CN103784851B - A kind of Chinese medicine preparation and preparation method for the treatment of Menieres disease - Google Patents
A kind of Chinese medicine preparation and preparation method for the treatment of Menieres disease Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine preparation and preparation method for the treatment of Menieres disease, belong to the field of Chinese medicines; The raw material of Chinese medicine preparation effective ingredient of the present invention consists of: Periostracum Cicadae, Radix Polygalae, the Fructus Evodiae, Semen Cassiae, Radix Aeschynomenes indicae, Rhizoma Polygonati Odorati, Fructus Aristolochiae Kwangsiensis, Fructus Amomi Rotundus, Herba leerisae hexandrae, Herba Micromeriae Biflorae, Fructus Akebiae, Bulbus Lycoridis Radiatae, Semen Ziziphi Spinosae, the Radix Angelicae Dahuricae, Radix Perillae and Rhizoma Acori Calami; Selected by Chinese medicine preparation of the present invention, Chinese crude drug compatibility is suitable, meet Chinese medicine and modern medicine and pharmacology research theory, there is effect of suppressing the hyperactive liver to relieve the wind syndrome, activating QI to alleviate the depression, all kinds of symptoms that Meniere syndrome causes can be treated, and thorough cure diseases, more do not recur after, safety has no side effect, and has filled up the blank of healing U.S. Neil formula syndrome medicament.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation and preparation method for the treatment of Menieres disease.
Background technology
Menieres disease is a kind of disease of inner ear with hydrolabyrinth.Primary disease is with the rotatory vertigo of sudden recurrent exerbation, undulatory property auditory dysesthesia, the vexed swollen sense of tinnitus ear and nystagmus for main clinical manifestation, and dizzy have obvious stage of attack and intermission.Primary disease is multiple to be born in 30 ~ 50 years old, adolescence, and child is rare.Men and women falls ill without significant difference.Ears are suffered from patient and are accounted for 10% ~ 50%.
The cause of disease of Menieres disease is still indefinite at present, talks about publicly diverse and confused.The cause of disease known at present comprises following factor: various infective agent (antibacterial, virus etc.), damage (comprising mechanical injuries or acoustic trauma), otosclerosis, syphilis, inherited genetic factors, allergy, tumor, leukemia and autoimmune disease etc.
Between Menieres disease stage of attack patient open eyes or rotation head then symptom can increase the weight of, therefore most patient is closed order and is reposed, and head and health all dare not rotate.There is one-sided tinnitus and deafness when showing effect in most patient, minority is bilateral.Patient existing tinnitus and deaf appearance before outbreak of about 25%, and in outbreak postemphasis.Stage of attack transfers the intermission to two kinds of forms: one is dizzy and simultaneous phenomenon suddenly disappears, and one dizzyly gradually becomes giddy and disappear gradually.The intermission of Meniere is different in size, from several months to several years, each outbreak and degree also different.And audition is faded along with the increase of attack times, finally cause deafness.
