CN87100537A - A kind of preparation method for the treatment of the traumatic surface medicine - Google Patents
A kind of preparation method for the treatment of the traumatic surface medicine Download PDFInfo
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- CN87100537A CN87100537A CN87100537.9A CN87100537A CN87100537A CN 87100537 A CN87100537 A CN 87100537A CN 87100537 A CN87100537 A CN 87100537A CN 87100537 A CN87100537 A CN 87100537A
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Abstract
A kind of preparation method for the treatment of the traumatic surface medicine.The present invention makes raw material with Blatta seu periplaneta, therefrom extract the method that medicinal active ingredient prepares medicine, this method makes water solublity extractum by steps such as polypide drying and crushing, soak with ethanol extraction, concentrating under reduced pressure, defat filtrations, adds dispersant then in proportion, and antiseptic and distilled water are formulated.Simple, the easy row of this method technology.The medicine that is prepared into has special efficacy to promoting granulation tissue growth, acceleration body injury tissue repair and antiinflammatory, and the energy raise immunity, goes back diseases such as oral administration treatment gastric ulcer, duodenal ulcer, tuberculosis and abscess.
Description
The extract that the present invention relates to insecticide is the method that active ingredient prepares medicine, and especially the extract with Blatta seu periplaneta is the method that active ingredient prepares medicine.
Belgian patent application BE882829 has disclosed a kind of war wound that is used to handle, antibiotic and the antifungal drug of wounds such as burn, this drug main will contain histotroph, especially sugar and reactive compound, especially iodate polyvinylpyrrolidone, this kind medicine is a kind of mixture of homogeneous, the histotrophic nutrition antibacterial that wherein contains (A) 10～80 parts of weight, (B) antibiotic (antifungal) agent of 1 part of weight and (C) certain amount of dispersant, when directly applying to the war wound that exposes or tissue of burn, can adhere to medicine spongy or the topped thing of gauze shape on, make medicine rest on wound site.Component (A), (B) and (C) be physically, chemically with pharmacology on compatible, (C) on weight, constitute 1/3 of prescription.(A) sucrose, glucose, fructose, Mel or syrup can be preferentially adopted, crystal sugar can be adopted usually; (B) available iodate polyvinylpyrrolidone (being iodate PVP).Above-mentioned composition is stable, non-antigenic and tasteless, and ability with sterilization and antifungal (microbicidel and antibiosis), it can promote healing, cleaning surrounding tissue to impel granulation hyperplasia, regenerating tissues, reduce cicatrization and have cooling or local anesthesia effect, it can not adhere on the damaged tissue, and is easy to use.This kind medicine can be used for handling as scratch, abscess, acne, burn, degree of depth war wound, gangrene, fracture laceration, psoriasis, amputation wound surface, ulcer etc.Except that antibiotic, anti-fungal composition that contains 1 part of weight and certain amount of dispersant, mainly be the saccharide nutrient in the prescription of this kind medicine, shortage can significantly promote the medicinal component that damaged tissue is repaired, thereby makes its effect be subjected to certain restriction.
The purpose of this invention is to provide a kind of preparation method of extracting the treatment traumatic surface medicine of the medicinal active ingredient in the Blatta seu periplaneta polypide with alcoholic solution.
Preparation method of the present invention is made up of following steps:
One, the cockroach insect soma is dry, coarse pulverization,
Two, with the above-mentioned polypide of alcohol solution dipping, extract medicinal active ingredient wherein, filter then, filtering residue is separated with filtrate, and filtering residue is extracted repeatedly,
Three, filtrate is carried out concentrating under reduced pressure, reclaims ethanol, obtain thick thing,
Four, add distilled water in thick thing, filter then, discard upper strata grease and lower floor's residue, concentrating under reduced pressure filtrate obtains water solublity extractum,
Five, by above-mentioned water solublity extractum (being converted into dry weight) 0.4～1%(percentage by weight), antiseptic 0.2～0.5%(percentage by weight), cosolvent (or stabilizing agent) 10～12%(percentage by weight) and, the ratio of distilled water surplus is mixed with medicament.
The present invention adopts Blatta seu periplaneta as the raw material that extracts effective medicinal ingredient, the Blatta seu periplaneta polypide is toasted at a certain temperature, make its drying, but baking temperature should not be higher than 80 ℃, because when temperature is higher than 80 ℃, the effective medicinal ingredient in the Blatta seu periplaneta polypide has ruined possibility.In each step of preparation method of the present invention, temperature all should remain on below 80 ℃.
