CN106680523B - A kind of linear propulsion parallel processing reaction unit of integrated reagent set - Google Patents
A kind of linear propulsion parallel processing reaction unit of integrated reagent set Download PDFInfo
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- CN106680523B CN106680523B CN201710137566.2A CN201710137566A CN106680523B CN 106680523 B CN106680523 B CN 106680523B CN 201710137566 A CN201710137566 A CN 201710137566A CN 106680523 B CN106680523 B CN 106680523B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0437—Cleaning cuvettes or reaction vessels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0479—Details of actuating means for conveyors or pipettes hydraulic or pneumatic
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Abstract
The present invention discloses a kind of linear propulsion parallel processing reaction unit of integrated reagent set, including supporting rack, supporting rack both sides are equipped with matched linear slide, linear slide is equipped with several stations along slideway direction, linear slide is combined with the integrated card holder of linear synchronous propeller for integrated reagent card to be clamped, linear synchronous propeller pushes integrated reagent card to move forward and reset along linear slide, it is equipped with sample filling apparatus successively in linear slide, reaction solution filling apparatus, negative reaction device, negative pressure wash mill and luminous substrate liquid adding set, the integrated reagent of integrated reagent card preloaded completes sample-adding, reaction, washing and luminescent solution add operation.The present invention solve the problems, such as multi-index cluster at reagent set parallel processing with react, make the detection project group of patient two-by-two detection and report result interlude greatly shorten, improve immune detection efficiency.
Description
Technical field
The present invention discloses a kind of linear propulsion parallel processing reaction unit of integrated reagent set, is especially for in-vitro diagnosis
When detection multi objective arbitrarily combine the parallel processing reaction unit of project team.
Background technology
In instant detection process, parallel parsing and arbitrary combination multi objective is reported simultaneously as a result, with important reality
Meaning.Multi objective can provide more, more accurate diagnostic message for doctor, and correct diagnosis is made for doctor；And arbitrary multi objective
Parallel parsing is combined, the instant detection needs of different status of patient can be preferably met.During actually detected, each patient's
Illness is different, and test event, quantity are all different；The project team that each patient is detected examines as a unit integrated project group
Survey, it is necessary to have to this can synchronization process in groups device, realization synchronously completes reaction, and what it is for the parallel report result of project team is
When detect, these synchronization process processes are extremely important.
BioMerieux Vidas, the Mitsubishi of Denmark's thunder degree AQT90 FLEX immunity analysis instruments, France Mei Liai
PATHFAST is a kind of more typical instant detection device of whole blood sample multi objective, it can be achieved that particular area multi objective is parallel
Analysis and report result.Other liquid components are distributed into the integrated morphology of single part by this kind of device in advance, are added when without detecting
Reagent adding；It is that the test index reagent of a patient is completed into test with the formal machine organized when this kind of equipment detection；But it is this kind of
Instrument need to be after this group of index test, then starts project team's test of other patients.The project team of each patient surveys
Examination is usually 16~20 minutes, and the 2nd patient's stand-by period to be checked is long after the 1st Patient Sample A enters detection, and efficiency is low,
It is unfavorable for the full-page proof processing compared with multisample when such as outpatient service.
Luminex systems are a kind of Multiple detection reporting systems.The system is using fluidic cell cell resolution techniques, fluorescence
Coding microball identification technology, immunofluorescence label reporting techniques so that primary sample can simultaneously examining report many indexes, reason
By the index that can above reach 100 or more.But due to the finiteness of same patient's Testing index on Clinical practice, each index
The complexity of compatibility and apparatus structure between immunoreactant, Luminex systems do not become clinical examination routine hand
Section.In addition, used sample can only be serum or blood plasma, whole blood sample cannot be used, is not suitable for detection immediately.
Therefore, in instant detection scheme, study be suitble to the clinical automatic paralleling analytical technology of limited multi objective needed according to
It is so significant.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of integrated linear propulsion parallel processing reaction dresses of reagent set
Set, it is intended to solve the problems, such as multi-index cluster at reagent set parallel processing with react.The present invention is arbitrary to the multi objective of each patient
Integrated reagent reaction member parallel processing in project team and completion reaction process, and make the inspection of the detection project group of patient two-by-two
It surveys and report result interlude greatly shortens, improve immune detection efficiency.
In order to achieve the above objectives, the present invention is achieved by the following technical solutions：
A kind of linear propulsion parallel processing reaction unit of integrated reagent set comprising supporting rack, supporting rack both sides are equipped with phase
The linear slide of cooperation, linear slide are equipped with several stations along slideway direction, and linear slide is combined with linear synchronous propeller
Integrated card holder pushes integrated reagent card to move forward simultaneously along linear slide for integrated reagent card, linear synchronous propeller to be clamped
It resets, is equipped with sample filling apparatus, reaction solution filling apparatus, negative reaction device, negative pressure wash mill successively in linear slide
With luminous substrate liquid adding set, the integrated reagent for integrating reagent card preloaded completes sample-adding, reaction, washing and luminescent solution addition
Operation.
Further, at least one group integrated reagent card concurrent job in linear slide, each integrated reagent card group is by linear same
It walks propeller control to synchronize along linear slide Forward, integrated card gripping means grips integrate reagent card, linear synchronizing propeller
It pushes and integrates card holder and integrated reagent card and integrally advance a station, integrated card holder is released to be clamped and will simultaneously be integrated
Reagent card, which is positioned in linear slide, corresponds to station, and linear synchronizing propeller returns back to a upper work together with integrated card holder
Position then proceedes to next wheel clamping, promotes, homing action.
