CN106727245B - A kind of heat-clearing moisturizing lip-stick and preparation method thereof - Google Patents
A kind of heat-clearing moisturizing lip-stick and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
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Abstract
The invention discloses a kind of heat-clearing moisturizing lip-stick and preparation method thereof, the lip-stick includes the raw material components of following parts by weight: 30~50 parts of Semen Coicis, 10~30 parts of lily, 5~15 parts of Poria cocos, 5~10 parts of green cucumber, 30~50 parts of coconut oil, 5~10 parts of honey.The sufficiently effective effective component extracting of preparation method has effects that clearing heat and detoxicating, cooling and activating blood, profit lip, and edible, acts on human body object side effect, be commonly used, can prevent the chronic disease repeatedly such as bleb, the effect of bright lip so that many raw material components share.
Description
Technical field
The present invention relates to lipstick technical fields more particularly to a kind of heat-clearing moisturizing lip-stick and preparation method thereof.
Background technique
In dry season, due to the reason of air pollution and environment, human body lip tendency is more drier and drier, is easy to cause
Various lips diseases, such as lip decortication, are a lack of vitamin；Lip color is excessively red, and possible " excessive internal heat ", red represents in Chinese medicine
Heat symptom-complex hoards excessive heat in vivo, careful to get angry；Lip blistering, it may be possible to which herpes labialis is grown in lip or surrounding small water
Bubble, infectiousness is high, and the multiple resistances downward period such as with flu, fever and can be propagated, although herpes labialis is within these few days
Can disappear, but flavour it is very bad by；It is that the raw materials such as pigment, preservative are added mostly in existing moisturizing lip-stick, especially exists
When using raw material containing unsaturated compounds such as aldehyde, ketone, allergy is easily caused, Yi Yinqi skin allergy and stimulation, lip can not
Effective moisturizing moisture evaporation is accelerated, and becomes water shortage, dry and cracked, obscure and growth line trace, and when using lipstick, just inevitably
Enter in the stomach of people, accumulate over a long period, also can body to people according at certain injury.Therefore the shield of natural herb is needed to have
Lipstick solves problem above, so that the treatment of lip is significantly imitated in the case where not adding preservative, colour component
Fruit.
Summary of the invention
In view of this, the present invention provides a kind of heat-clearing moisturizing lip-stick, solves lip-stick and be unable to fire under heat-clearing, moist
The problem of moisturizing.
The technological means that the present invention uses is as follows: a kind of heat-clearing moisturizing lip-stick, the raw material components including following parts by weight:
30~50 parts of Semen Coicis, 10~30 parts of lily, 5~15 parts of Poria cocos, 5~10 parts of green cucumber, 30~50 parts of coconut oil, 5~10 parts of honey.
Preferably, including following weight part ratio component: 40 parts of Semen Coicis, 22 parts of lily, 10 parts of Poria cocos, 7 parts of green cucumber, coconut oil
35 parts, 5 parts of honey.
The invention also includes a kind of preparation methods of heat-clearing moisturizing lip-stick, comprising the following steps:
The preparation of (1) first concentrate: by Semen Coicis, lily and Poria cocos 1~2h of raw material soaking, crushing is dried, use is dense
Degree is extracted for 50%~70% ethanol water, is obtained leaching liquor, is evaporated solvent to leaching liquor, 0.08~
Concentration is heated under the conditions of 0.1Mpa；
The preparation of (2) second concentrates: green cucumber raw material is added into water crushing and beating, obtains slurry；Pectase is added, adjusts pH
Value, 1~2h of heat preservation is carried out in water-bath, is centrifuged after enzyme deactivation, supernatant liquor is taken to be concentrated；
(3) preparation of coconut oil: the coconut meat of drying is crushed, and is put into cold pressing expeller after progress cold pressing, into
Row supercritical CO2Extraction, obtains coconut oil.
(4) the first concentrate and the second concentrate are mixed evenly, obtain mixed liquor, adjust pH value, then by coconut oil
Divide equally in 2~3 portions of involvement mixed liquors with honey, stirs evenly, obtain lotion；
(5) sterilization cooling: cooling down after lotion is sterilized, and after sterilization temperature is 100~120 DEG C, is cooled to 50~70
℃；
(6) form, demoulding.