Blatta seu periplaneta after drying should carry out coarse pulverization, so that extract wherein active ingredient with alcoholic solution.When extracting with alcoholic solution, certain soak time should be arranged, so that various active ingredient can be extracted out fully, soak time was generally 12～24 hours.Used concentration of ethanol is also influential to extraction effect, and concentration of alcohol is appropriate, and effective ingredient such as each seed amino acid and polyhydric alcohol etc. in the Blatta seu periplaneta are extracted fully, and some invalid components such as albumen, polysaccharide etc. then produce and solidify or insoluble and by elimination.In use, concentration of ethanol may be selected to be 85～95%, and comparatively desirable with 90～95%.
Thick thing after concentrating under reduced pressure is sloughed ethanol is part oil-soluble and the water soluble ingredient in the Blatta seu periplaneta.In the method, the method for taking to add distilled water is carried out oil-water separation.After the adding distilled water stirs, thick thing promptly becomes upper, middle and lower-ranking, and the upper strata is an oil reservoir, and the middle level is a water layer, lower floor is a slag blanket, has carried out separating (being defat) with regard to making with other parts with the part of the oils and fats in the Blatta seu periplaneta polypide that alcoholic solution extracted like this.The water intaking layer carries out concentrating under reduced pressure, the effective medicinal components that has promptly obtained extracting from Blatta seu periplaneta-water solublity extractum contains eight kinds of still undetermined compositions of main aminoacid, multiple polyhydric alcohol and some structures such as alanine, proline, threonine, valine, leucine, glycine in this kind extractum.
In method of the present invention, Blatta seu periplaneta can be adopted periplaneta americana (Periplaneta americana) or Periplaneta burmister (Periplaneta burmister).
In order to prevent that preparation from going mouldy and the growth of other antibacterial, also can add antiseptic in the method, used antiseptic can be sodium benzoate (C
6H
5COONa), benzoic acid (C
6H
5COOH), parabens (parabens) etc., its addition is generally 0.2～0.5%.
In the method for the invention, cosolvent (or stabilizing agent) can adopt polyhydric alcohol such as glycerol (glycerol), propylene glycol, poly-second triol, but is good with glycerol.The existence of cosolvent (or stabilizing agent) can increase the dissolubility of effective medicinal components in water that extracts from the Blatta seu periplaneta polypide, make it give full play to curative effect, and can make preparation stabilization, and is not perishable, extends the expiration date.In the method, the consumption of cosolvent (or stabilizing agent) is 10～12%.
Be embodiments of the invention below:
Select 10 kilograms of the fresh polypides of periplaneta americana for use, scald dead with boiling water, placing baking oven to keep temperature is to carry out drying about 60 ℃, is ground into the fragment of Semen Benincasae shape size then in pulverizer, adds 30 liters of 95% ethanol and soaks 12 hours down in 60 ℃, filter, as above repetitive operation is 4 times, filtrate is decompressed to 300 millimetress of mercury reclaims etoh solvent under 60 ℃, makes solute be concentrated into heavy-gravity syrupy shape, add again and give heat to 20 liters of 60 ℃ distilled water, stir, leave standstill, make its layering, remove upper strata grease, lower aqueous solution is filtered, and filtering residue discards, and is decompressed to 250 millimetress of mercury under 60 ℃, evaporation is anhydrated, and promptly obtains water solublity extractum.
Choose sodium benzoate 2.5 grams, be dissolved in the distilled water, add 100 milliliters of glycerol mix homogeneously again, determine the water content of above-mentioned water solublity extractum, convert out dry weight, add 5 grams (by dry weight) in above-mentioned mixed solution, add distilled water to 1000 milliliter again, fully stir, promptly obtain water soluble medicament.