Because the Meniere cause of disease and pathogenesis are failed to understand, there is no the Therapeutic Method that primary disease is fully recovered at present.Many employings at present regulate autonomic nervous function, improve inner ear microcirculation, remove hydrolabyrinth is main Drug therapy and operative treatment.Because Drug therapy and operative treatment can only play mitigation, can not fundamentally disease therapy, disease brings huge puzzlement to the life of patient, and impact is lived normally, and develop a kind of medicine can treating Menieres disease has become research topic important in medical history for this reason.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of Menieres disease; Selected by Chinese medicine preparation of the present invention, Chinese crude drug compatibility is suitable, meet Chinese medicine and modern medicine and pharmacology research theory, there is effect of suppressing the hyperactive liver to relieve the wind syndrome, activating QI to alleviate the depression, all kinds of symptoms that Meniere syndrome causes can be treated, and thorough cure diseases, more do not recur after, safety have no side effect, filled up healing U.S. Neil formula syndrome medicament blank.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for Menieres disease, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Periostracum Cicadae 40 ~ 70 parts of Radix Polygalaes 30 ~ 60 portions of Fructus Evodiaes 30 ~ 60 parts of Semen Cassiaes 30 ~ 55 parts
20 ~ 45 parts, Radix Aeschynomenes indicae 25 ~ 55 portions of Rhizoma Polygonati Odorati 25 ~ 50 parts of Fructus Aristolochiae Kwangsiensiss 20 ~ 50 parts of Fructus Amomi Rotunduss
Herba leerisae hexandrae 20 ~ 45 parts of Herba Micromeriae Bifloraes 15 ~ 45 parts of Fructus Akebiaes 15 ~ 45 portions of Bulbus Lycoridis Radiataes 10 ~ 45 parts
Semen Ziziphi Spinosae 10 ~ 40 parts of Radixs Angelicae Dahuricae 8 ~ 40 parts of Radix Perillae 8 ~ 35 parts of Rhizoma Acori Calami 6 ~ 30 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Periostracum Cicadae 45 ~ 65 parts of Radix Polygalaes 35 ~ 55 portions of Fructus Evodiaes 35 ~ 55 parts of Semen Cassiaes 34 ~ 51 parts
24 ~ 41 parts, Radix Aeschynomenes indicae 30 ~ 50 portions of Rhizoma Polygonati Odorati 29 ~ 46 parts of Fructus Aristolochiae Kwangsiensiss 25 ~ 45 parts of Fructus Amomi Rotunduss
Herba leerisae hexandrae 24 ~ 41 parts of Herba Micromeriae Bifloraes 20 ~ 40 parts of Fructus Akebiaes 20 ~ 40 portions of Bulbus Lycoridis Radiataes 16 ~ 39 parts
Semen Ziziphi Spinosae 15 ~ 35 parts of Radixs Angelicae Dahuricae 13 ~ 35 parts of Radix Perillae 12 ~ 31 parts of Rhizoma Acori Calami 10 ~ 26 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Periostracum Cicadae 50 ~ 60 parts of Radix Polygalaes 40 ~ 50 portions of Fructus Evodiaes 40 ~ 50 parts of Semen Cassiaes 39 ~ 47 parts
28 ~ 37 parts, Radix Aeschynomenes indicae 35 ~ 45 portions of Rhizoma Polygonati Odorati 33 ~ 42 parts of Fructus Aristolochiae Kwangsiensiss 30 ~ 40 parts of Fructus Amomi Rotunduss
Herba leerisae hexandrae 28 ~ 37 parts of Herba Micromeriae Bifloraes 25 ~ 35 parts of Fructus Akebiaes 25 ~ 35 portions of Bulbus Lycoridis Radiataes 22 ~ 33 parts
Semen Ziziphi Spinosae 20 ~ 30 parts of Radixs Angelicae Dahuricae 18 ~ 30 parts of Radix Perillae 16 ~ 27 parts of Rhizoma Acori Calami 14 ~ 22 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Periostracum Cicadae 55 parts of Radix Polygalaes 45 portions of Fructus Evodiaes 45 parts of Semen Cassiaes 43 parts
33 parts, Radix Aeschynomenes indicae 40 portions of Rhizoma Polygonati Odorati 38 parts of Fructus Aristolochiae Kwangsiensiss 35 parts of Fructus Amomi Rotunduss
Herba leerisae hexandrae 33 parts of Herba Micromeriae Bifloraes 30 parts of Fructus Akebiaes 30 portions of Bulbus Lycoridis Radiataes 28 parts
Semen Ziziphi Spinosae 25 parts of Radixs Angelicae Dahuricae 24 parts of Radix Perillae 21 parts of Rhizoma Acori Calami 18 parts.