Preferably, extraction temperature is 60~80 DEG C in the step (1), and extraction time is 2~3h, and extracting times are 2~3
It is secondary.
Preferably, it is concentrated in the step (2) with Rotary Evaporators, obtains the second concentrate.
Preferably, after pectase being added in the step (2), enzymolysis processing is carried out, 40 DEG C~55 DEG C of hydrolysis temperature, is digested
Time 1h~2h.
Preferably, the weight ratio of slurry and pectase is 3:1~5:1 in the step (2).
Preferably, it is 3~5 that pH value is adjusted in the step (2)
Preferably, cold pressing temperature is 40~60 DEG C in the step (3).
Preferably, pH value is 4.5~7 in the step (4).
Using a kind of heat-clearing moisturizing lip-stick provided by the present invention, have the advantage that the lip-stick mainly nourishes mouth
Lip, it is fiery under heat-clearing, prevent various lips diseases, and there is edibility, property nontoxic to the human body.Wherein Semen Coicis is because containing there are many dimensions
Raw element and minerals, boost metabolism, and vitamin E, the vitamin B contained in Semen Coicis can improve lip color, tool
There is effect fiery under moisturizing；Coconut oil is obtained and naturally squeezing, and has ensured the effect without side effect, and with other raw material components
Melting is significant.The preparation method passes through the abundant extraction of the first concentrate and the second concentrate, effective component is extracted, group
Divide collocation rationally, it is curative for effect, it acts on and stablizing persistently.
Semen Coicis pharmacological action: Semen Coicis is sweet in flavor, light, cold nature, returns spleen, stomach, lung channel；There are invigorating spleen for diuresis, dampness removing eliminating impediment, heat-clearing
The effect of apocenosis, eliminating dampness and heat；It can be used for treating the diseases such as oedema, tinea pedis, acute appendicitis.Semen Coicis is because containing multivitamin and mineral
Matter boosts metabolism and reduces stomach and intestine burden；It is also effective to diseases such as chronic enteritis, indigestions；Semen Coicis energy
Enhance renal function, and has reducing fever and causing diuresis effect；Semen Coicis plays the role of anti-cancer, can effectively inhibit the proliferation of cancer cell；It can be with skin
Gloss is fine and smooth, eliminates acne, color spot, improves the colour of skin, and it has wart as caused by virus infection etc. certain treatment
Effect.
Lily pharmacological action: moistening lung to arrest cough, lily fresh goods contain lymphatic temperament, have moistening for dryness and clearing away heat effect, in medical treatment
The diseases such as the dryness of the lung or cough with lung heat can often be proved effective.Antitoxic heart-soothing and sedative, lily enter the heart channel of Hang-Shaoyin, cold nature, energy relieving restlessness and restlessness, antitoxic heart-soothing and sedative, use
After pyreticosis waste heat do not disappear, be lost in a reverie, insomnia and dreamful sleep, feeling depressed, the illnesss such as susceptible to sorrow and being about to weep.Beautifying face and moistering lotion, lily are clean
Bai Jiaoyan, fresh goods is rich in lymphatic temperament and vitamin, beneficial to skin cell metabolism, often eats lily, there is certain beautification function.
Cancer-resisting, lily contain a variety of alkaloids, have prevention effect, energy hemocytes increasing, to chemotherapy and radiation to leukopenia
Property treatment after cytopenia have therapeutic effect.Lily can also promote and enhance in vivo monocyte system and phagocytic function,
The humoral immunity ability of body is improved, therefore lily has preferable preventing iron-smelting effect to kinds cancer, this product sweet and cool-natured is clear and rich, and master enters
The lung heart, is longer than clearing away the lungheat and moisturizing cough-relieving, and clearing away the heart fire and tranquillizing arresting convulsion is uneasy common by xeropulmonary cough, dysphoria.