Further, linear synchronous propeller includes integrated card holder and propulsion motor, wherein integrated card holder
It is a pair including integrated card clamping beam, link mechanism and clamping motor, integrated card clamping beam, each integrated card clamping beam is set to
On the outside of corresponding linear slide, integrated card clamping beam is equipped with several clip tooths, and two integrated card clamping beams pass through link mechanism and clamping
Motor, which is connected, realizes holding action, and integrated card holder is connect with propulsion motor realizes Forward action.
Further, sample filling apparatus includes sample injector holder and sample injector, and sample injector branch is erected on supporting rack, both sides
Line line slideway is located in sample injector holder, and sample injector is arranged on the crossbeam of sample injector holder and is slid along the crossbeam, sample injector
Including sample-adding control structure and the sample introduction head being connected, integrated reagent card of the sample-adding control structure control sample introduction head to sample-adding station
The quantitative sample of injection in upper each reagent cup, the crossbeam of sample injector holder are equipped with several optical sensors control sample injector and shift whereabouts
Realization is in place to detect and is loaded product, does not leak and adds, does not also add accidentally.
Further, reaction solution filling apparatus includes reaction solution sample introduction holder and reaction solution injector, reaction solution sample introduction holder
It is erected on supporting rack, both sides linear slide is located in reaction solution sample introduction holder, and reaction solution injector is arranged in reaction solution sample introduction
It is slid on the crossbeam of holder and along the crossbeam, reaction solution injector includes reaction solution sample introduction control structure and the sample introduction that is connected
Head, reaction solution sample introduction control structure controls sample introduction head, and injection is quantitative in each reagent cup on the integrated reagent card for add reaction solution station
Reaction solution, the crossbeam of reaction solution sample introduction holder are equipped with several optical sensors control reaction solution injector displacement whereabouts and realize in place
Product are detected and be loaded, does not leak and adds, are not also added accidentally.
Further, negative reaction device includes negative reaction device holder, top board, negative pressure control making sheet and negative pressure cavity, vacuum pump,
Top board and negative pressure control making sheet are connected in reactor frame and can move towards and be clamped on the integrated reagent card of reaction station
Each integrated Reagent Tube, negative pressure control making sheet are equipped with the film big envelope coordinated with each reagent cup, and film big envelope is top-opening type hatch frame, respectively
Film big envelope is connect by negative-pressure guide pipe with negative pressure cavity and vacuum pump.
Further, the top board of negative reaction device pushes down the cup body upper edge in integrated Reagent Tube, and negative pressure control making sheet is put down upwards
Row movement is integrating the open-top film big envelope of nozzle of Reagent Tube and is being inserted into, integrated Reagent Tube is made to communicate to form negative pressure shape with negative pressure cavity
State, the negative pressure driving that vacuum pump is formed integrate sample and reaction solution in Reagent Tube and move downward to be formed and wear film reaction, vacuum pump shape
At the negative pressure power of flow-controllable and time.
Further, negative pressure cavity is connected to by negative-pressure guide pipe with waste liquid bottle, passes through gas-guide tube and surge flask at the top of waste liquid bottle
It is connected, surge flask is connect by gas-guide tube with vacuum pump.
Further, negative pressure wash mill includes washing liquid device holder, washing lotion sample injector, film big envelope, negative pressure cavity and vacuum pump, is washed
Liquid device branch is erected on supporting rack, and washing lotion sample injector is several and is fixed on the crossbeam of washing liquid device holder that film big envelope is located at
Below washing lotion sample injector, film big envelope is corresponding with the cooperation of integrated Reagent Tube, and film big envelope is top-opening type hatch frame, and each film big envelope passes through
Negative-pressure guide pipe is connect with negative pressure cavity and vacuum pump, and sample introduction head and the film big envelope of washing lotion sample injector move towards, washing lotion sample injector
Sample introduction head downwardly against washing station integrated reagent cup edge suitable for reading, and by pressure sensor open outlet discharge wash
Liquid, the open-top film big envelope of catheter of reagent cup make integrated reagent cup communicate to form negative pressure state with negative pressure cavity, by integrated reagent cup
Intracavitary residue, scrub raffinate are evacuated in the waste liquid bottle outside pipe.
Further, luminous substrate liquid adding set includes luminescent support, luminescent solution sample feeding controller and sample introduction needle, and shine branch
Frame is arranged on supporting rack, and luminescent solution sample feeding controller is arranged the crossbeam in luminescent support and can be slid along the crossbeam, luminescent solution
Sample feeding controller connection sample introduction needle injects quantitative luminescence substrate on the integrated reagent card for the station that shines in each integrated reagent cup
Liquid.
Further, it is to be molded one-time formed plastics card structure to integrate reagent card, has several and integrated examination among the card
The matched hole of agent, integrated reagent card both ends have the wedge structure to concave to be clamped and push collection for the clip tooth of integrated card clamping beam
Moved at card, the reagent cup of integrated reagent is made of cup body and catheter, cup body intracavitary have fixed dry type marker film and
Solid phase membrane structure, solid phase has antigen/antibody on immobilon-p, forms area for reaction, immobilization antigen/antibody and sample on membrane fiber
Middle object to be measured object combines, and forms immune response chain with marker on marker film, and unreacted reactant is worn downwards by intermembrane space
Film, which migrates, to be drained into outside reagent cup.Integrated reagent is loaded on integrated card by integrator intelligent integrated, is constituted one and is waited for patient
It is whole to survey the project implementation（The overwhelming majority is in this way, primary do not complete integrates another integrated reagent card again）Project team's parallel detection
Integrated reagent card.