Treat a preparation method for the Chinese medicine preparation of Menieres disease, comprise following processing step:
(1) by Periostracum Cicadae, Semen Cassiae, Fructus Aristolochiae Kwangsiensis, Semen Ziziphi Spinosae and the Radix Angelicae Dahuricae with mix, carry out pulverization process after mix homogeneously, grind into powder, cross 160 order fine powders, for subsequent use;
(2) Radix Polygalae, Radix Aeschynomenes indicae, Herba leerisae hexandrae, Herba Micromeriae Biflorae, Radix Perillae and Rhizoma Acori Calami are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.12 ~ 1.17, for subsequent use;
(3) Fructus Evodiae and Bulbus Lycoridis Radiatae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Rhizoma Polygonati Odorati, Fructus Amomi Rotundus and Fructus Akebiae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 70% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 60 DEG C, relative density is the thick paste of 1.11 ~ 1.15, for subsequent use;
(5) by fine powder, thick paste and the juice mixing obtained by above-mentioned steps (1) ~ (4), make tablet or capsule, obtain the Chinese medicine preparation for the treatment of Menieres disease of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Periostracum Cicadae: sweet in the mouth, cold in nature; Return lung, Liver Channel.Loose wind heat extraction, sore-throat relieving rash, nebula removing spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus." detailed outline " carries: " control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva.”
Radix Polygalae: bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian.To calm the nerves Fructus Alpiniae Oxyphyllae, eliminating phlegm for diminishing swelling.The insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain." Mingyi Bielu " carries: " centering gas, spasmolytic is throbbed with fear, benefit essence, goes heat in heart intake of food in the morning and vomitting in the evening gas, skin, appearance yellow.”
The Fructus Evodiae: sour-puckery flavor, slightly warm in nature; Enter liver, stomach warp.Invigorating the liver and kidney, arresting seminal emission gas, Gu collapse, stomach invigorating tonifying YANG.The traditional Chinese medical science is conventional to treat soreness of waist and knee joint, dizzy, tinnitus, and seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse, neurasthenia, the diseases such as menoxenia.Modern medicine study confirms, the Fructus Evodiae can suppress dysentery bacterium, Bacillus typhi, golden yellow puckery staphylococcus and some dermatophytes, has diuresis, blood pressure lowering, protective effect on cancer risk.
Semen Cassiae: sweet in the mouth, hardship, salty, cold nature; Return liver, large intestine channel.Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, headache Menieres disease, poor vision, constipation." Japan hanako materia medica " carries: " help irritability, beneficial smart water; Adjust end to be coated with, detumescence poison, Xie temple control headache, paste again the brain heart and stop epistaxis; Make pillow victory Semen sojae atricolor, control wind syndrome of head, improving eyesight.”
Radix Aeschynomenes indicae: sweet in the mouth, cold in nature; Return lung, stomach, urinary bladder channel.Clearing away heat-damp and promoting diuresis, removing food stagnancy detoxifies.Cure mainly stranguria with blood, have loose bowels, dysentery, infantile malnutrition, blurred vision, toothache, furuncle." Jiangxi medical herbs ": " clearing away heat-damp and promoting diuresis, detumescence hemostasis.”
Rhizoma Polygonati Odorati: sweet in the mouth, property is put down; Enter lung, stomach warp.Nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Cure mainly cough caused by dryness, chronic cough, the dry throat and mouth of calentura cloudy liquid consumption wound, interior-heat is quenched one's thirst, deficiency of YIN diseases caused by exogenous pathogenic factor, dizzy dizzy, muscle arteries and veins spasm and pain.Supplement to the Herbal carries: " main clever, adjust vim and vigour, make us strong." modern medicine study confirmation, tonification the five internal organs, nourish QI and blood, put down and mend and moisten, and hold concurrently and remove effect of wind heat.
