30 minutes, filter, obtain first time decoction liquor and the dregs of a decoction again;
(2), the dregs of a decoction add 6 times of bulk drug gross weight to measure water, high heat decoction is to seething with excitement, then with being cooked by slow fire 25 minutes, filtering is obtained
Second of decoction liquor;
(3), merge decoction liquor twice, boil by intense fire, then produced with being cooked by slow fire 15 minutes.
The present invention can both treat ulcer or treat scrofula, and cure rate is high, and good effect, the cycle is short, no recurrence.
Specific embodiment
The embodiment of the present invention is described in further details below in conjunction with example.
Embodiment 1
The present invention is by following weight meter:Processed rhizoma typhonii or radix aconiti corean 5g, Rhizoma Arisaematis (processed) 6g, stringy stonecrop 20g, moutan bark 10g, radix scrophulariae 8g,
Cordate houttuynia 8g, blackberry lily 8g, subprostrate sophora 6g, Radix Astragali 15g, ganoderma lucidum 8g, Verbena officinalis 8g, grass river car 6g, cactus 15g make bulk drug system
Into;Preparation method is:
(1), above-mentioned raw materials medicine cut into slices respectively, is mixed, add water to cook twice, for the first time plus bulk drug gross weight 8
Amount water, high heat decoction boiling 10 minutes, then with being cooked by slow fire 30 minutes, filter, obtain first time decoction liquor and the dregs of a decoction again;
(2), the dregs of a decoction add 6 times of bulk drug gross weight to measure water, high heat decoction is to seething with excitement, then with being cooked by slow fire 25 minutes, filtering is obtained
Second of decoction liquor;
(3), merge decoction liquor twice, boil by intense fire, then produced with being cooked by slow fire 15 minutes.
Embodiment 2
The present invention is by following weight meter:Processed rhizoma typhonii or radix aconiti corean 2g, Rhizoma Arisaematis (processed) 2g, stringy stonecrop 12g, moutan bark 4g, radix scrophulariae 6g, fish
Raw meat grass 2g, blackberry lily 2g, subprostrate sophora 2g, Radix Astragali 8g, ganoderma lucidum 4g, Verbena officinalis 4g, careless river car 4g and cactus 12g make bulk drug system
Into;Preparation method is:
(1), above-mentioned raw materials medicine cut into slices respectively, is mixed, add water to cook twice, for the first time plus bulk drug gross weight 8
Amount water, high heat decoction boiling 10 minutes, then with being cooked by slow fire 30 minutes, filter, obtain first time decoction liquor and the dregs of a decoction again;
(2), the dregs of a decoction add 6 times of bulk drug gross weight to measure water, high heat decoction is to seething with excitement, then with being cooked by slow fire 25 minutes, filtering is obtained
Second of decoction liquor;
(3), merge decoction liquor twice, boil by intense fire, then produced with being cooked by slow fire 15 minutes.
Embodiment 3
The present invention is by following weight meter:Processed rhizoma typhonii or radix aconiti corean 8g, Rhizoma Arisaematis (processed) 10g, stringy stonecrop 30g, moutan bark 15g, radix scrophulariae
12g, cordate houttuynia 12g, blackberry lily 12g, subprostrate sophora 8g, Radix Astragali 30g, ganoderma lucidum 15g, Verbena officinalis 12g, careless river car 10g and cactus 30g
It is made as bulk drug;Preparation method is:
(1), above-mentioned raw materials medicine cut into slices respectively, is mixed, add water to cook twice, for the first time plus bulk drug gross weight 8
Amount water, high heat decoction boiling 10 minutes, then with being cooked by slow fire 30 minutes, filter, obtain first time decoction liquor and the dregs of a decoction again;
(2), the dregs of a decoction add 6 times of bulk drug gross weight to measure water, high heat decoction is to seething with excitement, then with being cooked by slow fire 25 minutes, filtering is obtained
Second of decoction liquor;
(3), merge decoction liquor twice, boil by intense fire, then produced with being cooked by slow fire 15 minutes.
Embodiment 4
The present invention is by following weight meter:Processed rhizoma typhonii or radix aconiti corean 5g, Rhizoma Arisaematis (processed) 6g, stringy stonecrop 21g, moutan bark 9g, radix scrophulariae 9g, fish
Raw meat grass 7g, blackberry lily 7g, subprostrate sophora 5g, Radix Astragali 19g, ganoderma lucidum 10g, Verbena officinalis 8g, careless river car 7g and cactus 21g make bulk drug system
Into;Preparation method is:
(1), above-mentioned raw materials medicine cut into slices respectively, is mixed, add water to cook twice, for the first time plus bulk drug gross weight 8
Amount water, high heat decoction boiling 10 minutes, then with being cooked by slow fire 30 minutes, filter, obtain first time decoction liquor and the dregs of a decoction again;
(2), the dregs of a decoction add 6 times of bulk drug gross weight to measure water, high heat decoction is to seething with excitement, then with being cooked by slow fire 25 minutes, filtering is obtained
Second of decoction liquor;
(3), merge decoction liquor twice, boil by intense fire, then produced with being cooked by slow fire 15 minutes.
In said medicine,
Processed rhizoma typhonii or radix aconiti corean:Net rhizoma typhonii is taken, soaks, water is changed daily 2~3 times, as played glutinous foam after a few days, changes after water plus alum is (every
100kg rhizoma typhoniis, use alum 2kg), bubble 1 day after carry out changing water again, to mouth taste it is micro- have numb feeling in the tongue for degree, take out, by ginger slice,
Alum powder is put in pot plus suitable quantity of water, after boiling, is poured into rhizoma typhonii and is boiled altogether to without the white heart, pull out, is removed ginger slice, is dried in the air to 6 seventy percent
Thousand, sheet is cut, is dried.(per 100kg rhizoma typhoniis, with ginger, each 12.5kg of alum);With wind-dispelling phlegm, detoxicating and resolving a mass of jerking of calming the frightened,
Analgesic.For heap soil or fertilizer over and around the roots of apoplexy phlegm, Kou Yan wai are oblique, dysphasia, infantile convulsion epilepsy, lockjaw, phlegm and headache, migraine and general headache, scrofula phlegm
Core, venomous snake bite.
Rhizoma Arisaematis (processed):Net rhizoma arisaematis is taken, is soaked in water, water is changed daily 2~3 times, when such as playing foam, is changed after water plus alum
(per 100kg rhizoma arisaematis, plus alum 2kg), bubble is after one day, then carries out changing water, to cutting opening taste it is micro- have numb feeling in the tongue when take out.Will be raw
After ginger splices, alum are put in pot plus suitable quantity of water boils, pour into when rhizoma arisaematis is boiled to without the dry heart altogether and take out, remove ginger splices, dry in the air to four to
Sixty percent is dry, shave, dries (per 100kg rhizoma arisaematis, with ginger, each 12.5kg of alum);With eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion,
Mass dissipating and swelling eliminating.For stupid productive cough, paralysis dizziness, heap soil or fertilizer over and around the roots of apoplexy phlegm, Kou Yan wai are oblique, hemiplegia, epilepsy, infantile convulsion, lockjaw, outside
With controlling carbuncle swells, snake bite and insect sting.
Stringy stonecrop:Remove impurity, segment.It is clearing heat and detoxicating with removing dampness through diuresis and removing jaundice.For jaundice with damp-heat pathogen, difficult urination, carbuncle swells
Sore.
Moutan bark:Rapid to clean, shave after profit is dried.It is promoting blood circulation and removing blood stasis with clearing heat and cooling blood.Enter ying blood for heat, temperature
Poison hair spot, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, the pain of injury caused by falling and tumbling, carbuncle sore tumefacting virus.
Radix scrophulariae:Clean, run through, shave, dry.With clearing heat and cooling blood, nourishing Yin and falling fire, detoxicating and resolving a mass.Joined the army for heat
Blood, febrile virulent maculae, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder constipation, hectic fever due to yin phthisical cough, hot eyes, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.
Cordate houttuynia:Impurity is removed, rapid to clean, segment is dried.With clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.With
In lung carbuncle pyemesis, phlegm heat panting is coughed, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.
Blackberry lily:Impurity is removed, cleans, runs through, shave, is dried.With clearing heat and detoxicating, dissolving phlegm, relieving sore-throat.For heat toxin phlegm
Water pent-up, abscess of throat, sputum carbuncle is contained.Cough and asthma.
Subprostrate sophora:Residual stem and impurity are removed, is soaked, is cleaned, is run through, cut sheet, is dried.With clearing heat and detoxicating, detumescence profit
Pharynx.Pented up for fiery poison, tonsillitis and larynx numbness, abscess of throat, gingivitis, aphthae.
The Radix Astragali:Impurity is removed, is cleaned, is run through, cut sheet, is dried.With tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema is raw
Tianjin blood-nourishing, the stagnant logical numbness of row, pus draining and toxin expelling, expelling pus and promoting granulation.For treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, just
Metrorrhagia is leaked, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, Heat Diabetes, blood deficiency chlorosis, hemiplegia, and numbness pain is numb, ulcer is difficult to burst, is burst long not
Hold back.
Ganoderma lucidum:Impurity is removed, is dried in the shade.It is relieving cough and asthma with invigorating qi for tranquilization.For having no peace of mind, palpitaition of having a sleepless night, tuberculosis is coughed
Breathe heavily, consumptive disease is losed heart, do not feel like eating.
Verbena officinalis:Undesirable root and impurity are removed, cleans, slightly moistens, segment, is dried.With promoting blood circulation to remove blood stasis, removing toxic substances, Li Shui is moved back
Huang, preventing malaria.For a lump in the abdomen causing distension and pain, dysmenorrhoea Amenorrhea, larynx numbness, carbuncle swells, oedema, jaundice, malaria.
Careless river car:Clean, cut into slices, dry.With clearing heat and detoxicating, subside a swelling, calm the frightened, hemostasis.For pyreticosis frightened epilepsy, enteritis,
Dysentery, ulcer, hemoptysis, bleeding from five sense organs or subcutaneous tissue, snake bite and insect sting.
Cactus:Clean, cut into slices, dry.It is clearing heat and detoxicating with the promoting flow of qi and blood circulation.For heart and stomach pain, lump in the abdomen, dysentery, hemorrhoid
Blood, coughs, laryngalgia, lung carbuncle, acute mastitis, furunculosis, burn and scald, snakebite.
From the foregoing, the present invention fundamentally removes the wet poison in patient's body according to differential diagnosis in tcm therapy, and through clinic
Very well, short treating period, instant effect is uneasy to recur, and its clinical data is as follows for experimental effect:
First, case is selected
It is every in outpatient service or inpatient, there is abscess, tumour, lipoma, acne knurl, or have chestnut shape sample purulence on skin on skin
The red and swollen distending pain of Tou , inflammation heat, extends rapidly, purulence head increases in succession to surrounding and deep, in the seedpod of the lotus, cellular after ulceration, triggers complete
Body pyogenic infection, or cervical lymph node enlargement, pain and the local symptom crowd such as rubescent, alternatively pair of case
As.
2nd, diagnostic criteria
Primary symptom:Enlargement of lymph nodes, pain is rubescent, dermapostasis, tumour, chestnut shape sample purulence head, red and swollen distending pain, is in the seedpod of the lotus after diabrosis
Shape, cellular, systemic pyogenic infection.
Secondary disease:Lipoma, acne knurl, lymph node Silent Neuritis enlargement, without being adhered, part is red, swollen, hot, pain.
Possess above primary symptom 2, secondary disease 3, you can be diagnosed as this disease.
Exclusion standard:
1. fever with aversion to cold, localized edema erythema.
2. pregnant woman, children, elderly and infirm.
3. weakness of the spleen and the stomach person.
4. hypertension, heart disease, dry, renal insufficiency, epilepsy, lockjaw, hyperthyroid patient.
3rd, therapeutic scheme
Patient daily oral one is secondary(200ml)Pharmaceutical composition of the present invention, warmly takes in two times, later half small respectively at breakfast and supper
When take, seven days are course for the treatment of, take progress curative effect inspection after a course for the treatment of, and set control group and carry out randomized controlled treatment comparison.This
Invention pharmaceutical composition is A groups.Xihuang pills are B groups, orally, one time 1 bottle (3g), 2 times a day, and seven days are a course for the treatment of, are taken
Curative effect inspection is carried out after one course for the treatment of, is contrasted.
4th, therapeutic effect of syndrome evaluation criteria
1st, clinical recovery:Symptom, sign disappear or basic disappearance, and syndrome integral reduces >=95%.
2nd, it is effective:Symptom, sign are obviously improved, and syndrome integral reduces >=70%.
3rd, effectively:Symptom, sign take a favorable turn, and syndrome integral reduces >=30%.
4th, it is invalid:Symptom, sign are not improved, even aggravating, syndrome integral is reduced less than 30%.Calculation formula(Buddhist nun
Not Horizon method)For:【(Integrated before treatment after integration-treatment)Integrated before ÷ treatments】×100%.
5th, statistical disposition
Through carrying out contrast treatment to 93 ulcer scrofula patients, it is divided to two groups, the wherein people of A groups 48, the people of B groups 45, by treatment side at random
Case is taken and checked after one week, and by statistics, its efficacy result is as follows:
A and bis- groups of B clinical efficacy is contrasted
Medicine | Case | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate(%) |
A | 48 | 19 | 15 | 12 | 2 | 95.8% |
B | 45 | 8 | 11 | 13 | 13 | 71.1% |
A groups are substantially better than B groups in terms of clinical efficacy(P < 0.01)
A and two groups of comparitive studies in main clinic symptoms of B
A groups are also superior to B groups in terms of the curative effect of main clinic symptoms.
6th, conclusion
Pharmaceutical composition of the present invention is better than Xihuang pills on clinical efficacy it can be seen from above-mentioned situation, and preparation technology is also simpler
It is single, it is only necessary to which that simple extraction concentration can take, and with wide market prospects, there is huge economic benefit and social benefit.
Claims (6)
1. a kind of pharmaceutical composition for treating ulcer scrofula, it is characterised in that be by following weight meter:2~8g of processed rhizoma typhonii or radix aconiti corean,
2~10g of Rhizoma Arisaematis (processed), 12~30g of stringy stonecrop, 4~15g of moutan bark, 6~12g of radix scrophulariae, 2~12g of cordate houttuynia, 2~12g of blackberry lily,
2~8g of subprostrate sophora, 8~30g of the Radix Astragali, 4~15g of ganoderma lucidum, 4~12g of Verbena officinalis, careless river 4~10g of car and 12~30g of cactus make
Bulk drug is made.
2. the pharmaceutical composition for the treatment of ulcer scrofula according to claim 1, it is characterised in that be by following weight meter
's:Processed rhizoma typhonii or radix aconiti corean 5g, Rhizoma Arisaematis (processed) 6g, stringy stonecrop 20g, moutan bark 10g, radix scrophulariae 8g, cordate houttuynia 8g, blackberry lily 8g, subprostrate sophora 6g,
Radix Astragali 15g, ganoderma lucidum 8g, Verbena officinalis 8g, grass river car 6g, cactus 15g are made as bulk drug.
3. the pharmaceutical composition for the treatment of ulcer scrofula according to claim 1, it is characterised in that be by following weight meter
's:Processed rhizoma typhonii or radix aconiti corean 2g, Rhizoma Arisaematis (processed) 2g, stringy stonecrop 12g, moutan bark 4g, radix scrophulariae 6g, cordate houttuynia 2g, blackberry lily 2g, subprostrate sophora 2g,
Radix Astragali 8g, ganoderma lucidum 4g, Verbena officinalis 4g, careless river car 4g and cactus 12g are made as bulk drug.
4. the pharmaceutical composition for the treatment of ulcer scrofula according to claim 1, it is characterised in that be by following weight meter
's:Processed rhizoma typhonii or radix aconiti corean 8g, Rhizoma Arisaematis (processed) 10g, stringy stonecrop 30g, moutan bark 15g, radix scrophulariae 12g, cordate houttuynia 12g, blackberry lily 12g, mountain beans
Root 8g, Radix Astragali 30g, ganoderma lucidum 15g, Verbena officinalis 12g, careless river car 10g and cactus 30g are made as bulk drug.
5. the pharmaceutical composition for the treatment of ulcer scrofula according to claim 1, it is characterised in that be by following weight meter
's:Processed rhizoma typhonii or radix aconiti corean 5g, Rhizoma Arisaematis (processed) 6g, stringy stonecrop 21g, moutan bark 9g, radix scrophulariae 9g, cordate houttuynia 7g, blackberry lily 7g, subprostrate sophora 5g,
Radix Astragali 19g, ganoderma lucidum 10g, Verbena officinalis 8g, careless river car 7g and cactus 21g are made as bulk drug.
6. the preparation method of the pharmaceutical composition of the treatment ulcer scrofula described in claim 1-5 any one, it is characterised in that
Step is as follows:
(1), above-mentioned raw materials medicine cut into slices respectively, is mixed, add water to cook twice, for the first time plus bulk drug gross weight 8
Amount water, high heat decoction boiling 10 minutes, then with being cooked by slow fire 30 minutes, filter, obtain first time decoction liquor and the dregs of a decoction again;
(2), the dregs of a decoction add 6 times of bulk drug gross weight to measure water, high heat decoction is to seething with excitement, then with being cooked by slow fire 25 minutes, filtering is obtained
Second of decoction liquor;
(3), merge decoction liquor twice, boil by intense fire, then produced with being cooked by slow fire 15 minutes.
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WO2011160684A1 (en) * | 2010-06-22 | 2011-12-29 | Parabolic Biologicals Sprl | Use of uleine for the prevention and/or the treatment of infectious diseases |
CN103463519A (en) * | 2013-10-08 | 2013-12-25 | 潘健 | Traditional Chinese medicine for treating blood stasis vein disease type scrofula |
CN105878868A (en) * | 2014-06-27 | 2016-08-24 | 黎秋萍 | Medicine capable of clearing away heat and toxic materials, eliminating carbuncles and removing stasis |
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Publication number | Priority date | Publication date | Assignee | Title |
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WO2011160684A1 (en) * | 2010-06-22 | 2011-12-29 | Parabolic Biologicals Sprl | Use of uleine for the prevention and/or the treatment of infectious diseases |
CN103463519A (en) * | 2013-10-08 | 2013-12-25 | 潘健 | Traditional Chinese medicine for treating blood stasis vein disease type scrofula |
CN105878868A (en) * | 2014-06-27 | 2016-08-24 | 黎秋萍 | Medicine capable of clearing away heat and toxic materials, eliminating carbuncles and removing stasis |
CN105998727A (en) * | 2014-06-27 | 2016-10-12 | 黎秋萍 | Medicine for clearing heat, removing toxicity, eliminating carbuncle and removing stasis |
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