CN106619778A - Natural ultra-micro calcium oral spray - Google Patents
Natural ultra-micro calcium oral spray Download PDFInfo
- Publication number
- CN106619778A CN106619778A CN201610878686.3A CN201610878686A CN106619778A CN 106619778 A CN106619778 A CN 106619778A CN 201610878686 A CN201610878686 A CN 201610878686A CN 106619778 A CN106619778 A CN 106619778A
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- micro
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/614—Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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Abstract
The invention discloses a natural ultra-micro calcium oral spray to solve the problem that an oral spray in the prior art takes effect by covering one smell with another, is high in sugar content, and cannot achieve an aim of purifying an oral cavity fundamentally. The natural ultra-micro calcium oral spray consists of ultra-micro calcium powder and auxiliary materials, wherein the weight percentage of the ultra-micro calcium powder is 0.5-1%, and the auxiliary materials include a corrigent, an absorption enhancer, a bacteria remover, a deodorant and a solvent; the weight percentage of the corrigent is 1-5%, the weight percentage of the absorption enhancer is 0.5-2%, the weight percentage of the bacteria remover is 2-5%, the weight percentage of the deodorant is 0.2-0.5%, the solvent is pure water, and the weight percentage of the solvent is 90-95%. In the formula, the selected ultra-micro calcium powder has the effects of clearing away heat and toxic materials, astringing sores and stopping bleeding, activating cells, and killing bacteria, a honeysuckle extract can effectively kill microorganisms to treat oral ulcers, and paeonol can relieve swelling and pain, prevent dental caries, cover up halitosis, clean oral cavity and the like.
Description
Technical field
The present invention relates to spray technology field, particularly relates to a kind of natural micro-calcium oral spray.
Background technology
Today's society, with the improvement of people's living standards, people increasingly focus on modifying the profile of oneself, clean and tidy instrument
Hold, self-confident smile, pure and fresh implication can strengthen self-confidence during human communication.But the serious shadow of halitosiss (halitosis)
Ring social activity, daily life, work and the commercial interest and inter personal contact of people.Halitosis is broadly divided into two big types, and one, exempt from
Epidemic disease. visceral dysfunction halitosis disease；2nd, pure oral cavity halitosis disease.It is aobvious according to the investigation of Third National oral health epidemiological
Show：Up to 97% adult is perplexed by oral problem, and in other words, most of Chinese adult has oral cavity
Problem, and show effect for a long time.Oral problem includes dental calculuss, dental caries, gingiva problem, sensitivity of tooth, implication problem, tooth stain and tooth
Bacterial plaque, wants away from oral problem, and at present about 20% people (2.6 hundred million) is with stomatitis, and oral ulcer, oral cavity is routed
Infectionss sickness rate is only second to dental caries and periodontal disease.
To meet the needs of etiquette, most people are clear by using chewing gum and alcoholic collutory or implication
New agent is covering halitosiss, but chewing gum contains sugar and plasticizer, unhealthful, pollutes environment, the usual taste of alcohol type product
Road is choked very much, and zest is big, and poor durability, it is impossible to keep pure and fresh effect for a long time.For this situation, it is proposed not on market
Few product related to oral cavity health, such as chewing gum, mouth containing bag.But these dosage forms, comparatively, slowly effect, and use
Come inconvenient, be especially embodied in old people or have with the crowd of oral disease.
At present, the treatment to oral disease adopts chemistry, antibiotics mostly, although playing certain work at that time
With, but with the Reusability of these medicines, a series of adverse effect is brought, many drug-fast strains are generated, to flesh
Body brings toxic and side effects, and due to the complexity of oral environment, there is the incorrect situation using with Drug abuse, causes anti-
Recurrence is made, and ingredient easily enters human body by oral cavity, potentially hazardous so as to produce to body.In recent years, enzyme
The treatment of oral disease is used for, but a kind of enzyme can only act on one kind or a class material, and also the effect of enzyme needs to fit
Suitable temperature and pH, with significant limitation.