Fructus Aristolochiae Kwangsiensis: bitter in the mouth, cold in nature; Return stomach warp.Heat-clearing and toxic substances removing, regulating QI to relieve pain, relaxing muscles and tendons and activating QI and blood in the collateral.For acute gastroenteritis, taste-blindness rate, pharyngolaryngitis, pulmonary tuberculosis, ulcer sore pain, stomachache, abdominalgia with intestinal abscess, rheumatic arthralgia, treating swelling and pain by traumatic injury." register planted by Guangxi medicine " carries: " refrigerantly to bring down a fever, removing toxic substances.Control dizziness, laryngalgia, gastropathy, stomachache, skin ulcer scabies, knife injury, snakebite.”
Fructus Amomi Rotundus: acrid in the mouth, hot in nature; Return lung, spleen, stomach warp.Cold expelling dampness, alcoholic intoxication, removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear." book on Chinese herbal medicine is original " carries: " tonifying the spleen and stomach, mill is stagnant, and adjust cold scattering gas very fast, it is the most suitable that weakness can not drink trencherman, alcoholic intoxication of holding concurrently.”
Herba leerisae hexandrae: taste is put down, and property is pungent.Dispelling wind to relieve the exterior syndrome, dampness removing, removing obstruction in the collateral to relieve pain.Cure mainly flu, headache body pain, malaria, leucorrhea, lower limbs edema, dysuria, arthralgia pain is numb." Traditional Chinese Medicine in Sichuan will " carries: " energy expelling cold and relieving exterior syndrome, the meridian dredging.Treating malaria disease, flu head-body-pain.”
Herba Micromeriae Biflorae: bitter in the mouth, pungent, warm in nature.Expelling cold and relieving exterior syndrome, stomach invigorating in wet, removing dampness removing food stagnancy.Cure mainly anemofrigid cold, pain relieving, cold syndrome of the stomach gastralgia, abdominal distention, nausea and vomiting, dysphagic, stomachache, stomachache, has loose bowels, dysentery, lump in the abdomen, colic of cold type." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " dry spleen warming the stomach, enters diet, the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards.Treat nine kinds of gastric qi pain, the cold pain in face, chest and diaphragm flatulence, tripe abdomen cold type of pain, vomiting is felt sick, dysphagic regurgitation of food from the stomach, and five kinds of masses in the chest and abdomen six gathers, mass in the abdomen pain, and man's colic of cold type trace aches, and gynecological mass in abdomen becomes pain.”
Fructus Akebiae: sweet in the mouth, cold in nature; Return liver, stomach, urinary bladder channel.Liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, and uterus drops." Shaanxi Chinese herbal medicine " carries: " Shugan Yishen, invigorating the spleen and regulating the stomach.Control dyspepsia, stomachache, dysentery, hernia, uterus drops.”
Bulbus Lycoridis Radiatae: acrid in the mouth, sweet, warm in nature, poisonous.Eliminate the phlegm emetic, detoxicating and resolving stagnation of pathogens.Cure mainly acute throat trouble, single bilateral tonsillitis, laryngopharynx swelling and pain, sputum is jammed, alimentary toxicosis, breast abdomen hydrops, malignant boil toxic swelling, sucutaneous nodule scrofula, anal fistula, traumatic injury, rheumatic arthritis, stubborn dermatitis, burn and scald, venom.
Semen Ziziphi Spinosae: sweet in the mouth, acid, property is put down; GUIXIN, spleen, liver, gallbladder meridian.Mind tranquilizing and the heart calming, nourishing the liver arresting sweating.For deficiency of YIN-blood, severe palpitation, insomnia forgetfulness, the empty hyperhidrosis of body." not Lu " carries: " main vexatious must not eye, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong.”
The Radix Angelicae Dahuricae, acrid in the mouth, warm in nature; Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.For soft tissue contusion, hyperosteogeny, muscular strain, rheumatic myositis, fracture, costal chondritis, scapulohumeral periarthritis, the treatment of the diseases such as intercostal neuralgia.The Radix Angelicae Dahuricae all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.
