CN106715718B - 用于检测和分析结核分枝杆菌的组合物和方法 - Google Patents

用于检测和分析结核分枝杆菌的组合物和方法 Download PDF

Info

Publication number
CN106715718B
CN106715718B CN201580049410.8A CN201580049410A CN106715718B CN 106715718 B CN106715718 B CN 106715718B CN 201580049410 A CN201580049410 A CN 201580049410A CN 106715718 B CN106715718 B CN 106715718B
Authority
CN
China
Prior art keywords
mtb
sample
dna
samples
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580049410.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN106715718A (zh
Inventor
唐宁
G.勒基
V.帕哈拉瓦塔
A.弗兰克
J.兰皮宁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Molecular Inc
Original Assignee
Abbott Molecular Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Molecular Inc filed Critical Abbott Molecular Inc
Priority to CN202110659815.0A priority Critical patent/CN113652492A/zh
Publication of CN106715718A publication Critical patent/CN106715718A/zh
Application granted granted Critical
Publication of CN106715718B publication Critical patent/CN106715718B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201580049410.8A 2014-07-24 2015-07-07 用于检测和分析结核分枝杆菌的组合物和方法 Active CN106715718B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110659815.0A CN113652492A (zh) 2014-07-24 2015-07-07 用于检测和分析结核分枝杆菌的组合物和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462028527P 2014-07-24 2014-07-24
US62/028527 2014-07-24
PCT/US2015/039362 WO2016014240A2 (en) 2014-07-24 2015-07-07 Compositions and methods for the detection and analysis of mycobacterium tuberculosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202110659815.0A Division CN113652492A (zh) 2014-07-24 2015-07-07 用于检测和分析结核分枝杆菌的组合物和方法

Publications (2)

Publication Number Publication Date
CN106715718A CN106715718A (zh) 2017-05-24
CN106715718B true CN106715718B (zh) 2021-07-06

Family

ID=55163935

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580049410.8A Active CN106715718B (zh) 2014-07-24 2015-07-07 用于检测和分析结核分枝杆菌的组合物和方法
CN202110659815.0A Pending CN113652492A (zh) 2014-07-24 2015-07-07 用于检测和分析结核分枝杆菌的组合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202110659815.0A Pending CN113652492A (zh) 2014-07-24 2015-07-07 用于检测和分析结核分枝杆菌的组合物和方法

Country Status (11)

Country Link
US (3) US10072306B2 (pt)
EP (4) EP3835430B1 (pt)
JP (2) JP6596066B2 (pt)
CN (2) CN106715718B (pt)
AP (1) AP2017009731A0 (pt)
BR (1) BR112017001500A2 (pt)
CA (1) CA2955771C (pt)
ES (3) ES2962636T3 (pt)
MX (1) MX2017001134A (pt)
RU (1) RU2697502C2 (pt)
WO (1) WO2016014240A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106715718B (zh) 2014-07-24 2021-07-06 雅培分子公司 用于检测和分析结核分枝杆菌的组合物和方法
US10526664B2 (en) * 2015-07-14 2020-01-07 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis
EP3501282A1 (en) * 2017-12-22 2019-06-26 F. Hoffmann-La Roche AG Composition for processing a sputum sample
WO2020162996A2 (en) * 2018-11-13 2020-08-13 The University Of North Carolina At Chapel Hill Analysis systems with microfluidic devices, microfluidic devices and related methods
KR102368506B1 (ko) * 2019-11-12 2022-02-28 에이비아이(주) 결핵균과 비결핵 항산균 검출을 위한 객담의 전처리 조성물과 그 방법 및 프라이머와 프로브, 이를 이용한 장치

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101023170A (zh) * 2004-04-26 2007-08-22 和光纯药工业株式会社 结核菌检测用的引物和探针以及使用它们检测人型结核菌的方法
CN101868542A (zh) * 2007-06-22 2010-10-20 凯津公司 具有改进的经修饰的寡核苷酸的定向核苷酸交换
EP2514838A1 (en) * 2007-04-13 2012-10-24 Abbott Laboratories Primer and probe sequences for detecting chlamydia trachomatis
CN103635575A (zh) * 2011-06-15 2014-03-12 盖立复治疗公司 用于测定人免疫缺陷病毒(hiv)的方法、组合物和试剂盒
CN103687961A (zh) * 2011-05-06 2014-03-26 赛卢拉有限公司 用于等温全基因组扩增的方法和组合物

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948882A (en) 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
DE3650699T2 (de) 1985-03-15 1999-04-15 Antivirals Inc Immunotestmittel für Polynukleotid und Verfahren
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5491224A (en) 1990-09-20 1996-02-13 Bittner; Michael L. Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
US5168039A (en) * 1990-09-28 1992-12-01 The Board Of Trustees Of The University Of Arkansas Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5464746A (en) 1991-12-17 1995-11-07 Abbott Laboratories Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives
US5424414A (en) 1991-12-17 1995-06-13 Abbott Laboratories Haptens, tracers, immunogens and antibodies for 3-phenyl-1-adamantaneacetic acids
CA2119188A1 (en) * 1993-04-05 1994-10-06 Patricia A. Spears Detection and identification of mycobacteria
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5714330A (en) 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5631130A (en) * 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
CA2126952C (en) 1994-06-28 2010-12-14 Sithian Pandian Probe, kit, and method of amplification for increasing the sensitivity of nucleic acid hybridization assays
EP0777749B1 (en) 1994-08-19 2002-10-30 PE Corporation (NY) Coupled amplification and ligation method
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
EP0892808B1 (en) 1996-04-12 2008-05-14 PHRI Properties, Inc. Detection probes, kits and assays
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
EP1028970A1 (en) 1997-10-10 2000-08-23 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
US6642000B1 (en) 1999-11-12 2003-11-04 University Of Chicago PCR amplification on microarrays of gel immobilized oligonucleotides
AU2001282881B2 (en) 2000-07-07 2007-06-14 Visigen Biotechnologies, Inc. Real-time sequence determination
US7668697B2 (en) 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US20110111389A1 (en) 2001-11-07 2011-05-12 Diagcor Bioscience Incorporation Limited Rapid genotyping analysis for human papillomavirus and the device thereof
PT1338657E (pt) * 2002-02-25 2007-06-21 Pasteur Institut Sequências especificamente deletadas do genoma de mycobacterium tuberculosis e o seu uso em diagnóstico e como vacinas.
AU2004254552B2 (en) 2003-01-29 2008-04-24 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
CA2533667A1 (en) 2003-07-29 2005-02-10 Universite Laval Obesity markers and uses thereof
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
RU2338789C2 (ru) * 2003-12-09 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч Способ детекции патогенных микобактерий в клинических образцах
GB0403039D0 (en) 2004-02-11 2004-03-17 Health Prot Agency TB resistance assay
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
EP2857523A1 (en) 2005-02-01 2015-04-08 Applied Biosystems, LLC Method for identifying a sequence in a polynucleotide