The present invention is after adopting the above technical scheme, integrated reagent set walks propulsion, the collection of one group of group according to the time interval of setting
Luminous substrate addition position is integrated and gradually pushed to by arbitrary project team at reagent card, that is, Reagent Project group, completes whole detection process
Process, up to luminous value measures and reports as a result, making propulsion and the completion reaction parallel in a manner of groups of of patient's detection project, with
Realize efficient electrochemiluminescent immunoassay detection instant in groups and analysis.
Beneficial effects of the present invention are as follows：
1. making the multiple determination project of each patient with burst mode parallel processing and reaction, external electrochemiluminescent immunoassay is improved
The instant detection efficiency of multi objective.
2. the reacting space time between each patient between detection project group is made to greatly shorten, make the stand-by period of patient
It greatly shortens, full-page proof processing when in favor of compared with multisample.
3. the composite reaction of the arbitrary project team of the achievable multi objective of the present invention, greatly increases instrument and is applicable in detection project model
It encloses, ensure that multi objective, the detection of more diseases, diagnosis needs.
Description of the drawings
Fig. 1 is schematic diagram of the embodiment of the present invention.
Fig. 2 is the integrated reagent set parallel processing reactor schematic diagram of the present invention.
Fig. 3 is the integrated reagent set of present invention washing and addition luminous substrate liquid device schematic diagram parallel.
Fig. 4 is the integrated reagent card of the present invention and integrated reagent schematic diagram.
Specific implementation mode
The invention will be further described below in conjunction with the accompanying drawings：
Embodiment：It please refers to Fig.1 to Fig.4, a kind of integrated linear propulsion parallel processing reaction unit of reagent set comprising branch
Support 11,11 both sides of supporting rack are equipped with matched linear slide 12, and linear slide 12 is equipped with several stations along slideway direction, such as
A, B, C, D, E, F, G, H, I, J, K, M, N in Fig. 1, linear slide 12 are combined with the integrated card clamping dress of linear synchronous propeller 2
It sets for integrated reagent card 3 to be clamped, linear synchronous propeller 2, which pushes, to be integrated reagent card 3 along the Forward of linear slide 12 and reset, edge
Sample filling apparatus 4, reaction solution filling apparatus 5, negative reaction device 6, negative pressure wash mill 7 and hair are equipped in linear slide successively
Light substrate solution adding set 8 integrates integrated reagent completion sample-adding, reaction, washing and the luminescent solution addition work of 3 preloaded of reagent card
Industry.
It can be 2 groups, 3 groups or more as shown in Figure 1, at least one group integrated 3 concurrent job of reagent card in linear slide 12
The integrated reagent card concurrent job of group, each integrated reagent card group are moved forward by the control of linear synchronous propeller 2 is synchronous along linear slide, collection
Integrated reagent card 3 is clamped at card holder, linear synchronizing propeller 2 pushes integrated card holder and integrated reagent card whole
Body one station of advance, integrated card holder, which releases to be clamped and integrated reagent card is positioned in linear slide, corresponds to station,
Linear synchronizing propeller returns back to a upper station together with integrated card holder, then proceedes to next wheel clamping, promotes, resets
Action.Linear synchronous propeller 2 of the present invention includes integrated card holder and propulsion motor 21, wherein integrated card holder packet
Integrated card clamping beam 22, link mechanism and clamping motor 23 are included, link mechanism includes longeron 24, cross bar 25, vertical rod 26 and horse
Up to connecting rod 27, integrated card clamping beam 22 is a pair, and each integrated card clamping beam is set to 12 outside of corresponding linear slide, integrated card
Clamping beam is equipped with several clip tooths 28, and two integrated card clamping beams, which are connected by link mechanism with clamping motor 23, realizes that clamping is dynamic
Make, the longeron of integrated card holder, which is connect by propulsion motor connecting rod 29 with propulsion motor, realizes Forward action.
As shown in Figure 1, inventive samples filling apparatus 4 includes sample injector holder 40 and sample injector, sample injector holder 40 is set
On supporting rack 11, two side line line slideways 12 are located in sample injector holder, and the crossbeam 41 in sample injector holder is arranged in sample injector 41
It above and along the crossbeam slides, sample injector includes the sample introduction head 43 for being loaded control structure 42 with being connected, sample-adding control structure control
Injection quantifies sample to sample introduction head in each reagent cup on the integrated reagent card of sample-adding station, if the crossbeam of sample injector holder is equipped with
Dry optical sensor control sample injector displacement whereabouts realize detection in place and sample-adding product, do not leak plus, also not accidentally plus.
As shown in Figures 1 and 2, reaction solution filling apparatus 5 includes reaction solution sample introduction holder 50 and reaction solution injector, reaction
Liquid sample introduction holder 50 is erected on supporting rack 11, and both sides linear slide 12 is located in reaction solution sample introduction holder, reaction solution injector
It is arranged on the crossbeam 51 of reaction solution sample introduction holder and is slid along the crossbeam, reaction solution injector includes reaction solution sample introduction control knot
Structure 52 and the sample introduction head 53 being connected, reaction solution sample introduction control structure 52 control sample introduction head 53 to the integrated examination for adding reaction solution station
Quantitative reaction liquid is injected on agent card in each reagent cup, the crossbeam 51 of reaction solution sample introduction holder 50 is controlled equipped with several optical sensors
The displacement whereabouts realization of reaction solution injector is in place to detect and is loaded product, does not leak and adds, does not also add accidentally.Negative reaction device 6 includes negative pressure
Reactor frame 61, top board 62, negative pressure control making sheet 63 and negative pressure cavity 64, vacuum pump 65, top board 62 and negative pressure control making sheet 63
It is connected in reactor frame 61 and can move towards and each integrated Reagent Tube or cup on the integrated reagent card of reaction station is clamped,
Negative pressure control making sheet 63 is equipped with the film big envelope 68 coordinated with each reagent cup, and film big envelope 68 is top-opening type hatch frame, film big envelope 68
Opening form multiple film mountings 681, if cross open or rice word are open, each film big envelope by negative-pressure guide pipe 640 with it is negative
Chamber 64 and vacuum pump 65 is pressed to connect.The upper edge-pressing strip 621 of negative reaction device top board pushes down the cup body upper edge in integrated Reagent Tube,
Negative pressure control making sheet 63 moves in parallel upwards, in the nozzle or the open-top film big envelope of catheter that integrate Reagent Tube cup and is inserted into, makes to integrate
Reagent Tube communicates to form negative pressure state with negative pressure cavity, the negative pressure driving that vacuum pump is formed integrate in Reagent Tube sample and reaction solution to
Film reaction is worn in lower movement formation, and vacuum pump forms the negative pressure power of flow-controllable and time.Negative pressure cavity 64 passes through negative-pressure guide pipe
640 are connected to waste liquid bottle 66, are connected with surge flask by gas-guide tube at the top of waste liquid bottle, surge flask passes through gas-guide tube and vacuum pump 65
Connection.
As shown in Figures 1 and 3, negative pressure wash mill 7 includes washing liquid device holder 70, washing lotion sample injector 71, film big envelope 72, bears
Pressure chamber 73 and vacuum pump 74, washing liquid device holder 70 are located on supporting rack 11, and washing lotion sample injector 71 is several and is fixed on washing lotion
On the crossbeam of device holder, film big envelope 72 is located at 71 lower section of washing lotion sample injector, and film big envelope is corresponding with the cooperation of integrated Reagent Tube, film big envelope
72 be top-opening type hatch frame, and the opening of film big envelope forms multiple film mountings, if cross open or rice word are open, each film big envelope
It is connect with negative pressure cavity 73 and vacuum pump 74 by negative-pressure guide pipe 730, the sample introduction head and film big envelope 72 of washing lotion sample injector 71 are opposite
Mobile, the sample introduction head of washing lotion sample injector 71 and passes through pressure sensing downwardly against the integrated reagent cup edge suitable for reading of washing station
Device 701 opens outlet discharge washing lotion, the open-top film big envelope of catheter of reagent cup, make integrated reagent cup communicated with negative pressure cavity to be formed it is negative
Integrated reagent cup intracavitary residue, scrub raffinate are evacuated in the waste liquid bottle 75 outside pipe by pressure condition, waste liquid bottle 75 and vacuum pump it
Between be additionally provided with surge flask 76.Luminous substrate liquid adding set 8 includes luminescent support 80, luminescent solution sample feeding controller 81 and sample introduction needle
82, luminescent support 80 be arranged on supporting rack 11, luminescent solution sample feeding controller be arranged luminescent support 80 crossbeam and can along should
Crossbeam slides, and luminescent solution sample feeding controller 81 connects each integrated reagent cup on the integrated reagent card for the station that shines of sample introduction needle 82
Interior injection quantitative luminescence substrate solution.
Such as Fig. 1 and Fig. 4, it is to be molded one-time formed plastics card structure to integrate reagent card 3, has several and collection among the card
At 32 matched hole 31 of reagent, integrated 3 both ends of reagent card have the wedge structure to concave or groove 33 for integrated card clamping beam
Clip tooth clamping and push integrated card movement, the reagent cup of integrated reagent to be made of cup body and catheter, cup body intracavitary has solid
Fixed dry type marker film and solid phase membrane structure, solid phase has antigen/antibody on immobilon-p, and area is formed for reaction, solid on membrane fiber
Phaseization antigen/antibody is combined with object to be measured object in sample, and forms immune response chain, unreacted with marker on marker film
Object, which by intermembrane space is worn downwards film and migrated, to be drained into outside reagent cup.Integrated reagent is to be loaded into integrated card by integrator intelligent integrated
On, one is constituted to the patient's project implementation to be measured whole（The overwhelming majority is in this way, primary do not complete integrates another integrated reagent again
Card）The integrated reagent card of project team's parallel detection.
As shown in Figure 1 to Figure 4, the linear propulsion parallel processing reaction unit of a kind of integrated reagent set, i.e., a kind of immune detection refer to more
Mark integrates the linear propulsion parallel processing of reagent set and reaction unit, linear synchronous propeller are described as follows, linear synchronizing propeller
The linear synchronizing propeller and linear track composition, linear track of propulsion motor and the clamping motor driving of integrated reagent card are located at line
On the inside of shape synchronizing propeller, be provided on track station A, B that corresponding operating is carried out for integrating reagent card, C, D, E, F, G, H, I,
J, K, M, N coordinate with other structures, are respectively completed respective handling process herein.Linear synchronizing propeller is located under linear track
Portion and outside.Linear synchronizing propeller propeller includes that clamping, propulsion motor and the connecting rod being attached thereto and integrated clip hold knot
Structure；Linear synchronizing propeller promotes multigroup integrated reagent card to synchronize and migrates a station, then reset under propulsion motor driving.
Integrated card holding structure is pushed away including clamping motor, integrated card clamping motor, connecting rod, linear synchronizing propeller longeron, linear synchronize
Into device crossbeam, linear synchronizing propeller vertical rod, linear synchronizing propeller integrated card clamping beam, linear synchronizing propeller longeron collection
At gripper teeth.When work, clip tooth is clamped under clamping motor driving and integrates reagent card both ends groove, and online shape synchronizing propeller exists
Together with whole one station of parallel advances of linear synchronizing propeller propeller, integrated reagent card under propulsion motor driving, then will collect
It is positioned over linear track corresponding A at reagent card --- on N stations.Motor is clamped and releases clamping, linear synchronizing propeller is promoting
Returned back to together with linear synchronizing propeller propeller, integrated reagent card under motor driving it is upper, it is static as defined in after the time, continue
The clamping of next setting, propulsion, reset action.In this way, each integrated reagent card is completed from A stations to the whole of N stations
Reaction and corresponding processing are completed in operation.Sample filling apparatus is fixed on linear synchronizing propeller integrated card clamping beam including one
The upward sample injector holder in outside, the sample injector slideway along the traveling of integrated reagent card longitudinal direction（That is crossbeam）, one can be fixed along slideway
The sample injector control structure and sample injector sample introduction head that point slides.When Reagent Project group, which integrates reagent card, enters sample-adding station B, instrument
Device starts sampling action, and sample injector control structure is completed to be directed at the integrated Reagent Tube to be loaded by sample injector sample introduction head after sampling
（Integrated reagent cup）, the sample of specified amount is injected into integrated Reagent Tube.And rule are injected into each integrated reagent successively along slideway
Quantitative sample, until being fully integrated reagent in same integrated card completes sample-adding, integrated each reagent of reagent card enters reactiveness.
Linear synchronizing propeller will add the integrated reagent card of sample to be advanced into next station C reactions again.The slideway（Sample-adding
Device rack beam）It is equipped with optical sensor and controls sample pipetting volume device control structure whereabouts, realize detection in place and sample-adding product, do not leak
Add, does not also add accidentally.Reaction solution filling apparatus include one be fixed on it is upward anti-on the outside of linear synchronizing propeller integrated card clamping beam
Answer liquid sample introduction holder, horizontal reaction solution sample introduction slideway along the traveling of integrated reagent card longitudinal direction, one can be pinpointed along slideway slide it is anti-
Answer liquid sample introduction control structure and reaction solution sample introduction head.When the integrated reagent card of Reagent Project group, which enters, adds reaction solution station E, instrument
Start filling reaction solution action, the completion of reaction solution sample introduction control structure to be loaded integrated by the alignment of reaction solution sample introduction head after sampling
Reagent Tube（Integrated reagent cup）, the reaction solution of specified amount is injected into integrated Reagent Tube, and along slideway successively to each integrated reagent
It is interior injection specified amount reaction solution, until be fully integrated reagent complete filling reaction solution, with wash integrate Reagent Tube sample cavity and
Marker film, integrating each reagent of reagent card, the reaction was continued.Linear synchronizing propeller will add the integrated reagent card of reaction solution again
It is advanced into next station F reactions.The slideway is equipped with optical sensor and controls reaction solution sample introduction control structure whereabouts, realizes
It is in place to detect and add reaction solution, it does not leak and adds, also do not add accidentally.Negative reaction device is driven by negative reaction device holder, negative reaction device
Motor, top board holder, top board, edge-pressing strip, negative pressure board mount, negative pressure control making sheet, top-opening type film big envelope, top-opening type film envelope
It is piece, negative-pressure guide pipe, negative pressure cavity, negative-pressure guide pipe, waste liquid bottle, waste liquid row mouth control valve, gas-guide tube, surge flask, negative pressure cavity, true
Empty pump group at.The integrated online shape synchronizing propeller of reagent card enters station F under promoting, pressed in the driving of negative reaction device drive motor
Plate and negative pressure control making sheet relative motion.Top board is pushed down integrates reagent cup cup body upper edge in reaction, and lower part negative pressure control making sheet is upward
It moves in parallel, integrates the open-top film mounting of reagent catheter in reaction, so that integrated reagent reaction tube lower part is entered negative pressure state, drive
Sample and reaction solution move downward in integrated Reagent Tube, and film reaction is worn in formation.The negative pressure device under vacuum pumping action, in
Negative pressure is formed in each pipeline and bottle, and is in flow-controllable and negative pressure time state.Each integrated reagent card undergoes several
Negative pressure wears film reaction process, until film reaction is worn in whole samples realization, ensures the accuracy of testing result to greatest extent.Negative pressure is washed
Device is washed by washing liquid device holder, washing lotion sample introduction head frame, washing lotion filling control structure, washing lotion sample introduction head, pressure sensor, top
Open type film big envelope is arranged mouth control valve with film mounting drive motor, negative-pressure guide pipe, negative pressure cavity, waste liquid bottle, waste liquid, gas-guide tube, is delayed
Rush bottle, negative pressure cavity, vacuum pump group at.When integrated reagent card enters M stations, washing lotion sample introduction head, top-opening type film big envelope and film mounting
It moves toward one another.Washing lotion sample introduction head pushes down integrated Reagent Tube edge suitable for reading, and opens washing lotion head by pressure sensor and washing lotion is discharged.
The open-top film mounting of integrated reagent diversion pipe makes integrated reagent reaction tube lower part enter negative pressure state, and integrated Reagent Tube intracavitary is residual
Object, scrub raffinate is stayed to be evacuated to outside pipe.So punching, pumping, row, fully wash, until washing to the defined time.Luminous substrate liquid adds
Feeder apparatus by luminous substrate liquid addition structure stand, luminous substrate liquid sample feeding controller, luminous substrate liquid sample introduction needle form.
When integrated reagent card enters N stations, instrument starts luminous substrate liquid sample feeding controller, and luminous substrate liquid sample introduction needle is along luminous substrate
The luminous substrate liquid of specified amount is added in liquid sample introduction slideway into each integrated reagent reaction tube successively, shines until completing all additions
Substrate solution.It is transferred to luminescence assays darkroom by other mechanisms again added with the integrated reagent reaction tube of luminous substrate liquid, is measured one by one
A integrated Reagent Tube relative luminous intensity calculates object content, reports that each integrated reagent corresponds to target concentration and sentences parallel
Determine result.
As shown in Figure 1 to Figure 4, the linear propulsion parallel processing reaction unit of a kind of integrated reagent set, i.e., a kind of immune detection refer to more
Mark integrates the linear propulsion parallel processing of reagent set and reaction unit, a kind of linear propulsion parallel processing of integrated reagent set of immune detection
With reaction unit, including linear synchronizing propeller and track, sample filling apparatus, reaction solution filling apparatus and negative reaction device,
Negative pressure wash mill, luminous substrate addition structure, the integrated compositions such as reagent card and integrated reagent, realize from sample-adding product to wash,
Add luminous substrate to walk operation processing parallel, while reporting result.
As shown in Fig. 1 and Fig. 4, integrated card is that the integrated card of integrated reagent card 3 integrates load reagents position or the loading of hole 31
Enter fixing bracket after integrated reagent 32（Supporting rack 11）On linear slideway 12 A stations.Integrated card clamping motor 21 passes through
Motor link 29, linear synchronizing propeller longeron 24, linear synchronizing propeller cross bar 25, linear synchronizing propeller is clamped in integrated card
Vertical rod 26, linear synchronizing propeller integrated card clamping beam 22 drive linear synchronizing propeller longeron to integrate gripper teeth 28 and are clamped
It is mounted with 3 groove of integrated reagent card of integrated reagent, along the online shape synchronizing propeller propulsion motor 21 of linear track and linear same
It walks under the effect of propeller propulsion motor connection-rod linkage, migrating to sample by A stations is added position B stations, implements sample introduction.
As shown in Figure 1, the sample injector control structure 42 on sample injector holder 40 is advanced into along sample injector slideway 41 and waits being loaded
Integrated reagent card integrates reagent position, and the sample of set amount is added to integrated Reagent Tube by sample injector sample introduction head 43.Complete a collection
After Reagent Tube sample introduction, the sample of specified amount is injected into each integrated reagent successively along slideway, until in same integrated reagent card
It is fully integrated reagent and completes sample-adding, integrated each reagent of reagent card enters reactiveness.The slideway is equipped with optical sensor control
Sample preparation product sample injector control structure whereabouts, realization is in place to detect and is loaded product, does not leak and adds, does not also add accidentally.Linear synchronizing propeller
The integrated reagent card of sample will have been added to be advanced into the reaction of C, D, E station successively again.
As shown in Figure 1, when integrated reagent card is in E stations, the reaction solution sample introduction control on reaction solution sample introduction holder 50
Structure 52 is advanced into reaction solution to be added along reaction solution sample introduction slideway 51 and integrates the integrated reagent position of reagent card, by reaction solution sample introduction head 53
The reaction solution of set amount is added to integrated Reagent Tube.After completing an integrated Reagent Tube addition reaction solution, along slideway successively to each
The reaction solution of injection specified amount in integrated reagent, until reagent is fully integrated in same integrated reagent card completes addition reaction solution,
Integrated each reagent of reagent card the reaction was continued state.The slideway is equipped with optical sensor and controls reaction solution sample injector control structure
Whereabouts, realization is in place to be detected and adds reaction solution, is not leaked and is added, does not also add accidentally.Linear synchronizing propeller will add reaction solution again
Integrated reagent card is advanced into the reaction of F stations.
As shown in Figure 1, when integrated reagent card is in F stations, the negative reaction device driving on negative reaction device holder 61
Motor 601 drives the edge-pressing strip 621 on top board 62 to push down and is integrated on reagent cup body 603 in reaction via top board holder 602
Opening's edge, while negative reaction device drive motor 601 drives negative pressure control making sheet 63 to move upwards via negative pressure board mount 604, anti-
Reagent catheter 6030 should be integrated to contact with top-opening type film big envelope 64, open-top top-opening type film mounting 641 is connect by negative-pressure guide pipe 640
Enter negative pressure cavity 64, integrated reagent card has integrated reagent position to enter negative pressure leaching reactiveness.It is formed by the work of vacuum pump 65
Under suction function, via negative pressure cavity 64, gas-guide tube 660 and surge flask 67, exhaust gas, waste liquid are drained by 640 water conservancy diversion of negative-pressure guide pipe
Waste liquid bottle 66 so completes negative pressure and wears film reaction.In linear track F-K, realize that negative pressure wears film reaction process.Linear synchronization
The integrated reagent card for negative pressure is completed wearing film reaction is advanced into the washing of M stations by propeller again.
As shown in Figure 1, when integrated reagent card is in M stations, the washing lotion sample introduction head on washing liquid device holder 70 is fixed
Frame（Crossbeam）, the washing lotion sample introduction head of each washing lotion sample injector 71 is in washing lotion filling control structure control and the effect of pressure sensor 701
Under, downlink pushes down integrated reagent upper edge hole, opens liquid injecting function, and cleaning solution is filled to there is integrated reagent position.So simultaneously, open-top
Formula film big envelope 72 is driven up movement with film mounting drive motor, and integrated reagent catheter is contacted with top-opening type film big envelope 72, is pushed up
It opens top-opening type film mounting and negative pressure cavity 73 is accessed by negative-pressure guide pipe 730, integrated reagent card has integrated reagent position to enter negative pressure leaching
Washing state.In the case where the work of vacuum pump 74 is formed by vacuum action, via negative pressure cavity 73, gas-guide tube 750 and surge flask 76, give up
Gas, waste liquid drain into waste liquid bottle 75 by 730 water conservancy diversion of negative-pressure guide pipe, so complete negative pressure washing.Linear synchronizing propeller again will
The integrated reagent card that completion negative pressure wears film reaction is advanced into N stations addition luminous substrate liquid.
As shown in Figure 1, when integrated reagent card is in N stations, luminous substrate liquid adds the luminous bottom on structure stand 80
Thing liquid sample feeding controller 81 is along luminous substrate liquid sample introduction slideway（Crossbeam）It is integrated to be advanced into the integrated reagent card of luminous substrate liquid to be added
The luminous substrate liquid of set amount is added to integrated Reagent Tube by luminous substrate liquid sample introduction needle 82 in reagent position.Complete an integrated examination
After agent pipe adds luminous substrate liquid, the luminous substrate liquid of specified amount is injected into each integrated reagent successively along slideway, until same
It is fully integrated reagent in integrated reagent card and completes addition luminous substrate liquid, integrated each reagent of reagent card enters luminescence-producing reaction state.
It is transferred to luminescence assays darkroom by other mechanisms again added with the integrated reagent reaction tube of luminous substrate liquid, measures an integrated examination one by one
Agent pipe relative luminous intensity calculates object content, reports that each integrated reagent corresponds to target concentration and judgement as a result, complete parallel
At the detection operation of an integrated reagent card.
The foregoing descriptions are merely the embodiment using this origination techniques content, any those skilled in the art use this wound
Make done modifications and changes, all belong to the scope of the claims of this creation opinion, and is not limited to those disclosed embodiments.
Claims (9)
1. a kind of linear propulsion parallel processing reaction unit of integrated reagent set, it is characterised in that：Including supporting rack, supporting rack both sides
Equipped with matched linear slide, linear slide is equipped with several stations along slideway direction, and linear slide is combined with linear synchronous and pushes away
Integrated card holder into device pushes integrated reagent card along linear slide for integrated reagent card, linear synchronous propeller to be clamped
It moves forward and resets, be equipped with sample filling apparatus, reaction solution filling apparatus, negative reaction device, negative pressure successively in linear slide and wash
Device and luminous substrate liquid adding set are washed, the integrated reagent for integrating reagent card preloaded completes sample-adding, reaction, washing and shines
Liquid adds operation；At least one group integrated reagent card concurrent job, each integrated reagent card group are pushed away by linear synchronous in linear slide
It moves forward into device control is synchronous along linear slide, integrated card gripping means grips integrate reagent card, and linear synchronizing propeller pushes
Integrated card holder and integrated reagent card integrally advance a station, integrate card holder and release clamping and by integrated reagent
Card, which is positioned in linear slide, corresponds to station, and linear synchronizing propeller returns back to a upper station together with integrated card holder, so
After continue the clamping of next wheel, promote, homing action.
2. a kind of integrated linear propulsion parallel processing reaction unit of reagent set according to claim 1, it is characterised in that：Line
Property synchronizing propeller include integrated card holder and propulsion motor, wherein integrated card holder include integrated card clamping beam,
Link mechanism and clamping motor, integrated card clamping beam are a pair, and each integrated card clamping beam is set on the outside of corresponding linear slide,
Integrated card clamping beam is equipped with several clip tooths, and two integrated card clamping beams, which are connected by link mechanism with clamping motor, realizes that clamping is dynamic
Make, Forward action is realized in being connect with propulsion motor for integrated card holder.
3. a kind of integrated linear propulsion parallel processing reaction unit of reagent set according to claim 1, it is characterised in that：It is negative
Pressure reactor includes negative reaction device holder, top board, negative pressure control making sheet and negative pressure cavity, vacuum pump, top board and vacuum cavitations
Plate is connected in reactor frame and can move towards and each integrated Reagent Tube on the integrated reagent card of reaction station is clamped, negative pressure
Control panel is equipped with the film big envelope coordinated with each reagent cup, and film big envelope is top-opening type hatch frame, and each film big envelope is led by negative pressure
Flow tube is connect with negative pressure cavity and vacuum pump.
4. a kind of integrated linear propulsion parallel processing reaction unit of reagent set according to claim 1, it is characterised in that：It is negative
The top board of pressure reactor pushes down the cup body upper edge in integrated Reagent Tube, and negative pressure control making sheet moves in parallel upwards, in integrated reagent
The open-top film big envelope of nozzle of pipe is simultaneously inserted into, and integrated Reagent Tube is made to communicate to form negative pressure state with negative pressure cavity, and vacuum pump is formed negative
Pressure driving integrates sample and reaction solution in Reagent Tube and moves downward to be formed and wear film reaction, and vacuum pump forms flow-controllable and time
Negative pressure power, negative pressure cavity are connected to by negative-pressure guide pipe with waste liquid bottle, are connected with surge flask by gas-guide tube at the top of waste liquid bottle, are delayed
Bottle is rushed to connect with vacuum pump by gas-guide tube.
5. a kind of integrated linear propulsion parallel processing reaction unit of reagent set according to claim 1, it is characterised in that：It is negative
It includes washing liquid device holder, washing lotion sample injector, film big envelope, negative pressure cavity and vacuum pump to press wash mill, and washing liquid device branch is erected at support
On frame, washing lotion sample injector is several and is fixed on the crossbeam of washing liquid device holder that film big envelope is located at below washing lotion sample injector, film
Big envelope and integrated Reagent Tube coordinate, and film big envelope is top-opening type hatch frame, each film big envelope by negative-pressure guide pipe and negative pressure cavity and
Vacuum pump connects, and sample introduction head and the film big envelope of washing lotion sample injector move towards, and the sample introduction head of washing lotion sample injector is downwardly against washing
The integrated reagent cup edge suitable for reading of station, and discharge washing lotion in outlet is opened by pressure sensor, the catheter of reagent cup is open-top
Film big envelope makes integrated reagent cup communicate to form negative pressure state with negative pressure cavity, and integrated reagent cup intracavitary residue, scrub raffinate are taken out
In waste liquid bottle outside to pipe.
6. a kind of integrated linear propulsion parallel processing reaction unit of reagent set according to claim 1, it is characterised in that：Sample
Product filling apparatus includes sample injector holder and sample injector, and sample injector branch is erected on supporting rack, and two side line line slideways are located at sample-adding
In device holder, sample injector is arranged on the crossbeam of sample injector holder and is slid along the crossbeam, and sample injector includes sample-adding control structure
With the sample introduction head being connected, sample-adding control structure controls sample introduction head and is injected in each reagent cup on the integrated reagent card of sample-adding station
Quantitative sample, the crossbeam of sample injector holder are equipped with several optical sensors control sample injector and shift whereabouts realization detection in place and add
Sample.
7. a kind of integrated linear propulsion parallel processing reaction unit of reagent set according to claim 1, it is characterised in that：Instead
It includes reaction solution sample introduction holder and reaction solution injector to answer liquid filling apparatus, and reaction solution sample introduction holder is erected on supporting rack, and two
Linear slideway is located in reaction solution sample introduction holder, and reaction solution injector is arranged on the crossbeam of reaction solution sample introduction holder and along this
Crossbeam slides, and reaction solution injector includes reaction solution sample introduction control structure and the sample introduction head that is connected, and the control of reaction solution sample introduction is tied
Structure controls sample introduction head and injects quantitative reaction liquid, reaction solution sample introduction branch in each reagent cup on the integrated reagent card for add reaction solution station
The crossbeam of frame is equipped with several optical sensors control reaction solution injector and shifts whereabouts realization detection in place and add reaction solution.
8. a kind of integrated linear propulsion parallel processing reaction unit of reagent set according to claim 1, it is characterised in that：Hair
Light substrate solution adding set includes luminescent support, luminescent solution sample feeding controller and sample introduction needle, and luminescent support is arranged on supporting rack,
Luminescent solution sample feeding controller is arranged the crossbeam in luminescent support and can be slid along the crossbeam, and luminescent solution sample feeding controller connects sample introduction
Needle injects quantitative luminescence substrate solution on the integrated reagent card for the station that shines in each integrated reagent cup.
9. a kind of integrated linear propulsion parallel processing reaction unit of reagent set according to one of claim 1 to 8, feature
It is：Integrated reagent card is to be molded one-time formed plastics card structure, has several and the matched sky of integrated reagent among the card
Cave, integrated reagent card both ends have the wedge structure to concave to be clamped and push integrated card movement for the clip tooth of integrated card clamping beam,
The reagent cup of integrated reagent is made of cup body and catheter, and cup body intracavitary has fixed dry type marker film and immobilon-p knot
Structure, solid phase has antigen/antibody on immobilon-p, forms area for reaction, immobilization antigen/antibody and mesh to be measured in sample on membrane fiber
It marks object to combine, and immune response chain is formed with marker on marker film, unreacted reactant wears downwards film by intermembrane space and migrates row
To outside reagent cup.
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| CN110967496B (en) * | 2018-09-29 | 2023-11-10 | 深圳市帝迈生物技术有限公司 | sample analyzer |
| CN113419073B (en) * | 2020-03-30 | 2024-05-31 | 厦门先明生物技术有限公司 | High-flux full-automatic microfluidic fluorescence immunoassay device |
| CN111983249A (en) * | 2020-08-28 | 2020-11-24 | 沈阳瑞好生物科技有限公司 | Chemiluminescence immunodetection analyzer for in-situ luminescence determination and detection method |
| CN117405905B (en) * | 2023-12-15 | 2024-02-20 | 广州誉康医药有限公司 | Reagent card selecting system |
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| JP5496581B2 (en) * | 2009-08-31 | 2014-05-21 | シスメックス株式会社 | Sample processing equipment |
| CN102419375B (en) * | 2011-08-24 | 2013-08-28 | 四川迈克生物科技股份有限公司 | Full-automatic chemoluminescence immunoassay analyzer |
| CN204769670U (en) * | 2015-07-14 | 2015-11-18 | 厦门先明生物技术有限公司 | Washing device of immunodetection analytical instrument |
| CN204789606U (en) * | 2015-07-14 | 2015-11-18 | 厦门先明生物技术有限公司 | Autoinjection device of immunodetection analytical instrument |
| CN105242036B (en) * | 2015-10-08 | 2016-08-17 | 徐恩良 | A kind of electrochemiluminescent immunoassay detection integrated Reagent Tube and using method thereof |
| CN105628947B (en) * | 2016-02-02 | 2017-08-08 | 徐恩良 | Whole blood automatic luminous immunoassay instant detector |
| CN206540925U (en) * | 2017-03-09 | 2017-10-03 | 厦门先明生物技术有限公司 | A kind of linear propulsion parallel processing reaction unit of integrated reagent set |
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