Radix Perillae: acrid in the mouth, warm in nature, nontoxic; Enter lung, spleen two warp.Expelling wind and cold, lowering the adverse-rising QI and dispelling phlegm, and in antiabortive.Cure mainly dizziness, general pain, nasal obstruction watery nasal discharge, cough with dyspnea, septum pectorale is drunk, and costalgia uncomfortable in chest, stomachache is had loose bowels, vomiting during pregnancy, frequent fetal movement." Traditional Chinese Medicine in Sichuan will " carries: " expelling wind, dissipating cold, eliminate the phlegm sending down the abnormal ascending QI.Control cough with dyspnea, chest and diaphragm phlegm retention, dizzy general pain and nasal obstruction watery nasal discharge.”
Rhizoma Acori Calami: acrid in the mouth, hardship, warm in nature; GUIXIN, liver, stomach warp.Waking up the patient from unconsciousness by dissipating phlegm, dehumidifying stomach invigorating, killing parasites for relieving itching.Cure mainly coma due to phlegm syncope, apoplexy, epilepsy, palpitate with fear forgetful, Hiccough and deaf, abdominal pain due to retention of food, dysentery is had loose bowels, rheumatalgia, eczema, scabies.
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, Chinese crude drug compatibility is suitable, meet Chinese medicine and modern medicine and pharmacology research theory, there is effect of suppressing the hyperactive liver to relieve the wind syndrome, activating QI to alleviate the depression, all kinds of symptoms that Meniere syndrome causes can be treated, and thorough cure diseases, more do not recur after, safety have no side effect, filled up healing U.S. Neil formula syndrome medicament blank.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Periostracum Cicadae 65g Radix Polygalae 55g Fructus Evodiae 55g Semen Cassiae 51g
Radix Aeschynomenes indicae 50g Rhizoma Polygonati Odorati 46g Fructus Aristolochiae Kwangsiensis 45g Fructus Amomi Rotundus 41g
Herba leerisae hexandrae 41g Herba Micromeriae Biflorae 40g Fructus Akebiae 40g Bulbus Lycoridis Radiatae 39g
Semen Ziziphi Spinosae 35g Radix Angelicae Dahuricae 35g Radix Perillae 31g Rhizoma Acori Calami 26g.
The preparation method of Chinese medicine preparation of the present invention, comprises following processing step:
(1) by Periostracum Cicadae, Semen Cassiae, Fructus Aristolochiae Kwangsiensis, Semen Ziziphi Spinosae and the Radix Angelicae Dahuricae with mix, carry out pulverization process after mix homogeneously, grind into powder, cross 160 order fine powders, for subsequent use;
(2) Radix Polygalae, Radix Aeschynomenes indicae, Herba leerisae hexandrae, Herba Micromeriae Biflorae, Radix Perillae and Rhizoma Acori Calami are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.12 ~ 1.17, for subsequent use;
(3) Fructus Evodiae and Bulbus Lycoridis Radiatae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Rhizoma Polygonati Odorati, Fructus Amomi Rotundus and Fructus Akebiae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 70% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 60 DEG C, relative density is the thick paste of 1.11 ~ 1.15, for subsequent use;
(5) by fine powder, thick paste and the juice mixing obtained by above-mentioned steps (1) ~ (4), make tablet or capsule, obtain the Chinese medicine preparation for the treatment of Menieres disease of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2 (every 0.5g), warm water delivery service after meal; Within 5 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Periostracum Cicadae 60g Radix Polygalae 50g Fructus Evodiae 50g Semen Cassiae 47g
Radix Aeschynomenes indicae 45g Rhizoma Polygonati Odorati 42g Fructus Aristolochiae Kwangsiensis 40g Fructus Amomi Rotundus 37g
Herba leerisae hexandrae 37g Herba Micromeriae Biflorae 35g Fructus Akebiae 35g Bulbus Lycoridis Radiatae 33g
Semen Ziziphi Spinosae 30g Radix Angelicae Dahuricae 30g Radix Perillae 27g Rhizoma Acori Calami 22g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Periostracum Cicadae 45g Radix Polygalae 35g Fructus Evodiae 35g Semen Cassiae 35g
Radix Aeschynomenes indicae 30g Rhizoma Polygonati Odorati 30g Fructus Aristolochiae Kwangsiensis 25g Fructus Amomi Rotundus 25g
Herba leerisae hexandrae 25g Herba Micromeriae Biflorae 20g Fructus Akebiae 20g Bulbus Lycoridis Radiatae 15g
Semen Ziziphi Spinosae 15g Radix Angelicae Dahuricae 13g Radix Perillae 13g Rhizoma Acori Calami 11g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Periostracum Cicadae 50g Radix Polygalae 40g Fructus Evodiae 40g Semen Cassiae 39g
Radix Aeschynomenes indicae 35g Rhizoma Polygonati Odorati 33g Fructus Aristolochiae Kwangsiensis 30g Fructus Amomi Rotundus 28g
Herba leerisae hexandrae 28g Herba Micromeriae Biflorae 25g Fructus Akebiae 25g Bulbus Lycoridis Radiatae 22g
Semen Ziziphi Spinosae 20g Radix Angelicae Dahuricae 18g Radix Perillae 16g Rhizoma Acori Calami 14g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.Embodiment 5
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Periostracum Cicadae 45g Radix Polygalae 35g Fructus Evodiae 35g Semen Cassiae 34g
Radix Aeschynomenes indicae 30g Rhizoma Polygonati Odorati 29g Fructus Aristolochiae Kwangsiensis 25g Fructus Amomi Rotundus 24g
Herba leerisae hexandrae 24g Herba Micromeriae Biflorae 20g Fructus Akebiae 20g Bulbus Lycoridis Radiatae 16g
Semen Ziziphi Spinosae 15g Radix Angelicae Dahuricae 13g Radix Perillae 12g Rhizoma Acori Calami 10g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of Menieres disease, select the routine clinical observation of Menieres disease patient 200 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 100 example, wherein male 55 example, women 45 example, 50 ~ 75 years old age, 62.5 years old mean age, the shortest person of the course of disease 6 months, most elder 8 years, average 4.1 years.Matched group 100 example, wherein male 54 example, women 46 example, 51 ~ 76 years old age, 63.7 years old mean age, the shortest person of the course of disease 5 months, most elder 7 years, average 3.8 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2 (every 0.5g), warm water delivery service after meal; Within 5 days, be 1 course for the treatment of, take 2 ~ 3 courses for the treatment of continuously, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes metoclopramide sheet, oral, be grown up one time 1 ~ 2,3 times on the one, every day 3 times, 30 minutes before the meal clothes 6 days are 1 course for the treatment of, 1 course for the treatment of of the lighter, take continuously 2 ~ 3 courses for the treatment of can, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, efficacy determination:
(1) cure: the clinical symptom disappearance such as the vexed swollen sense of the rotatory vertigo of sudden recurrent exerbation, undulatory property auditory dysesthesia, tinnitus ear and nystagmus, without rebound phenomenon, patient body recovers normal.
(2) effective: above-mentioned symptom disappears substantially, without recurrent exerbation sign.
(3) effective: above-mentioned symptom is alleviated to some extent.
(4) invalid: after patient consumes, symptom is without obvious change.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 40 examples, effective 30 examples, effective 26 examples, invalid 4 examples, cure rate 40%, total effective rate 96%.
10 examples are cured, effective 20 examples, effective 30 examples, invalid 40 examples, cure rate 10%, total effective rate 60% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Wei, man, 53 years old, people from Xuzhou.Patient has a dizzy spell for many years, often looks thing and rotates, companion's nausea and vomiting, Hiccough and deaf, sweating, pale complexion, recurrent exerbation.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, the symptoms such as dizzy, tinnitus, deafness slightly alleviate, and do not occur nausea and vomiting phenomenon, sweating due to debility phenomenon disappears, then after taking 1 course for the treatment of, transference cure, complexion is normal.
2, poplar, female, 65 years old, Taiyuan, Shanxi people.Patient is dizzy from recurrent dizziness the year before, blurred vision, tinnitus companion sweating above the waist, more than falling ill without obvious inducement night, morbidity in every 4 ~ 5 days 1 time, continue about 10 ~ 20 minutes at every turn, ignore thing to rotate and tending to vomit of feeling sick, during morbidity, sweating above the waist increases, awareness of defecation strengthens even fecal incontinence, has a strong impact on the life of patient and household thereof.Body of being admitted to hospital is looked into as Menieres disease.To our hospital afterwards, take Chinese medicine preparation of the present invention, after taking 1 course for the treatment of, above-mentioned symptom alleviates, and after taking the 2nd course for the treatment of, symptomatology disappears, and follows up a case by regular visits to and do not recur after 1 year.
3, Zhang, man, 71 years old, Jinan, Shandong Province people.Patient has a dizzy spell, and depending on thing running, closes order and namely stops.To our hospital afterwards, take Chinese medicine preparation of the present invention, after taking 1 course for the treatment of, symptom of having a dizzy spell disappears substantially, and after continuing to take 1 course for the treatment of, transference cure, follows up a case by regular visits to after half a year and do not recur.
Claims (5)
1. treat a Chinese medicine preparation for Menieres disease, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Periostracum Cicadae 40 ~ 70 parts of Radix Polygalaes 30 ~ 60 portions of Fructus Evodiaes 30 ~ 60 parts of Semen Cassiaes 30 ~ 55 parts
20 ~ 45 parts, Radix Aeschynomenes indicae 25 ~ 55 portions of Rhizoma Polygonati Odorati 25 ~ 50 parts of Fructus Aristolochiae Kwangsiensiss 20 ~ 50 parts of Fructus Amomi Rotunduss
Herba leerisae hexandrae 20 ~ 45 parts of Herba Micromeriae Bifloraes 15 ~ 45 parts of Fructus Akebiaes 15 ~ 45 portions of Bulbus Lycoridis Radiataes 10 ~ 45 parts
Semen Ziziphi Spinosae 10 ~ 40 parts of Radixs Angelicae Dahuricae 8 ~ 40 parts of Radix Perillae 8 ~ 35 parts of Rhizoma Acori Calami 6 ~ 30 parts, making described Chinese medicine preparation is following processing step:
(1) by Periostracum Cicadae, Semen Cassiae, Fructus Aristolochiae Kwangsiensis, Semen Ziziphi Spinosae and the Radix Angelicae Dahuricae with mix, carry out pulverization process after mix homogeneously, grind into powder, cross 160 order fine powders, for subsequent use;
(2) Radix Polygalae, Radix Aeschynomenes indicae, Herba leerisae hexandrae, Herba Micromeriae Biflorae, Radix Perillae and Rhizoma Acori Calami are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.12 ~ 1.17, for subsequent use;
(3) Fructus Evodiae and Bulbus Lycoridis Radiatae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Rhizoma Polygonati Odorati, Fructus Amomi Rotundus and Fructus Akebiae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 70% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 60 DEG C, relative density is the thick paste of 1.11 ~ 1.15, for subsequent use;
(5) by fine powder, thick paste and the juice mixing obtained by above-mentioned steps (1) ~ (4), make tablet or capsule, obtain the Chinese medicine preparation of described treatment Menieres disease.