RU2376387C2 (ru) 2005-12-26 2009-12-20 Учреждение Российской академии наук Институт молекулярной биологии им. В.А. Энгельгардта РАН Способ одновременного обнаружения микобактерий туберкулезного комплекса и идентификации мутаций в днк микобактерий, приводящих к устойчивости микроорганизмов к рифампицину и изониазиду, на биологических микрочипах, набор праймеров, биочип и набор олигонуклеотидных зондов, используемые в способе
JP5178528B2 (ja) 2005-12-29 2013-04-10 アボット ポイント オブ ケア インコーポレイテッド 分子診断用増幅システムおよび方法
US7282337B1 (en) 2006-04-14 2007-10-16 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing
JPWO2007141912A1 (ja) 2006-06-07 2009-10-15 住友ベークライト株式会社 Rna検出方法
US20080241951A1 (en) 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Method and apparatus for moving stage detection of single molecular events
US8652782B2 (en) * 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
WO2008140478A2 (en) * 2006-11-01 2008-11-20 Immport Therapeutics, Inc. Compositions and methods for immunodominant antigens
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
GB2457851B (en) 2006-12-14 2011-01-05 Ion Torrent Systems Inc Methods and apparatus for measuring analytes using large scale fet arrays
US20100273854A1 (en) * 2007-06-15 2010-10-28 Hagar Kalinski Compositions and methods for inhibiting nadph oxidase expression
EP2171088B1 (en) 2007-06-19 2015-10-14 Stratos Genomics Inc. High throughput nucleic acid sequencing by expansion
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010132054A1 (en) * 2009-05-13 2010-11-18 Immport Therapeutics, Inc. Compositions and methods for immunodominant antigens of mycobacterium tuberculosis
WO2011140237A2 (en) 2010-05-04 2011-11-10 The Government Of The Usa Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Process for detection of multidrug resistant tuberculosis using real-time pcr and high resolution melt analysis
KR101158649B1 (ko) 2010-05-27 2012-06-26 울산대학교 산학협력단 이중 실시간 중합효소연쇄반응법을 이용한 결핵균과 항산성비결핵균의 검출 방법
KR101152061B1 (ko) * 2010-05-27 2012-06-08 울산대학교 산학협력단 이중 중합효소연쇄반응법을 이용한 결핵균과 항산성비결핵균의 검출 방법
US20130345079A1 (en) * 2010-10-27 2013-12-26 Infectious Disease Research Institute Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity
CN102618625B (zh) 2011-01-27 2013-09-11 博奥生物有限公司 一种检测结核分枝杆菌耐药性的方法和试剂盒
US9045803B2 (en) 2012-02-29 2015-06-02 Abbott Molecular Inc. Hepatitis B virus typing and resistance assay
CN103312221A (zh) 2012-03-13 2013-09-18 鸿富锦精密工业(深圳)有限公司 太阳能板清洁系统
US9249398B2 (en) 2012-05-30 2016-02-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Use of mycobacterium smegmatis trehalose dimycolate hydrolase
CN106906306B (zh) 2013-03-15 2020-07-10 达雅高生命科技有限公司 快速并灵敏基因型鉴定及核酸检测
US10738347B2 (en) 2013-11-19 2020-08-11 Brandeis University Multiplex target detection assay
CN106715718B (zh) * 2014-07-24 2021-07-06 雅培分子公司 用于检测和分析结核分枝杆菌的组合物和方法
JP6599606B2 (ja) 2014-10-24 2019-10-30 アサヒビール株式会社 非発酵ビール様発泡性飲料
US10582714B2 (en) 2015-07-10 2020-03-10 Mead Johnson Nutrition Company Nutritional compositions and methods for promoting cognitive development
US10526664B2 (en) 2015-07-14 2020-01-07 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101023170A (zh) * 2004-04-26 2007-08-22 和光纯药工业株式会社 结核菌检测用的引物和探针以及使用它们检测人型结核菌的方法
EP2514838A1 (en) * 2007-04-13 2012-10-24 Abbott Laboratories Primer and probe sequences for detecting chlamydia trachomatis
CN101868542A (zh) * 2007-06-22 2010-10-20 凯津公司 具有改进的经修饰的寡核苷酸的定向核苷酸交换
CN103687961A (zh) * 2011-05-06 2014-03-26 赛卢拉有限公司 用于等温全基因组扩增的方法和组合物
CN103635575A (zh) * 2011-06-15 2014-03-12 盖立复治疗公司 用于测定人免疫缺陷病毒(hiv)的方法、组合物和试剂盒

