CN107037146A - 一种复方木鸡颗粒质量控制的方法 - Google Patents
一种复方木鸡颗粒质量控制的方法 Download PDFInfo
- Publication number
- CN107037146A CN107037146A CN201710084910.6A CN201710084910A CN107037146A CN 107037146 A CN107037146 A CN 107037146A CN 201710084910 A CN201710084910 A CN 201710084910A CN 107037146 A CN107037146 A CN 107037146A
- Authority
- CN
- China
- Prior art keywords
- compound
- peak
- wooden
- wooden chicken
- chicken
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 79
- 150000001875 compounds Chemical class 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims abstract description 37
- 239000002245 particle Substances 0.000 claims abstract description 58
- 239000003814 drug Substances 0.000 claims abstract description 26
- 238000012360 testing method Methods 0.000 claims abstract description 25
- 241000219784 Sophora Species 0.000 claims abstract description 22
- 210000000582 semen Anatomy 0.000 claims abstract description 22
- 235000014075 Juglans mandschurica Nutrition 0.000 claims abstract description 21
- 244000264601 Juglans mandschurica Species 0.000 claims abstract description 21
- 239000013558 reference substance Substances 0.000 claims abstract description 18
- 230000000857 drug effect Effects 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 239000004480 active ingredient Substances 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 238000005516 engineering process Methods 0.000 claims abstract description 8
- 238000013461 design Methods 0.000 claims abstract description 6
- 238000010828 elution Methods 0.000 claims abstract description 5
- 108010076282 Factor IX Proteins 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 63
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 33
- 235000001368 chlorogenic acid Nutrition 0.000 claims description 21
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims description 19
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims description 19
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims description 19
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims description 19
- 229940074393 chlorogenic acid Drugs 0.000 claims description 19
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims description 19
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims description 19
- OVSQVDMCBVZWGM-IDRAQACASA-N Hirsutrin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)C1=C(c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O OVSQVDMCBVZWGM-IDRAQACASA-N 0.000 claims description 17
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 claims description 17
- GXMWXESSGGEWEM-UHFFFAOYSA-N isoquercitrin Natural products OCC(O)C1OC(OC2C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C1O GXMWXESSGGEWEM-UHFFFAOYSA-N 0.000 claims description 17
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 claims description 17
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 15
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 15
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 15
- 235000005875 quercetin Nutrition 0.000 claims description 15
- 229960001285 quercetin Drugs 0.000 claims description 15
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- 230000014759 maintenance of location Effects 0.000 claims description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 8
- 239000008103 glucose Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 210000004185 liver Anatomy 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 238000003556 assay Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 6
- 238000002137 ultrasound extraction Methods 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 5
- 238000010219 correlation analysis Methods 0.000 claims description 4
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 claims description 4
- 150000001793 charged compounds Chemical class 0.000 claims description 3
- 230000009514 concussion Effects 0.000 claims description 3
- HQVFCQRVQFYGRJ-UHFFFAOYSA-N formic acid;hydrate Chemical compound O.OC=O HQVFCQRVQFYGRJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000012044 organic layer Substances 0.000 claims description 3
- 230000003285 pharmacodynamic effect Effects 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 229940126678 chinese medicines Drugs 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims 1
- 238000007689 inspection Methods 0.000 claims 1
- 238000005374 membrane filtration Methods 0.000 claims 1
- 239000012488 sample solution Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 21
- 239000002023 wood Substances 0.000 description 15
- 239000000523 sample Substances 0.000 description 12
- 238000011156 evaluation Methods 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 241000700159 Rattus Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000003908 quality control method Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 4
- 244000144730 Amygdalus persica Species 0.000 description 3
- 235000006040 Prunus persica var persica Nutrition 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000012417 linear regression Methods 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 208000034189 Sclerosis Diseases 0.000 description 2
- 241000222355 Trametes versicolor Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 description 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 229910021642 ultra pure water Inorganic materials 0.000 description 2
- 239000012498 ultrapure water Substances 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 240000004528 Catalpa ovata Species 0.000 description 1
- 235000010005 Catalpa ovata Nutrition 0.000 description 1
- 241000110637 Cuscuta chinensis Species 0.000 description 1
- 241000758789 Juglans Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- LUJAXSNNYBCFEE-UHFFFAOYSA-N Quercetin 3,7-dimethyl ether Natural products C=1C(OC)=CC(O)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(O)C(O)=C1 LUJAXSNNYBCFEE-UHFFFAOYSA-N 0.000 description 1
- PUTDIROJWHRSJW-UHFFFAOYSA-N Quercitrin Natural products CC1OC(Oc2cc(cc(O)c2O)C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O PUTDIROJWHRSJW-UHFFFAOYSA-N 0.000 description 1
- 241000123725 Sophora tonkinensis Species 0.000 description 1
- OXGUCUVFOIWWQJ-XIMSSLRFSA-N acanthophorin B Natural products O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-XIMSSLRFSA-N 0.000 description 1
- 108010065394 aminopherase Proteins 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 239000012490 blank solution Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 230000010006 flight Effects 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- DWCZIOOZPIDHAB-UHFFFAOYSA-L methyl green Chemical compound [Cl-].[Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC(=CC=1)[N+](C)(C)C)=C1C=CC(=[N+](C)C)C=C1 DWCZIOOZPIDHAB-UHFFFAOYSA-L 0.000 description 1
- 238000005220 pharmaceutical analysis Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- OEKUVLQNKPXSOY-UHFFFAOYSA-N quercetin 3-O-beta-D-glucopyranosyl(1->3)-alpha-L-rhamnopyranosyl(1->6)-beta-d-galactopyranoside Natural products OC1C(O)C(C(O)C)OC1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OEKUVLQNKPXSOY-UHFFFAOYSA-N 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 description 1
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
组别 | 肝指数 | ALT | AST | 综合评分 |
空白组 | 2.204±0.340* | 41.233±4.767* | 98.700±20.382* | - |
模型组 | 2.666±0.603 | 59.813±0.601 | 206.381±22.912 | - |
配伍1 | 2.351±0.444 | 46.296±3.441* | 162.463±11.809 | 0.711 |
配伍2 | 1.956±0.392* | 50.792±2.823 | 200.804±12.420 | 0.629 |
配伍3 | 2.257±0.227* | 58.435±5.828 | 184.625±10.20 | 0.607 |
配伍4 | 2.342±0.386 | 51.074±0.682 | 175.038±3.889* | 0.657 |
配伍5 | 2.057±0.308* | 52.804±10.831 | 185.775±2.068 | 0.637 |
配伍6 | 2.192±0.225* | 35.638±7.320 | 198.363±0.990 | 0.747 |
配伍7 | 2.082±0.255* | 50.554±4.372 | 136.850±16.281* | 0.756 |
配伍8 | 2.092±0.243* | 64.004±0.224 | 186.838±16.935 | 0.587 |
配伍9 | 2.068±0.195* | 44.107±5.892* | 148.988±3.217* | 0.765 |
峰号 | 保留时间tR(min) | 关联系数 | 峰号 | 保留时间tR(min) | 关联系数 |
1 | 4.041 | 0.5286 | 11 | 20.387 | 0.5456 |
2 | 5.028 | 0.5084 | 12 | 21.372 | 0.9937 |
3 | 5.691 | 0.6288 | 13 | 23.835 | 0.8827 |
4 | 6.163 | 0.6569 | 14 | 29.405 | 0.6049 |
5 | 6.469 | 0.6678 | 15 | 40.395 | 0.9868 |
6 | 11.850 | 0.5335 | 16 | 41.916 | 0.5876 |
7 | 13.942 | 0.6257 | 17 | 45.416 | 0.5952 |
8 | 16.518 | 0.6927 | 18 | 55.307 | 0.7774 |
9 | 18.463 | 0.5911 | 19 | 76.904 | 0.6145 |
10 | 19.715 | 0.6774 | --- | --- | --- |
峰号 | 保留时间tR(min) | [M-H]- | 色谱峰指认名称 |
8 | 16.518 | 483.0802 | 2,6-二没食子酰基-葡萄糖 |
10 | 19.715 | 707.1856 | 双绿原酸 |
12 | 21.372 | 483.0801 | 1,6-二没食子酰基-葡萄糖 |
13 | 23.835 | 353.0887 | 绿原酸 |
15 | 40.395 | 463.0903 | 异槲皮苷 |
18 | 55.307 | 301.0370 | 槲皮素 |
样品 | S1 | S2 | S3 | S4 | S5 | S6 | S7 | S8 | S9 | S10 | S11 |
S1 | 1 | 0.996 | 0.998 | 0.998 | 0.984 | 0.997 | 0.958 | 0.951 | 0.967 | 0.965 | 0.965 |
S2 | 0.996 | 1 | 0.998 | 0.998 | 0.988 | 0.999 | 0.963 | 0.951 | 0.974 | 0.972 | 0.973 |
S3 | 0.998 | 0.998 | 1 | 0.999 | 0.988 | 0.999 | 0.962 | 0.955 | 0.972 | 0.971 | 0.971 |
S4 | 0.998 | 0.998 | 0.999 | 1 | 0.988 | 0.999 | 0.964 | 0.957 | 0.974 | 0.973 | 0.972 |
S5 | 0.984 | 0.988 | 0.988 | 0.988 | 1 | 0.988 | 0.979 | 0.966 | 0.982 | 0.982 | 0.982 |
S6 | 0.997 | 0.999 | 0.999 | 0.999 | 0.988 | 1 | 0.96 | 0.953 | 0.973 | 0.971 | 0.971 |
S7 | 0.958 | 0.963 | 0.962 | 0.964 | 0.979 | 0.96 | 1 | 0.978 | 0.988 | 0.987 | 0.988 |
S8 | 0.951 | 0.951 | 0.955 | 0.957 | 0.966 | 0.953 | 0.978 | 1 | 0.99 | 0.991 | 0.989 |
S9 | 0.967 | 0.974 | 0.972 | 0.974 | 0.982 | 0.973 | 0.988 | 0.99 | 1 | 0.999 | 0.999 |
S10 | 0.965 | 0.972 | 0.971 | 0.973 | 0.982 | 0.971 | 0.987 | 0.991 | 0.999 | 1 | 0.999 |