Preparation method's step of the present invention is simple, and solvent for use ethanol is inexpensive, be easy to get, extraction effect is good, and can reclaim after use, and is safe and reliable during recovery. Degreasing process of the present invention is not taked the method for traditional adding benzinum, and adds entry, has both reduced cost, has simplified again technology, makes its separation and Extraction safety, easily goes. Several amino acids, polyalcohol and some structures that the prepared medicine of the inventive method owing to contain by a certain percentage cooperates be undetermined effective medicinal components still, the comprehensive effect of these compounds makes this medicine have special curative effect to the growth of promotion granulation tissue, acceleration body injury tissue repair and anti-inflammatory, and can strengthen immunologic function. According to clinical testing, with this pharmaceutical treatment 337 example burn and social traumatic surfaces, total effective rate is 92%, wherein the blister burn surface of a wound and eschar burn granulation face 164 examples, and effective 152 examples, efficient is 92.7%; Soft tissue infection's surface of a wound 79 examples, effective 75 examples, efficient is 94.9%; Opening soft tissue injury 24 examples, effective 23 examples, efficient is 95.8%; Chronic ulcer face 45 examples of a variety of causes, effective 37 examples, efficient is 82.2%; Various types of fistula 24 examples, effective 18 examples, effective 18 examples, efficient is 75%; Treatment war wound 121 examples, wherein 117 examples all reach good result for the treatment of, good efficient be 96.7%.
The medicine that the method for the invention makes is a kind of water-soluble drops, except external application, goes back the diseases such as oral administration treatment gastric ulcer, duodenal ulcer, tuberculosis and abscess. This medicine is easy to use, and storage life is 5 years, and no side effects, also need not special installation in the production process, be easy to suitability for industrialized production.
Claims (5)
1, a kind of preparation method for the treatment of the traumatic surface medicine, the extract that relates in particular to Blatta seu periplaneta is the method that effective ingredient prepares medicine, it is characterized in that being lower than under 80 ℃ the temperature:
(a) the cockroach insect soma is dry, coarse pulverization,
(b) with the above-mentioned polypide of alcohol solution dipping, extract effective medicinal components wherein, then filtering residue separated with filtrate, and filtering residue is extracted repeatedly,
(c) filtrate is carried out concentrating under reduced pressure, reclaims ethanol, obtain thick thing,
(d) add distilled water in thick thing, filter then, discard upper strata grease and lower floor's residue, concentrating under reduced pressure filtrate obtains water solublity extractum,
(e) ratio in above-mentioned water solublity extractum (being converted into dry weight) 0.4～1% (percentage by weight), antiseptic 2～5% (percentage by weight), dispersant 10～12% (percentage by weight), distilled water surplus is mixed with medicament.
2, preparation method according to claim 1 is characterized in that Blatta seu periplaneta can adopt periplaneta americana (Periplaneta americana) or Periplaneta burmister (Periplaneta burmister).
3, preparation method according to claim 1, the concentration that it is characterized in that used alcoholic solution is 85～95%.
4, preparation method according to claim 1 is characterized in that described antiseptic can be sodium benzoate (C
6H
5COONa), benzoic acid (C
6H
5COOH) or parabens (parabens).
5, preparation method according to claim 1 is characterized in that powder can be glycerol, propylene glycol or Polyethylene Glycol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN87100537A CN1010828B (en) | 1987-01-27 | 1987-01-27 | Process for preparing drugs of treating traumatic wound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN87100537A CN1010828B (en) | 1987-01-27 | 1987-01-27 | Process for preparing drugs of treating traumatic wound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN87100537A true CN87100537A (en) | 1988-08-31 |
| CN1010828B CN1010828B (en) | 1990-12-19 |
Family
ID=4812915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN87100537A Expired CN1010828B (en) | 1987-01-27 | 1987-01-27 | Process for preparing drugs of treating traumatic wound |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1010828B (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067243C (en) * | 1994-12-09 | 2001-06-20 | 大理医学院 | Xinmailong extract and Xinmailong medical preparation for curing angiocardiopath |
| WO2006056097A1 (en) * | 2004-11-23 | 2006-06-01 | Weichang You | A pharmaceutical composition for treating senile dementia |