Poria cocos pharmacological action: nature and flavor, it is mild-natured, it is sweet in flavor, light.Clearing damp and promoting diuresis, invigorating the spleen calming heart.To staphylococcus aureus, greatly
Enterobacteria, proteus etc. have inhibiting effect, and Poria cocos has direct relexation to family's rabbits infestines, to rat pylorus ligation
Being formed by ulcer has preventive effect, and can drop gastric acid.Separately there is significant protective effect to Liver Damage in Rats caused by CCl4, makes paddy
Pyruvic transaminase activity is substantially reduced, and prevents necrosis of liver cells.
Green cucumber pharmacological action: cucumber is sweet in flavor, cool in nature, bitter, nontoxic, enters spleen, stomach, large intestine channel；Clearing away heat and promoting diuresis, removing toxicity for detumescence,
It promotes the production of body fluid to quench thirst.Cure mainly the hot polydipsia of body, abscess of throat, wind-heat eye illness, jaundice with damp-heat pathogen, the illnesss such as difficult urination.It is antitumor: in cucumber
The cucurbitacin C contained has the function of raising immune function of human body, reaches antitumor purpose.Anti-aging: containing abundant in cucumber
Vitamin E, can play the role of promoting longevity, anti-aging；Cucumber chitinase in cucumber has very strong bioactivity, can be effective
The metabolism of ground promotion body.Juice is smash with cucumber and embrocates skin, there is moisturizing, unfolds wrinkle effect.Invigorating brain and relieving mental uneasiness: cucumber contains
Vitamin B1, to improving, brain and nervous system function is advantageous, energy tranquilizing the mind, auxiliary treatment of insomnia disease.
Coconut oil pharmacological action: driving away summer heat gas.Control scabies, pernio.Treat tooth disease, pernio.Put neurodermatitis on the skin.
Honey pharmacological action: honey is sweet in flavor, mild-natured, enters lung, spleen, large intestine channel；There is bowl spares to moisturize, relieves pain, the effect of removing toxic substances；
For physically weak, xeropulmonary cough, dry constipation of intestines, gastral cavity pain, nasosinusitis, aphtha, the burning hot wound of soup.The ingredient of blood can be improved, promoted
Heart and brain and vascular function；Honey has protective effect to liver；Honey can regain one's strength of body rapidly, eliminate fatigue, enhance to disease
Resistance；There are also the effects of sterilization for honey, often eat honey, not only without prejudice to tooth, moreover it is possible to sterilization is played in oral cavity
The effect of disinfection；Honey can treat the skin damage of moderate, especially scald, when honey is regarded skin wound dressing, bacterium
It can not grow；Honey can be with relax bowel and defecation (as long as the real honey of mature native has the effect of relax bowel and defecation).
Specific embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
Embodiment 1
A kind of heat-clearing moisturizing lip-stick, including raw material components below: Semen Coicis 30g, lily 10g, Poria cocos 5g, green cucumber 5g,
Coconut oil 30g, honey 5g.
A kind of preparation method of heat-clearing moisturizing lip-stick, comprising the following steps:
The preparation of (1) first concentrate: by Semen Coicis, lily and Poria cocos 1~2h of raw material soaking, crushing is dried, use is dense
Degree is extracted for 50% ethanol water, and extraction temperature is 60 DEG C, extraction time 2h, and extracting times are 2 times, must be extracted
Liquid is evaporated solvent to leaching liquor, and concentration is heated under the conditions of 0.08Mpa；
The preparation of (2) second concentrates: green cucumber raw material is added into water crushing and beating, obtains slurry；Pectase is added, adjusts pH value
3, enzymolysis processing is carried out, 40 DEG C of hydrolysis temperature, enzymolysis time 1h carries out heat preservation 1h in water-bath, is centrifuged after enzyme deactivation, takes upper layer
Clear liquid is concentrated with Rotary Evaporators；The weight ratio of slurry and pectase is 3:1.
(3) preparation of coconut oil: the coconut meat of drying is crushed, and is put into cold pressing expeller after progress cold pressing, low
Warm pressing temperature is 40 DEG C, carries out supercritical CO2Extraction, obtains coconut oil.
(4) the first concentrate and the second concentrate are mixed evenly, obtain mixed liquor, adjust pH value, pH value 4.5,
Coconut oil and honey are divided equally in 2 portions of involvement mixed liquors again, stirs evenly, obtains lotion；
(5) sterilization cooling: cooling down after lotion is sterilized, and after sterilization temperature is 100 DEG C, is cooled to 50 DEG C；
(6) form, demoulding.
Embodiment 2
A kind of heat-clearing moisturizing lip-stick, including raw material components below: Semen Coicis 50g, lily 30g, Poria cocos 15g, green cucumber
10g, coconut oil 50g, honey 10g.
A kind of preparation method of heat-clearing moisturizing lip-stick, comprising the following steps:
The preparation of (1) first concentrate: by Semen Coicis, lily and Poria cocos raw material soaking 2h, crushing is dried, is with concentration
70% ethanol water is extracted, and extraction temperature is 80 DEG C, extraction time 3h, and extracting times are 3 times, obtains leaching liquor,
Solvent is evaporated to leaching liquor, concentration is heated under the conditions of 0.1Mpa；
The preparation of (2) second concentrates: green cucumber raw material is added into water crushing and beating, obtains slurry；Pectase is added, adjusts pH value
5, enzymolysis processing is carried out, 55 DEG C of hydrolysis temperature, enzymolysis time 2h carries out heat preservation 2h in water-bath, is centrifuged after enzyme deactivation, takes upper layer
Clear liquid is concentrated with Rotary Evaporators；The weight ratio of slurry and pectase is 5:1.
(3) preparation of coconut oil: the coconut meat of drying is crushed, and is put into cold pressing expeller after progress cold pressing, low
Warm pressing temperature is 60 DEG C, carries out supercritical CO2Extraction, obtains coconut oil.
(4) the first concentrate and the second concentrate are mixed evenly, obtain mixed liquor, adjust pH value, pH value 7, then
Coconut oil and honey are divided equally in 3 portions of involvement mixed liquors, stirs evenly, obtains lotion；
(5) sterilization cooling: cooling down after lotion is sterilized, and after sterilization temperature is 120 DEG C, is cooled to 70 DEG C；
(6) form, demoulding.
Embodiment 3
A kind of heat-clearing moisturizing lip-stick, the raw material components including following parts by weight: Semen Coicis 35g, lily 20g, Poria cocos 10g,
Green cucumber 7g, coconut oil 40g, honey 6g.
A kind of preparation method of heat-clearing moisturizing lip-stick, comprising the following steps:
The preparation of (1) first concentrate: by Semen Coicis, lily and Poria cocos raw material soaking 2h, crushing is dried, is with concentration
60% ethanol water is extracted, and extraction temperature is 70 DEG C, extraction time 3h, and extracting times are 3 times, obtains leaching liquor,
Solvent is evaporated to leaching liquor, concentration is heated under the conditions of 0.09Mpa；
The preparation of (2) second concentrates: green cucumber raw material is added into water crushing and beating, obtains slurry；Pectase is added, adjusts pH
Value carries out enzymolysis processing, and 45 DEG C of hydrolysis temperature, enzymolysis time 2h carries out heat preservation 2h in water-bath, is centrifuged after enzyme deactivation, takes upper layer
Clear liquid is concentrated with Rotary Evaporators；The weight ratio of slurry and pectase is 4:1.
(3) preparation of coconut oil: the coconut meat of drying is crushed, and is put into cold pressing expeller after progress cold pressing, low
Warm pressing temperature is 50 DEG C, carries out supercritical CO2Extraction, obtains coconut oil.
(4) the first concentrate and the second concentrate are mixed evenly, obtain mixed liquor, adjust pH value, pH value 6, then
Coconut oil and honey are divided equally in 3 portions of involvement mixed liquors, stirs evenly, obtains lotion；
(5) sterilization cooling: cooling down after lotion is sterilized, and after sterilization temperature is 110 DEG C, is cooled to 60 DEG C；
(6) form, demoulding.
Embodiment 4
A kind of heat-clearing moisturizing lip-stick, the raw material components including following parts by weight: Semen Coicis 45g, lily 22g, Poria cocos 12g,
Green cucumber 8g, coconut oil 45g, honey 8g.
A kind of preparation method of heat-clearing moisturizing lip-stick, comprising the following steps:
The preparation of (1) first concentrate: by Semen Coicis, lily and Poria cocos raw material soaking 2h, crushing is dried, is with concentration
70% ethanol water is extracted, and extraction temperature is 70 DEG C, extraction time 3h, and extracting times are 2 times, obtains leaching liquor,
Solvent is evaporated to leaching liquor, concentration is heated under the conditions of 0.08Mpa；
The preparation of (2) second concentrates: green cucumber raw material is added into water crushing and beating, obtains slurry；Pectase is added, adjusts pH
Value carries out enzymolysis processing, and 50 DEG C of hydrolysis temperature, enzymolysis time 2h carries out heat preservation 1h in water-bath, is centrifuged after enzyme deactivation, takes upper layer
Clear liquid is concentrated with Rotary Evaporators；The weight ratio of slurry and pectase is 5:1.
(3) preparation of coconut oil: the coconut meat of drying is crushed, and is put into cold pressing expeller after progress cold pressing, low
Warm pressing temperature is 60 DEG C, carries out supercritical CO2Extraction, obtains coconut oil.
(4) the first concentrate and the second concentrate are mixed evenly, obtain mixed liquor, adjust pH value, pH value 6, then
Coconut oil and honey are divided equally in 3 portions of involvement mixed liquors, stirs evenly, obtains lotion；
(5) sterilization cooling: cooling down after lotion is sterilized, and after sterilization temperature is 120 DEG C, is cooled to 60 DEG C；
(6) form, demoulding.
Embodiment 5
A kind of heat-clearing moisturizing lip-stick, the raw material components including following parts by weight: 40 parts of Semen Coicis, 22 parts of lily, Poria cocos 10
Part, 7 parts of green cucumber, 35 parts of coconut oil, 5 parts of honey.
A kind of preparation method of heat-clearing moisturizing lip-stick, comprising the following steps:
The preparation of (1) first concentrate: by Semen Coicis, lily, Poria cocos and raw material soaking 2h, crushing is dried, uses concentration
It is extracted for 65% ethanol water, extraction temperature is 70 DEG C, extraction time 3h, and extracting times are 3 times, must be extracted
Liquid is evaporated solvent to leaching liquor, and concentration is heated under the conditions of 0.081Mpa；
The preparation of (2) second concentrates: green cucumber raw material is added into water crushing and beating, obtains slurry；Pectase is added, adjusts pH
Value carries out enzymolysis processing, and 55 DEG C of hydrolysis temperature, enzymolysis time 2h carries out heat preservation 2h in water-bath, is centrifuged after enzyme deactivation, takes upper layer
Clear liquid is concentrated with Rotary Evaporators；The weight ratio of slurry and pectase is 4:1.
(3) preparation of coconut oil: the coconut meat of drying is crushed, and is put into cold pressing expeller after progress cold pressing, low
Warm pressing temperature is 55 DEG C, carries out supercritical CO2Extraction, obtains coconut oil.
(4) the first concentrate and the second concentrate are mixed evenly, obtain mixed liquor, adjust pH value, pH value 6, then
Coconut oil and honey are divided equally in 3 portions of involvement mixed liquors, stirs evenly, obtains lotion；
(5) sterilization cooling: cooling down after lotion is sterilized, and after sterilization temperature is 110 DEG C, is cooled to 60 DEG C；
(6) form, demoulding.
In order to verify beneficial effects of the present invention, following experiment has been done:
One, 1, materials and methods
1.1 trial drugs: lotion prepared by melting embodiment 5.
1.2 experimental animals: experiment mice, 20~30g of weight are selected.
1.3 acute toxicity tests: it takes 50 mouse to be randomly divided into 2 groups, every group 25, test group: trial drug is melted
Melt drug gastric infusion, blank group is to provide normally ingest, drink water.Uniform intervals are administered 3 times in 1d, and dosage is containing total medicine
The case where measuring 30%, being administered 14 days, and observe mouse, survival condition, mouse poisoning symptom is put to death mouse, and is carried out after 14 days
Pathologic examination.
1.4 cumulative toxicity tests: taking 80 mouse to be randomly divided into 4 groups, and every group 20 is only raised, and embodiment 5 is melted
Drug be divided into small dose group (total content of dispersion 10%), middle dose group (total content of dispersion 40%), high dose group (total content of dispersion
70%) and blank group (normal water) carries out stomach-filling amount.Mouse ordinary circumstance is observed, after administration 1 month, mouse is extracted and carries out the heart
Dirty blood sampling checks physiochemical indice and blood biochemical analysis index.Important organ is taken after experiment, claims its weight in wet base, calculates internal organs system
Number.
2, result
2.1 acute toxicity tests:
| Group | Drug | Number of mice (only) | Death toll (only) | The death rate (%) |
| Test group | Melt lip-stick | 25 | 0 | 0 |
| Blank group | Water | 25 | 0 | 0 |
2.2 cumulative toxicity tests:
| Group | Drug | Number of mice (only) | Death toll (only) | The death rate (%) |
| Small dose group | Total content of dispersion 10% | 20 | 0 | 0 |
| Middle dose group | Total content of dispersion 40% | 20 | 0 | 0 |
| High dose group | Total content of dispersion 70% | 20 | 0 | 0 |
| Blank group | Water | 20 | 0 | 0 |
The organ coefficient of each mouse in cumulative toxicity test
3, it discusses
Mouse in acute toxicity test in test group and blank group is showed no death toll, shows that lip-stick of the present invention does not contain
Toxic ingredient does not injure human body.
Mouse in cumulative toxicity test in test combinations blank group also has no death toll, shows that lip-stick of the present invention does not contain
Toxic ingredient does not injure human body, and the organ coefficient index in each test group and blank group difference it is not significant (P >
0.05)。
Two, control group is set
Control group 1: the control group and the difference of embodiment 5 are, do not contain Semen Coicis.Preparation method and 5 phase of embodiment
Together.
Control group 2: the control group and the difference of embodiment 5 are, do not contain Semen Coicis, lily, coconut oil.Preparation method
It is same as Example 5.
Control group 3: the control group and the preparation method difference of embodiment 5 are, directly raw material components are concentrated: will
Semen Coicis, lily and Poria cocos raw material soaking 2h, are dried crushing, are extracted with the ethanol water that concentration is 65%, extract
Temperature is 70 DEG C, extraction time 3h, and extracting times are 3 times, obtains leaching liquor, is evaporated solvent to leaching liquor,
Concentration is heated under the conditions of 0.081Mpa.
Control group 4: the control group and the preparation method difference of embodiment 5 are, directly raw material components are concentrated: will
Semen Coicis, lily and Poria cocos raw material add water crushing and beating, obtain slurry；Pectase is added, adjusts pH value, carries out enzymolysis processing, enzymatic hydrolysis
55 DEG C of temperature, enzymolysis time 2h carries out heat preservation 2h in water-bath, is centrifuged after enzyme deactivation, and supernatant liquor is taken to be carried out with Rotary Evaporators
Concentration；The weight ratio of slurry and pectase is 4:1.
Performance of keeping humidity test experiments:
Using lip as test position when test, lip-stick is smeared, in 25 DEG C, the indoor environment of relative humidity 50%,
With moisture of skin measuring instrument to the moisture content for carrying out lip on female consumer lip of every group of 20 ages between 18~50 years old
Content measuring, result is indicated by the humidity measurements (H) set, to evaluate the replenishing water and preserving moisture performance of the product.
Wherein: the lip humidity H value before H1-smearing lip-stick, the lip humidity after H2-smearing lip-stick in 10 minutes
H value, lip humidity H3 value after H3-smearing lip-stick 1 hour.Make-up water percentage=H2/H1 × 100%, moisturizing rate=H3/H2 ×
100%.
It is as shown in table 1 below that its performance of keeping humidity tests table:
| Group | H1 | H2 | H3 | Make-up water percentage (%) | Moisturizing rate (%) |
| Embodiment 1 | 35.6 | 66.1 | 62.6 | 184 | 94.7 |
| Embodiment 2 | 35.6 | 66.6 | 63.4 | 183 | 95.2 |
| Embodiment 3 | 35.6 | 67.2 | 63.1 | 183 | 93.9 |
| Embodiment 4 | 35.6 | 66.8 | 63.3 | 185 | 94.8 |
| Embodiment 5 | 35.6 | 68.5 | 65.7 | 192 | 96.0 |
| Control group 1 | 35.6 | 60.5 | 45.8 | 170 | 75.7 |
| Control group 2 | 35.6 | 58.2 | 43.4 | 163 | 74.6 |
| Control group 3 | 35.6 | 62.3 | 50.6 | 175 | 81.2 |
| Control group 4 | 35.6 | 62.8 | 52.4 | 176 | 83.4 |
By 1 test data of table it is found that heat-clearing moisturizing lip-stick compared with the control group of the invention, the present invention have good
Moisturizing performance and performance of keeping humidity.Control group 1 is compared with Example 5 compared with Semen Coicis has multivitamin and minerals, the present invention
The vitamin in Semen Coicis is extracted by corresponding preparation method, kidney splenic function can be enhanced, is had centainly to edema
Curative effect, and lip color can be improved, it is the raw material of help；Arrange in pairs or groups lily, coconut oil raw material so that the lip-stick have it is good
Effect；Preparation method uses different extracting methods according to the heterogeneity selection of raw material, adequately extracts active principle
Out, so that lip-stick has the effect of heat-clearing moisturizing.
Fiery performance test experiment under heat-clearing:
Selection suffers from patient 20 of lip herpe simplex, and random point 2 groups, every group 10, experimental group is to smear embodiment 5
The lip-stick of production, control group smear certain commercially available brand lip-stick anti-drying with moisturizing, and experimental period is 3 days, experiment
As a result as shown in table 2 below:
As shown in Table 2, lip-stick of the present invention has significant curative effect achievement in treatment herpe simplex, selects compared with control group
Lip-stick it is significant in efficacy.
Support temperament energy test experiments:
Occur around lip too red, too deep, excessively light white or skin of lip chap of black circle, lip color etc. have with
The health status of spleen has certain relationship.It is control by experimental group, certain commercially available brand lipstick of five kinds of lipsticks of the embodiment of the present invention
Group, to lip color, too red patient is tested.Test method are as follows: 30 patients are divided into 6 groups, every morning, sleep before
It smears once, the using effect of tester was observed and recorded in every two days, as a result as shown in table 3 below:
| Group | Time (2 days) | Time (5 days) |
| Embodiment 1 | Lip discoloration is shallow | It is almost recovered |
| Embodiment 2 | Lip color is soft and moist | Recovery from illness |
| Embodiment 3 | Lip color is soft and moist | It is almost recovered |
| Embodiment 4 | Lip discoloration is shallow | Recovery from illness |
| Embodiment 5 | Lip color is soft and moist | It fully recovers (gain color) |
| Control group | It is constant | It is slight to improve |
As seen from the results in Table 3, control group advanced symptoms are basically unchanged, and there is slight improvement in the later period, it may be possible to patient's itself
Adjustment effect, and the lipstick of experimental group use production begins with significant improvement two days later, has fully recovered substantially after the 5th day,
Illustrate lip-stick of the present invention have improve lip color health so that lip discoloration obtain it is soft and moist.
In conclusion using a kind of heat-clearing moisturizing lip-stick provided by the present invention and preparation method thereof, lip-stick master
Lip is nourished, it is fiery under heat-clearing, prevent various lips diseases, and there is edibility, property nontoxic to the human body.Wherein Semen Coicis is because containing
There are many vitamin and minerals, boost metabolism, vitamin E, the vitamin B contained in Semen Coicis, Ke Yigai
Kind lip color, with effect fiery under moisturizing；Lily has sweet and cool-natured clear and rich, and master enters the lung heart, has moistening for dryness and clearing away heat effect；Coconut oil is logical
It crosses natural squeezing and obtains, ensured the effect without side effect, and significant with the melting of other raw material components.The preparation method passes through the
The abundant extraction of one concentrate and the second concentrate, effective component is extracted, and component collocation is rationally, curative for effect, effect
It is lasting to stablize.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent substitution, improvement and etc. done be should be included within the scope of the present invention.