S11 | 0.965 | 0.973 | 0.971 | 0.972 | 0.982 | 0.971 | 0.988 | 0.989 | 0.999 | 0.999 | 1 |
R | 0.986 | 0.99 | 0.99 | 0.991 | 0.993 | 0.99 | 0.984 | 0.982 | 0.994 | 0.993 | 0.993 |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710084910.6A CN107037146B (zh) | 2017-02-17 | 2017-02-17 | 一种复方木鸡颗粒质量控制的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710084910.6A CN107037146B (zh) | 2017-02-17 | 2017-02-17 | 一种复方木鸡颗粒质量控制的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107037146A true CN107037146A (zh) | 2017-08-11 |
CN107037146B CN107037146B (zh) | 2020-12-15 |
Family
ID=59534337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710084910.6A Active CN107037146B (zh) | 2017-02-17 | 2017-02-17 | 一种复方木鸡颗粒质量控制的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107037146B (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107982383A (zh) * | 2018-01-25 | 2018-05-04 | 辽东学院 | 一种治疗肝癌的中药组合物及其制备方法和应用 |
CN109187820A (zh) * | 2018-11-09 | 2019-01-11 | 湖南国华制药有限公司 | 一种复方菝葜颗粒uplc指纹图谱的建立方法及其指纹图谱与应用 |
CN110031595A (zh) * | 2019-03-06 | 2019-07-19 | 湖南中医药大学 | 一种动态性与传递性综合控制的中药物质基准制备方法及其产品 |
CN110646600A (zh) * | 2019-10-12 | 2020-01-03 | 辽宁中医药大学 | 一种基于抗肝癌生物活性的复方木鸡颗粒质量控制与评价方法 |
CN110702809A (zh) * | 2019-10-12 | 2020-01-17 | 辽宁中医药大学 | 一种基于抗肝纤维化生物活性的复方木鸡颗粒质量控制与评价方法 |
CN112485209A (zh) * | 2020-09-21 | 2021-03-12 | 丹东药业集团有限公司 | 一种基于抗肝炎生物活性的复方木鸡颗粒质量控制与评价方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1421229A (zh) * | 2002-12-05 | 2003-06-04 | 丹东药业有限公司 | 一种治疗肝硬化、肝炎、肝癌的中药 |
CN101013117A (zh) * | 2007-02-13 | 2007-08-08 | 美晨集团股份有限公司 | 构建菟丝子药材hplc标准指纹图谱和鉴别药材质量的方法 |
CN103592390A (zh) * | 2013-11-22 | 2014-02-19 | 中国人民解放军总医院第一附属医院 | 茵木愈肝颗粒中绿原酸的质量检测方法 |
CN103604879A (zh) * | 2013-11-07 | 2014-02-26 | 培力(南宁)药业有限公司 | 云芝及含有云芝的制剂的检测方法 |
CN103837619A (zh) * | 2014-03-20 | 2014-06-04 | 常熟雷允上制药有限公司 | 中药肝炎灵注射液及其原料药材的指纹图谱检测方法 |
CN104007198A (zh) * | 2014-05-23 | 2014-08-27 | 无限极(中国)有限公司 | 一种灵芝皇制剂hplc标准指纹图谱及其构建方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5244795A (en) * | 1991-03-18 | 1993-09-14 | Merck & Co., Inc. | Processes for preparing cholesterol lowering compounds |
US6379714B1 (en) * | 1995-04-14 | 2002-04-30 | Pharmaprint, Inc. | Pharmaceutical grade botanical drugs |
EP2078755B1 (en) * | 2007-12-18 | 2019-02-20 | Amin Karmali | Process for simultaneous extraction and purification of fine chemicals from spent mushroom compost, mushroom stems and partially degraded mushroom fruiting bodies |
-
2017
- 2017-02-17 CN CN201710084910.6A patent/CN107037146B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1421229A (zh) * | 2002-12-05 | 2003-06-04 | 丹东药业有限公司 | 一种治疗肝硬化、肝炎、肝癌的中药 |
CN101013117A (zh) * | 2007-02-13 | 2007-08-08 | 美晨集团股份有限公司 | 构建菟丝子药材hplc标准指纹图谱和鉴别药材质量的方法 |
CN100492000C (zh) * | 2007-02-13 | 2009-05-27 | 美晨集团股份有限公司 | 构建菟丝子药材hplc标准指纹图谱和鉴别药材质量的方法 |
CN103604879A (zh) * | 2013-11-07 | 2014-02-26 | 培力(南宁)药业有限公司 | 云芝及含有云芝的制剂的检测方法 |
CN103592390A (zh) * | 2013-11-22 | 2014-02-19 | 中国人民解放军总医院第一附属医院 | 茵木愈肝颗粒中绿原酸的质量检测方法 |
CN103837619A (zh) * | 2014-03-20 | 2014-06-04 | 常熟雷允上制药有限公司 | 中药肝炎灵注射液及其原料药材的指纹图谱检测方法 |
CN104007198A (zh) * | 2014-05-23 | 2014-08-27 | 无限极(中国)有限公司 | 一种灵芝皇制剂hplc标准指纹图谱及其构建方法和应用 |
Non-Patent Citations (6)
Title |
---|
时晓亚 等: "HPLC法测定复方木鸡颗粒中金丝桃苷的含量", 《中医药导报》 * |
李春沁 等: "波棱瓜子乙酸乙酯部位抗免疫性肝损伤活性谱效关系分析", 《中国实验方剂学杂志》 * |
王丽 等: "复方木鸡颗粒治疗乙肝肝纤维化疗效观察", 《辽宁中医杂志》 * |
谭喜莹 等: "菟丝子药材HPLC指纹图谱研究", 《中国药学杂志》 * |
郑阳阳 等: "复方木鸡颗粒对小鼠慢性肝损伤的影响", 《亚太传统医药》 * |
黄海燕 等: "复方木鸡颗粒检测方法研究", 《药物分析杂志》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107982383A (zh) * | 2018-01-25 | 2018-05-04 | 辽东学院 | 一种治疗肝癌的中药组合物及其制备方法和应用 |
CN109187820A (zh) * | 2018-11-09 | 2019-01-11 | 湖南国华制药有限公司 | 一种复方菝葜颗粒uplc指纹图谱的建立方法及其指纹图谱与应用 |
CN109187820B (zh) * | 2018-11-09 | 2021-07-23 | 湖南国华制药有限公司 | 一种复方菝葜颗粒uplc指纹图谱的建立方法 |
CN110031595A (zh) * | 2019-03-06 | 2019-07-19 | 湖南中医药大学 | 一种动态性与传递性综合控制的中药物质基准制备方法及其产品 |
CN110646600A (zh) * | 2019-10-12 | 2020-01-03 | 辽宁中医药大学 | 一种基于抗肝癌生物活性的复方木鸡颗粒质量控制与评价方法 |
CN110702809A (zh) * | 2019-10-12 | 2020-01-17 | 辽宁中医药大学 | 一种基于抗肝纤维化生物活性的复方木鸡颗粒质量控制与评价方法 |
CN112485209A (zh) * | 2020-09-21 | 2021-03-12 | 丹东药业集团有限公司 | 一种基于抗肝炎生物活性的复方木鸡颗粒质量控制与评价方法 |
Also Published As
Publication number | Publication date |
---|---|
CN107037146B (zh) | 2020-12-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107037146A (zh) | 一种复方木鸡颗粒质量控制的方法 | |
Chen et al. | Analysis of the high‐performance liquid chromatography fingerprints and quantitative analysis of multicomponents by single marker of products of fermented Cordyceps sinensis | |
CN105675739B (zh) | 一种治疗风热感冒中药的hplc特征图谱的构建方法 | |
CN106404942B (zh) | 一种康肾颗粒指纹图谱的构建方法及其标准指纹图谱 | |
CN105067747B (zh) | 一种麝香保心丸中苏合香药味成分指纹图谱的检测方法及其应用 | |
CN101028460B (zh) | 一种中药制剂金嗓清音丸的质量检测方法 | |
CN105738519B (zh) | 一种基于量效色卡的气滞胃痛颗粒抗溃疡质量控制方法 | |
CN102359942B (zh) | 一种青鹏软膏及其制剂的质量检测方法 | |
CN109490442A (zh) | 一种厚朴辐照前后质量检测方法 | |
CN113759035A (zh) | 小承气汤指纹图谱的构建方法 | |
CN112858497A (zh) | 一种北豆根标准汤剂特征图谱的构建及质量检测方法 | |
CN105510452B (zh) | 益肝明目口服液的多指标成分含量测定、指纹图谱构建和制备方法 | |
CN114441685B (zh) | 一种重楼标准汤剂质量检测方法 | |
CN110243986A (zh) | 一种活血消瘿片hplc指纹图谱及其制备方法 | |
CN110261514A (zh) | 救心丸中蟾酥的含量测定方法 | |
CN110292617A (zh) | 肺力咳胶囊浸膏及其用途和质量控制方法 | |
CN106950289B (zh) | 一种冠心舒通胶囊一测多评含量检测方法 | |
CN113368185A (zh) | 一种百合地黄汤物质基准的制备工艺及其质量控制方法 | |
CN107389827A (zh) | 益母草或其复方制剂中盐酸水苏碱含量的测定方法 | |
Li et al. | Application of microscopy technique and high-performance liquid chromatography for quality assessment of the flower bud of Tussilago farfara L.(Kuandonghua) | |
CN103604898A (zh) | 益心舒制剂的指纹图谱检测方法及其指纹图谱 | |
CN109521119A (zh) | 一种复方南板蓝根颗粒指纹图谱的测定方法 | |
CN110308213B (zh) | 滋肾育胎丸指纹图谱构建方法及其在质量检测中的应用 | |
CN107894466B (zh) | 一种金桑芪抗毒制剂hplc指纹图谱的测定方法及金桑芪抗毒制剂质量控制方法 | |
CN109696489B (zh) | 一种肝复乐制剂的指纹图谱的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A method for quality control of Compound Muji granules Effective date of registration: 20210305 Granted publication date: 20201215 Pledgee: Dandong Bank Co.,Ltd. Yuanbao sub branch Pledgor: DANDONG PHARMACEUTICAL GROUP Co.,Ltd. Registration number: Y2021210000008 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20201215 Pledgee: Dandong Bank Co.,Ltd. Yuanbao sub branch Pledgor: DANDONG PHARMACEUTICAL GROUP CO.,LTD. Registration number: Y2021210000008 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A method for quality control of compound Muji granules Granted publication date: 20201215 Pledgee: Dandong Bank Co.,Ltd. Huiyin Branch Pledgor: DANDONG PHARMACEUTICAL GROUP CO.,LTD. Registration number: Y2024210000019 |