2. a kind of Chinese medicine preparation for the treatment of Menieres disease according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Periostracum Cicadae 45 ~ 65 parts of Radix Polygalaes 35 ~ 55 portions of Fructus Evodiaes 35 ~ 55 parts of Semen Cassiaes 34 ~ 51 parts
24 ~ 41 parts, Radix Aeschynomenes indicae 30 ~ 50 portions of Rhizoma Polygonati Odorati 29 ~ 46 parts of Fructus Aristolochiae Kwangsiensiss 25 ~ 45 parts of Fructus Amomi Rotunduss
Herba leerisae hexandrae 24 ~ 41 parts of Herba Micromeriae Bifloraes 20 ~ 40 parts of Fructus Akebiaes 20 ~ 40 portions of Bulbus Lycoridis Radiataes 16 ~ 39 parts
Semen Ziziphi Spinosae 15 ~ 35 parts of Radixs Angelicae Dahuricae 13 ~ 35 parts of Radix Perillae 12 ~ 31 parts of Rhizoma Acori Calami 10 ~ 26 parts.
3. a kind of Chinese medicine preparation for the treatment of Menieres disease according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Periostracum Cicadae 50 ~ 60 parts of Radix Polygalaes 40 ~ 50 portions of Fructus Evodiaes 40 ~ 50 parts of Semen Cassiaes 39 ~ 47 parts
28 ~ 37 parts, Radix Aeschynomenes indicae 35 ~ 45 portions of Rhizoma Polygonati Odorati 33 ~ 42 parts of Fructus Aristolochiae Kwangsiensiss 30 ~ 40 parts of Fructus Amomi Rotunduss
Herba leerisae hexandrae 28 ~ 37 parts of Herba Micromeriae Bifloraes 25 ~ 35 parts of Fructus Akebiaes 25 ~ 35 portions of Bulbus Lycoridis Radiataes 22 ~ 33 parts
Semen Ziziphi Spinosae 20 ~ 30 parts of Radixs Angelicae Dahuricae 18 ~ 30 parts of Radix Perillae 16 ~ 27 parts of Rhizoma Acori Calami 14 ~ 22 parts.
4. a kind of Chinese medicine preparation for the treatment of Menieres disease according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Periostracum Cicadae 55 parts of Radix Polygalaes 45 portions of Fructus Evodiaes 45 parts of Semen Cassiaes 43 parts
33 parts, Radix Aeschynomenes indicae 40 portions of Rhizoma Polygonati Odorati 38 parts of Fructus Aristolochiae Kwangsiensiss 35 parts of Fructus Amomi Rotunduss
Herba leerisae hexandrae 33 parts of Herba Micromeriae Bifloraes 30 parts of Fructus Akebiaes 30 portions of Bulbus Lycoridis Radiataes 28 parts
Semen Ziziphi Spinosae 25 parts of Radixs Angelicae Dahuricae 24 parts of Radix Perillae 21 parts of Rhizoma Acori Calami 18 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the Chinese medicine preparation of Menieres disease, it is characterized in that: be following processing step:
(1) by Periostracum Cicadae, Semen Cassiae, Fructus Aristolochiae Kwangsiensis, Semen Ziziphi Spinosae and the Radix Angelicae Dahuricae with mix, carry out pulverization process after mix homogeneously, grind into powder, cross 160 order fine powders, for subsequent use;
(2) Radix Polygalae, Radix Aeschynomenes indicae, Herba leerisae hexandrae, Herba Micromeriae Biflorae, Radix Perillae and Rhizoma Acori Calami are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.12 ~ 1.17, for subsequent use;
(3) Fructus Evodiae and Bulbus Lycoridis Radiatae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Rhizoma Polygonati Odorati, Fructus Amomi Rotundus and Fructus Akebiae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 70% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 60 DEG C, relative density is the thick paste of 1.11 ~ 1.15, for subsequent use;
(5) by fine powder, thick paste and the juice mixing obtained by above-mentioned steps (1) ~ (4), make tablet or capsule, obtain the Chinese medicine preparation of described treatment Menieres disease.
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| CN1096450A (en) * | 1993-06-18 | 1994-12-21 | 王景芳 | Chinese patent medicine of treatment Meniere and preparation method thereof |
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2014
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| CN103028097A (en) * | 2011-09-29 | 2013-04-10 | 马静华 | Traditional Chinese medicine recipe for treating meniere syndrome |
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