CN106619731A - Medicine for treating hepatitis C - Google Patents
Medicine for treating hepatitis C Download PDFInfo
- Publication number
- CN106619731A CN106619731A CN201611258362.6A CN201611258362A CN106619731A CN 106619731 A CN106619731 A CN 106619731A CN 201611258362 A CN201611258362 A CN 201611258362A CN 106619731 A CN106619731 A CN 106619731A
- Authority
- CN
- China
- Prior art keywords
- ethanol
- hepatitis
- extract
- medicine
- cockroach
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Insects & Arthropods (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicine for treating hepatitis C. The medicine for treating the hepatitis C is prepared by a method comprising the following steps: soaking periplaneta americana in ethanol which is 60-95% in concentration; conducting ultrasonic extraction at 30-50 DEG C for 3-5 times; decompressing and concentrating obtained extracting solutions; adding water to obtained concentrated periplaneta americana ethanol liquid, stirring the concentrated liquid, preserving heat and standing by until the concentrated liquid is layered; decompressing and concentrating obtained lower water liquid, so that a periplaneta americana extractum for treating the hepatitis C is obtained; and drying and crushing the extractum so as to a a periplaneta americana extract for treating the hepatitis C, uniformly mixing the periplaneta americana extract and ribavirin at the ratio of 1-4: 5, and adding a pharmaceutically acceptable carrier, so that the medicine for treating the hepatitis C is prepared. The medicine can take an inhibitory effect on hepatitis C viruses, remove the viruses, relieve hepatic inflammation activity and fibrosis and prevent the further development of the hepatitis C into liver cirrhosis, and moreover, the medicine can promote the tissue regeneration of hepatic cells, accelerate exfoliation of necrotic hepatic cells and repair damaged hepatic cells at a high speed, so that purposes of repairing and protecting liver and curing the hepatitis C are achieved.
Description
Technical field
The present invention relates to a kind of process for preparing medicine, more particularly to a kind of treat medicine of hepatitis and preparation method thereof.
Background technology
Hepatitis are a kind of virus hepatitis caused by HCV (HCV) infection, main Jing transfuses blood, pin is perverse,
Drug abuse etc. is propagated, and is counted according to the World Health Organization, and the infection rate of global HCV is about 3%, estimates that about 1.8 hundred million people infect
HCV, it is annual newly to send out hepatitis C case about 3.5 ten thousand.Hepatitis C is in global prevalence, and liver chronic inflammation can be caused bad
Dead and fibrillatable, some patientss can develop into cirrhosis even hepatocellular carcinoma (HCC).Cirrhosis is a kind of common Chronic Liver
Disease.Many reasons cause liver damage, and liver is in progressive, diffusivity, fibrous lesions.It is embodied in liver cell diffusivity
, there is proliferation of fibrous tissue and the regeneration of liver cell nodules shape then in degeneration necrosis, and these three change staggeredly is carried out repeatedly, as a result liver
Leaflet structure and blood circulation path are gradually reconstructed, and made liver deformation, be hardened and cause cirrhosis.The disease early stage is without obvious disease
There is a series of different degrees of portal hypertensions and hepatosis in shape, stage, until there is UGB, liver property
The complication such as encephalopathic and cause death.To have carried out using albumin preparation in existing doctor trained in Western medicine and treat hepatopathy, but costly, the course for the treatment of
It is long, need to use all the life, and cure rate is very low, can only control symptom.
Without this saying of hepatitis in China's traditional Chinese medicine document, but, according to its symptom, sign, can be summarized in
The category of traditional Chinese medicine jaundice, hypochondriac pain, its cause of disease is more due to eating and drinking without temperance, delicious food of being addicted to drink, the damp and hot heresy of diseases caused by external factors virus, causes functions of spleen and stomach
Can be impaired, the dysfunction of the spleen in transport, damp retention in middle-jiao accumulates and steams in liver and gall, and liver is not familiar to let out, and bile is excessive, impregnated in skin, dirty in bladder,
Jaundice, stagnant heat in the liver and gall, functional activity of QI being not smooth are formed, therefore coerces distending pain.Therefore middle treatment hepatitis, can be by regulating functional activities of qi, promoting blood circulation and removing blood stasis, improvement
Body interior environment, adjusts body immunity, improves immunologic mechanism, improves cellular immunity and humoral immunity, so as to suppress disease
Poison growth, aids in clearing heat and detoxicating medicine so as to thoroughly remove hepatitis C virus, is allowed to not recur, dead stroke.
In recent years, medicine for treatment of the domestic and international many enterprises to hepatitis also had very big progress, but the current country is still
The listing of oral hepatitis curative without import or independent research, therefore for the patient of China, there is somewhat expensive, purchase is difficult
The problems such as, these deficiencies are occupy, in order to meet the demand of China country hepatitis C infections patient, a kind of effective, inexpensive, secondary work of exploitation
It is imperative with the high original new drug of the cost performance of little treatment hepatitis.
The content of the invention
It is an object of the present invention to provide a kind of process for preparing medicine for treating hepatitis C, the medicine obtained using the preparation method
Thing not only has significant effect to curing hepatitis, and can promote liver cell regeneration in therapeutic process, accelerates downright bad liver
Cell detachment, quickly repairs wounded hepatocytes, so as to reach maintenance, protection liver, cures the purpose of hepatitis.
The present invention realizes above-mentioned purpose using following methods：
A, dry American cockroach is crossed 10-40 mesh sieve crushing, be 60%～95% by gained American cockroach meal concentration
Ethanol soaks, and makes ethanol liquid level be higher by meal 5～10cm of liquid level, and closed preservation one more than week less than 18 months, is obtained thick
Powder mixed liquor；
B, by step A gained meal mixed liquor 3～5 ultrasonic extractions are carried out at a temperature of 30～50 DEG C, ultrasonic power is：
20-30KHz, when carrying out extracting for the first time to meal mixed liquor, the ethanol of 5～8 times of amount concentration 60%～95% of overstriking grain weight amount is carried
The time is taken for 30～60min；Extract the ethanol of 3～6 times of amount concentration 60%～95% of overstriking grain weight amount after second every time, extract
Time is 2～50min；Merge extract, filter to obtain American cockroach ethanol extract；
C, by step B gained ethanol extract reduce pressure dense under conditions of vacuum -0.05～-0.06MPa, 50～60 DEG C of temperature
Contracting, to proportion be 1.05～1.15 when, obtain American cockroach ethanol concentrate；
D, the purified water that step C gained American cockroach ethanol concentrate is added 7～10 times of amounts of its weight, warming while stirring is extremely
85～95 DEG C, then constant temperature stir 10～60 minutes, mixing speed be 20～60 revs/min, then insulation stand be allowed within 1～5 hour
Layering；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate 60～80 DEG C of temperature, vacuum -0.05～-
Be evaporated under the conditions of 0.06MPa proportion for 1.25～1.35 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract；
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 60-80 DEG C, by weight
Amount number meter, by gained American-cockroach-extract：Ribavirin=1-4:5 are well mixed, auxiliary pharmaceutically acceptable carrier,
The medicine for the treatment of hepatitis C is obtained.
Preferably, in step F, step E gained medicinal extract must be treated into U.S. of hepatitis after dries pulverizing under the conditions of 60-80 DEG C
The big Lian extracts in continent, count by weight, by gained American-cockroach-extract：Ribavirin=1-2:5 are well mixed, auxiliary medicine
Acceptable carrier on, that is, be obtained the medicine for the treatment of hepatitis C.
Preferably, step B is completed in four times, is operated as follows：Step A gained meal mixed liquor is carried out into ultrasonic extraction 4 times：
First time ultrasonic extraction：30～35 DEG C of temperature, ultrasonic power 20-25KHz, 5～8 times of amount concentration 60% of overstriking grain weight amount～
95% ethanol, extraction time is 30～60min；
Second ultrasonic extraction：35～40 DEG C of temperature, ultrasonic power 23-28KHz, 3～6 times of amount concentration 60% of overstriking grain weight amount～
95% ethanol, extraction time is 20～50min；
Third time ultrasonic extraction：40～45 DEG C of temperature, ultrasonic power 25-30KHz, 3～6 times of amount concentration 60% of overstriking grain weight amount～
95% ethanol, extraction time is 35～50min；
4th ultrasonic extraction：45～50 DEG C of temperature, ultrasonic power 28-30KHz, 5～8 times of amount concentration 60% of overstriking grain weight amount～
95% ethanol, extraction time is 45～60min；
Merge No. four extracts, filter to obtain American cockroach ethanol extract.
It is highly preferred that step B is completed in four times, operate as follows：Step A gained meal mixed liquor is carried out into ultrasonic extraction 4
It is secondary：
First time ultrasonic extraction：Temperature 30-35 DEG C, ultrasonic power 20-22KHz, 5～8 times of amount concentration 75% of overstriking grain weight amount～
95% ethanol, extraction time is 35～45min.
Second ultrasonic extraction：Temperature 35-40 DEG C, ultrasonic power 23-25KHz, 3～6 times of amount concentration 75% of overstriking grain weight amount
～95% ethanol, extraction time is 35～45min.
Third time ultrasonic extraction：Temperature 40-45 DEG C, ultrasonic power 28-30KHz, 3～6 times of amount concentration 95% of overstriking grain weight amount
Ethanol, extraction time be 45～50min.
4th ultrasonic extraction：Temperature 45-50 DEG C, ultrasonic power 30KHz, 7～8 times of amount concentration 75-95% of overstriking grain weight amount
Ethanol, extraction time be 55～60min.
It is highly preferred that in step D, step C gained American cockroach ethanol concentrate is added into the pure of 7～10 times of amounts of its weight
Change water, warming while stirring is to 85～90 DEG C, then constant temperature is stirred 45～60 minutes, and mixing speed is 45～60 revs/min, Ran Houbao
Temperature stands and is allowed to be layered for 4～5 hours.
Beneficial effect：
1st, insoluble matter amount in the American-cockroach-extract medicinal extract water of the treatment hepatitis for obtaining is extracted using income approach of the present invention low
In 5%, total amino acid content is higher than 15%, and pyrimidine alkali content is higher than 0.1%.
2nd, the medicine for the treatment of hepatitis C of the present invention, not only there is inhibitory action to hepatitis C virus, removes virus, mitigates
Hepatic fibrosis and fibrillatable, prevent from being further development of cirrhosis by hepatitis C, and may additionally facilitate liver cell group
Regeneration is knitted, is accelerated downright bad liver cell and is come off, quickly repair wounded hepatocytes, so as to reach maintenance, protection liver, cure hepatitis
Purpose.
3rd, the medicine for the treatment of hepatitis C of the present invention, by adjusting human immune system and cell anti-virus mechanism,
The environment for being unfavorable for virus replication is set up in patient's body, reduces the various side effects brought using Ribavirin.
Specific embodiment
Embodiment 1
A kind of medicine for treating hepatitis C, is realized using following methods：
A, dry American cockroach is crossed the crushing of 10 mesh sieve, by the immersion of ethanol that gained American cockroach meal concentration is 90%,
Make ethanol liquid level be higher by meal liquid level 5cm, in one week of closed preservation, meal mixed liquor is obtained；
B, step A gained meal mixed liquor is carried out into ultrasonic extraction 4 times：
First time ultrasonic extraction：30 DEG C of temperature, ultrasonic power 20KHz, the ethanol of 5 times of amount concentration 90% of overstriking grain weight amount, during extraction
Between be 30min；
Second ultrasonic extraction：40 DEG C of temperature, ultrasonic power 23KHz, the ethanol of 3 times of amount concentration 90% of overstriking grain weight amount, during extraction
Between be 20min；
Third time ultrasonic extraction：Temperature 45 C, ultrasonic power 25KHz, the ethanol of 3 times of amount concentration 90% of overstriking grain weight amount, during extraction
Between be 35min；
4th ultrasonic extraction：Temperature 50 C, ultrasonic power 28KHz, the ethanol of 5 times of amount concentration 90% of overstriking grain weight amount, during extraction
Between be 45min；
Merge No. four extracts, filter to obtain American cockroach ethanol extract；
C, by step B gained ethanol extract reduced pressure concentration under conditions of vacuum -0.05MPa, temperature 50 C, be to proportion
When 1.05, American cockroach ethanol concentrate is obtained；
D, the purified water that step C gained American cockroach ethanol concentrate is added 7 times of amounts of its weight, warming while stirring to 85
DEG C, then constant temperature stir 10 minutes, mixing speed be 20 revs/min, then insulation stand be allowed to be layered within 1 hour；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate is in temperature 60 C, vacuum -0.05MPa conditions
Under be evaporated to proportion for 1.25 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract.
Insoluble matter amount in the American-cockroach-extract medicinal extract water of the treatment hepatitis for obtaining is extracted using income approach of the present invention
3.4%, total amino acid content 18.5%, pyrimidine alkali content 0.16%.
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 80 DEG C, press
Parts by weight meter, by gained American-cockroach-extract 20g, Ribavirin 100g is well mixed, and active ingredient mixture is obtained, and takes
Above-mentioned active ingredient mixture mixes with starch, dextrin, microcrystalline cellulose, the common 210g of sodium carboxymethyl starch according to common process
Even, then granulation routinely adds magnesium stearate, mixes, and is pressed into 1000, obtains final product oral tablet.
Case-data and packet：10 patients, age 21-56 year, average age：33 ± 8.9, the course of disease at -5 years 7 months,
Average course of disease：36 ± 9.5 months, patient's Jing hospital diagnosis were suffering from different degrees of chronic hepatitis C, patient have it is tired or
It is weak, to detest greasy or receive difference, the symptom such as uncomfortable liver area has small number of patients to have upper right abdominal pressure pain, hepatomegaly, skin icteric sclera etc.,
ALT is in normal or has light moderate to raise, and HCV-Ab IgG and HCV-RNA are positive.Patient is randomly divided into treatment group 5, it is right
According to group 5.
Treatment method：Patient monthly did not received any treatment with regard to hepatitis C for one before the treatment.Treatment group's mouth
The medicine of the treatment hepatitis C prepared by the present embodiment is taken, per natural gift morning, the noon, is taken for late three times, each take 3, serve on
30 days.Control group per natural gift morning, the noon, is taken for late three times only with oral ribavirin 1000mg/d.All patients are controlling
Good diet is kept to be accustomed to work and rest during treatment.
Criterion of therapeutical effect（1）It is effective：After the course for the treatment of terminates, cardinal symptom disappears or basic disappearance, and ALT recovers normal；（3）Have
Effect：Symptom improves, and ALT declines>L/3；（3）It is invalid：Cardinal symptom, sign are not improved, and ALT is without significant change or adds
Weight.
Treatment results：Treatment group is effective 3, effective 2, invalid 0；Control group is effective 1, effective 2, invalid 2,
Two groups are compared, and therapeutic effect has significant difference.Meanwhile, HCV-RNA turns out cloudy 3 after treatment group's treatment, turns out cloudy within 1 year after treatment 2
Example；HCV-RNA turns out cloudy 1 after treatment of control group, turns out cloudy 1 within 1 year after treatment, and two groups relatively have significant difference.Therapeutic process
In, treatment group patient has no bad reaction；There is poor appetite 2, mild rash 1 in control group patient.
Embodiment 2
A kind of medicine for treating hepatitis C, is realized using following methods：
A, dry American cockroach is crossed the crushing of 40 mesh sieve, by the immersion of ethanol that gained American cockroach meal concentration is 70%,
Ethanol liquid level is set to be higher by meal liquid level 10cm, closed preservation 18 months is obtained meal mixed liquor；
B, step A gained meal mixed liquor is carried out into ultrasonic extraction 4 times：
First time ultrasonic extraction：35 DEG C of temperature, ultrasonic power 25KHz, the ethanol of 8 times of amount concentration 70% of overstriking grain weight amount, during extraction
Between be 60min；
Second ultrasonic extraction：40 DEG C of temperature, ultrasonic power 28KHz, the ethanol of 6 times of amount concentration 75% of overstriking grain weight amount, during extraction
Between be 50min；
Third time ultrasonic extraction：40 DEG C of temperature, ultrasonic power 30KHz, the ethanol of 6 times of amount concentration 75% of overstriking grain weight amount, during extraction
Between be 50min；
4th ultrasonic extraction：Temperature 45 C, ultrasonic power 30KHz, the ethanol of 8 times of amount concentration 80% of overstriking grain weight amount, during extraction
Between be 60min；
Merge No. four extracts, filter to obtain American cockroach ethanol extract；
C, by step B gained ethanol extract reduced pressure concentration under conditions of vacuum -0.06MPa, temperature 60 C, be to proportion
When 1.15, American cockroach ethanol concentrate is obtained；
D, the purified water that step C gained American cockroach ethanol concentrate is added 10 times of amounts of its weight, warming while stirring to 95
DEG C, then constant temperature stir 60 minutes, mixing speed be 60 revs/min, then insulation stand be allowed to be layered within 5 hours；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate is in 80 DEG C of temperature, vacuum -0.06MPa conditions
Under be evaporated to proportion for 1.35 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract.
Insoluble matter amount in the American-cockroach-extract medicinal extract water of the treatment hepatitis for obtaining is extracted using income approach of the present invention
3.5%, total amino acid content 17.5%, pyrimidine alkali content 0.2%.
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 80 DEG C, press
Parts by weight meter, by gained American-cockroach-extract 25g, Ribavirin 100g is well mixed, and active ingredient mixture is obtained, and takes
Above-mentioned active ingredient mixture mixes with starch, dextrin, microcrystalline cellulose, the common 210g of sodium carboxymethyl starch according to common process
Even, then granulation routinely adds magnesium stearate, mixes, and is pressed into 1000, obtains final product oral tablet.
Case-data and packet：8 patients, age 22-53 year, average age：35 ± 6.5, the course of disease was at 7 months -5.8
Year, average course of disease：37 ± 4.1 months, patient's Jing hospital diagnosis were suffering from different degrees of chronic hepatitis C, and patient has tired
Or it is weak, to detest greasy or receive difference, the symptom such as uncomfortable liver area has small number of patients to have upper right abdominal pressure pain, hepatomegaly, skin icteric sclera
Deng, ALT in normal or have light moderate to raise, HCV-Ab IgG and HCV-RNA are positive.Patient is randomly divided into treatment group 4
Example, control group 4.
Treatment method：Patient monthly did not received any treatment with regard to hepatitis C for one before the treatment.Treatment group's mouth
The medicine of the treatment hepatitis C prepared by the present embodiment is taken, per natural gift morning, the noon, is taken for late three times, each take 3, serve on
30 days.Control group per natural gift morning, the noon, is taken for late three times only with oral ribavirin 1000mg/d.All patients are controlling
Good diet is kept to be accustomed to work and rest during treatment.
Criterion of therapeutical effect（1）It is effective：After the course for the treatment of terminates, cardinal symptom disappears or basic disappearance, and ALT recovers normal；（3）Have
Effect：Symptom improves, and ALT declines>L/3；（3）It is invalid：Cardinal symptom, sign are not improved, and ALT is without significant change or adds
Weight.
Treatment results：Treatment group is effective 2, effective 2, invalid 0, and control group is effective 0, effective 2, invalid 2.
Two groups are compared, and therapeutic effect has significant difference.Meanwhile, HCV-RNA turns out cloudy 2 after treatment group's treatment, turns out cloudy within 1 year after treatment 2
Example；HCV-RNA turns out cloudy 1 after treatment of control group, turns out cloudy 0 within 1 year after treatment, and two groups relatively have significant difference.Therapeutic process
In, the patient for the treatment of group has no bad reaction；There is poor appetite 2, mild rash 1 in control group patient.
Embodiment 3
A kind of medicine for treating hepatitis C, is realized using following methods：
A, dry American cockroach is crossed the crushing of 20 mesh sieve, by the immersion of ethanol that gained American cockroach meal concentration is 75%,
Ethanol liquid level is set to be higher by meal liquid level 6cm, closed preservation 12 months is obtained meal mixed liquor；
B, step A gained meal mixed liquor is carried out into ultrasonic extraction 4 times：
First time ultrasonic extraction：30 DEG C of temperature, ultrasonic power 20KHz, the ethanol of 5 times of amount concentration 75% of overstriking grain weight amount, during extraction
Between be 35～45min；
Second ultrasonic extraction：40 DEG C of temperature, ultrasonic power 23KHz, the ethanol of 3 times of amount concentration 80% of overstriking grain weight amount, during extraction
Between be 35min；
Third time ultrasonic extraction：Temperature 45 C, ultrasonic power 28KHz, the ethanol of 3 times of amount concentration 85% of overstriking grain weight amount, during extraction
Between be 45min；
4th ultrasonic extraction：Temperature 45 C, ultrasonic power 30KHz, the ethanol of 7 times of amount concentration 85% of overstriking grain weight amount, during extraction
Between be 55min；
Merge No. four extracts, filter to obtain American cockroach ethanol extract；
C, by step B gained ethanol extract reduced pressure concentration under conditions of vacuum -0.05MPa, temperature 50 C, be to proportion
When 1.05, American cockroach ethanol concentrate is obtained；
D, the purified water that step C gained American cockroach ethanol concentrate is added 7 times of amounts of its weight, warming while stirring to 85
DEG C, then constant temperature stir 50 minutes, mixing speed be 50 revs/min, then insulation stand be allowed to be layered within 4 hours；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate is in temperature 70 C, vacuum -0.05MPa conditions
Under be evaporated to proportion for 1.25 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract.
Insoluble matter amount in the American-cockroach-extract medicinal extract water of the treatment hepatitis for obtaining is extracted using income approach of the present invention
2.9%, total amino acid content 19.6%, pyrimidine alkali content 0.25%.
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 60 DEG C, press
Parts by weight meter, by step F gained American-cockroach-extract 35g, Ribavirin 100g is well mixed, and active ingredient mixing is obtained
Thing, takes above-mentioned active ingredient mixture and mixes according to common process with microcrystalline cellulose, lactose, the common 200g of sodium carboxymethylcellulose
Uniformly, pelletize, then routinely add magnesium stearate, mix, filled hard capsules obtain final product oral hard capsule agent into 2000.
Case-data and packet：8 patients, age 21-56 year, average age：33 ± 8.9, the course of disease was at 7 months -5.6
Year, average course of disease：34 ± 9.5 months, patient's Jing hospital diagnosis were suffering from different degrees of chronic hepatitis C, and patient has tired
Or it is weak, to detest greasy or receive difference, the symptom such as uncomfortable liver area has small number of patients to have upper right abdominal pressure pain, hepatomegaly, skin icteric sclera
Deng, ALT in normal or have light moderate to raise, HCV-Ab IgG and HCV-RNA are positive.Patient is randomly divided into treatment group 6, is compareed
Group 2.
Treatment method：Patient monthly did not received any treatment with regard to hepatitis C, treatment group's mouth for one before the treatment
The medicine of the treatment hepatitis C prepared by embodiment 3 is taken, per natural gift morning, the noon, is taken for late three times, each take 6, serve on 30
My god.Control group per natural gift morning, the noon, is taken for late three times only with oral ribavirin 1000mg/d.All patients are in treatment
Period keeps good diet to be accustomed to work and rest.
Criterion of therapeutical effect（1）It is effective：After the course for the treatment of terminates, cardinal symptom disappears or basic disappearance, and ALT recovers normal；（3）Have
Effect：Symptom improves, and ALT declines>L/3；（3）It is invalid：Cardinal symptom, sign are not improved, and ALT is without significant change or adds
Weight.
Treatment results：Treatment group is effective 3, effective 3, invalid 0；Control group is effective 0, effective 1, invalid 1.
Two groups are compared, and therapeutic effect has significant difference.Meanwhile, HCV-RNA turns out cloudy 3 after treatment group's treatment, turns out cloudy within 1 year after treatment 2
Example；HCV-RNA turns out cloudy 0 after treatment of control group, turns 0 within 1 year after treatment, and two groups relatively have significant difference.Therapeutic process
In, treatment group patient has no bad reaction, and poor appetite 1, mild rash 0 occurs in control group patient.
Embodiment 4
A kind of medicine for treating hepatitis C, is realized using following methods：
A, dry American cockroach is crossed the crushing of 30 mesh sieve, by the immersion of ethanol that gained American cockroach meal concentration is 80%,
Ethanol liquid level is set to be higher by meal liquid level 10cm, closed preservation 6 months is obtained meal mixed liquor；
B, step A gained meal mixed liquor is carried out into ultrasonic extraction 4 times：
First time ultrasonic extraction：35 DEG C of temperature, ultrasonic power 22KHz, the ethanol of 8 times of amount concentration 80% of overstriking grain weight amount, during extraction
Between be 45min；
Second ultrasonic extraction：40 DEG C of temperature, ultrasonic power 25KHz, the ethanol of 6 times of amount concentration 80% of overstriking grain weight amount, during extraction
Between be 45min；
Third time ultrasonic extraction：Temperature 45 C, ultrasonic power 30KHz, the ethanol of 6 times of amount concentration 85% of overstriking grain weight amount, during extraction
Between be 50min；
4th ultrasonic extraction：Temperature 50 C, ultrasonic power 30KHz, the ethanol of 8 times of amount concentration 85% of overstriking grain weight amount, during extraction
Between be 60min；
Merge No. four extracts, filter to obtain American cockroach ethanol extract；
C, by step B gained ethanol extract reduced pressure concentration under conditions of vacuum -0.06MPa, temperature 60 C, be to proportion
When 1.15, American cockroach ethanol concentrate is obtained；
D, the purified water that step C gained American cockroach ethanol concentrate is added 10 times of amounts of its weight, warming while stirring to 90
DEG C, then constant temperature stir 60 minutes, mixing speed be 60 revs/min, then insulation stand be allowed to be layered within 5 hours；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate is in 80 DEG C of temperature, vacuum -0.06MPa conditions
Under be evaporated to proportion for 1.35 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract.
Insoluble matter amount in the American-cockroach-extract medicinal extract water of the treatment hepatitis for obtaining is extracted using income approach of the present invention
3.4%, total amino acid content 17%, pyrimidine alkali content 0.2%.
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 60 DEG C, press
Parts by weight meter, by step F gained American-cockroach-extract 60g, Ribavirin 100g is well mixed, and active ingredient mixing is obtained
Thing, takes above-mentioned active ingredient mixture and mixes according to common process with microcrystalline cellulose, lactose, the common 200g of sodium carboxymethylcellulose
Uniformly, pelletize, then routinely add magnesium stearate, mix, filled hard capsules obtain final product oral hard capsule agent into 2000.
Case-data and packet：9 patients, age 20-59 year, average age：32 ± 9.5 years old, the course of disease 7 months-
6.2, average course of disease：36 ± 4.2 months, patient's Jing hospital diagnosis were suffering from different degrees of chronic hepatitis C, and patient has tired
It is tired or weak, to detest greasy or receive difference, the symptom such as uncomfortable liver area has small number of patients to have upper right abdominal pressure pain, hepatomegaly, skin icteric sclera
Deng, ALT in normal or have light moderate to raise, HCV-Ab IgG and HCV-RNA are positive.Patient is randomly divided into treatment group 5, it is right
According to group 4.
Treatment method：Patient monthly did not received any treatment with regard to hepatitis C, treatment group's mouth for one before the treatment
The medicine of the treatment hepatitis C prepared by embodiment 3 is taken, per natural gift morning, the noon, is taken for late three times, each take 6, serve on 30
My god.Control group per natural gift morning, the noon, is taken for late three times only with oral ribavirin 1000mg/d.All patients are in treatment
Period keeps good diet to be accustomed to work and rest.
Criterion of therapeutical effect（1）It is effective：After the course for the treatment of terminates, cardinal symptom disappears or basic disappearance, and ALT recovers normal；（3）Have
Effect：Symptom improves, and ALT declines>L/3；（3）It is invalid：Cardinal symptom, sign are not improved, and ALT is without significant change or adds
Weight.
Treatment results：Treatment group is effective 3, effective 2, invalid 1；Control group is effective 1, effective 2, invalid 2.
Two groups are compared, and therapeutic effect has significant difference.Meanwhile, HCV-RNA turns out cloudy 3 after treatment group's treatment, turns out cloudy within 1 year after treatment 2
Example；HCV-RNA turns out cloudy 1 after treatment of control group, turns out cloudy 1 within 1 year after treatment, and two groups relatively have significant difference.Therapeutic process
In, there is poor appetite 1 in treatment group's bad reaction, and poor appetite 1 occurs in mild rash 0, control group patient, slightly
Fash 1.
Embodiment 5
A kind of medicine for treating hepatitis C, is realized using following methods：
A, dry American cockroach is crossed the crushing of 30 mesh sieve, by the immersion of ethanol that gained American cockroach meal concentration is 85%,
Ethanol liquid level is set to be higher by meal liquid level 8cm, closed preservation 8 months is obtained meal mixed liquor；
B, step A gained meal mixed liquor is carried out into ultrasonic extraction 4 times：
First time ultrasonic extraction：35 DEG C of temperature, ultrasonic power 21KHz, the ethanol of 7 times of amount concentration 85% of overstriking grain weight amount, during extraction
Between be 40min；
Second ultrasonic extraction：40 DEG C of temperature, ultrasonic power 24KHz, the ethanol of 5 times of amount concentration 85% of overstriking grain weight amount, during extraction
Between be 40min；
Third time ultrasonic extraction：Temperature 45 C, ultrasonic power 28KHz, the ethanol of 5 times of amount concentration 90% of overstriking grain weight amount, during extraction
Between be 50min；
4th ultrasonic extraction：Temperature 45 C, ultrasonic power 30KHz, the ethanol of 7 times of amount concentration 90% of overstriking grain weight amount, during extraction
Between be 55min；
Merge No. four extracts, filter to obtain American cockroach ethanol extract；
C, by step B gained ethanol extract reduced pressure concentration under conditions of vacuum -0.06MPa, 55 DEG C of temperature, be to proportion
When 1.05, American cockroach ethanol concentrate is obtained；
D, the purified water that step C gained American cockroach ethanol concentrate is added 8 times of amounts of its weight, warming while stirring to 85
DEG C, then constant temperature stir 50 minutes, mixing speed be 50 revs/min, then insulation stand be allowed to be layered within 5 hours；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate is in temperature 70 C, vacuum -0.050MPa conditions
Under be evaporated to proportion for 1.35 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract.
Insoluble matter amount in the American-cockroach-extract medicinal extract water of the treatment hepatitis for obtaining is extracted using income approach of the present invention
4.1%, total amino acid content 18.2%, pyrimidine alkali content 0.2%.
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 80 DEG C, press
Parts by weight meter, by gained American-cockroach-extract 80g, Ribavirin 100g is well mixed, and active ingredient mixture is obtained, and takes
Above-mentioned active ingredient mixture mixes with starch, dextrin, microcrystalline cellulose, the common 210g of sodium carboxymethyl starch according to common process
Even, then granulation routinely adds magnesium stearate, mixes, and is pressed into 1000, obtains final product oral tablet.
Case-data and packet：7 patients, age 22-55 year, average age：34 ± 7.5, the course of disease was at 7 months -5.6
Year, average course of disease：35 ± 5.1 months, patient's Jing hospital diagnosis were suffering from different degrees of chronic hepatitis C, and patient has tired
Or it is weak, to detest greasy or receive difference, the symptom such as uncomfortable liver area has small number of patients to have upper right abdominal pressure pain, hepatomegaly, skin icteric sclera
Deng, ALT in normal or have light moderate to raise, HCV-Ab IgG and HCV-RNA are positive.Patient is randomly divided into treatment group 4, is compareed
Group 3.
Treatment method：Patient monthly did not received any treatment with regard to hepatitis C, treatment group's mouth for one before the treatment
The medicine of the treatment hepatitis C prepared by the present embodiment is taken, per natural gift morning, the noon, is taken for late three times, each take 3, serve on
30 days.Control group per natural gift morning, the noon, is taken for late three times only with oral ribavirin 1000mg/d.All patients are controlling
Good diet is kept to be accustomed to work and rest during treatment.
Criterion of therapeutical effect（1）It is effective：After the course for the treatment of terminates, cardinal symptom disappears or basic disappearance, and ALT recovers normal；（3）Have
Effect：Symptom improves, and ALT declines>L/3；（3）It is invalid：Cardinal symptom, sign are not improved, and ALT is without significant change or adds
Weight.
Treatment results：Treatment group is effective 2, effective 2, invalid 0；Control group is effective 0, effective 2, invalid 1.
Two groups are compared, and therapeutic effect has significant difference.Meanwhile, HCV-RNA turns out cloudy 2 after treatment group's treatment, turns out cloudy within 1 year after treatment 2
Example；HCV-RNA turns out cloudy 1 after treatment of control group, turns 0 within 1 year after treatment, and two groups relatively have significant difference.Therapeutic process
In, there is poor appetite 0 to there is poor appetite 1, mild rash 1, control group patient in treatment group's bad reaction, slightly
Fash 1.
Embodiment 6
A kind of medicine for treating hepatitis C, is realized using following methods：
A, dry American cockroach is crossed the crushing of 10 mesh sieve, by the immersion of ethanol that gained American cockroach meal concentration is 90%,
Make ethanol liquid level be higher by meal liquid level 5cm, in one week of closed preservation, meal mixed liquor is obtained；
B, by step A gained meal mixed liquor 5 ultrasonic extractions are carried out at a temperature of 30 DEG C, ultrasonic power is：20-30KHz,
When carrying out extracting for the first time to meal mixed liquor, the ethanol of 5 times of amount concentration 65% of overstriking grain weight amount, extraction time is 60min；The
Extract the ethanol of 5 times of amount concentration 65% of overstriking grain weight amount after secondary every time, extraction time is 40min；Merge extract, filter
Obtain American cockroach ethanol extract；
C, by step B gained ethanol extract reduced pressure concentration under conditions of vacuum -0.05MPa, temperature 50 C, be to proportion
When 1.05, American cockroach ethanol concentrate is obtained；
D, the purified water that step C gained American cockroach ethanol concentrate is added 7 times of amounts of its weight, warming while stirring to 85
DEG C, then constant temperature stir 10 minutes, mixing speed be 20 revs/min, then insulation stand be allowed to be layered within 1 hour；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate is in temperature 60 C, vacuum -0.05MPa conditions
Under be evaporated to proportion for 1.25 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract.
Insoluble matter amount in the American-cockroach-extract medicinal extract water of the treatment hepatitis for obtaining is extracted using income approach of the present invention
4.0%, total amino acid content 17.8%, pyrimidine alkali content 0.17%.
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 70 DEG C, press
Parts by weight meter, by step F gained American-cockroach-extract 40g, Ribavirin 100g is well mixed, and active ingredient mixing is obtained
Thing, takes above-mentioned active ingredient mixture and mixes according to common process with microcrystalline cellulose, lactose, the common 200g of sodium carboxymethylcellulose
Uniformly, pelletize, then routinely add magnesium stearate, mix, filled hard capsules obtain final product oral hard capsule agent into 2000.
Case-data and packet：5 patients, age 23-58 year, average age：33 ± 9.1, the course of disease was at 7 months -5.2
Year, average course of disease：34 ± 9.5 months, patient's Jing hospital diagnosis were suffering from different degrees of chronic hepatitis C, and patient has tired
Or it is weak, to detest greasy or receive difference, the symptom such as uncomfortable liver area has small number of patients to have upper right abdominal pressure pain, hepatomegaly, skin icteric sclera
Deng, ALT in normal or have light moderate to raise, HCV-Ab IgG and HCV-RNA are positive.Patient is randomly divided into treatment group 3, is compareed
Group 2.
Treatment method：Patient monthly did not received any treatment with regard to hepatitis C, treatment group's mouth for one before the treatment
The medicine of the treatment hepatitis C prepared by the present embodiment 6 is taken, per natural gift morning, the noon, is taken for late three times, each take 6, serve on
30 days.Control group per natural gift morning, the noon, is taken for late three times only with oral ribavirin 1000mg/d.All patients are in treatment
Period keeps good diet to be accustomed to work and rest.
Criterion of therapeutical effect（1）It is effective：After the course for the treatment of terminates, cardinal symptom disappears or basic disappearance, and ALT recovers normal；（3）Have
Effect：Symptom improves, and ALT declines>L/3；（3）It is invalid：Cardinal symptom, sign are not improved, and ALT is without significant change or adds
Weight.
Treatment results：Treatment group is effective 2, effective 1, invalid 0；Control group is effective 0, effective 1, invalid 1.
Two groups are compared, and therapeutic effect has significant difference.Meanwhile, HCV-RNA turns out cloudy 2 after treatment group's treatment, turns out cloudy within 1 year after treatment 1
Example；HCV-RNA turns out cloudy 1 after treatment of control group, turns out cloudy 0 within 1 year after treatment, and two groups relatively have significant difference.Therapeutic process
In, there is poor appetite 0 in treatment group's bad reaction, and poor appetite 1, slight skin occurs in mild rash 1, control group patient
Rash 0.
Embodiment 7
A kind of medicine for treating hepatitis C, is realized using following methods：
A, dry American cockroach is crossed the crushing of 20 mesh sieve, by the immersion of ethanol that gained American cockroach meal concentration is 60%,
Ethanol liquid level is set to be higher by meal liquid level 6cm, closed preservation 12 months is obtained meal mixed liquor；
B, by step A gained meal mixed liquor 3 ultrasonic extractions are carried out at a temperature of 50 DEG C, ultrasonic power is：25KHz is right
When meal mixed liquor carries out extracting for the first time, the ethanol of 8 times of amount concentration 60% of overstriking grain weight amount, extraction time is 50min；Second
Extract the ethanol of 4 times of amount concentration 60% of overstriking grain weight amount after secondary every time, extraction time is 50min；Merge extract, filter
American cockroach ethanol extract；
C, by step B gained ethanol extract reduced pressure concentration under conditions of vacuum -0.05MPa, temperature 50 C, be to proportion
When 1.05, American cockroach ethanol concentrate is obtained；
D, the purified water that step C gained American cockroach ethanol concentrate is added 7 times of amounts of its weight, warming while stirring to 85
DEG C, then constant temperature stir 50 minutes, mixing speed be 50 revs/min, then insulation stand be allowed to be layered within 4 hours；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate is in temperature 70 C, vacuum -0.05MPa conditions
Under be evaporated to proportion for 1.25 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract.
Insoluble matter amount in the American-cockroach-extract medicinal extract water of the treatment hepatitis for obtaining is extracted using income approach of the present invention
3.5%, total amino acid content 18.5%, pyrimidine alkali content 0.22%.
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 70 DEG C, press
Parts by weight meter, by step F gained American-cockroach-extract 40g, Ribavirin 100g is well mixed, and active ingredient mixing is obtained
Thing, takes above-mentioned active ingredient mixture and mixes according to common process with microcrystalline cellulose, lactose, the common 200g of sodium carboxymethylcellulose
Uniformly, pelletize, then routinely add magnesium stearate, mix, filled hard capsules obtain final product oral hard capsule agent into 2000.
Case-data and packet：8 patients, 36 ± 5.7 years old age, average age：39.2 years old, the course of disease at -6 years 7 months,
Average course of disease：35 ± 4.5 months, patient's Jing hospital diagnosis were suffering from different degrees of chronic hepatitis C, patient have it is tired or
It is weak, to detest greasy or receive difference, the symptom such as uncomfortable liver area has small number of patients to have upper right abdominal pressure pain, hepatomegaly, skin icteric sclera etc.,
ALT is in normal or has light moderate to raise, and HCV-Ab IgG and HCV-RNA are positive.Patient is randomly divided into treatment group 4, control group 4
Example.
Treatment method：Patient monthly did not received any treatment with regard to hepatitis C, treatment group's mouth for one before the treatment
The medicine of the treatment hepatitis C prepared by the present embodiment 6 is taken, per natural gift morning, the noon, is taken for late three times, each take 6, serve on
30 days.Control group per natural gift morning, the noon, is taken for late three times only with oral ribavirin 1000mg/d.All patients are in treatment
Period keeps good diet to be accustomed to work and rest.
Criterion of therapeutical effect（1）It is effective：After the course for the treatment of terminates, cardinal symptom disappears or basic disappearance, and ALT recovers normal；（3）Have
Effect：Symptom improves, and ALT declines>L/3；（3）It is invalid：Cardinal symptom, sign are not improved, and ALT is without significant change or adds
Weight.
Treatment results：Treatment group is effective 2, effective 2, invalid 0；Control group is effective 1, effective 1, invalid 2,
Two groups are compared, and therapeutic effect has significant difference.Meanwhile, HCV-RNA turns out cloudy 2 after treatment group's treatment, turns out cloudy within 1 year after treatment 2
Example；HCV-RNA turns out cloudy 1 after treatment of control group, turns out cloudy 1 within 1 year after treatment, and two groups relatively have significant difference.Therapeutic process
In, there is poor appetite 1 in treatment group's bad reaction, and poor appetite 1, slight skin occurs in mild rash 1, control group patient
Rash 1.
Claims (5)
1. a kind of medicine for treating hepatitis C, it is characterised in that realize above-mentioned purpose using following methods：
A, dry American cockroach is crossed 10-40 mesh sieve crushing, be 60%～95% by gained American cockroach meal concentration
Ethanol soaks, and makes ethanol liquid level be higher by meal 5～10cm of liquid level, and closed preservation one more than week less than 18 months, is obtained thick
Powder mixed liquor；
B, by step A gained meal mixed liquor 3～5 ultrasonic extractions are carried out at a temperature of 30～50 DEG C, ultrasonic power is：
20-30KHz, when carrying out extracting for the first time to meal mixed liquor, the ethanol of 5～8 times of amount concentration 60%～95% of overstriking grain weight amount is carried
The time is taken for 30～60min；Extract the ethanol of 3～6 times of amount concentration 60%～95% of overstriking grain weight amount after second every time, extract
Time is 2～50min；Merge extract, filter to obtain American cockroach ethanol extract；
C, by step B gained ethanol extract reduce pressure dense under conditions of vacuum -0.05～-0.06MPa, 50～60 DEG C of temperature
Contracting, to proportion be 1.05～1.15 when, obtain American cockroach ethanol concentrate；
D, the purified water that step C gained American cockroach ethanol concentrate is added 7～10 times of amounts of its weight, warming while stirring is extremely
85～95 DEG C, then constant temperature stir 10～60 minutes, mixing speed be 20～60 revs/min, then insulation stand be allowed within 1～5 hour
Layering；
E, step D gained lower floor aqueous are released, Jing after filter paper is filtered, filtrate 60～80 DEG C of temperature, vacuum -0.05～-
Be evaporated under the conditions of 0.06MPa proportion for 1.25～1.35 when, obtain final product treatment hepatitis American-cockroach-extract medicinal extract；
F, the American-cockroach-extract that step E gained medicinal extract must be treated hepatitis after dries pulverizing under the conditions of 60-80 DEG C, by weight
Amount number meter, by gained American-cockroach-extract：Ribavirin=1-4:5 are well mixed, auxiliary pharmaceutically acceptable carrier,
The medicine for the treatment of hepatitis C is obtained.
2. a kind of medicine for treating hepatitis C according to claim 1, it is characterised in that in step F, by step E institute
Obtaining medicinal extract must treat the American-cockroach-extract of hepatitis after dries pulverizing under the conditions of 60-80 DEG C, count by weight, by gained
American-cockroach-extract：Ribavirin=1-2:5 are well mixed, auxiliary pharmaceutically acceptable carrier, that is, the third type liver for the treatment of is obtained
Scorching medicine.
3. a kind of medicine for treating hepatitis C according to claim 1, it is characterised in that step B is completed in four times, behaviour
Make as follows：
First time ultrasonic extraction：30～35 DEG C of temperature, ultrasonic power 20-25KHz, 5～8 times of amount concentration 60% of overstriking grain weight amount～
95% ethanol, extraction time is 30～60min；
Second ultrasonic extraction：35～40 DEG C of temperature, ultrasonic power 23-28KHz, 3～6 times of amount concentration 60% of overstriking grain weight amount～
95% ethanol, extraction time is 20～50min；
Third time ultrasonic extraction：40～45 DEG C of temperature, ultrasonic power 25-30KHz, 3～6 times of amount concentration 60% of overstriking grain weight amount～
95% ethanol, extraction time is 35～50min；
4th ultrasonic extraction：45～50 DEG C of temperature, ultrasonic power 28-30KHz, 5～8 times of amount concentration 60% of overstriking grain weight amount～
95% ethanol, extraction time is 45～60min；
Merge No. four extracts, filter to obtain American cockroach ethanol extract.
4. a kind of medicine for treating hepatitis C according to claim 1 or 3, it is characterised in that step B is complete in four times
Into operation is as follows：
First time ultrasonic extraction：Temperature 30-35 DEG C, ultrasonic power 20-22KHz, 5～8 times of amount concentration 75% of overstriking grain weight amount～
95% ethanol, extraction time is 35～45min；
Second ultrasonic extraction：Temperature 35-40 DEG C, ultrasonic power 23-25KHz, 3～6 times of amount concentration 75% of overstriking grain weight amount～
95% ethanol, extraction time is 35～45min；
Third time ultrasonic extraction：Temperature 40-45 DEG C, ultrasonic power 28-30KHz, the second of 3～6 times of amount concentration 95% of overstriking grain weight amount
Alcohol, extraction time is 45～50min；
4th ultrasonic extraction：Temperature 45-50 DEG C, ultrasonic power 30KHz, the second of 7～8 times of amount concentration 75-95% of overstriking grain weight amount
Alcohol, extraction time is 55～60min.
5. a kind of medicine for treating hepatitis C according to claim 1, it is characterised in that in step D, by step C institute
The purified waters that American cockroach ethanol concentrate adds 7～10 times of amounts of its weight are obtained, warming while stirring is to 85～90 DEG C, then constant temperature
Stirring 45～60 minutes, mixing speed is 45～60 revs/min, and then insulation stands and is allowed to be layered for 4～5 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611258362.6A CN106619731B (en) | 2016-12-30 | 2016-12-30 | Medicine for treating hepatitis C |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611258362.6A CN106619731B (en) | 2016-12-30 | 2016-12-30 | Medicine for treating hepatitis C |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106619731A true CN106619731A (en) | 2017-05-10 |
| CN106619731B CN106619731B (en) | 2020-06-12 |
Family
ID=58837449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611258362.6A Active CN106619731B (en) | 2016-12-30 | 2016-12-30 | Medicine for treating hepatitis C |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106619731B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424052A (en) * | 2003-01-07 | 2003-06-18 | 昆明赛诺制药有限公司 | Medicine for treating chronic hepatitis B |
| CN1647813A (en) * | 2004-05-28 | 2005-08-03 | 曹春林 | Medicine for treating hepatitis and its preparing method |
| WO2008082488A1 (en) * | 2006-12-22 | 2008-07-10 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
| CN102885856A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Production method for producing medicine for treating hepatitis B by periplaneta americana extract |
| CN102885855A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Production method for preparing medicine for treating peptic ulcer by periplaneta americana extract |
| CN102885858A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Method for preparing American cockroach extract for treating hepatitis B |
| CN104367594A (en) * | 2013-08-12 | 2015-02-25 | 成都百草和济科技有限公司 | New application of drug residues after alcohol extraction of American cockroach |
| CN105055730A (en) * | 2015-09-08 | 2015-11-18 | 山东中医药大学附属医院 | Method for preparing nursing plaster for treating angina |
-
2016
- 2016-12-30 CN CN201611258362.6A patent/CN106619731B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424052A (en) * | 2003-01-07 | 2003-06-18 | 昆明赛诺制药有限公司 | Medicine for treating chronic hepatitis B |
| CN1647813A (en) * | 2004-05-28 | 2005-08-03 | 曹春林 | Medicine for treating hepatitis and its preparing method |
| WO2008082488A1 (en) * | 2006-12-22 | 2008-07-10 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
| CN102885856A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Production method for producing medicine for treating hepatitis B by periplaneta americana extract |
| CN102885855A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Production method for preparing medicine for treating peptic ulcer by periplaneta americana extract |
| CN102885858A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Method for preparing American cockroach extract for treating hepatitis B |
| CN104367594A (en) * | 2013-08-12 | 2015-02-25 | 成都百草和济科技有限公司 | New application of drug residues after alcohol extraction of American cockroach |
| CN105055730A (en) * | 2015-09-08 | 2015-11-18 | 山东中医药大学附属医院 | Method for preparing nursing plaster for treating angina |
Non-Patent Citations (1)
| Title |
|---|
| 田凌云 等: "中药联合派罗欣及利巴韦林治疗慢性丙型肝炎32例", 《中西医结合肝病杂志》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106619731B (en) | 2020-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101143171B (en) | Traditional Chinese medicine and its preparation method and its application | |
| CN104173696A (en) | Dressing used for postoperative nursing of appendicitis and preparation method of dressing | |
| CN101342194B (en) | Traditional Chinese medicine preparation for treating median or late-stage malignant tumors, chronic hepatitis B, and preparation method thereof | |
| CN101433590A (en) | Chinese medicine for treating skin erosion and pruritus and preparation method thereof | |
| CN108936178A (en) | It is a kind of for preventing and treating the solid beverage and preparation method thereof of dysmenorrhea and gynaecological imflammation | |
| CN108904742A (en) | A kind of clearing damp Chinese medicine composition | |
| CN100431568C (en) | Chinese medicine for treating puerperal hypogalactia | |
| CN106619731A (en) | Medicine for treating hepatitis C | |
| CN102988747B (en) | Aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia and preparation method thereof | |
| CN104888004A (en) | Chinese medicinal herb granules for treating coronary heart diseases and preparation method thereof | |
| CN103417669B (en) | Drug for treatment of abdominal pain and diarrhea | |
| CN103860788A (en) | Traditional Chinese medicinal preparation for treating fatty liver and preparation method of traditional Chinese medicinal preparation | |
| CN103054979A (en) | Traditional Chinese medical formula for treating neonatal jaundice | |
| CN109758537A (en) | A kind of Chinese medicine composition for preventing and treating liver and gallbladder real example disease | |
| CN103784851B (en) | A kind of Chinese medicine preparation and preparation method for the treatment of Menieres disease | |
| CN102462785A (en) | Medicinal composition for treating acquired immune deficiency syndrome viruses and preparation method thereof | |
| CN100490874C (en) | Chinese medicine composition for treating diabetes and method for preparing the same | |
| CN106237063A (en) | A kind of capsule treating pulmonary fibrosis disease | |
| CN105311485A (en) | Preparation method of oral liquid for treating and treating toxic and side effect reactions of radiotherapy and chemotherapy | |
| CN104666659A (en) | Traditional Chinese medicine preparation for treating fatty liver and preparation method of traditional Chinese medicine preparation | |
| CN112472758A (en) | Acid-reducing tea for relieving gout and preparation method thereof | |
| CN104971315A (en) | Antibacterial gel for treating injury wound infection and preparation method of antibacterial gel | |
| CN104435950A (en) | Traditional Chinese medicinal styptic powder for treating upper gastrointestinal hemorrhage and preparation method thereof | |
| CN102961681A (en) | Chinese patent medicine for treating viral myocarditis | |
| CN114288354A (en) | Medicinal liquor for treating helicobacter pylori and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |