CN102885855A - Production method for preparing medicine for treating peptic ulcer by periplaneta americana extract - Google Patents
Production method for preparing medicine for treating peptic ulcer by periplaneta americana extract Download PDFInfo
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Abstract
The invention provides a production method for preparing a medicine for treating peptic ulcer by a periplaneta americana extract, comprising the following steps of: A, dissolving, B, diluting, C, filtering and D, filling. A method for extracting the periplaneta americana extract for treating peptic ulcer comprises the following steps of: a, crushing, b, soaking, c, extracting, d, primarily concentrating, e, degreasing and d, secondarily concentrating. In the extraction process, hydrolysis of active substances for treating peptic ulcer in the extract can be prevented, and the curative effect of the medicine can be improved due to reasonable control on each process parameter; by using the medicine prepared by the method, the cure rate of peptic ulcer can achieve more than 55-70%, and the total effective rate of the medicine can achieve 97-99%; and due to addition of glycerol in the medicine solution, the taste of the medicine solution can be improved, and the synergistic effect of the curative effects can be acted together with the periplaneta americana extract for treating peptic ulcer. The production method disclosed by the invention is short in the process route, and capable of reducing production cost and increasing production efficiency.
Description
Technical field
The present invention relates to medical technical field, relate in particular to a kind of production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine.
Background technology
Periplaneta americana (Periplaneta americana) is the insecticide of volume maximum in the Blattidae, becomes long 29～35 millimeters of polypide, bronzing, and wing is longer than abdomen end.Feeler is very long, larger butterfly brown speckle is arranged in the middle of the pronotary, and the trailing edge of speckle has complete yellow band stricture of vagina, originates in South America, feeding habits extensively, happiness sugar and starch, contaminated food.
Periplaneta americana is traditional Chinese crude drug, is used as medicine with adult.Salty in the mouth cold in nature, poisonous, acid is arranged, dissipating blood stasis is arranged, the function such as removing food stagnancy, detoxifcation, diuretic, detumescence.Modern study is found, the periplaneta americana epidermis contains the elements such as sclerotin, chitin, bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium, muscle is hydrolyzed 13 seed amino acids, health is preserved the plain B1 of little life, B2, nicotinic acid and ascorbic acid etc., lymph contains trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc., all contains ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.
The dry polypide extract of periplaneta americana, contain WHF (polyalcohols, epidermal growth factor), sticking propylhomoserin, sticking sugared propylhomoserin and several amino acids isoreactivity material, having antiinflammatory, detumescence, promotion cell proliferation and new granulation tissue increases, accelerate the disease damage tissue repair, accelerate slough and come off, improve the effects such as body's immunity.
Periplaneta americana all has application at aspects such as treatment burn and scald, oral ulcer, gastric ulcer, hemorrhoid, anal fissure, gastritis and peptic gastric ulcer, gastric ulcer colitis, gynaecopathia, diaper rash, allergic rhinitis, antitumor at present, but, present application mostly is the Chinese medicine application mode, certain applications be dry adult as the part of medicament composing prescription, part is with the use of its extract and other drug compatibility.
Although there are some open to the extracting method of American-cockroach-extract,, the contained composition of periplaneta americana is more, and the composition that different extracting modes obtains is difference to some extent also, and extract obtained also have different effects to different diseases.But present disclosed technology is extracted the technical matters that is used for the treatment of certain disease for the specific active ingredient of periplaneta americana still immature, and deep processing and the depth extraction of carrying out for the treatment specified disease will become new development trend.
Summary of the invention
The purpose of this invention is to provide a kind of production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine, using this method produces, can make in the American-cockroach-extract the effective composition of digestive tract ulcer is kept well, to improve the cure rate of digestive tract ulcer.
The present invention adopts following technology to realize above-mentioned purpose:
Production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine may further comprise the steps:
A, dissolving: count by weight, get 50～100 parts of 6～10 parts of American-cockroach-extracts, medicinal glycerins, 10～25 parts of antiseptic that the treatment digestive tract ulcer is used, add 500 parts of purified water, 70-80 ℃ of lower the stirring 10～30 minutes, the American-cockroach-extract that the treatment digestive tract ulcer is used fully dissolves the dense medicinal liquid that must prepare;
B, dilution: get above-mentioned dense medicinal liquid, add 1000 parts of purified water ad pond oms, stir and be heated to 60～80 ℃, insulated and stirred makes it naturally be cooled to room temperature after 10～30 minutes, namely get rare medicinal liquid;
C, filtration: get above-mentioned rare medicinal liquid, through filter paper filtering, collect filtrate, namely get the medicinal liquid for the treatment of digestive tract ulcer;
D, fill: the medicinal liquid of getting the treatment digestive tract ulcer carries out fill and namely makes oral liquid.
The extracting method of the American-cockroach-extract that described treatment digestive tract ulcer is used may further comprise the steps:
A, pulverizing: the periplaneta americana polypide of drying is pulverized, cross 24 mesh sieves, make the periplaneta americana coarse powder;
B, immersion: with the soak with ethanol of step a gained periplaneta americana coarse powder with concentration 90%～95%, make the ethanol liquid level exceed the airtight preservation of coarse powder liquid level 5～10cm, make the coarse powder mixed liquor;
C, extraction: step b gained coarse powder mixed liquor is carried out reflux, extract, 3～5 times under 70～85 ℃ temperature, when the coarse powder mixed liquor is carried out extracting the first time, the ethanol of 5～8 times of amounts of overstriking grain weight amount concentration 90%～95%, extraction time is 4～6 hours; Each ethanol that extracts 3～6 times of amounts of overstriking grain weight amount concentration 90%～95% for the second time, extraction time is 3～5 hours; Merge extractive liquid, filters to get ethanol extract;
D, one-level are concentrated: with step c gained ethanol extract vacuum-0.05～-condition of 50～60 ℃ of 0.06MPa, temperature under concentrating under reduced pressure, to proportion be 1.05～1.15 o'clock, get the ethanol concentrated solution;
E, defat: the purified water that steps d gained ethanol concentrated solution is added 7～10 times of amounts of ethanol concentrated solution weight, behind warming while stirring to 85～95 ℃, stirred 10～60 minutes, mixing speed is 20～60 rev/mins, and then insulation is left standstill and made the profit layering in 1～5 hour;
F, secondary concentrate: step e gained lower layer of water liquid is emitted, behind filter paper filtering, filtrate 60～80 ℃ of temperature, vacuum-0.05～-the 0.06MPa condition under concentrating under reduced pressure, being concentrated into proportion is 1.25～1.35 o'clock, must treat the American-cockroach-extract that digestive tract ulcer is used.
Medicinal glycerol in the described steps A, the distilled water that adds before use 60～80 ℃ of 1～2.5 times of amounts of medicinal glycerin weight dilutes rear use.
Described step c can be by the following technical solutions: step B gained coarse powder mixed liquor is carried out reflux, extract, 4 times under 75～80 ℃ temperature, when the coarse powder mixed liquor is carried out extracting the first time, add the ethanol of 5 times of amounts of coarse powder concentration 92%, extraction time is 5 hours; Each ethanol that adds 4 times of amounts of coarse powder concentration 92% that extracts for the second time, extraction time is 4 hours, merge extractive liquid, filters to get ethanol extract.
Described step e can be by the following technical solutions: the purified water that steps d gained ethanol concentrated solution is added 8 times of amounts of ethanol concentrated solution weight, behind warming while stirring to 85～95 ℃, stirred 40 minutes, mixing speed is 40 rev/mins, and then insulation is left standstill and made the profit layering in 4 hours.
Described antiseptic be sodium benzoate, Nipagin ester.
Beneficial effect of the present invention:
The method of the invention is devoted to be used to specified disease, the development of specific active ingredient application direction by pure Chinese medicine, the process route that adopts can make in the periplaneta americana to be assembled the specific active ingredient for the treatment of digestive tract ulcer, thereby improves simple American-cockroach-extract to the therapeutic effect for the treatment of digestive tract ulcer.The beneficial effect that concrete technology has is as follows:
1, adopt this process route to extract, can effectively remove a large amount of protein that contain in the periplaneta americana, the grease removal rate is high, and the extract oils and fats content (ligroin extraction) that obtains is in the A(trap)/W(weight) be no more than 0.30.
2, with the soak with ethanol coarse powder of concentration 90%～95%, can prevent that not only microbial reproduction from causing the periplaneta americana coarse powder putrid and deteriorated, prolong the holding time, and can improve the specific active ingredient yield for the treatment of digestive tract ulcer.
3, adopt technological process of the present invention, can be up to 13%～22% to the effectively final extractive content of digestive tract ulcer, and adopt the medicine of the treatment digestive tract ulcer of this extract preparation, and its cure rate to digestive tract ulcer can reach more than the 55-70%, and total effective rate can reach 97-99%.
4, adopt process route of the present invention to extract, reasonable because of each process parameter control, therefore can prevent that the active substance to the treatment digestive tract ulcer is hydrolyzed in the extract, improve its curative effect of medication.
5, add glycerol both can improve medicinal liquid in medicinal liquid mouthfeel, can play the drug effect synergism with the American-cockroach-extract that the treatment digestive tract ulcer is used again.
6, adopt the method for the invention production, the product Determination of Free Amino Acids is greater than 0.8mg/ml, and pH value can be controlled between the 4.5-7.5;
7, the used process route of the present invention is brief, can reduce production costs, and enhances productivity.
Specific embodiment
Embodiment 1
Production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine may further comprise the steps:
A, dissolving: get the American-cockroach-extract 6Kg that uses for the treatment of digestive tract ulcer, distilled water 50Kg that medicinal glycerin 50Kg adds 80 ℃ before use and dilute the distilled water 50Kg that rear use, sodium benzoate 10Kg add 80 ℃ before use and dilute rear use, add purified water 500L, 80 ℃ of lower stirrings 10 minutes, the American-cockroach-extract that the treatment digestive tract ulcer is used fully dissolves the dense medicinal liquid that must prepare;
B, dilution: get above-mentioned dense medicinal liquid, add purified water to cumulative volume 1000L, stir and be heated to 80 ℃, insulated and stirred makes it naturally be cooled to room temperature after 10 minutes, namely get rare medicinal liquid;
C, filtration: get above-mentioned rare medicinal liquid, through filter paper filtering, collect filtrate, namely get the medicinal liquid for the treatment of digestive tract ulcer;
D, fill: the medicinal liquid of getting the treatment digestive tract ulcer carries out fill, can be made into the mixture of 30ml, 50ml, 100ml and 150ml, and the oral liquid of 10ml dress.
The extracting method of the American-cockroach-extract that the treatment digestive tract ulcer is used may further comprise the steps:
A, pulverizing: the periplaneta americana polypide of 200Kg drying is pulverized, cross 24 mesh sieves, make the periplaneta americana coarse powder;
B, immersion: with the soak with ethanol of step a gained periplaneta americana coarse powder with concentration 95%, make the ethanol liquid level exceed the airtight preservation of coarse powder liquid level 5cm, make the coarse powder mixed liquor;
C, extraction: step b gained coarse powder mixed liquor is dropped in the extraction pot, under 70～85 ℃ temperature, carry out reflux, extract, 3 times, when the coarse powder mixed liquor is carried out extracting the first time, the ethanol of 1000Kg concentration 95%, extraction time is 4 hours; Each ethanol that adds 600Kg concentration 95% that extracts for the second time, extraction time is 3 hours; Merge extractive liquid, filters to get ethanol extract;
D, one-level are concentrated: step c gained ethanol extract is put into haplo-effect concentrator, vacuum-0.05～-condition of 50～60 ℃ of 0.06MPa, temperature under concentrating under reduced pressure, to proportion be 1.08 o'clock, get the ethanol concentrated solution;
E, defat: steps d gained ethanol concentrated solution is moved in the degreasing tank, add the 380Kg purified water, behind warming while stirring to 85～95 ℃, stirred 10 minutes, mixing speed is 60 rev/mins, then is incubated to leave standstill to make the profit layering in 1 hour;
F, secondary concentrate: step e gained lower layer of water liquid is emitted, behind filter paper filtering, filtrate moves into concentrator, 60～80 ℃ of temperature, vacuum-0.05～-the 0.06MPa condition under concentrating under reduced pressure, being concentrated into proportion is 1.28 o'clock, must treat the American-cockroach-extract that digestive tract ulcer is used.
Adopt above-mentioned technological process, to digestive tract ulcer effectively final extract extract yield reach 12.6%, content can be up to 16.3%, and adopts the medicine of the treatment digestive tract ulcer of this extract preparation, its cure rate to digestive tract ulcer can reach 63.4%, and total effective rate can reach 98.9%.Fat content (ligroin extraction) counts 0.24 with A/W.
Embodiment 2
Production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine may further comprise the steps:
A, dissolving: get the American-cockroach-extract 8Kg that uses for the treatment of digestive tract ulcer, distilled water 120Kg that medicinal glycerin 80Kg adds 60～80 ℃ before use and dilute the distilled water 120Kg that rear use, sodium benzoate 15Kg add 60～80 ℃ before use and dilute rear use, add purified water 500L, 75 ℃ of lower stirrings 20 minutes, the American-cockroach-extract that the treatment digestive tract ulcer is used fully dissolves the dense medicinal liquid that must prepare;
B, dilution: get above-mentioned dense medicinal liquid, add purified water to cumulative volume 1000L, stir and be heated to 70 ℃, insulated and stirred makes it naturally be cooled to room temperature after 20 minutes, namely get rare medicinal liquid;
C, filtration: get above-mentioned rare medicinal liquid, through filter paper filtering, collect filtrate, namely get the medicinal liquid for the treatment of digestive tract ulcer;
D, fill: the medicinal liquid of getting the treatment digestive tract ulcer carries out fill, can be made into the mixture of 30ml, 50ml, 100ml and 150ml, and the oral liquid of 10ml dress.
The extracting method of the American-cockroach-extract that the treatment digestive tract ulcer is used may further comprise the steps:
A, pulverizing: the periplaneta americana polypide of 200Kg drying is pulverized, cross 24 mesh sieves, make the periplaneta americana coarse powder;
B, immersion: with the soak with ethanol of step a gained periplaneta americana coarse powder with concentration 92%, make the ethanol liquid level exceed the airtight preservation of coarse powder liquid level 8cm, make the coarse powder mixed liquor;
C, extraction: step b gained coarse powder mixed liquor is dropped in the extraction pot, under 70～85 ℃ temperature, carry out reflux, extract, 4 times, when the coarse powder mixed liquor is carried out extracting the first time, the ethanol of 1000Kg concentration 92%, extraction time is 5 hours; Each ethanol that adds 800Kg concentration 92% that extracts for the second time, extraction time is 4 hours; Merge extractive liquid, filters to get ethanol extract;
D, one-level are concentrated: step c gained ethanol extract is put into haplo-effect concentrator, vacuum-0.05～-condition of 50～60 ℃ of 0.06MPa, temperature under concentrating under reduced pressure, to proportion be 1.11 o'clock, get the ethanol concentrated solution;
E, defat: steps d gained ethanol concentrated solution is moved in the degreasing tank, add the 416Kg purified water, behind warming while stirring to 85～95 ℃, stirred 40 minutes, mixing speed is 40 rev/mins, then is incubated to leave standstill to make the profit layering in 4 hours;
F, secondary concentrate: step e gained lower layer of water liquid is emitted, behind filter paper filtering, filtrate moves into concentrator, 60～80 ℃ of temperature, vacuum-0.05～-the 0.06MPa condition under concentrating under reduced pressure, being concentrated into proportion is 1.32 o'clock, must treat the American-cockroach-extract that digestive tract ulcer is used.
Adopt above-mentioned technological process, to digestive tract ulcer effectively final extract extract yield reach 15.7%, content can be up to 17.1%, and adopts the medicine of the treatment digestive tract ulcer of this extract preparation, its cure rate to digestive tract ulcer can reach 59.5%, and total effective rate can reach 97.2%.Fat content (ligroin extraction) counts 0.19 with A/W.
Embodiment 3
Production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine may further comprise the steps:
A, dissolving: get the American-cockroach-extract 10Kg that uses for the treatment of digestive tract ulcer, distilled water 250Kg that medicinal glycerin 100Kg adds 60 ℃ before use and dilute the distilled water 250Kg that rear use, Nipagin ester 25Kg add 60 ℃ before use and dilute rear use, add purified water 500L, 70 ℃ of lower stirrings 30 minutes, the American-cockroach-extract that the treatment digestive tract ulcer is used fully dissolves the dense medicinal liquid that must prepare;
B, dilution: get above-mentioned dense medicinal liquid, add purified water to cumulative volume 1000L, stir and be heated to 60 ℃, insulated and stirred makes it naturally be cooled to room temperature after 30 minutes, namely get rare medicinal liquid;
C, filtration: get above-mentioned rare medicinal liquid, through filter paper filtering, collect filtrate, namely get the medicinal liquid for the treatment of digestive tract ulcer;
D, fill: the medicinal liquid of getting the treatment digestive tract ulcer carries out fill, can be made into the mixture of 30ml, 50ml, 100ml and 150ml, and the oral liquid of 10ml dress.
The extracting method of the American-cockroach-extract that the treatment digestive tract ulcer is used may further comprise the steps:
A, pulverizing: the periplaneta americana polypide of 200Kg drying is pulverized, cross 24 mesh sieves, make the periplaneta americana coarse powder;
B, immersion: with the soak with ethanol of step a gained periplaneta americana coarse powder with concentration 90%, make the ethanol liquid level exceed the airtight preservation of coarse powder liquid level 10cm, make the coarse powder mixed liquor;
C, extraction: step b gained coarse powder mixed liquor is dropped in the extraction pot, under 70～85 ℃ temperature, carry out reflux, extract, 5 times, when the coarse powder mixed liquor is carried out extracting the first time, the ethanol of 1600Kg concentration 90%, extraction time is 6 hours; Each ethanol that adds 1200Kg concentration 90% that extracts for the second time, extraction time is 5 hours; Merge extractive liquid, filters to get ethanol extract;
D, one-level are concentrated: step c gained ethanol extract is put into haplo-effect concentrator, vacuum-0.05～-condition of 50～60 ℃ of 0.06MPa, temperature under concentrating under reduced pressure, to proportion be 1.14 o'clock, get the ethanol concentrated solution;
E, defat: steps d gained ethanol concentrated solution is moved in the degreasing tank, add the 430Kg purified water, behind warming while stirring to 85～95 ℃, stirred 60 minutes, mixing speed is 20 rev/mins, then is incubated to leave standstill to make the profit layering in 5 hours;
F, secondary concentrate: step e gained lower layer of water liquid is emitted, behind filter paper filtering, filtrate moves into concentrator, 60～80 ℃ of temperature, vacuum-0.05～-the 0.06MPa condition under concentrating under reduced pressure, being concentrated into proportion is 1.26 o'clock, must treat the American-cockroach-extract that digestive tract ulcer is used.
Adopt above-mentioned technological process, to digestive tract ulcer effectively final extract extract yield reach 16.1%, content can be up to 15.7%, and adopts the medicine of the treatment digestive tract ulcer of this extract preparation, its cure rate to digestive tract ulcer can reach 63.8%, and total effective rate can reach 99.1%.Fat content (ligroin extraction) counts 0.21 with A/W.
Embodiment 4
The medicine of the American-cockroach-extract preparation that the treatment digestive tract ulcer is used and treatment case:
Case-data and grouping: 79 examples are diagnosed as gastric ulcer or stomach and duodenum plyability ulcer through the stomach fiberendoscope; All without complication; Be divided into treatment group 45 example and matched group 34 examples.Treatment group man 28 examples, women 17 examples; 15 ~ 62 years old age; The course of disease 6 months ~ 17 years; Gastric ulcer 38 examples (84.4%), plyability ulcer 7 examples (15.6%).Matched group man 20 examples, women 14 examples, 16 ~ 60 years old age; The course of disease 6 months ~ 15 years; Gastric ulcer 26 examples (76.5%), plyability ulcer 8 examples (23.5%).
Method: matched group adopts triple therapy (the triple therapy scheme that the helicobacter pylori Collaboration on Scientific Research meeting of the whole nation, Hainan in 1999 is recommended): omeprazole 20mg+ amoxicillin 1g+ tinidazole 0.5g, and every day 2 times, early, take before the supper.Treatment group adds above-mentioned (embodiment 2) oral liquid 10ml to be taken on the treatment of control group basis, every day 3 times, sooner or later ante cibum and sleep before each 1 time, took at least 40 minutes with first three connection medicine interval.Two groups of case medications were for 2 weeks, and period in a medicine is quitted smoking, wine and vinegar-pepper irritable food.Treatment finishes rear 4 weeks and checked in 1 year.
Curative effect judging standard: (1) cures: subjective symptoms and sign disappear, the ulcer surface healing; (2) take a turn for the better: subjective symptoms and sign obviously alleviate, and ulcer surface dwindles more than 50%; (3) invalid: subjective symptoms and sign have no and alleviate, and ulcer surface has no and dwindles; (4) recurrence: healing or the front part or all of symptom of rear appearance treatment that takes a turn for the better, and through stomach fiberendoscopy pathological changes positive.(1) cures and to add (2) and transfer to well effectively.
The result: treatment group is cured 30 examples (66.7%), 14 examples that take a turn for the better (31.1%), invalid 1 example (2.2%), effective percentage 97.8%.Matched group is cured 15 examples (44.1%), 13 examples that take a turn for the better (38.2%), invalid 6 examples (17.6%), effective percentage 82.4%.The treatment group cure rate is higher than matched group.
Claims (10)
1. with the production method of American-cockroach-extract preparation treatment digestive tract ulcer medicine, it is characterized in that may further comprise the steps:
A, dissolving: count by weight, get 50～100 parts of 6～10 parts of American-cockroach-extracts, medicinal glycerins, 10～25 parts of antiseptic that the treatment digestive tract ulcer is used, add 500 parts of purified water, 70-80 ℃ of lower the stirring 10～30 minutes, the American-cockroach-extract that the treatment digestive tract ulcer is used fully dissolves the dense medicinal liquid that must prepare;
B, dilution: get above-mentioned dense medicinal liquid, add 1000 parts of purified water ad pond oms, stir and be heated to 60～80 ℃, insulated and stirred makes it naturally be cooled to room temperature after 10～30 minutes, namely get rare medicinal liquid;
C, filtration: get above-mentioned rare medicinal liquid, through filter paper filtering, collect filtrate, namely get the medicinal liquid for the treatment of digestive tract ulcer;
D, fill: the medicinal liquid of getting the treatment digestive tract ulcer carries out fill and namely makes oral liquid.
2. the production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine according to claim 1 is characterized in that, the extracting method of the American-cockroach-extract that described treatment digestive tract ulcer is used may further comprise the steps:
A, pulverizing: the periplaneta americana polypide of drying is pulverized, cross 24 mesh sieves, make the periplaneta americana coarse powder;
B, immersion: with the soak with ethanol of step a gained periplaneta americana coarse powder with concentration 90%～95%, make the ethanol liquid level exceed the airtight preservation of coarse powder liquid level 5～10cm, make the coarse powder mixed liquor;
C, extraction: step b gained coarse powder mixed liquor is carried out reflux, extract, 3～5 times under 70～85 ℃ temperature, when the coarse powder mixed liquor is carried out extracting the first time, the ethanol of 5～8 times of amounts of overstriking grain weight amount concentration 90%～95%, extraction time is 4～6 hours; Each ethanol that extracts 3～6 times of amounts of overstriking grain weight amount concentration 90%～95% for the second time, extraction time is 3～5 hours; Merge extractive liquid, filters to get ethanol extract;
D, one-level are concentrated: with step c gained ethanol extract vacuum-0.05～-condition of 50～60 ℃ of 0.06MPa, temperature under concentrating under reduced pressure, to proportion be 1.05～1.15 o'clock, get the ethanol concentrated solution;
E, defat: the purified water that steps d gained ethanol concentrated solution is added 7～10 times of amounts of ethanol concentrated solution weight, behind warming while stirring to 85～95 ℃, stirred 10～60 minutes, mixing speed is 20～60 rev/mins, and then insulation is left standstill and made the profit layering in 1～5 hour;
F, secondary concentrate: step e gained lower layer of water liquid is emitted, behind filter paper filtering, filtrate 60～80 ℃ of temperature, vacuum-0.05～-the 0.06MPa condition under concentrating under reduced pressure, being concentrated into proportion is 1.25～1.35 o'clock, must treat the American-cockroach-extract that digestive tract ulcer is used.
3. the production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine according to claim 1, it is characterized in that, medicinal glycerol in the described steps A, the distilled water that adds before use 60～80 ℃ of 1～2.5 times of amounts of medicinal glycerin weight dilutes rear use.
4. the production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine according to claim 2, it is characterized in that, medicinal glycerol in the described steps A, the distilled water that adds before use 60～80 ℃ of 1～2.5 times of amounts of medicinal glycerin weight dilutes rear use.
5. the described production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine of any one according to claim 1-4, it is characterized in that, the distilled water that used antiseptic adds 60～80 ℃ of 5～10 times of antiseptic weight amounts before use in the described steps A dilute rear use.
6. the described production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine of any one according to claim 1-4, it is characterized in that, described step c can be by the following technical solutions: step B gained coarse powder mixed liquor is carried out reflux, extract, 4 times under 75～80 ℃ temperature, when the coarse powder mixed liquor is carried out extracting the first time, add the ethanol of 5 times of amounts of coarse powder concentration 92%, extraction time is 5 hours; Each ethanol that adds 4 times of amounts of coarse powder concentration 92% that extracts for the second time, extraction time is 4 hours, merges three times extracting solution, filters to get ethanol extract.
7. the production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine according to claim 5, it is characterized in that, described step c can be by the following technical solutions: step B gained coarse powder mixed liquor is carried out reflux, extract, 4 times under 75～80 ℃ temperature, when the coarse powder mixed liquor is carried out extracting the first time, add the ethanol of 5 times of amounts of coarse powder concentration 92%, extraction time is 5 hours; Each ethanol that adds 4 times of amounts of coarse powder concentration 92% that extracts for the second time, extraction time is 4 hours, merges three times extracting solution, filters to get ethanol extract.
8. the described production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine of any one according to claim 1-4, it is characterized in that, described step e can be by the following technical solutions: the purified water that steps d gained ethanol concentrated solution is added 8 times of amounts of ethanol concentrated solution weight, behind warming while stirring to 85～95 ℃, stirred 40 minutes, mixing speed is 40 rev/mins, and then insulation is left standstill and made the profit layering in 4 hours.
9. the production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine according to claim 5, it is characterized in that, described step e can be by the following technical solutions: the purified water that steps d gained ethanol concentrated solution is added 8 times of amounts of ethanol concentrated solution weight, behind warming while stirring to 85～95 ℃, stirred 40 minutes, mixing speed is 40 rev/mins, and then insulation is left standstill and made the profit layering in 4 hours.
10. the production method with American-cockroach-extract preparation treatment digestive tract ulcer medicine according to claim 6, it is characterized in that, described step e can be by the following technical solutions: the purified water that steps d gained ethanol concentrated solution is added 8 times of amounts of ethanol concentrated solution weight, behind warming while stirring to 85～95 ℃, stirred 40 minutes, mixing speed is 40 rev/mins, and then insulation is left standstill and made the profit layering in 4 hours.
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| CN104224848A (en) * | 2013-06-06 | 2014-12-24 | 四川好医生药业集团有限公司 | Preparation method and application of periplaneta americana double-layer gastric floating tablet |
| CN104274619A (en) * | 2014-10-27 | 2015-01-14 | 徐自升 | Externally-applied pharmaceutical composition for preventing and treating cow mastitis and preparation method of externally-applied pharmaceutical composition |
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| CN105497133A (en) * | 2015-12-19 | 2016-04-20 | 昆明赛诺制药有限公司 | Periplaneta Americana medicine composition for treating pharyngitis and tonsillitis and preparation method thereof |
| CN105878291A (en) * | 2015-09-24 | 2016-08-24 | 陈光健 | Medicine for treating ulcer diseases and preparation method of medicine |
| CN105878292A (en) * | 2015-09-24 | 2016-08-24 | 陈光健 | Periplaneta americana extract and preparation process thereof |
| CN106166165A (en) * | 2016-08-25 | 2016-11-30 | 昆明赛诺制药股份有限公司 | A kind of American cockroach medicament composition being effectively improved various clinical treating correlative diseases effect and preparation method thereof |
| CN106619731A (en) * | 2016-12-30 | 2017-05-10 | 昆明赛诺制药股份有限公司 | Medicine for treating hepatitis C |
| CN105434450B (en) * | 2014-11-19 | 2018-02-09 | 四川好医生攀西药业有限责任公司 | Blattaria glucosides and its pharmaceutical composition and its application in pharmacy and health products |
| CN111714521A (en) * | 2020-07-06 | 2020-09-29 | 天津中医药大学 | Periplaneta americana intestinal flora metabolite extract, preparation method thereof and application thereof in preparing anti-inflammatory or anti-ulcer products |
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| CN103239482A (en) * | 2013-05-29 | 2013-08-14 | 四川好医生攀西药业有限责任公司 | Intragastric floating tablet for periplaneta americana as well as preparation method and application of intragastric floating tablet |
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| CN104224848B (en) * | 2013-06-06 | 2018-04-06 | 四川好医生药业集团有限公司 | The preparation method and applications of American cockroach bilayer gastric floating tablet |
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