| CN100361649C (en) * | 2003-05-22 | 2008-01-16 | 福州金象中药制药有限公司 | Prepn process of alive adult roach extract |
| CN100525781C (en) * | 2006-09-30 | 2009-08-12 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
| CN102198190A (en) * | 2011-05-02 | 2011-09-28 | 李恒畅 | Traditional Chinese medicine lotion for external washing and composition ointment for external application for treating burn and scald |
| CN101292997B (en) * | 2007-04-26 | 2012-03-21 | 四川科伦药业股份有限公司 | Pharmaceutical composition for treating empyrosis or gastric ulcer, and preparation method thereof |
| CN102885857A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Extraction method of periplaneta americana extract for treating peptic ulcer |
| CN102885855A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Production method for preparing medicine for treating peptic ulcer by periplaneta americana extract |
| CN102895263A (en) * | 2012-11-10 | 2013-01-30 | 昆明赛诺制药有限公司 | Method for removing oil in american cockroach extractive and method for detecting same |
| CN102973610A (en) * | 2012-12-22 | 2013-03-20 | 昆明赛诺制药有限公司 | Method for preparing phthisic adjuvant with extractum of Periplaneta americana |
| CN103239482A (en) * | 2013-05-29 | 2013-08-14 | 四川好医生攀西药业有限责任公司 | Intragastric floating tablet for periplaneta americana as well as preparation method and application of intragastric floating tablet |
| CN104173386A (en) * | 2013-09-24 | 2014-12-03 | 陈光健 | Use of periplaneta Americana extract in preparing drugs for resisting AQP3 (aquaporin 3) decline, skin care products or daily chemical products |
| CN108186826A (en) * | 2018-02-13 | 2018-06-22 | 云南诺漫斯生物科技有限公司 | A kind of anti-acne ointment of the ingredient containing American cockroach and preparation method thereof |
| WO2021068909A1 (en) * | 2019-10-11 | 2021-04-15 | 凉山佳能达生物原料养殖有限公司 | American cockroach extract, preparation thereof, preparation methods therefor and applications thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156875B (en) * | 2007-04-25 | 2011-10-05 | 深圳信立泰药业股份有限公司 | Cockroach extractive for treating cardiovascular disease, preparation method and its composition |
-
1987
- 1987-01-27 CN CN87100537A patent/CN1010828B/en not_active Expired
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067243C (en) * | 1994-12-09 | 2001-06-20 | 大理医学院 | Xinmailong extract and Xinmailong medical preparation for curing angiocardiopath |
| CN100361649C (en) * | 2003-05-22 | 2008-01-16 | 福州金象中药制药有限公司 | Prepn process of alive adult roach extract |
| WO2006056097A1 (en) * | 2004-11-23 | 2006-06-01 | Weichang You | A pharmaceutical composition for treating senile dementia |
| CN100525781C (en) * | 2006-09-30 | 2009-08-12 | 耿福能 | American falx extract, medicinal composition containing it and its making method |
| CN101292997B (en) * | 2007-04-26 | 2012-03-21 | 四川科伦药业股份有限公司 | Pharmaceutical composition for treating empyrosis or gastric ulcer, and preparation method thereof |
| CN102198190A (en) * | 2011-05-02 | 2011-09-28 | 李恒畅 | Traditional Chinese medicine lotion for external washing and composition ointment for external application for treating burn and scald |
| CN102895263A (en) * | 2012-11-10 | 2013-01-30 | 昆明赛诺制药有限公司 | Method for removing oil in american cockroach extractive and method for detecting same |
| CN102885855A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Production method for preparing medicine for treating peptic ulcer by periplaneta americana extract |
| CN102885857A (en) * | 2012-11-10 | 2013-01-23 | 昆明赛诺制药有限公司 | Extraction method of periplaneta americana extract for treating peptic ulcer |
| CN102885857B (en) * | 2012-11-10 | 2014-05-28 | 昆明赛诺制药有限公司 | Extraction method of periplaneta americana extract for treating peptic ulcer |
| CN102895263B (en) * | 2012-11-10 | 2014-12-10 | 昆明赛诺制药有限公司 | Method for removing oil in american cockroach extractive and method for detecting same |
| CN102973610A (en) * | 2012-12-22 | 2013-03-20 | 昆明赛诺制药有限公司 | Method for preparing phthisic adjuvant with extractum of Periplaneta americana |
| CN103239482A (en) * | 2013-05-29 | 2013-08-14 | 四川好医生攀西药业有限责任公司 | Intragastric floating tablet for periplaneta americana as well as preparation method and application of intragastric floating tablet |
| CN104173386A (en) * | 2013-09-24 | 2014-12-03 | 陈光健 | Use of periplaneta Americana extract in preparing drugs for resisting AQP3 (aquaporin 3) decline, skin care products or daily chemical products |
| CN108186826A (en) * | 2018-02-13 | 2018-06-22 | 云南诺漫斯生物科技有限公司 | A kind of anti-acne ointment of the ingredient containing American cockroach and preparation method thereof |
| WO2021068909A1 (en) * | 2019-10-11 | 2021-04-15 | 凉山佳能达生物原料养殖有限公司 | American cockroach extract, preparation thereof, preparation methods therefor and applications thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1010828B (en) | 1990-12-19 |
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