CN106942271A - A kind of compound potassium hydrogen persulfate disinfectant and preparation method thereof - Google Patents
A kind of compound potassium hydrogen persulfate disinfectant and preparation method thereof Download PDFInfo
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- CN106942271A CN106942271A CN201710278811.1A CN201710278811A CN106942271A CN 106942271 A CN106942271 A CN 106942271A CN 201710278811 A CN201710278811 A CN 201710278811A CN 106942271 A CN106942271 A CN 106942271A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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Abstract
The present invention relates to disinfectant, more particularly to a kind of compound potassium hydrogen persulfate disinfectant and preparation method thereof, the disinfectant mainly includes following weight percent composition：Potassium hydrogen persulfate 20~65%, sodium chloride wrappage 1~10%, acidizer 5~30%, effervescent agent 0~15%, APG 1~10%, lubricant 0~5%, metal-chelator 1~20%, anti-caking agent 1~20%.The invention provides a kind of compound potassium hydrogen persulfate disinfectant and its preparation technology, the disinfectant contains sodium chloride wrappage, contained sodium chloride wrappage has inoxidizability, avoid sodium chloride from contacting with other components to react, stability is stronger, and the disinfectant contains APG, compared with the compound potassium hydrogen persulfate disinfectant for not containing APG, bactericidal activity is stronger.
Description
Technical field
The present invention relates to disinfectant, more particularly to a kind of compound potassium hydrogen persulfate disinfectant and preparation method thereof.
Background technology
With developing rapidly for modern farming enterprise's aquaculture, highly dense, enclosed rearing conditions make it that livestock and poultry are caused
The serious threat of sick microorganism, causes the generation of many diseases.These diseases not only endanger the health of animal, have also threatened the mankind
Health, and govern the development of national economy.
Sterilization, is to kill pathogenic microorganism in environment, cut-out route of transmission, one kind weight for the generation for preventing and controlling epidemic disease
Want measure.Sterilization is through the various aspects in our lives, and such as medical institutions' disinfecting, public place environment disappears
Poison, home care sterilization, the sterilization of food and medicine production environment, aquaculture, farming and animal husbandry cultivation sterilization etc..Sterilization is to national economy
Even running also play vital effect, people increasingly pay attention to the application of disinfectant.
At present, conventional disinfectant mainly has acid, bases disinfectant, halogen disinfectant, quaternary ammonium disinfectant, phenols
With aldehyde disinfectant and peroxide disinfectant.The common disinfectant of in the market have Peracetic acid, glutaraldehyde, PVP-I,
Quaternary ammonium salt etc..Above-mentioned disinfectant has respective shortcoming, and such as stability is poor, corrosivity is big, excitant is strong, narrow antimicrobial spectrum, has
Even also carcinogenic danger, so being had some limitations in clinical practice.Therefore, develop a kind of environmental protection,
Broad-spectrum high efficacy, low toxicity are non-stimulated, stablize strong disinfectant, it has also become trend of the times.
The content of the invention
In a first aspect, the present invention provides a kind of compound over cure containing APG and oxidation resistant sodium chloride wrappage
Potassium hydrogen phthalate disinfectant, oxidation resistant sodium chloride wrappage, is difficult the moisture absorption, with inoxidizability, and can significantly improve disinfectant
Stability, extends storage life；And APG, there are synergistic effect and synergic remove to disinfectant sterilization.
A kind of compound potassium hydrogen persulfate disinfectant, the disinfectant mainly includes following weight percent composition：Persulfuric acid
Hydrogen potassium 20~65%, sodium chloride wrappage 1~10%, acidizer 5~30%, effervescent agent 0~15%, APG 1~10%,
Lubricant 0~5%, metal-chelator 1~20%, anti-caking agent 1~20%.
It is preferred that, the sodium chloride wrappage is mainly made up of sodium chloride and film forming agent, and the film forming agent is sodium alginate.
In the sodium chloride wrappage, the sodium chloride is wrapped core.
In a preferred embodiment, the sodium alginate is the sodium alginate that content is more than 95%, such as 99.6%
Sodium alginate.
It is preferred that, the sodium chloride in the sodium chloride wrappage is the sodium chloride of 100 μm~1200 μm of particle diameter.
In above-mentioned sodium chloride wrappage, the sodium chloride is graininess.
It is preferred that, the percentage by weight of the sodium chloride wrappage is 3~7%, more preferably 3~5%.
Contain oxidation resistant sodium chloride wrappage in the compound potassium hydrogen persulfate disinfectant of the present invention, be difficult the moisture absorption, have
Inoxidizability, and the stability of disinfection tablet can be significantly improved, extend storage life.
It is preferred that, the percentage by weight of the APG is 3~7%, more preferably 3~5%.
In the compound potassium hydrogen persulfate disinfectant of the present invention, sterilization of the APG to disinfectant plays synergistic effect.
In a preferred embodiment, described APG is APG powder.
In another preferred embodiment, described APG is the APG of content more than 90%.
Wherein, the acidizer is used for the optimum pH for providing reaction, stable to react the active oxygen and its derivative produced,
Preferably solid acid agent, the solid acid agent may be selected from including sulfamic acid, citric acid, tartaric acid, malic acid, oxalic acid,
One or more in citric acid, salicylic acid, niter cake, potassium acid sulfate.
Wherein, the effervescent agent is used to accelerate disinfectant to dissolve and scattered, promotes reaction to carry out, is carried for the progress for reaction
For power, energy, it may be selected from including the one or more in natrium carbonicum calcinatum, sodium bicarbonate.
Wherein, the lubricant can reduce frictional force between particle, improve mobility, particularly in tablets, can enter
One step ensure compressing tablet be smoothed out and tablet surface is bright and clean, may be selected from including one kind in talcum powder, magnesium stearate, gas-phase silicon
Or a variety of, more preferably gas-phase silicon.
Wherein, the metal ion that the chelating agent is used in chelate solution, prevents metal ion from occurring chemical reaction and is formed
Sediment, effectively suppresses metal ion to the catalytic decomposition of Strong oxdiative composition, may be selected from including sodium tripolyphosphate, polyphosphoric acids
One or more in sodium, calgon, sodium pyrophosphate, edta and its sodium salt.
Wherein, the anti-caking agent be used for absorb excessive moisture, effectively reduce intergranular absorption adhesion, prevent particle or
Granular material aggregation is lumpd, keeps it loose or flow freely, and may be selected from including anhydrous magnesium carbonate, anhydrous magnesium sulfate and anhydrous chlorine
Change the one or more of magnesium.
It is preferred that, the disinfectant also includes the flavouring agent of 0.01~0.2% percentage by weight.
It is preferred that, the disinfectant also includes the pigment of 0.01~0.3% percentage by weight, can be used as storage cycle instruction
Agent.
It is preferred that, described flavouring agent is to play the material for producing specific fragrance or sensation, more preferably including perfume (or spice)
One or more in Lan Su, Long Yanxiang.
It is preferred that, the pigment includes the one or more in amaranth, famille rose, beet red.
It is preferred that, the preparation of the sodium chloride wrappage is prepared by fluidized bed coating method.
It is preferred that, the preparation of the sodium chloride wrappage is obtained by the method comprised the following steps：By film forming agent and water
Film forming solution is obtained by mixing, wherein, the mass ratio of the film forming agent and water is 0.001:1~0.1:1；Pass through fluid bed bag again
Clothing is wrapped up sodium chloride using film forming solution, wherein, the mass ratio of the film forming solution and sodium chloride is 0.2:1~10:
1。
It is preferred that, the arrange parameter of the fluidized bed coating is：35~105 DEG C of EAT；10~60Hz of blower fan frequency；
0.1~0.5MPa of atomizing pressure.
In a preferred embodiment, the preparation of the sodium chloride wrappage comprises the following steps：
(1) by film forming agent and water according to 0.001:1~0.1:1 mass ratio mixing, obtains film forming solution；
(2) according to film forming solution：Sodium chloride is 0.2:1~10:1 mass ratio, film forming solution is sprayed into and is placed in fluid bed
Sodium chloride in the spray of bottom, is coated, sodium chloride wrappage is made.
Pass through above method, the sodium chloride wrappage for the parcel that can succeed, it is observed that surface bag in Electronic Speculum
Wrap up in the sodium chloride crystal of thin film.
It is preferred that, the compound potassium hydrogen persulfate disinfectant is compound potassium hydrogen persulfate disinfectant powder or disinfection tablet.
In second aspect, the present invention provides a kind of method for preparing above-mentioned compound potassium hydrogen persulfate disinfectant, by described group
Obtained or alternatively further compressing tablet is obtained after point mixing, be combined potassium peroxydisulfate disinfectant.
It is preferred that, the component is mixed, is combined by a kind of method for preparing above-mentioned compound potassium hydrogen persulfate disinfectant
Potassium peroxydisulfate disinfectant powder.
It is preferred that, a kind of method for preparing above-mentioned compound potassium hydrogen persulfate disinfectant mixes the component, then compressing tablet,
Obtain compound potassium peroxydisulfate disinfection tablet.
In disinfectant in the present invention, sodium alginate is a kind of linear polysaccharide, by β-D mannuronic acids and ancient sieve of α-L
Uronic acid is constituted, biodegradable, with good biocompatibility and good film forming.Sodium alginate contain it is substantial amounts of-
COO—,-COO—, it is impossible to it is oxidized, so sodium alginate shows very strong antioxygenic property, the stabilization of disinfectant can be increased
Property.
Sodium chloride wrappage in the present invention is to be prepared by film forming agent of sodium alginate using fluidized bed coating, hence it is evident that
Improve the oxidation resistance and stability of product.
In Chinese patent disclosure CN101828550A, a kind of compound potassium hydrogen persulfate powder disinfection tablet, energy are disclosed
Various bacteriums and virus are killed, but during its placement, use, is easily made moist, especially its composition sodium chloride is in deliquescence
Afterwards, can be with hydrogen persulfate nak response, generation chlorine, and and organic acid reaction, hydrogen ion, oxygen radical etc. are produced, can be led
Active ingredient is caused to decline.In another Chinese patent disclosure CN105360162A, disclose a kind of containing sodium chloride parcel
The compound potassium hydrogen persulfate powder disinfectant of thing, but during use is placed：On the one hand, the film on sodium chloride wrappage surface is not
Possess antioxygenic property and by potassium hydrogen persulfate oxidation Decomposition, consumed potassium hydrogen persulfate, reduce active ingredient；The opposing party
Face, further, sodium chloride and potassium hydrogen persulfate, organic acid etc. react, and produce chlorine, hydrogen ion, oxygen radical etc., lead
Cause active ingredient reduction.
In the disinfectant of the present invention, APG is a kind of green, gentle, nontoxic new non-ionic surface-active
Agent, is generated by the condensation of carbohydrate and thing and higher alcohol.APG has conventional nonionic and anion surfactant concurrently
Numerous characteristics, surface-active height, low surface tension, strong detergency, foaming abundancy it is fine and smooth and stably, compatibility it is strong, with good
Ecological security and intermiscibility, it is nontoxic, non-stimulated to human body skin, it is biodegradable rapid thoroughly, can be with any types
Surfactant compound, cooperative effect is obvious.APG has stronger broad spectrum antibiotic activity, to peroxide disinfectant
Sterilization has synergistic effect.
The invention provides a kind of compound potassium hydrogen persulfate disinfectant and its preparation technology, the disinfectant contains sodium chloride
Wrappage, contained sodium chloride wrappage has inoxidizability, it is to avoid sodium chloride is contacted with other components and reacted, stable
Property is stronger, and the disinfectant contains APG powder, the compound potassium hydrogen persulfate disinfectant phase with not containing APG powder
Than bactericidal activity is stronger.
Brief description of the drawings
Fig. 1 is the sodium chloride wrappage of embodiment 1 and the electron microscope of sodium chloride.
Embodiment
The present invention is further described below in conjunction with specific embodiment.
The sodium chloride wrappage 100Kg of embodiment 1
The sodium chloride wrappage of the present embodiment is constituted by wrapped core and for the film forming agent of parcel, wrapped core
Material is the sodium chloride salt that 250 μm~550 μm of particle diameter is in granular form, and the film forming agent for parcel is sodium alginate.
The preparation of the sodium chloride wrappage of the present embodiment uses fluidized bed coating, comprises the following steps that：
(1) by film forming agent sodium alginate and water according to 0.02:1 mass ratio mixing, forms the film forming with certain viscosity
Solution；
(2) by film forming solution and sodium chloride according to 4:1 mass ratio, film forming solution is sprayed into and is placed in the spray of fluid bed bottom
Sodium chloride, is coated, and sodium chloride wrappage is made, wherein, fluid bed parameter is set to：55 DEG C of EAT；Blower fan frequency
40Hz；Atomizing pressure 0.3MPa；It is coated flow velocity 0.6L/min.
The sodium chloride wrappage that the present embodiment is prepared done respectively with sodium chloride ESEM carry out it is microcosmic compared, such as
Shown in Fig. 1, wherein A (1)-A (4) is the stereoscan photograph that sodium chloride amplifies different multiples, and B (1)-B (4) wraps up for sodium chloride
Thing amplifies the stereoscan photograph of different multiples；By Fig. 1, we can significantly see, sodium chloride crystal in B (1)-B (4)
Surface coating thin film, illustrates that the sodium chloride of the present embodiment is wrapped up successfully.
The sodium chloride wrappage 50Kg of embodiment 2
The sodium chloride wrappage of the present embodiment is constituted by wrapped core and for the film forming agent of parcel, wrapped core
Material is the sodium chloride salt that 380 μm~550 μm of particle diameter is in granular form, and the film forming agent for parcel is sodium alginate.
The sodium chloride wrappage of the present embodiment is prepared using fluidized bed coating, is comprised the following steps that：
(1) by film forming agent sodium alginate and water according to 0.02:1 mass ratio mixing, forms the film forming with certain viscosity
Solution；
(2) by film forming solution and sodium chloride according to 4:1 mass ratio, film forming solution is sprayed into and is placed in the spray of fluid bed bottom
Sodium chloride, is coated, and sodium chloride wrappage is made, wherein, fluid bed parameter setting is as follows：45 DEG C of EAT；Blower fan is frequently
Rate 30Hz；Atomizing pressure 0.26MPa；It is coated flow velocity 0.6L/min.
The compound potassium hydrogen persulfate disinfectant of embodiment 3
The component of the present embodiment is by weight percentage：Potassium hydrogen persulfate 50%, sodium chloride wrappage 3% is (from real
Apply example 1), APG powder 5%, solid acid agent 19%, effervescent agent 8%, lubricant 1.24%, metal-chelator 5%, resistive connection
Block agent 8.62%, flavouring agent 0.06%, pigment 0.08%.
The compound potassium hydrogen persulfate disinfectant of embodiment 4
The component of the present embodiment is by weight percentage：Potassium hydrogen persulfate 55%, sodium chloride wrappage 3% is (from real
Apply example 1), APG powder 5%, solid acid agent 19%, metal-chelator 8%, anti-caking agent 9.86%, flavouring agent
0.06%th, pigment 0.08%.
Embodiment 5
A kind of compound potassium hydrogen persulfate disinfectant, mainly comprising following weight percent composition：Potassium hydrogen persulfate 30%, chlorine
Change sodium wrappage 10%, salicylic acid 30%, natrium carbonicum calcinatum 15%, APG 10%, gas-phase silicon 0.5%, sodium tripolyphosphate
3%th, anhydrous magnesium carbonate 1%, dragon prolong perfume 0.2%, amaranth 0.3%.
Sodium chloride wrappage be using sodium alginate as film forming agent, using the sodium chloride of 1000 μm of particle diameters as wrapped core,
Prepared by the method with embodiment 2.
Embodiment 6
A kind of compound potassium hydrogen persulfate disinfectant, mainly comprising following weight percent composition：Potassium hydrogen persulfate 60%, chlorine
Change sodium wrappage 5%, salicylic acid 15%, APG 2%, sodium tripolyphosphate 12%, anhydrous magnesium carbonate 5.9%, Long Yanxiang
0.05%th, 0.05% amaranth.
Sodium chloride wrappage be using sodium alginate as film forming agent, using the sodium chloride of 1000 μm of particle diameters as wrapped core,
Prepared by the method with embodiment 2.
Test example 1
Using the Ministry of Public Health 2002 editions《Disinfection technology standard》Accelerated test, by the compound over cure of the embodiment of the present invention 3
Potassium hydrogen phthalate disinfection tablet is other materials with the potassium hydrogen persulfate disinfection tablet containing not wrapped sodium chloride and containing film forming agent
The compound potassium hydrogen persulfate disinfection tablet of sodium chloride wrappage is compared, and studies the compound potassium hydrogen persulfate disinfection tablet of the present invention
Stability.
Wherein, the composite sulfur potassium hydrogen phthalate disinfection tablet of the embodiment of the present invention 3 is for 1 group, 2 groups of composite sulfur potassium hydrogen phthalate disinfection tablet
Film forming agent is hydroxymethyl cellulose, and other components are identical with 1 group of sulfate composite disinfection tablet, and 3 groups of control group uses what is do not wrapped up
Sodium chloride replaces the sodium chloride wrappage in 1 group, and other components are identical with 1 group.
Respectively by 1 group, 2 groups, 3 groups of composite sulfur potassium hydrogen phthalate disinfection tablet temperature be 40 DEG C ± 2 DEG C, relative humidity RH be
Under conditions of 75% ± 5%, place 6 months, respectively at January, 2 months, March, the sampling of 6 the end of month, its available chlorine content is carried out
Determine, every group of sample carries out 3 batch parallel tests, as a result as shown in table 1.
Stability result under the conditions of each disinfection tablet accelerated test of table 1
| Group | Time (moon) | Available chlorine content/% |
| 1 group | 0 | 10.71 |
| 1 group | 1 | 10.65 |
| 1 group | 2 | 10.61 |
| 1 group | 3 | 10.55 |
| 1 group | 6 | 10.42 |
| 2 groups | 0 | 10.71 |
| 2 groups | 1 | 10.58 |
| 2 groups | 2 | 10.44 |
| 2 groups | 3 | 10.30 |
| 2 groups | 6 | 9.91 |
| 3 groups | 0 | 10.69 |
| 3 groups | 1 | 10.47 |
| 3 groups | 2 | 10.26 |
| 3 groups | 3 | 10.04 |
| 3 groups | 6 | 9.44 |
Further the rate of descent of the available chlorine content of 6 months can be calculated from the result of table 1,1 group of rate of descent
For 2.65%, and 2 groups of rate of descent is 7.47%, and 3 groups of rate of descent is 11.69%, be can be seen that from this result of the invention real
The good stability of composite sulfur potassium hydrogen phthalate disinfection tablet of example 3 is applied in the composite sulfur potassium hydrogen phthalate sterilization using hydroxymethyl cellulose as film forming agent
Piece, is further better than the composite sulfur potassium hydrogen phthalate disinfection tablet of unused film forming agent.
Test example 2
Using the Ministry of Public Health 2002 editions《Disinfection technology standard》Accelerated test, by the compound over cure of the embodiment of the present invention 4
Potassium hydrogen persulfate disinfectant powder and be other materials containing film forming agent that potassium hydrogen phthalate disinfection tablet powder contains not wrapped sodium chloride
The compound potassium hydrogen persulfate disinfectant powder of sodium chloride wrappage is compared, and studies the compound potassium hydrogen persulfate disinfectant powder of the present invention
Stability.
Wherein, the composite sulfur potassium hydrogen phthalate disinfectant powder of the embodiment of the present invention 4 is for 4 groups, 5 groups of composite sulfur potassium hydrogen phthalate disinfectant powder
Film forming agent is PVA, and other components are identical with 4 groups of sulfate composite disinfectant powder, and 6 groups of control group is replaced using the sodium chloride not wrapped up
Sodium chloride wrappage in 1 group, other components are identical with 4 groups.
Respectively by 4 groups, 5 groups, 6 groups of disinfectant powder in the bar that temperature is 40 DEG C ± 2 DEG C, relative humidity RH is 75% ± 5%
Under part, place 6 months, respectively at January, 2 months, March, the sampling of 6 the end of month, its available chlorine content is measured respectively, every group
3 batch parallel tests are tested, as a result as shown in table 2.
Stability result under the conditions of each disinfectant powder accelerated test of table 2
| Group | Time (moon) | Available chlorine content/% |
| 4 groups | 0 | 11.62 |
| 4 groups | 1 | 11.56 |
| 4 groups | 2 | 11.50 |
| 4 groups | 3 | 11.43 |
| 4 groups | 6 | 11.27 |
| 5 groups | 0 | 11.64 |
| 5 groups | 1 | 11.48 |
| 5 groups | 2 | 11.31 |
| 5 groups | 3 | 11.16 |
| 5 groups | 6 | 10.71 |
| 6 groups | 0 | 11.59 |
| 6 groups | 1 | 11.35 |
| 6 groups | 2 | 11.09 |
| 6 groups | 3 | 10.89 |
| 6 groups | 6 | 10.15 |
Further the rate of descent of the available chlorine content of 6 months can be calculated from the result of table 2,4 groups of rate of descent
For 3.07%, and 5 groups of rate of descent is 7.96%, and 6 groups of rate of descent is 12.43%, be can be seen that from this result of the invention real
The good stability of composite sulfur potassium hydrogen phthalate disinfection tablet of example 4 is applied in the composite sulfur potassium hydrogen phthalate disinfection tablet using PVA as film forming agent, more enters one
Step is better than the composite sulfur potassium hydrogen phthalate disinfection tablet of unused film forming agent.
It these results suggest that, compared with other film forming agents and disinfectant without using the sodium chloride of film forming agent, using marine alga
The compound potassium hydrogen persulfate disinfectant that sour sodium is done the sodium chloride wrappage of film forming agent preparation and prepared with this, its active ingredient declines
Amount is significantly reduced, and can be significantly increased the inoxidizability and stability of disinfectant, be extended the shelf life.
Test example 3
3 kinds of compound potassium hydrogen persulfate disinfectant tablets and 3 kinds of compound potassium hydrogen persulfate disinfectant powders are prepared respectively, according to 2002
Version《Disinfection technology standard》Sterilization test is carried out to 3 kinds of disinfection tablets and 3 kinds of disinfectant powders, compares their bactericidal effect.3 kinds of sterilizations
The component of piece and 3 kinds of disinfectant powders is as described below.
Disinfection tablet 1, the composition of composition is by weight percentage：Potassium hydrogen persulfate 50%, anti-caking agent 12.62%, chlorination
Sodium wrappage 3% (comes from embodiment 1), solid acid agent 20%, effervescent agent 8%, lubricant 1.24%, metal-chelator 5%,
Flavouring agent 0.06%, pigment 0.08%.
Disinfection tablet 2, the composition of composition is by weight percentage：Potassium hydrogen persulfate 50%, APG powder 2%, agglomeration resistance
Agent 10.62%, sodium chloride wrappage 3% (comes from embodiment 1), solid acid agent 20%, effervescent agent 8%, lubricant 1.24%,
Metal-chelator 5%, flavouring agent 0.06%, pigment 0.08%.
Disinfection tablet 3, the composition of composition is by weight percentage：Potassium hydrogen persulfate 50%, APG powder 5%, agglomeration resistance
Agent 7.62%, sodium chloride wrappage 3% (comes from embodiment 1), solid acid agent 20%, effervescent agent 8%, lubricant 1.24%,
Metal-chelator 5%, flavouring agent 0.06%, pigment 0.08%.
Disinfectant powder 1, the composition of composition is by weight percentage：Potassium hydrogen persulfate 50%, anti-caking agent 13.86%, chlorination
Sodium wrappage 3% (comes from embodiment 2), solid acid agent 23%, metal-chelator 10%, flavouring agent 0.06%, pigment
0.08%.
Disinfectant powder 2, the composition of composition is by weight percentage：Potassium hydrogen persulfate 50%, APG powder 2%, agglomeration resistance
Agent 11.86%, sodium chloride wrappage 3% (comes from embodiment 2), solid acid agent 23%, metal-chelator 10%, flavouring agent
0.06%, pigment 0.08%.
Disinfectant powder 3, the composition of composition is by weight percentage：Potassium hydrogen persulfate 50%, APG powder 5%, agglomeration resistance
Agent 8.86%, sodium chloride wrappage 3% (comes from embodiment 2), solid acid agent 23%, metal-chelator 10%, flavouring agent
0.06%, pigment 0.08%.
This six kinds of disinfectant (including 3 kinds of disinfection tablets and 3 kinds of disinfectant powders) is configured to 0.25% aqueous solution with water respectively,
Using 2002 editions《Disinfection technology standard》Method is to staphylococcus aureus ATCC 6538, Escherichia coli 8099, Candida albicans
ATCC10231 carries out the sterilization test of different time (5min, 10min, 15min), calculates and kills logarithm value, the results are shown in Table 3.
Killing logarithm value of the disinfectant of table 3 to different strain
From table 3 it can be seen that the compound potassium hydrogen persulfate disinfection tablet that with the addition of APG, which is significantly better than, is not added with alkyl
The compound potassium hydrogen persulfate disinfection tablet of glucosides, with the addition of the compound potassium hydrogen persulfate disinfectant powder of APG significantly better than being not added with
The compound potassium hydrogen persulfate disinfectant powder of APG；This explanation, APG has obvious collaboration in disinfectant to sterilization
Sterilized synergistic effect；Further, in the APG concentration range of the present invention, synergic remove is with APG concentration
Increasing and strengthen.
The above, is only the preferably specific embodiment of the present invention, but protection scope of the present invention is not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Design is subject to equivalent or change, should all cover within the scope of the present invention.
Claims (10)
1. a kind of compound potassium hydrogen persulfate disinfectant, it is characterised in that the disinfectant mainly includes following percentage by weight group
Point：Potassium hydrogen persulfate 20~65%, sodium chloride wrappage 1~10%, acidizer 5~30%, effervescent agent 0~15%, alkyl sugar
Glycosides 1~10%, lubricant 0~5%, metal-chelator 1~20%, anti-caking agent 1~20%.
2. a kind of compound potassium hydrogen persulfate disinfectant according to claim 1, it is characterised in that the sodium chloride wrappage
Mainly it is made up of sodium chloride and film forming agent, the film forming agent is sodium alginate.
3. a kind of compound potassium hydrogen persulfate disinfectant according to claim 1, it is characterised in that the sodium chloride wrappage
In sodium chloride be 100 μm~1200 μm of particle diameter sodium chloride.
4. according to any described a kind of compound potassium hydrogen persulfate disinfectant in claims 1 to 3, it is characterised in that the chlorine
The percentage by weight for changing sodium wrappage is 3~7%, more preferably 3~5%.
5. according to any described a kind of compound potassium hydrogen persulfate disinfectant in Claims 1-4, it is characterised in that the alkane
The percentage by weight of base glucosides is 3~7%, more preferably 3~5%.
6. according to any described a kind of compound potassium hydrogen persulfate disinfectant in claim 1 to 5, it is characterised in that the acid
Property agent be solid acid agent, selected from including sulfamic acid, citric acid, tartaric acid, malic acid, oxalic acid, citric acid, salicylic acid, sulphur
One or more in sour hydrogen sodium, potassium acid sulfate；And/or, the effervescent agent in including natrium carbonicum calcinatum, sodium bicarbonate one
Plant or a variety of；And/or, one or more of the lubricant in including talcum powder, magnesium stearate, gas-phase silicon, more preferably
Gas-phase silicon；And/or, the chelating agent, which is selected from, includes sodium tripolyphosphate, sodium polyphosphate, calgon, sodium pyrophosphate, second two
One or more in amine tetraacethyl and its sodium salt；And/or, the anti-caking agent, which is selected from, includes anhydrous magnesium carbonate, anhydrous slufuric acid
The one or more of magnesium and anhydrous magnesium chloride.
7. according to any described a kind of compound potassium hydrogen persulfate disinfectant in claim 1 to 6, it is characterised in that described to disappear
Toxic agent also includes the flavouring agent of 0.01~0.2% percentage by weight；And/or, the disinfectant also includes 0.01~0.3% weight
The pigment of percentage.
8. a kind of compound potassium hydrogen persulfate disinfectant according to claim 7, it is characterised in that the flavouring agent is selected from bag
Include the one or more in vanillic aldehyde, Long Yanxiang；And/or, the pigment is in including amaranth, famille rose, beet red
It is one or more.
9. according to any described a kind of compound potassium hydrogen persulfate disinfectant in claim 1 to 8, it is characterised in that the chlorine
The preparation for changing sodium wrappage is obtained by the method comprised the following steps：Film forming agent and water are obtained by mixing film forming solution, its
In, the mass ratio of the film forming agent and water is 0.001:1~0.1:1；Film forming solution is used to chlorination by fluidized bed coating again
Sodium is wrapped up, wherein, the mass ratio of the film forming solution and sodium chloride is 0.2:1~10:1.
10. a kind of method for preparing the compound potassium hydrogen persulfate disinfectant according to claim 1-9, it is characterised in that will
Obtained after the component mixing or alternatively further compressing tablet is obtained.
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| CN108184828A (en) * | 2017-12-29 | 2018-06-22 | 佛山市南海东方澳龙制药有限公司 | A kind of potassium hydrogen persulfate composite powder for preventing caking and its preparation method and application |
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| CN109156474A (en) * | 2018-08-06 | 2019-01-08 | 山东华实药业有限公司 | A kind of potassium hydrogen persulfate disinfection tablet |
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| CN111280180A (en) * | 2020-02-17 | 2020-06-16 | 四川水王子环境科技有限公司 | Potassium hydrogen peroxymonosulfate composite salt disinfection powder and preparation method thereof |
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| CN111956604A (en) * | 2020-07-10 | 2020-11-20 | 福建孚兴药业有限公司 | Preparation method of balancing liquid |
| CN112450227A (en) * | 2020-12-02 | 2021-03-09 | 岳阳才益精细化工有限公司 | Preparation method of potassium hydrogen persulfate composite salt effervescent tablets |
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| CN114057280A (en) * | 2021-11-23 | 2022-02-18 | 重庆誉康欣生物技术有限公司 | Formula and production process of potassium hydrogen persulfate tablet |
| CN114106936A (en) * | 2021-12-10 | 2022-03-01 | 广东腾骏药业股份有限公司 | Foaming type cleaning agent with disinfection function for farm |
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| CN111903674A (en) * | 2020-08-05 | 2020-11-10 | 马保臣 | Potassium hydrogen persulfate composite powder with uniform and stable quality and preparation process thereof |
| CN111903674B (en) * | 2020-08-05 | 2022-07-12 | 马保臣 | Potassium hydrogen persulfate composite powder with uniform and stable quality and preparation process thereof |
| CN112450227A (en) * | 2020-12-02 | 2021-03-09 | 岳阳才益精细化工有限公司 | Preparation method of potassium hydrogen persulfate composite salt effervescent tablets |
| CN112931528A (en) * | 2021-01-28 | 2021-06-11 | 清远海贝生物技术有限公司 | Safe disinfectant special for raw fish overwintering culture water body and application thereof |
| CN112741110A (en) * | 2021-02-23 | 2021-05-04 | 湖南广安动物保健品有限公司 | Green disinfectant capable of disinfecting by belt |
| CN113287627A (en) * | 2021-05-25 | 2021-08-24 | 中山市迈微环保科技有限公司 | Cleaning disinfectant containing potassium hydrogen persulfate compound, and use method and application thereof |
| CN113287627B (en) * | 2021-05-25 | 2021-12-17 | 中山市迈微环保科技有限公司 | Cleaning disinfectant containing potassium hydrogen persulfate compound, and use method and application thereof |
| CN114057280A (en) * | 2021-11-23 | 2022-02-18 | 重庆誉康欣生物技术有限公司 | Formula and production process of potassium hydrogen persulfate tablet |
| CN114106936A (en) * | 2021-12-10 | 2022-03-01 | 广东腾骏药业股份有限公司 | Foaming type cleaning agent with disinfection function for farm |
| CN114766507A (en) * | 2022-05-12 | 2022-07-22 | 镇江威特药业有限责任公司 | High-efficiency potassium hydrogen persulfate effervescent tablet |
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