CN107001264B - 作为登革热病毒复制抑制剂的单取代的或二取代的吲哚衍生物 - Google Patents

作为登革热病毒复制抑制剂的单取代的或二取代的吲哚衍生物 Download PDF

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Publication number
CN107001264B
CN107001264B CN201580053446.3A CN201580053446A CN107001264B CN 107001264 B CN107001264 B CN 107001264B CN 201580053446 A CN201580053446 A CN 201580053446A CN 107001264 B CN107001264 B CN 107001264B
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CN
China
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compound
chloro
general formula
methoxyphenyl
enantiomer
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Active
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CN201580053446.3A
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English (en)
Chinese (zh)
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CN107001264A (zh
Inventor
B.R.R.科斯特勒恩
J-F.邦范蒂
T.H.M.乔恩克斯
P.J-M.B.拉博伊斯森
D.A.M-E.巴迪奥特
A.D.M.马钱德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Janssen Pharmaceuticals Inc
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Katholieke Universiteit Leuven
Janssen Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201580053446.3A 2014-10-01 2015-09-30 作为登革热病毒复制抑制剂的单取代的或二取代的吲哚衍生物 Active CN107001264B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14187374.5 2014-10-01
EP14187374 2014-10-01
EP15159164 2015-03-16
EP15159164.1 2015-03-16
PCT/EP2015/072551 WO2016050841A1 (en) 2014-10-01 2015-09-30 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Publications (2)

Publication Number Publication Date
CN107001264A CN107001264A (zh) 2017-08-01
CN107001264B true CN107001264B (zh) 2021-06-15

Family

ID=54199687

Family Applications (1)

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CN201580053446.3A Active CN107001264B (zh) 2014-10-01 2015-09-30 作为登革热病毒复制抑制剂的单取代的或二取代的吲哚衍生物

Country Status (32)

Country Link
US (1) US9944598B2 (enExample)
EP (1) EP3201176B1 (enExample)
JP (1) JP6732736B2 (enExample)
KR (1) KR102478311B1 (enExample)
CN (1) CN107001264B (enExample)
AU (1) AU2015326930B2 (enExample)
BR (1) BR112017006299A2 (enExample)
CA (1) CA2959573A1 (enExample)
CL (1) CL2017000782A1 (enExample)
CY (1) CY1121874T1 (enExample)
DK (1) DK3201176T3 (enExample)
EA (1) EA032546B1 (enExample)
ES (1) ES2714074T3 (enExample)
HR (1) HRP20190199T1 (enExample)
HU (1) HUE041888T2 (enExample)
IL (1) IL251396A0 (enExample)
LT (1) LT3201176T (enExample)
MA (1) MA40768B1 (enExample)
ME (1) ME03360B (enExample)
MX (1) MX2017004299A (enExample)
PH (1) PH12017500571A1 (enExample)
PL (1) PL3201176T3 (enExample)
PT (1) PT3201176T (enExample)
RS (1) RS58461B1 (enExample)
SG (1) SG11201702463YA (enExample)
SI (1) SI3201176T1 (enExample)
SM (1) SMT201900162T1 (enExample)
TW (1) TWI681951B (enExample)
UA (1) UA121119C2 (enExample)
UY (1) UY36340A (enExample)
WO (1) WO2016050841A1 (enExample)
ZA (1) ZA201702301B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
JP6662865B2 (ja) 2014-10-01 2020-03-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ボロン酸誘導体
PL3201177T3 (pl) * 2014-10-01 2019-05-31 Janssen Pharmaceuticals Inc Mono- lub di-podstawione indole jako inhibitory replikacji wirusa dengi
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) * 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
WO2017167950A1 (en) 2016-03-31 2017-10-05 Janssen Pharmaceuticals, Inc. Substituted indole derivatives as dengue viral replication inhibitors
CN109069482B (zh) * 2016-04-01 2022-04-05 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物
JOP20170069B1 (ar) * 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
MX393586B (es) * 2017-05-22 2025-03-24 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue
PE20200342A1 (es) * 2017-05-22 2020-02-14 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue
CN121358711A (zh) * 2023-06-05 2026-01-16 载度思生命科学有限公司 治疗病毒感染的新的化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104024223A (zh) * 2011-09-26 2014-09-03 鲁汶天主教大学 病毒复制抑制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX336687B (es) * 2009-06-30 2016-01-28 Siga Technologies Inc Tratamiento y prevencion de infecciones del virus del dengue.
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104024223A (zh) * 2011-09-26 2014-09-03 鲁汶天主教大学 病毒复制抑制剂

Also Published As

Publication number Publication date
HRP20190199T1 (hr) 2019-04-05
RS58461B1 (sr) 2019-04-30
EP3201176B1 (en) 2018-12-12
LT3201176T (lt) 2019-03-25
US9944598B2 (en) 2018-04-17
EA201790758A1 (ru) 2017-07-31
CN107001264A (zh) 2017-08-01
JP2017531619A (ja) 2017-10-26
PL3201176T3 (pl) 2019-06-28
AU2015326930A1 (en) 2017-03-16
EP3201176A1 (en) 2017-08-09
SG11201702463YA (en) 2017-04-27
KR20170063802A (ko) 2017-06-08
PH12017500571A1 (en) 2017-08-30
CL2017000782A1 (es) 2017-11-03
US20170298017A1 (en) 2017-10-19
WO2016050841A1 (en) 2016-04-07
AU2015326930B2 (en) 2020-03-26
CA2959573A1 (en) 2016-04-07
WO2016050841A9 (en) 2016-06-02
JP6732736B2 (ja) 2020-07-29
SI3201176T1 (sl) 2019-05-31
ME03360B (me) 2019-10-20
EA032546B1 (ru) 2019-06-28
ES2714074T3 (es) 2019-05-27
MA40768B1 (fr) 2019-03-29
DK3201176T3 (en) 2019-03-25
UY36340A (es) 2016-04-01
CY1121874T1 (el) 2020-10-14
MA40768A (fr) 2017-09-08
ZA201702301B (en) 2018-12-19
TWI681951B (zh) 2020-01-11
HUE041888T2 (hu) 2019-06-28
KR102478311B1 (ko) 2022-12-15
SMT201900162T1 (it) 2019-05-10
UA121119C2 (uk) 2020-04-10
PT3201176T (pt) 2019-03-04
IL251396A0 (en) 2017-05-29
BR112017006299A2 (pt) 2018-01-16
TW201630879A (zh) 2016-09-01
MX2017004299A (es) 2017-07-19

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