CN106924693A - It is a kind of to treat pharmaceutical composition of avian nephropathogenic infectious bronchitis and preparation method thereof - Google Patents
It is a kind of to treat pharmaceutical composition of avian nephropathogenic infectious bronchitis and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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Abstract
Pharmaceutical composition of avian nephropathogenic infectious bronchitis and preparation method thereof is treated the invention discloses a kind of, belongs to traditional Chinese medicine for livestock composition.The pharmaceutical composition of the treatment avian nephropathogenic infectious bronchitis, is made up of following drug ingedient and parts by weight：13 parts of monkshood, 12 parts of rhizoma zingiberis, 13 parts of Radix Codonopsis, 13 parts of the Radix Astragali, 13 parts of Psoralea corylifolia, 14 parts of Radix Glycyrrhizae.Drug ingedient is Chinese medicine preparation employed in the present invention, without any medicament residue after use and determined curative effect, quick, the problems such as efficiently solve poor therapeutic effect present in prior art, medicament residue.
Description
Technical field
The present invention relates to a kind of traditional Chinese medicine for livestock composition, more particularly to a kind of medicine for treating avian nephropathogenic infectious bronchitis
Compositions and preparation method thereof.
Background technology
Avian nephropathogenic infectious bronchitis are caused by the kidney of the thermophilic kidney poison pearl infringement chicken of infectious bronchitis of chicken, with
Serious passage of loose stools and it is mixed with substantial amounts of lithate, serious dehydration, internal organ especially kidney and the obvious gout of joint manifestations is
A kind of acute, high degree in contact the infectious disease of feature.Vaccine inoculation is relied primarily on for the prevention of the disease at present, due to infecting
Property bronchitis virus have many serotypes, therefore cause the epidemic prevention effect of vaccine poor.
However, also be there are problems that at present for the treatment of this disease many：One is the antiviral chemical drug of people to this disease
Therapeutic effect it is very poor；Two is that the Ministry of Agriculture has forbidden for people to be used for veterinary clinic with antiviral chemical drug；Three are used exclusively for beast
Cure clinical antiviral chemical drug and also belong to blank；Four is that the theory of Chinese veterinarian's diagnosis and treatment sick to this is still far from perfect.Simultaneously
The chick of 20 ages in days or so is mainly encroached on due to this disease, Laying chicks occur this and not only result in large quantities of death after being ill, can also invade
The reproductive system of evil Laying chicks and influence the development of fallopian tubal to cause laying hen to forming the false hen do not laid eggs after the age in days for opening product；
There is this after being ill in broiler chicks, due to that without good treatment method, can cause large quantities of death, directly affect culture benefit.Therefore,
Preferable drug therapy avian nephropathogenic infectious bronchitis are needed at this stage.
The content of the invention
The shortcoming of prior art, avian nephropathogenic infectious branch is treated it is an object of the invention to provide one kind in view of the above
Pharmaceutical composition of tracheitis and preparation method thereof, overcomes many disadvantages present in prior art.
The clinical symptoms of avian nephropathogenic infectious bronchitis, the dialectical, interpretation of the cause, onset and process of an illness rules for the treatment of are as follows：
Main clinic symptoms：The diseased chicken for suffering from kidney type infective bronchitis mainly has slight respiratory symptom, and diseased chicken is gathered around
It is extruded into heap, cold clearly two legs are sent out cool, substantial amounts of lithate is mixed with passage of loose stools and loose stools, drink is intended to increase, and drink is not understood
Yearningly, it is dehydrated.
It is dialectical：Few cold sensation of the genitalia disease of the insufficiency of the kidney yang (kidney-yang deficiency) should be belonged to according to the above-mentioned main clinic symptoms diseases.