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Evaluation of multiplex Polymerase chain reaction utilising multiple targets in Mycobacterium tuberculosis direct test negative but culture positive cases:A potential method for enhancing the diagnosis of tuberculosis;Sharma K等;《Indian journal of medical microbiology》;20130926;第31卷(第4期);第371页左栏第7行-第372页左栏倒数第14行 *
结核/非结核分枝杆菌核酸快速检测方法临床应用价值;康丽军等;《中国防痨杂志》;20110510;第33卷(第5期);第263-266页 *

Also Published As

Publication number Publication date
ES2752761T3 (es) 2020-04-06
WO2016014240A3 (en) 2016-03-17
ES2864855T3 (es) 2021-10-14
CA2955771A1 (en) 2016-01-28
US20200347438A9 (en) 2020-11-05
JP2017521086A (ja) 2017-08-03
EP4282961A2 (en) 2023-11-29
JP6840207B2 (ja) 2021-03-10
US10072306B2 (en) 2018-09-11
JP2020010714A (ja) 2020-01-23
BR112017001500A2 (pt) 2018-02-20
US20160024561A1 (en) 2016-01-28
JP6596066B2 (ja) 2019-10-23
EP3191607B1 (en) 2019-08-21
EP3835430B1 (en) 2023-08-16
RU2017102991A3 (pt) 2019-01-23
EP3191607A4 (en) 2017-12-20
US11932911B2 (en) 2024-03-19
EP3578668A1 (en) 2019-12-11
ES2962636T3 (es) 2024-03-20
CN113652492A (zh) 2021-11-16
RU2017102991A (ru) 2018-08-27
EP3578668B1 (en) 2020-12-30
US20210198721A1 (en) 2021-07-01
US10975446B2 (en) 2021-04-13
AP2017009731A0 (en) 2017-02-28
EP3191607A2 (en) 2017-07-19
CA2955771C (en) 2022-08-30
CN106715718A (zh) 2017-05-24
EP4282961A3 (en) 2024-02-28
WO2016014240A9 (en) 2016-05-06
US20190048400A1 (en) 2019-02-14
EP3835430A1 (en) 2021-06-16
RU2697502C2 (ru) 2019-08-14
MX2017001134A (es) 2017-10-11
WO2016014240A2 (en) 2016-01-28

Similar Documents

Publication Publication Date Title
JP6840207B2 (ja) マイコバクテリウム・ツベルクロシスの検出および分析のための組成物および方法
US20080160527A1 (en) One-tube nested PCR for detecting Mycobacterium tuberculosis
EP2557156B1 (en) Primer and probe for detecting chlamydia trachomatis, and method for detecting chlamydia trachomatis using same
Dreier et al. Real-time polymerase chain reaction in transfusion medicine: applications for detection of bacterial contamination in blood products
US20100233717A1 (en) Methods for detecting toxigenic microbes
EP2898095A1 (en) Compositions and methods for detection of clostridium difficile
WO2013009340A1 (en) Methods and compositions for chlamydia trachomatis diagnostic testing
JP2015513921A (ja) 任意のポリメラーゼ伸長活性の高感度定量的測定と生細胞存在の決定とに有用なポリメラーゼ活性測定方法
WO2009032486A1 (en) Methods for detecting drug-resistant microbes
WO2024097392A1 (en) Compositions and methods for the detection and analysis of herpes simplex virus 1 (hsv-1), herpes simplex virus 2 (hsv-2) and varicella zoster virus (vzv)
Kalland et al. 11 Molecular Microbial Diagnostics
US20100092949A1 (en) Methods for detecting staphylococcus aureus
Dreier et al. Real-time NAT-based methods for detection of bacterial contamination in blood products.
US20150344975A1 (en) Compositions and methods for detecting, extracting, visualizing, and identifying protomyxzoa rhuematic
Ganas The developement of a Real-Time Polymerase Chain Reaction using TaqMan probes to determine the burden of multi-drug resistant tuberculosis (MDR-TB) in KwaZulu-Natal.

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant