CN107001266A - 用于生产艾达鲁吡啶的方法 - Google Patents
用于生产艾达鲁吡啶的方法 Download PDFInfo
- Publication number
- CN107001266A CN107001266A CN201580065028.6A CN201580065028A CN107001266A CN 107001266 A CN107001266 A CN 107001266A CN 201580065028 A CN201580065028 A CN 201580065028A CN 107001266 A CN107001266 A CN 107001266A
- Authority
- CN
- China
- Prior art keywords
- compound
- fluoro
- mixture
- solvent
- catalyst
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201400721 | 2014-12-12 | ||
DKPA201400721 | 2014-12-12 | ||
PCT/EP2015/079209 WO2016091997A1 (fr) | 2014-12-12 | 2015-12-10 | Procédé de fabrication d'idalopirdine |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107001266A true CN107001266A (zh) | 2017-08-01 |
Family
ID=59011415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201580065028.6A Pending CN107001266A (zh) | 2014-12-12 | 2015-12-10 | 用于生产艾达鲁吡啶的方法 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP3230265A1 (fr) |
JP (1) | JP2017537128A (fr) |
KR (1) | KR20170093821A (fr) |
CN (1) | CN107001266A (fr) |
AU (1) | AU2015359347A1 (fr) |
BR (1) | BR112017012021A2 (fr) |
CA (1) | CA2968770A1 (fr) |
CL (1) | CL2017001466A1 (fr) |
CO (1) | CO2017005357A2 (fr) |
IL (1) | IL252471A0 (fr) |
MA (1) | MA41148A (fr) |
MX (1) | MX2017007510A (fr) |
RU (1) | RU2017120216A (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR102972A1 (es) | 2014-12-12 | 2017-04-05 | Japan Tobacco Inc | Compuestos de dihidropirimidin-2-ona y su uso médico |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3042685A (en) * | 1962-07-03 | Process of making g-fluoro tryptamine | ||
CN101677547A (zh) * | 2007-03-23 | 2010-03-24 | 史密丝克莱恩比彻姆公司 | 作为ikk2抑制剂的吲哚甲酰胺 |
CN102656146A (zh) * | 2009-12-23 | 2012-09-05 | H.隆德贝克有限公司 | 药物活性剂的制造方法 |
-
2015
- 2015-12-09 MA MA041148A patent/MA41148A/fr unknown
- 2015-12-10 EP EP15821029.4A patent/EP3230265A1/fr not_active Withdrawn
- 2015-12-10 CN CN201580065028.6A patent/CN107001266A/zh active Pending
- 2015-12-10 BR BR112017012021A patent/BR112017012021A2/pt not_active Application Discontinuation
- 2015-12-10 AU AU2015359347A patent/AU2015359347A1/en not_active Abandoned
- 2015-12-10 KR KR1020177015206A patent/KR20170093821A/ko unknown
- 2015-12-10 JP JP2017531139A patent/JP2017537128A/ja active Pending
- 2015-12-10 CA CA2968770A patent/CA2968770A1/fr not_active Abandoned
- 2015-12-10 MX MX2017007510A patent/MX2017007510A/es unknown
- 2015-12-10 RU RU2017120216A patent/RU2017120216A/ru not_active Application Discontinuation
-
2017
- 2017-05-23 IL IL252471A patent/IL252471A0/en unknown
- 2017-05-26 CO CONC2017/0005357A patent/CO2017005357A2/es unknown
- 2017-06-08 CL CL2017001466A patent/CL2017001466A1/es unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3042685A (en) * | 1962-07-03 | Process of making g-fluoro tryptamine | ||
CN101677547A (zh) * | 2007-03-23 | 2010-03-24 | 史密丝克莱恩比彻姆公司 | 作为ikk2抑制剂的吲哚甲酰胺 |
US8071584B2 (en) * | 2007-03-23 | 2011-12-06 | Glaxosmithkline Llc | Indole carboxamides as IKK2 inhibitors |
CN102656146A (zh) * | 2009-12-23 | 2012-09-05 | H.隆德贝克有限公司 | 药物活性剂的制造方法 |
Non-Patent Citations (2)
Title |
---|
ADAM T. GILLMORE,等: "Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor", 《ORG. PROCESS RES. DEV.》 * |
SATHISH BOINI,等: "Development of a Manufacturing Process for 1-(1-Pyridin-2-yl methyl-piperidin-4-yl)-1H-indole: A Key Intermediate for Protein Kinase C Inhibitor LY317615", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 * |
Also Published As
Publication number | Publication date |
---|---|
CO2017005357A2 (es) | 2017-09-20 |
IL252471A0 (en) | 2017-07-31 |
MA41148A (fr) | 2017-10-17 |
JP2017537128A (ja) | 2017-12-14 |
CL2017001466A1 (es) | 2018-01-05 |
EP3230265A1 (fr) | 2017-10-18 |
KR20170093821A (ko) | 2017-08-16 |
MX2017007510A (es) | 2017-08-22 |
CA2968770A1 (fr) | 2016-06-16 |
BR112017012021A2 (pt) | 2018-03-13 |
AU2015359347A1 (en) | 2017-06-08 |
RU2017120216A (ru) | 2019-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170801 |