Claims (9)
1. a kind of heat-clearing moisturizing lip-stick, which is characterized in that the raw material components including following parts by weight: 30~50 parts of Semen Coicis, hundred
Close 10~30 parts, 5~15 parts of Poria cocos, 5~10 parts of green cucumber, 30~50 parts of coconut oil, 5~10 parts of honey；
The preparation method of the heat-clearing moisturizing lip-stick, comprising the following steps:
The preparation of (1) first concentrate: by Semen Coicis, lily and Poria cocos 1~2h of raw material soaking, crushing is dried, is with concentration
50%~70% ethanol water is extracted, and leaching liquor is obtained, and is evaporated solvent to leaching liquor, in 0.08~0.1Mpa item
Concentration is heated under part；
The preparation of (2) second concentrates: green cucumber raw material is added into water crushing and beating, obtains slurry；Pectase is added, adjusts pH value,
1~2h of heat preservation is carried out in water-bath, is centrifuged after enzyme deactivation, supernatant liquor is taken to be concentrated；
(3) preparation of coconut oil: the coconut meat of drying is crushed, and is put into cold pressing expeller after progress cold pressing, is surpassed
Critical CO2 extraction, obtains coconut oil；
(4) the first concentrate and the second concentrate are mixed evenly, obtain mixed liquor, adjust pH value, then by coconut oil and bee
Honey is divided equally in 2~3 portions of involvement mixed liquors, stirs evenly, obtains lotion；
(5) sterilization cooling: cooling down after lotion is sterilized, and after sterilization temperature is 100~120 DEG C, is cooled to 50~70 DEG C；
(6) form, demoulding.
2. a kind of heat-clearing moisturizing lip-stick according to claim 1, which is characterized in that including following weight part ratio component:
40 parts of Semen Coicis, 22 parts of lily, 10 parts of Poria cocos, 7 parts of green cucumber, 35 parts of coconut oil, 5 parts of honey.
3. a kind of heat-clearing moisturizing lip-stick according to claim 1, which is characterized in that extraction temperature in the step (1)
It is 60~80 DEG C, extraction time is 2~3h, and extracting times are 2~3 times.
4. a kind of heat-clearing moisturizing lip-stick according to claim 1, which is characterized in that steamed in the step (2) with rotation
Hair instrument is concentrated, and the second concentrate is obtained.
5. a kind of heat-clearing moisturizing lip-stick according to claim 1, which is characterized in that pectin is added in the step (2)
After enzyme, progress enzymolysis processing, 40 DEG C~55 DEG C of hydrolysis temperature, enzymolysis time 1h~2h.
6. a kind of heat-clearing moisturizing lip-stick according to claim 1, which is characterized in that slurry and fruit in the step (2)
The weight ratio of glue enzyme is 3:1~5:1.
7. a kind of heat-clearing moisturizing lip-stick according to claim 1, which is characterized in that adjust pH value in the step (2)
It is 3~5.
8. a kind of heat-clearing moisturizing lip-stick according to claim 1, which is characterized in that cold pressing in the step (3)
Temperature is 40~60 DEG C.
9. a kind of heat-clearing moisturizing lip-stick according to claim 1, which is characterized in that pH value is 4.5 in the step (4)
~7.
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| KR20090073622A (en) * | 2007-12-31 | 2009-07-03 | 주식회사 코리아나화장품 | Cosmetic composition comprising a rhodochrosite extract, smithsonite extract and phytosteryl derivatives as active ingredient |
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| CN102440934A (en) * | 2010-10-13 | 2012-05-09 | 汪强 | Lip care balm capable of effectively preventing inflammation on lips |
| CN103040703A (en) * | 2012-12-18 | 2013-04-17 | 青岛博益特生物材料有限公司 | Honey lip balm |
| CN105581966A (en) * | 2016-02-29 | 2016-05-18 | 广西南岜仔科技有限公司 | Lithospermum erythrorhizon lipstick and preparation method thereof |
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| KR20090073622A (en) * | 2007-12-31 | 2009-07-03 | 주식회사 코리아나화장품 | Cosmetic composition comprising a rhodochrosite extract, smithsonite extract and phytosteryl derivatives as active ingredient |
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