CN106699760A - 美罗培南三水合物的合成方法 - Google Patents
美罗培南三水合物的合成方法 Download PDFInfo
- Publication number
- CN106699760A CN106699760A CN201611253417.4A CN201611253417A CN106699760A CN 106699760 A CN106699760 A CN 106699760A CN 201611253417 A CN201611253417 A CN 201611253417A CN 106699760 A CN106699760 A CN 106699760A
- Authority
- CN
- China
- Prior art keywords
- meropenem
- synthetic method
- meropenem trihydrate
- raw material
- trihydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(CSC(C1)C=NC1*(N(C)C)=O)C(C1C(C)O)N(CCCO*O)C1=O Chemical compound CC(CSC(C1)C=NC1*(N(C)C)=O)C(C1C(C)O)N(CCCO*O)C1=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611253417.4A CN106699760B (zh) | 2016-12-30 | 2016-12-30 | 美罗培南三水合物的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611253417.4A CN106699760B (zh) | 2016-12-30 | 2016-12-30 | 美罗培南三水合物的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106699760A true CN106699760A (zh) | 2017-05-24 |
CN106699760B CN106699760B (zh) | 2019-01-18 |
Family
ID=58904913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611253417.4A Active CN106699760B (zh) | 2016-12-30 | 2016-12-30 | 美罗培南三水合物的合成方法 |
Country Status (1)
Country | Link |
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CN (1) | CN106699760B (zh) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102133527A (zh) * | 2010-12-23 | 2011-07-27 | 西安凯立化工有限公司 | 一种用于美罗培南合成的钯锡炭催化剂及制备方法 |
CN102336756A (zh) * | 2010-07-20 | 2012-02-01 | 湖北益泰药业有限公司 | 美罗培南合成中脱保护基的方法 |
CN102348710A (zh) * | 2009-03-13 | 2012-02-08 | 株式会社大熊制药 | 利用锌粉制备美罗培南的改进方法 |
CN102372715A (zh) * | 2011-12-07 | 2012-03-14 | 凯莱英医药集团(天津)股份有限公司 | 一种制备美罗培南的方法 |
CN102731504A (zh) * | 2011-04-13 | 2012-10-17 | 石药集团中奇制药技术(石家庄)有限公司 | 一种美罗培南的制备方法 |
CN103894190A (zh) * | 2014-04-29 | 2014-07-02 | 西安凯立化工有限公司 | 一种用于美罗培南合成的钯炭催化剂的制备方法 |
-
2016
- 2016-12-30 CN CN201611253417.4A patent/CN106699760B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102348710A (zh) * | 2009-03-13 | 2012-02-08 | 株式会社大熊制药 | 利用锌粉制备美罗培南的改进方法 |
CN102336756A (zh) * | 2010-07-20 | 2012-02-01 | 湖北益泰药业有限公司 | 美罗培南合成中脱保护基的方法 |
CN102133527A (zh) * | 2010-12-23 | 2011-07-27 | 西安凯立化工有限公司 | 一种用于美罗培南合成的钯锡炭催化剂及制备方法 |
CN102731504A (zh) * | 2011-04-13 | 2012-10-17 | 石药集团中奇制药技术(石家庄)有限公司 | 一种美罗培南的制备方法 |
CN102372715A (zh) * | 2011-12-07 | 2012-03-14 | 凯莱英医药集团(天津)股份有限公司 | 一种制备美罗培南的方法 |
CN103894190A (zh) * | 2014-04-29 | 2014-07-02 | 西安凯立化工有限公司 | 一种用于美罗培南合成的钯炭催化剂的制备方法 |
Also Published As
Publication number | Publication date |
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CN106699760B (zh) | 2019-01-18 |
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Date | Code | Title | Description |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200803 Address after: 256100 Yiyuan Economic Development Zone, Shandong, Zibo Patentee after: SHANDONG XINQUAN PHARMACEUTICAL Co.,Ltd. Address before: 256100 Yiyuan Economic Development Zone, Shandong, Zibo Patentee before: ZIBO XINQUAN PHARMACEUTICAL TECHNOLOGY SERVICE Co.,Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Synthesis of meropenem trihydrate Effective date of registration: 20211216 Granted publication date: 20190118 Pledgee: Commercial Bank of China Yiyuan branch of Limited by Share Ltd. Pledgor: SHANDONG XINQUAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980015204 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220721 Granted publication date: 20190118 Pledgee: Commercial Bank of China Yiyuan branch of Limited by Share Ltd. Pledgor: SHANDONG XINQUAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980015204 |