At present, sugar and additive component on the market contained by most of sprays does not only play phase for user
The effect answered, is also easy to grow intraoral antibacterial because sugar is too high on the contrary, and then corrodes tooth.It is not appropriate for oral cavity cleaning
With treatment ulcer.
The content of the invention
The present invention proposes a kind of natural micro-calcium oral spray, and it is rich in sugar to solve oral spray in prior art,
And then to the problem in purification oral cavity can not be reached.
The technical scheme is that what is be achieved in that：A kind of natural micro-calcium oral spray, it is characterised in that the spray
Mist agent is made up of ultra micro calcium powder and adjuvant, and the percentage by weight of the ultra micro calcium powder is 0.5%～1%, and the adjuvant is taste masking
Agent, absorption enhancer, bacteria remover, eliminating smell agent, solvent,
Wherein, the correctivess are the one kind in maltose alcohol, xylitol, sucralose, mannitol, the correctivess
Percentage by weight be 1～5%；
The absorption enhancer is the one kind in Tween 80, edible glycerol, ethanol, the weight percent of the absorption enhancer
Than for 0.5～2%；
The bacteria remover is the one kind in Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Herba Menthae, the weight hundred of the bacteria remover
Divide than being 2%～5%；
The eliminating smell agent is the one kind in Fructus Citri Limoniae essence, paeonol, eugenol, tea polyphenols, the weight hundred of the eliminating smell agent
Divide than being 0.2%～0.5%；
The solvent is pure water, and the percentage by weight of the solvent is 90%～95%.
Preferably, the correctivess are xylitol, and the absorption enhancer is edible glycerol, and the bacteria remover is Flos Lonicerae
Extract, the eliminating smell agent is paeonol.
Preferably, the spray each component and weight ratio are：Ultra micro calcium powder 0.7%, xylitol 2%, edible glycerol
0.6%, Flos Lonicerae extract 4%, paeonol 0.3%, pure water 92.7%.
Preferably, the raw material of the ultra micro calcium powder is one or more in ocean Margarita, Concha Margaritifera and Corallium Japonicum Kishinouye.
Preferably, the ultra micro calcium powder is prepared according to patent ZL201410140698.7 technique, and powder particle diameter is 0.1～10
μm。
Beneficial effect of the present invention produced by compared with background technology：
Select ultra micro calcium powder, micro-calcium that there is the effect of hemostasis in formula, its activation clotting mechanism：Intracellular calcium is adjusted
A kind of albumen and calcium binding, complex of formation can activate the activity of internal various enzymes, if skin is hurt, occur
Bleed phenomenon, calcium ion sends at once signal, thrombin is activated step by step, start clotting mechanism, to stop blooding.And the grain of micro-calcium
Footpath is nanoscale, adsorbable oral cavity food debriss, goes the generation root that eliminates the unusual smell；One of raw material of micro-calcium is Margarita,《Herbal guiding principle
Mesh》In refer to, the effects such as Margarita has arresting convulsion of calming the nerves, heat-clearing and toxic substances removing, anti-inflammatory analgetic, skin, the closing in granulation promoting of moistening, therefore ultra micro
Calcium oral spray has the effect for promoting oral ulcer healing, and Margarita also has whitening effect, can remove dental plaque.
Flos Lonicerae extract is also selected in formula, its effective ingredient is chlorogenic acid, and its action and efficacy is embodied in antiinflammatory, antibacterial
Two aspects, putrid food easily grows the microorganisms such as a large amount of antibacterials in oral cavity, Flos Lonicerae extract can effective killing microorganisms, control
Oral ulcer is treated, prevents the generation of oral disease.
Paeonol is added in spray, energy reducing swelling and alleviating pain, prevents and treats dental caries, covers the effects such as halitosis, cleaning oral cavity.
Specific embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described enforcement
Example is only a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model of present invention protection
Enclose.
A kind of natural micro-calcium oral spray, it is characterised in that the spray is made up of ultra micro calcium powder and adjuvant, described
The percentage by weight of ultra micro calcium powder is 0.5%～1%, and the adjuvant is correctivess, absorption enhancer, bacteria remover, eliminating smell agent, molten
Agent,
Wherein, the correctivess are the one kind in maltose alcohol, xylitol, sucralose, mannitol, the correctivess
Percentage by weight be 1～5%；
The absorption enhancer is the one kind in Tween 80, edible glycerol, ethanol, the weight percent of the absorption enhancer
Than for 0.5～2%；
The bacteria remover is the one kind in Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Herba Menthae, the weight hundred of the bacteria remover
Divide than being 2%～5%；
The eliminating smell agent is the one kind in Fructus Citri Limoniae essence, paeonol, eugenol, tea polyphenols, the weight hundred of the eliminating smell agent
Divide than being 0.2%～0.5%；
The solvent is pure water, and the percentage by weight of the solvent is 90%～95%.
Preferably, the correctivess are xylitol, and the absorption enhancer is edible glycerol, and the bacteria remover is Flos Lonicerae
Extract, the eliminating smell agent is paeonol.
Preferably, the spray each component and weight ratio are：Ultra micro calcium powder 0.7%, xylitol 2%, edible glycerol
0.6%, Flos Lonicerae extract 4%, paeonol 0.3%, pure water 92.7%.
Preferably, the raw material of the ultra micro calcium powder is one or more in ocean Margarita, Concha Margaritifera and Corallium Japonicum Kishinouye.
Preferably, the ultra micro calcium powder is prepared according to patent ZL201410140698.7 technique, and powder particle diameter is 0.1～10
μm。
Embodiment one
A kind of natural micro-calcium oral spray, it is characterised in that the spray each component and weight ratio are：Micro-calcium
Powder 0.5%, xylitol 1%, edible glycerol 0.5%, Flos Lonicerae extract 2%, paeonol 0.2%, pure water 90%.
Embodiment two
A kind of natural micro-calcium oral spray, it is characterised in that the spray each component and weight ratio are：Micro-calcium
Powder 0.7%, xylitol 2%, edible glycerol 0.6%, Flos Lonicerae extract 4%, paeonol 0.3%, pure water 92.7%.
Embodiment three
A kind of natural micro-calcium oral spray, it is characterised in that the spray each component and weight ratio are：Micro-calcium
Powder 1%, xylitol 5%, edible glycerol 2%, Flos Lonicerae extract 5%, paeonol 0.5%, pure water 95%.
Effect of the oral spray to oral cavity bacterium is tested
Experiment equipment and reagent：Swab stick, 10mL test tubes, spreader, culture dish, plate count culture medium, normal saline
(0.85%).
Experimental procedure：
(1) sterilize：By swab stick, 10mL test tubes, spreader, culture dish, plate count culture medium, physiology required for experiment
Saline carries out 121 DEG C of high temperature sterilize 15min.
(2) it is down flat plate：Carry out being down flat plate technique culture medium under conditions of alcohol burner opens, pouring volume is 20mL or so,
It is waited to solidify.
(3) sample：Three parts of different oral fluids are taken respectively, confirm to contain staphylococcuses, streptococcus, large intestine bar after testing
Bacterium, Candida albicans, process mouth cavity liquid with the micro-calcium oral spray of three different embodiments respectively, after treatment 1s,
The aseptic swab stick that 3s, 5s, 10s, 15s have sterilized is sampled, the 10ml that the swab stick after sampling is added separately to sterilize
In normal saline, the sample for taking 1ml dilutions is coated flat board, flat board is inverted in 37 ± 1 DEG C of constant incubator and is cultivated
18-24h, records the total plate count of each flat board, as a result such as table 1 below.
| Packet | 1s clump counts | 3s clump counts | 5s clump counts | 10s clump counts | 15s clump counts |
| Embodiment one | 35 | 22 | 10 | 0 | 0 |
| Embodiment two | 35 | 20 | 7 | 0 | 0 |
| Embodiment three | 35 | 24 | 9 | 0 | 0 |
As can be seen from the above table, micro-calcium oral spray has good inhibiting effect to oral cavity bacterium.
Presently preferred embodiments of the present invention is the foregoing is only, not to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (5)
1. a kind of natural micro-calcium oral spray, it is characterised in that the spray is made up of ultra micro calcium powder and adjuvant is described super
The percentage by weight of micro- calcium powder is 0.5%～1%, and the adjuvant is correctivess, absorption enhancer, bacteria remover, eliminating smell agent, molten
Agent,
Wherein, the correctivess are the one kind in maltose alcohol, xylitol, sucralose, mannitol, the weight of the correctivess
Amount percentage ratio is 1～5%；
The absorption enhancer is the one kind in Tween 80, edible glycerol, ethanol, and the percentage by weight of the absorption enhancer is
0.5～2%；
The bacteria remover is the one kind in Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Herba Menthae, the percentage by weight of the bacteria remover
For 2%～5%；
The eliminating smell agent is the one kind in Fructus Citri Limoniae essence, paeonol, eugenol, tea polyphenols, the percentage by weight of the eliminating smell agent
For 0.2%～0.5%；
The solvent is pure water, and the percentage by weight of the solvent is 90%～95%.
2. a kind of natural micro-calcium oral spray as claimed in claim 1, it is characterised in that：
The correctivess are xylitol, and the absorption enhancer is edible glycerol, and the bacteria remover is Flos Lonicerae extract, described
Eliminating smell agent is paeonol.
3. a kind of natural micro-calcium oral spray as claimed in claim 2, it is characterised in that
The spray each component and weight ratio are：Ultra micro calcium powder 0.7%, xylitol 2%, edible glycerol 0.6%, Flos Lonicerae carries
Take thing 4%, paeonol 0.3%, pure water 92.7%.
4. a kind of natural micro-calcium oral spray as described in claim 1 or 3, it is characterised in that：
The raw material of the ultra micro calcium powder is one or more in ocean Margarita, Concha Margaritifera and Corallium Japonicum Kishinouye.
5. a kind of natural micro-calcium oral spray as claimed in claim 2, it is characterised in that：
The ultra micro calcium powder is prepared according to patent ZL201410140698.7 technique, and powder particle diameter is at 0.1～10 μm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610878686.3A CN106619778A (en) | 2016-10-09 | 2016-10-09 | Natural ultra-micro calcium oral spray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610878686.3A CN106619778A (en) | 2016-10-09 | 2016-10-09 | Natural ultra-micro calcium oral spray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106619778A true CN106619778A (en) | 2017-05-10 |
Family
ID=58853672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610878686.3A Pending CN106619778A (en) | 2016-10-09 | 2016-10-09 | Natural ultra-micro calcium oral spray |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106619778A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110934159A (en) * | 2019-12-24 | 2020-03-31 | 贵州贵安精准医学研究院股份有限公司 | Development and application of natural bactericidal spray |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721117A (en) * | 2015-02-12 | 2015-06-24 | 青岛食安生物工程有限公司 | Active calcium bacteriostatic mouth wash |
| CN103892285B (en) * | 2014-04-10 | 2015-08-19 | 青岛食安生物工程有限公司 | The preparation technology of pure natural ultra micro calcium powder |
-
2016
- 2016-10-09 CN CN201610878686.3A patent/CN106619778A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103892285B (en) * | 2014-04-10 | 2015-08-19 | 青岛食安生物工程有限公司 | The preparation technology of pure natural ultra micro calcium powder |
| CN104721117A (en) * | 2015-02-12 | 2015-06-24 | 青岛食安生物工程有限公司 | Active calcium bacteriostatic mouth wash |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110934159A (en) * | 2019-12-24 | 2020-03-31 | 贵州贵安精准医学研究院股份有限公司 | Development and application of natural bactericidal spray |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |
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| RJ01 | Rejection of invention patent application after publication |