The interpretation of the cause, onset and process of an illness：It is then cold (cold) that the insufficiency of the kidney yang will show the cold of insufficiency type, i.e. kidney deficiency, therefore diseased chicken squeezes heap, cold.The insufficiency of the kidney yang, meeting
Cause the gasification function of kidney not normal, the gasification function of kidney is not normal, make body fluid (aqueous) can not on hold in the part of the body cavity above the diaphragm housing the heart and lungs, moisture can not on hold
In the part of the body cavity above the diaphragm housing the heart and lungs, oral cavity is cannot get moistening for moisture, so chicken feels thirsty, it is thirsty will great quantity of water drinking.The gasification of kidney simultaneously
Malfunction, it is impossible to make to be held on body fluid in the part of the body cavity above the diaphragm housing the heart and lungs, it is impossible to above hold in the part of the body cavity above the diaphragm housing the heart and lungs, body fluid will directly go down Jiao, because chicken does not have bladder,
Rectum will be discharged to, be excreted with excrement, so clinical manifestation draining sample loose stools, body dehydration.Body fluid can not on hold
In the part of the body cavity above the diaphragm housing the heart and lungs, the water of intake can not be utilized for body and (be held on body fluid in upper defocused, broken out by a surname of the lungs positioned at part of the body cavity above the diaphragm housing the heart and lungs position
Whole body is spread to for body utilization with by body fluid), therefore chicken drink does not quench one's thirst.The insufficiency of the kidney yang, it is impossible to warm spleen sun, makes the transporting work(of spleen
Can be not normal, and cause body to produce substantial amounts of lithate, therefore substantial amounts of lithate will be contained in excrement, while lithate can also
Being deposited on internal organs especially will form gout after kidney and articular cavity.
The rules for the treatment of：Anxious kidney-replenishing, recuperating depleted yang, QI invigorating antidiarrheal.
Under the pathogenesis and principle of reatment of Chinese veterinarian's theory, in order to realize the purpose of the present invention or other purposes,
It is achieved through the following technical solutions：
A kind of pharmaceutical composition for treating avian nephropathogenic infectious bronchitis, by following drug ingedient and weight portion array
Into：Monkshood 1-3 parts, rhizoma zingiberis 1-2 parts, Radix Codonopsis 1-3 parts, Radix Astragali 1-3 parts, Psoralea corylifolia 1-3 parts, Radix Glycyrrhizae 1-4 parts.
The drug action of wherein each drug ingedient is：
Monkshood：It is the product of the big heat of great Xin, anxious kidney-replenishing, recuperating depleted yang.
Rhizoma zingiberis：It is the product of the big heat of great Xin, warming spleen and stomach for dispelling cold, warming and invigorating kidney Yang and spleen sun.
Radix Codonopsis：Tonifying middle-Jiao and Qi.Body tempestuously watery diarrhea, can not only lose substantial amounts of cloudy liquid, while can also lose big
The yang-energy of amount, because Chinese veterinarian thinks, interdependence between yin and yang, yin deficiency affecting yang, the deficiency of yang affecting yin, therefore treatment needs tonifying middle-Jiao and Qi.
The Radix Astragali：Tonifying Qi and lifting yang, tonifying Qi and lifting yang is advantageous for treating the diarrhea that causes of the cold of insufficiency type, because the deficiency of yang is the deficiency of vital energy enters one
Step development, therefore the deficiency of yang necessarily has a performance of the deficiency of vital energy, it is more empty that diarrhea may result in gas, the deficiency of vital energy will gas do not take the photograph the moon, gas does not take the photograph the moon, just
Diarrhoea can be aggravated, therefore tonifying Qi and lifting yang is conducive to treating the diarrhea that the cold of insufficiency type causes.
Psoralea corylifolia：Warming kidney and enhancing body, it is warming spleen and stopping diarrha.The insufficiency of the kidney yang may result in spleen sun deficiency, i.e. fire and not warm up soil (spleen pertaining to the earth),
Because spleen sun need to be continuously available the warm effect competence exertion function that The spleen has the function to transport and transform nutrients of kidney yang, spleen sun deficiency may result in body
Transportation capabilities are not normal and diarrhea.
Radix Glycyrrhizae：Coordinating the drug actions of a prescription, while the toxicity of monkshood mesaconitine can be solved.
The drug ingedient meets《Chinese veterinary pharmacopoeia》The ministerial standard of version two in 2015.
Preferably, the pharmaceutical composition of avian nephropathogenic infectious bronchitis is treated, is made up of following medicine and parts by weight：
1.2 parts of monkshood, 1.1 parts of rhizoma zingiberis, 1 part of Radix Codonopsis, 1 part of the Radix Astragali, 1.5 parts of Psoralea corylifolia, 1.2 parts of Radix Glycyrrhizae.
Present invention also offers a kind of method for preparing aforementioned pharmaceutical compositions, concretely comprise the following steps：Weigh by weight
Each medicine, and each medicine is crushed, 80-200 mesh shaking screens are crossed, mix, you can.
Preferably, the shaking screen is 100 mesh.
Present invention also offers a kind of application of aforementioned pharmaceutical compositions in avian nephropathogenic infectious bronchitis are prevented and treated, should
Used time directly admixes pharmaceutical composition in chicken feed, mixes, and the weight of wherein pharmaceutical composition accounts for feed relative
0.5%.
Pharmaceutical composition prepared by the present invention belongs to traditional Chinese powder medicine, because the aquaculture model of current chicken is mostly scale
Change, and kidney type infective bronchitis have very strong infectiousness, so using the dispensing side of mass prevention and mass treatment during medication
Formula, during pharmaceutical composition of the invention directly mixes feed, or will drink pharmaceutical composition is soluble in water to chicken group.Use
When, pharmaceutical composition by weight percentage 0.5% is mixed in admixing feed, medication 1-2 times in a day；The general 3rd during medication
It is just clearly better, 4-5 days can rehabilitation, drug withdrawal by rehabilitation.Therefore medication cycle is 4-5 days.
In summary, the present invention is prepared for a kind of pharmaceutical composition for treating avian nephropathogenic infectious bronchitis, and it is used
Composition is Chinese medicine preparation, without any medicament residue after use and determined curative effect, quick, efficiently solves in the prior art
The therapeutic effect of presence is poor, medicament residue the problems such as.
Specific embodiment
Embodiments of the present invention are illustrated below by way of particular specific embodiment, those skilled in the art can be by this explanation
Content disclosed by book understands other advantages of the invention and effect easily.The present invention can also be by different specific in addition
Implementation method is embodied or practiced, and the various details in this specification can also be based on different viewpoints and application, without the back of the body
Various modifications or alterations are carried out under spirit of the invention.It should be noted that, in the case where not conflicting, following examples and reality
Applying the feature in example can be mutually combined.
Embodiment 1
A kind of Chinese medicine composition for preventing and treating avian nephropathogenic infectious bronchitis, is made up of, monkshood agents and weight portion
30g, rhizoma zingiberis 20g, Radix Codonopsis 25g, Radix Astragali 25g, Psoralea corylifolia 30g, Radix Glycyrrhizae 30g.
Preparation method is：Each drug ingedient is weighed by weight, and each medicine is crushed, cross 80-200 mesh shaking screens,
Mix, you can obtain, according to every part of 10g, be divided into many parts it is standby.
Embodiment 2
A kind of Chinese medicine composition for preventing and treating avian nephropathogenic infectious bronchitis, is made up of, monkshood agents and weight portion
12g, rhizoma zingiberis 11g, Radix Codonopsis 10g, Radix Astragali 10g, Psoralea corylifolia 15g, Radix Glycyrrhizae 12g.
Preparation method is：Each drug ingedient is weighed by weight, and each medicine is crushed, cross 80-200 mesh shaking screens,
Mix, you can obtain, according to every part of 10g, be divided into many parts it is standby.
Embodiment 3
A kind of Chinese medicine composition for preventing and treating avian nephropathogenic infectious bronchitis, is made up of, monkshood agents and weight portion
10g, rhizoma zingiberis 10g, Radix Codonopsis 30g, Radix Astragali 30g, Psoralea corylifolia 10g, Radix Glycyrrhizae 40g.
Preparation method is：Each drug ingedient is weighed by weight, and each medicine is crushed, cross 80-200 mesh shaking screens,
Mix, you can obtain, according to every part of 10g, be divided into many parts it is standby.
Embodiment 4
A kind of Chinese medicine composition for preventing and treating avian nephropathogenic infectious bronchitis, is made up of, monkshood agents and weight portion
20g, rhizoma zingiberis 15g, Radix Codonopsis 15g, Radix Astragali 15g, Psoralea corylifolia 20g, Radix Glycyrrhizae 10g.
Preparation method is：Each drug ingedient is weighed by weight, and each medicine is crushed, cross 80-200 mesh shaking screens,
Mix, you can obtain, counted according to every part of 10g, be divided into many parts it is standby.
Comparative example 1
Monkshood 60g, rhizoma zingiberis 40g, Radix Glycyrrhizae 30g are taken, is soaked 1 hour after adding suitable quantity of water, decocted 2 times, the 1st decoction 1 is small
When, the 2nd decoction 20 minutes merges decoction liquor twice, obtains medicament, and mixing in appropriate drinking-water is added to when using.
Comparative example 2
Take rhizoma zingiberis 20g, Radix Codonopsis 25g, Radix Astragali 25g, Psoralea corylifolia 30g, Radix Glycyrrhizae 30g.Said components are crushed, 100 mesh is crossed and is shaken
Sieve is swung, the ratio after mixing in 0.5% is added in feed.
Comparative example 3
Take monkshood 30g, Radix Codonopsis 25g, Radix Astragali 25g, Psoralea corylifolia 30g, Radix Glycyrrhizae 30g.Said components are crushed, 100 mesh is crossed and is shaken
Sieve is swung, the ratio after mixing in 0.5% is added in feed.
Clinical test
Experimental example 1
In March, 2016, Dezhou City Shandong Province Ling County Zheng Jiazhai raisers raise big meat chicken 23000, raise to 21
During age in days, there are kidney type infective bronchitis.Three groups are divided into by 23000 chickens, first group uses medicine described in comparative example 1
Thing preparation for treating, second group of pharmaceutical composition using embodiment 2 is treated, the 3rd group of drug regimen using comparative example 3
Thing is treated, and carries out contrast test.
Result shows, is just taken a favorable turn after 5 days using the chicken group medication of the formula treatment of comparative example 1, just complete after medication 7 days
Rehabilitation, general mortality rate is 8.5%；And with just obvious good after the chicken group medication 3 days of the formula treatment of embodiment 2 and embodiment 3
Turn, chicken group returns to one's perfect health after medication 5 days, and general mortality rate is respectively 1.8%.
Experimental example 2
In December, 2015, Shandong Province Ling County Qian Sun towns raiser raises big meat chicken 20000, raises to 26 ages in days
When, there are kidney type infective bronchitis.Two groups are divided into by 20000 chickens, one group is controlled using formula described in comparative example 2
Treat, another group of prescription drug using embodiment 1 is treated, and carries out contrast test.
Result shows, is just taken a favorable turn after 7 days using the chicken group medication of the formula treatment of comparative example 2, the genius rehabilitation of medication 9,
General mortality rate is 11.2%；And chicken group after chicken group just obvious improvement after the chicken group's medication 3 days treated with embodiment 1, medication 5 days
Return to one's perfect health, general mortality rate is 2.1%.
Experimental example 3
In October, 2015, Shandong Province Ling County Bian Linzhen raisers raise big meat chicken 8000, raise during to 14 age in days,
Generation kidney type infective bronchitis.Two groups are divided into by 8000 chickens, one group is carried out using prescription drug described in comparative example 1
Treatment, another group of pharmaceutical composition for adopting embodiment 3 is treated, and carries out contrast test.
Result shows, is just taken a favorable turn after 6 days with the chicken group medication of the formula treatment of comparative example 3, the genius rehabilitation of medication 9, always
The death rate is 9.3%；And chicken group is complete after chicken group just obvious improvement after the chicken group's medication 3 days treated with embodiment 1, medication 5 days
Full rehabilitation, general mortality rate is 1.6%.
Experimental example 4
Medicine of the present invention is mixed in feed in 0.5% ratio, poultry free choice feeding is allowed.Inhaled by stomach and intestine after oral
Receipts reach the purpose for the treatment of disease.
In January, 2016, Shandong Province Ling County plant is raised during to 3 week old, chicken in certain big meat chicken 12000 of raising
There is slight respiratory symptom in group, does not cause raiser to note, after having spent the time of 1 week, the unexpected aggravation of chicken group, performance spirit
Depressed, necking down of hanging one's head, feather is fluffy and disorderly, and the white lithate loose stools of row, drink is intended to increase, and drink does not quench one's thirst, and cold, chicken feet is shrivelled.Day is dead
Die more than 200.Avian nephropathogenic infectious bronchitis are diagnosed as according to clinical symptoms and pathological change.Although being employed after morbidity many
Kind of remedy measures are still without controlling the state of an illness.
Residue survival chicken group is divided into four groups, embodiment 1, comparative example 1, comparative example 2, the medicine of comparative example 3 are given respectively
Compositions are treated, and are observed and the death rate after recording medicine, and record experimental result, and corresponding Mortality data sees below
Table：
To sum up, it is of the invention treatment avian nephropathogenic infectious bronchitis pharmaceutical composition can rapid, effective treatment chicken group
Kidney type infective bronchitis, reduce the death rate of chicken.Compared with other drugs, medicine composite for curing chicken group's of the invention
During kidney type infective bronchitis, the death rate is low, and administration time is short, it is seen that pharmaceutical composition determined curative effect of the invention.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
The personage for knowing this technology all can carry out modifications and changes under without prejudice to spirit and scope of the invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete with institute under technological thought without departing from disclosed spirit such as
Into all equivalent modifications or change, should be covered by claim of the invention.
Claims (5)
1. a kind of pharmaceutical composition for treating avian nephropathogenic infectious bronchitis, it is characterised in that by following drug ingedient and weight
Amount number composition：Monkshood 1-3 parts, rhizoma zingiberis 1-2 parts, Radix Codonopsis 1-3 parts, Radix Astragali 1-3 parts, Psoralea corylifolia 1-3 parts, Radix Glycyrrhizae 1-4 parts.
2. pharmaceutical composition as claimed in claim 1, it is characterised in that be made up of following drug ingedient and parts by weight：It is attached
1.2 parts of son, 1.1 parts of rhizoma zingiberis, 1 part of Radix Codonopsis, 1 part of the Radix Astragali, 1.5 parts of Psoralea corylifolia, 1.2 parts of Radix Glycyrrhizae.
3. the method for preparing claim 1-2 any one described pharmaceutical compositions, it is characterised in that concretely comprise the following steps：By weight
Number weighs each drug ingedient, and each medicine is crushed, and crosses 80-200 mesh shaking screens, mixes, you can obtain.
4. method as claimed in claim 3, it is characterised in that the shaking screen is 100 mesh.
5. application of any one of the claim 1-2 described pharmaceutical composition in avian nephropathogenic infectious bronchitis are prevented and treated, it is special
Levy and be, using when pharmaceutical composition directly admixed chicken feed, mix, the weight of wherein pharmaceutical composition accounts for feed
The 0.5% of weight.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115154561A (en) * | 2022-07-28 | 2022-10-11 | 郑佰有 | Traditional Chinese medicine composition for preventing chicken from having no peak egg laying after suffering from nephropathogenic infectious bronchitis before onset of parturition and preparation method thereof |
-
2017
- 2017-02-23 CN CN201710098910.1A patent/CN106924693A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 袁春红等: ""鸡肾型传染性支气管炎的辨证论治"", 《中兽医学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115154561A (en) * | 2022-07-28 | 2022-10-11 | 郑佰有 | Traditional Chinese medicine composition for preventing chicken from having no peak egg laying after suffering from nephropathogenic infectious bronchitis before onset of parturition and preparation method thereof |
| CN115154561B (en) * | 2022-07-28 | 2023-10-20 | 郑佰有 | Traditional Chinese medicine composition for preventing chicken from suffering from kidney-type infectious bronchitis before parturition and having no peak in egg production and preparation method thereof |
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