CA2968770A1 - Procede de fabrication d'idalopirdine - Google Patents

Procede de fabrication d'idalopirdine Download PDF

Info

Publication number
CA2968770A1
CA2968770A1 CA2968770A CA2968770A CA2968770A1 CA 2968770 A1 CA2968770 A1 CA 2968770A1 CA 2968770 A CA2968770 A CA 2968770A CA 2968770 A CA2968770 A CA 2968770A CA 2968770 A1 CA2968770 A1 CA 2968770A1
Authority
CA
Canada
Prior art keywords
compound
fluoro
mixture
solvent
alumina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2968770A
Other languages
English (en)
Inventor
Mikkel Fog Jacobsen
Ole Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Priority claimed from PCT/EP2015/079209 external-priority patent/WO2016091997A1/fr
Publication of CA2968770A1 publication Critical patent/CA2968770A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2968770A 2014-12-12 2015-12-10 Procede de fabrication d'idalopirdine Abandoned CA2968770A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201400721 2014-12-12
DKPA201400721 2014-12-12
PCT/EP2015/079209 WO2016091997A1 (fr) 2014-12-12 2015-12-10 Procédé de fabrication d'idalopirdine

Publications (1)

Publication Number Publication Date
CA2968770A1 true CA2968770A1 (fr) 2016-06-16

Family

ID=59011415

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2968770A Abandoned CA2968770A1 (fr) 2014-12-12 2015-12-10 Procede de fabrication d'idalopirdine

Country Status (13)

Country Link
EP (1) EP3230265A1 (fr)
JP (1) JP2017537128A (fr)
KR (1) KR20170093821A (fr)
CN (1) CN107001266A (fr)
AU (1) AU2015359347A1 (fr)
BR (1) BR112017012021A2 (fr)
CA (1) CA2968770A1 (fr)
CL (1) CL2017001466A1 (fr)
CO (1) CO2017005357A2 (fr)
IL (1) IL252471A0 (fr)
MA (1) MA41148A (fr)
MX (1) MX2017007510A (fr)
RU (1) RU2017120216A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102551018B1 (ko) 2014-12-12 2023-07-05 니뽄 다바코 산교 가부시키가이샤 디히드로피리미딘-2-온 화합물 및 그의 의약 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3042685A (en) * 1962-07-03 Process of making g-fluoro tryptamine
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
TW201139370A (en) * 2009-12-23 2011-11-16 Lundbeck & Co As H Processes for the manufacture of a pharmaceutically active agent

Also Published As

Publication number Publication date
CO2017005357A2 (es) 2017-09-20
BR112017012021A2 (pt) 2018-03-13
MX2017007510A (es) 2017-08-22
CL2017001466A1 (es) 2018-01-05
CN107001266A (zh) 2017-08-01
IL252471A0 (en) 2017-07-31
RU2017120216A (ru) 2019-01-15
AU2015359347A1 (en) 2017-06-08
EP3230265A1 (fr) 2017-10-18
JP2017537128A (ja) 2017-12-14
KR20170093821A (ko) 2017-08-16
MA41148A (fr) 2017-10-17

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20191210