RU2017120216A - Способ производства идалопирдина - Google Patents

Способ производства идалопирдина Download PDF

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Publication number
RU2017120216A
RU2017120216A RU2017120216A RU2017120216A RU2017120216A RU 2017120216 A RU2017120216 A RU 2017120216A RU 2017120216 A RU2017120216 A RU 2017120216A RU 2017120216 A RU2017120216 A RU 2017120216A RU 2017120216 A RU2017120216 A RU 2017120216A
Authority
RU
Russia
Prior art keywords
paragraphs
fluoro
solvent
hydrogenation
dimethylformamide
Prior art date
Application number
RU2017120216A
Other languages
English (en)
Russian (ru)
Inventor
Миккель Фог Якобсен
Оле НИЕЛСЕН
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Priority claimed from PCT/EP2015/079209 external-priority patent/WO2016091997A1/fr
Publication of RU2017120216A publication Critical patent/RU2017120216A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
RU2017120216A 2014-12-12 2015-12-10 Способ производства идалопирдина RU2017120216A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201400721 2014-12-12
DKPA201400721 2014-12-12
PCT/EP2015/079209 WO2016091997A1 (fr) 2014-12-12 2015-12-10 Procédé de fabrication d'idalopirdine

Publications (1)

Publication Number Publication Date
RU2017120216A true RU2017120216A (ru) 2019-01-15

Family

ID=59011415

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017120216A RU2017120216A (ru) 2014-12-12 2015-12-10 Способ производства идалопирдина

Country Status (13)

Country Link
EP (1) EP3230265A1 (fr)
JP (1) JP2017537128A (fr)
KR (1) KR20170093821A (fr)
CN (1) CN107001266A (fr)
AU (1) AU2015359347A1 (fr)
BR (1) BR112017012021A2 (fr)
CA (1) CA2968770A1 (fr)
CL (1) CL2017001466A1 (fr)
CO (1) CO2017005357A2 (fr)
IL (1) IL252471A0 (fr)
MA (1) MA41148A (fr)
MX (1) MX2017007510A (fr)
RU (1) RU2017120216A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017010471B1 (pt) 2014-12-12 2024-02-27 Japan Tobacco Inc Compostos de di-hidropirimidin-2-ona, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3042685A (en) * 1962-07-03 Process of making g-fluoro tryptamine
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
TW201139370A (en) * 2009-12-23 2011-11-16 Lundbeck & Co As H Processes for the manufacture of a pharmaceutically active agent

Also Published As

Publication number Publication date
BR112017012021A2 (pt) 2018-03-13
MX2017007510A (es) 2017-08-22
EP3230265A1 (fr) 2017-10-18
CL2017001466A1 (es) 2018-01-05
JP2017537128A (ja) 2017-12-14
MA41148A (fr) 2017-10-17
CA2968770A1 (fr) 2016-06-16
IL252471A0 (en) 2017-07-31
CN107001266A (zh) 2017-08-01
AU2015359347A1 (en) 2017-06-08
CO2017005357A2 (es) 2017-09-20
KR20170093821A (ko) 2017-08-16

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Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20181211