CN105055730A - Method for preparing nursing plaster for treating angina - Google Patents

Abstract

The invention discloses a method for preparing a nursing plaster for treating angina. The method is characterized by comprising the following steps: weighing the following raw materials in parts by weight: 9 parts of periplaneta americana, 9 parts of rhizoma acori graminei, 6 parts of frankincense, 3 parts of clove and 0.5 part of borneol; grinding the periplaneta americana into coarse powder, adding water and performing ultrasonic extraction at 0-10 DEG C; and decocting the hizoma acori graminei, the frankincense and the clove twice to prepare a cataplasm. The nursing plaster has the advantages of convenience in taking, constant-speed drug release, no adverse response, good curative effect and the like.

Description

A kind of preparation method for the treatment of angina pectoris nursing plaster

Technical field

The present invention relates to a kind of preparation method of nursing plaster, be specifically related to a kind of preparation method for the treatment of angina pectoris nursing plaster, belong to medical art.

Technical background

Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease, and referring to because coronary atherosclerosis causes myocardial ischemia, anoxia and the heart disease caused, is commonly encountered diseases, the frequently-occurring disease of a kind of serious harm human health and life.Angina pectoris is one of its main clinical manifestation.Primary disease belongs to Chinese medicine " precordial pain with cold limbs ", " angina pectoris ", " thoracic obstruction " category.Motherland's medical science except endo-medicine, also adopts interior disease external therapy to its treatment.External treatment has convenient drug administration, constant speed release medicine, alleviates adverse effect, maintains the stable and lasting advantage such as blood drug level, raising curative effect, minimizing times for spraying, in today that endo-medicine, intervention etc. highlight for the side effect of main flow control angina pectoris, external therapy of tcm still occupies a tiny space in the control of primary disease, especially for some patient because physical qualification limit, during other therapies such as unsuitable endo-medicine and application intervention, more show the unique effects of its external treatment.Angina pectoris external treatment embodies the organic conception of Chinese medicine, has through sick institute, an advantage such as fast, the multipath administration of proving effective, use safety, toxic and side effects are little.But also there is some shortcomings and limitation, the technique as preparation falls behind, and the effective ingredient dissolution rate of medicine is not high, absorbance is low, limits the performance of drug effect.At present, the report of external treatment of tcm treatment angina pectoris stresses to give clinical observation more, and the bibliographical information studying its method for making is few.Therefore, how to prepare and improve the absorbance of effective ingredient and infiltration rate, develop the dosage form of more convenient practicality, give full play to the advantage of external treatment of tcm treatment angina pectoris, by be at present in the urgent need to research emphasis.

Summary of the invention

The object of this invention is to provide a kind of preparation method for the treatment of angina pectoris nursing plaster, the nursing nursing plaster of preparation is used for the treatment of coronary heart disease heart wrest convenient drug administration, constant speed release medicine, alleviate adverse effect, maintain the stable and lasting advantage such as blood drug level, raising curative effect, minimizing time medicine number of times.

Object of the present invention is achieved through the following technical solutions.

Treat a preparation method for angina pectoris nursing plaster, it is characterized in that: the raw material taking off row weight proportion: periplaneta americana 9 parts, Rhizoma Acori Graminei 9 parts, Olibanum 6 parts, Flos Caryophylli 3 parts, Borneolum Syntheticum 0.5 part;

Standby in order to below legal system:

A periplaneta americana is ground into coarse powder by (), add 10 times of water gagings, at 0 ~ 10 DEG C of ultrasonic extraction 1 hour, extracting liquid filtering, centrifugal, obtains periplaneta americana extracting solution;

B Rhizoma Acori Graminei, Olibanum, Flos Caryophylli are decocted with water twice by (), add 6-8 times of water gaging for the first time, decoction 1-2 hour, and second time adds 4-6 times of water gaging, decocts 1-2 hour: merge twice decocting liquid, filters, the clear paste that concentrated filtrate extremely weighs with medical material etc.;

C () qinghuo reagent adds ethanol to 70%, place 24 hours, get supernatant in 4 DEG C, reclaims ethanol, obtains alcohol extract;

D (), by periplaneta americana extracting solution, alcohol extract merges, and less than 60 DEG C vacuum concentration are to relative density 1.2 extractum;

E () gets Babu cream substrate 20 parts of heat fused in water-bath, add extractum and Borneolum Syntheticum, stir, be applied on sark and get final product.

If the raw material of above weight proportion is in grams, be the consumption of 1 subsides, can increase according to corresponding ratio when producing or reduce, as large-scale production can by kilogram or in units of ton, but the weight proportion constant rate between each component.

So far complete the present invention, the usage that the present invention treats angina pectoris nursing plaster is, when angina pectoris attacks, nursing plaster is applied to pareordia.Nurse by the following method during medication: before enforcement sticks, first inquire whether patient uses medicine allergies, to some extent with or without skin allergy history, as cutaneous scarification, cloth hypersensitivity etc.To action principle and the using method of explain's chest pain plaster, to obtain understanding and the cooperation of patient.Check whether patient pareordia skin has erythra, the abnormal phenomena such as rubescent, damaged, as intact in skin without damaged, with hot towel, skin is cleaned, extremely should avoid sticking as skin has.Patient gets seat or clinostatism, and fully expose and stick position, angina pectoris nursing plaster is sticked on pareordia, and every day 1 pastes, and often pasting and retain 6h-12h, 10 days was 1 course for the treatment of.And polling patient local skin has numbness to generate heat, itch after medication every day, when taking off ointment, assisting patients cleans skin, observes local skin with or without drug allergy phenomenons such as rubescent, erythra.As occur point-like or lamellar ruddy, or there is erythra, itch pain person, should stop using.There is skin rubefaction in few patients, can spontaneous recovery after drug withdrawal.Above-mentioned symptom is caused to drug of topical application overlong time, after local skin takes a turn for the better, also can continue to use when the strict grasp drug of topical application time.

Angina pectoris frequently shows effect, and degree is heavier, often accompanies susceptible to lose temper due to restlessness, bitter taste in the mouth and dry throat.That will carry out patient in medication process dredges work, care for patient, says that obviously will, to the material impact of disease process, makes it keep phychology calmness happy to patient.

The present invention has convenient drug administration, constant speed release medicine, has no adverse reaction, maintains the stable and lasting advantage such as blood drug level, raising curative effect, minimizing oral medicine times for spraying.

The present invention is further illustrated below by test example.

One, angina pectoris nursing plaster is prepared

1. prepare Babu cream substrate

1) gelatin 30g is got, azone 3g, arabic gum 40g, Polyethylene Glycol (400) 50g, sodium polyacrylate 40g, glycerol 40g, zinc oxide 2g.

2) get sodium polyacrylate, glycerol, azone in mortar, grind even mixture.

3) get gelatin, that arabic gum adds suitable quantity of water is swelling, heating makes dissolving, in 50 DEG C of water-baths, constantly stirs, add zinc oxide, Polyethylene Glycol (400) and sodium polyacrylate, glycerol, azone three mixture mix homogeneously successively, obtain Babu cream substrate.

2. prepare Chinese medical concrete

1) periplaneta americana 900g is got, Rhizoma Acori Graminei 900g, Olibanum 600g, Flos Caryophylli 300g, Borneolum Syntheticum 50g;

2) in order to below legal system for extractum:

A periplaneta americana is ground into coarse powder by (), put in Multipurpose ultrasonic extractor that Beijing Hongxianglong Biotechnology Co., Ltd. produces, add 9kg water, at 5 DEG C of ultrasonic extraction 1 hour, extracting liquid filtering, centrifugal, obtains periplaneta americana extracting solution;

B Rhizoma Acori Graminei, Olibanum, Flos Caryophylli are decocted with water twice by (), first time adds 14kg water, decocts 2 hours, and second time adds 10kg water, decocts 1 hour: merge twice decocting liquid, filter, the clear paste that concentrated filtrate extremely weighs with medical material etc.;

C () qinghuo reagent adds ethanol to 70%, place 24 hours, get supernatant in 4 DEG C, reclaims ethanol, obtains alcohol extract;

D (), by periplaneta americana extracting solution, alcohol extract merges, and less than 60 DEG C vacuum concentration are to relative density 1.2 extractum.

3. prepare angina pectoris nursing plaster

Get Babu cream substrate 2kg heat fused in water-bath, add Chinese medical concrete and Borneolum Syntheticum, stir, be applied on non-woven fabrics, lid lining, is cut into 200 subsides.

Two, the nursing efficacy of angina pectoris nursing plaster treatment angina pectoris

1. physical data

Two group of 60 example is my institute inpatient's in July ,-2014 in June, 2013, the diagnostic criteria of " angina pectoris " in all meeting.Wherein man 44 example, female 16 example; Year mean age (57.63 ± 6.52); Average course of disease (16 ± 1.5) sky; Sick 19 examples of complicated hypertension, diabetes mellitus in 2 patients, hyperlipemia 6 example.The data such as two groups of sexes, age, the course of disease and complication are roughly the same, through statistical procedures there was no significant difference, have comparability.

2. treatment and care method

1) matched group adopts oral or intravenous drip nitrate esters, antiplatelet, anticoagulant class Drug therapy, and controls blood pressure, blood glucose, blood fat, corrects cardiac insufficiency.Simultaneously according to angina pectoris nursing routine Implementing.

2) treatment group implements angina pectoris nursing plaster on the basis that treatment of control group is nursed, and nursing plaster is applied to pareordia, and every day 1 pastes, and often putting up cream and retain 10h, 10 days is 1 treatment.

Nurse by the following method during medication: before enforcement sticks, first inquire whether patient uses medicine allergies, to some extent with or without skin allergy history, as cutaneous scarification, cloth hypersensitivity etc.To action principle and the using method of explain's chest pain plaster, to obtain understanding and the cooperation of patient.Check whether patient pareordia skin has erythra, the abnormal phenomena such as rubescent, damaged, as intact in skin without damaged, with hot towel, skin is cleaned, extremely should avoid sticking as skin has.After medication every day, polling patient local skin has numbness to generate heat, itch, and when taking off ointment, assisting patients cleans skin, observes local skin with or without drug allergy phenomenons such as rubescent, erythra.As occur point-like or lamellar ruddy, or there is erythra, itch pain person, should stop using.There is skin rubefaction in few patients, can spontaneous recovery after drug withdrawal.Above-mentioned symptom is caused to drug of topical application overlong time, after local skin takes a turn for the better, also can continue to use when the strict grasp drug of topical application time.

3. criterion of therapeutical effect

Effective: after treatment, angina pectoris attacks number of times, degree and persistent period reduce 80%; Effective: angina pectoris attacks number of times after treatment, degree and persistent period reduce 50% one 80%; Invalid: after treatment, angina pectoris attacks number of times, degree and persistent period reduce less than 50%.

4. therapeutic outcome

Therapeutic outcome is in table 1.

Table 1 liang group therapeutic outcome and comparitive study [number of cases (%)]

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate
						Matched group	30	16(53.3)	8(26.7)	6(20.0)	80
Treatment group	30	20(66.7)	10(33.3)	0(0.0)	100

Result illustrates, the in addition angina pectoris nursing plaster treatment on the basis of routine care, curative effect significantly improves.

Specific embodiment

Embodiment 1

Get periplaneta americana 9kg, Rhizoma Acori Graminei 9kg, Olibanum 6kg, Flos Caryophylli 3kg, Borneolum Syntheticum 0.5kg;

Standby in order to below legal system:

A periplaneta americana is ground into coarse powder by (), add 9kg water, at 10 DEG C of ultrasonic extraction 1 hour, extracting liquid filtering, centrifugal, obtains periplaneta americana extracting solution;

B Rhizoma Acori Graminei, Olibanum, Flos Caryophylli are decocted with water twice by (), first time adds 108kg water, decocts 1.5 hours, and second time adds 108kg water, decocts 1 hour: merge twice decocting liquid, filter, the clear paste that concentrated filtrate extremely weighs with medical material etc.;

C () qinghuo reagent adds ethanol to 70%, place 24 hours, get supernatant in 4 DEG C, reclaims ethanol, obtains alcohol extract;

D (), by periplaneta americana extracting solution, alcohol extract merges, and less than 60 DEG C vacuum concentration are to relative density 1.2 extractum;

E () gets Babu cream substrate 20kg heat fused in water-bath, add extractum and Borneolum Syntheticum, stir, and is applied on cotton, makes 1000 subsides.

Embodiment 2

Get periplaneta americana 9kg, Rhizoma Acori Graminei 9kg, Olibanum 6kg, Flos Caryophylli 3kg, Borneolum Syntheticum 0.5kg;

Standby in order to below legal system:

A periplaneta americana is ground into coarse powder by (), add 9kg water, at 0 DEG C of ultrasonic extraction 1 hour, extracting liquid filtering, centrifugal, obtains periplaneta americana extracting solution;

B Rhizoma Acori Graminei, Olibanum, Flos Caryophylli are decocted with water twice by (), first time adds 144kg water, decocts 1 hour, and second time adds 72kg water, decocts 1 hour: merge twice decocting liquid, filter, the clear paste that concentrated filtrate extremely weighs with medical material etc.;

C () qinghuo reagent adds ethanol to 70%, place 24 hours, get supernatant in 4 DEG C, reclaims ethanol, obtains alcohol extract;

D (), by periplaneta americana extracting solution, alcohol extract merges, and less than 60 DEG C vacuum concentration are to relative density 1.2 extractum;

E () gets Babu cream substrate 20kg heat fused in water-bath, add extractum and Borneolum Syntheticum, stir, and is applied on cotton, makes 1000 subsides.

Embodiment 3

Get periplaneta americana 9kg, Rhizoma Acori Graminei 9kg, Olibanum 6kg, Flos Caryophylli 3kg, Borneolum Syntheticum 0.5kg;

Standby in order to below legal system:

A periplaneta americana is ground into coarse powder by (), add 9kg water, at 5 DEG C of ultrasonic extraction 1 hour, extracting liquid filtering, centrifugal, obtains periplaneta americana extracting solution;

B Rhizoma Acori Graminei, Olibanum, Flos Caryophylli are decocted with water twice by (), first time adds 130kg water, decocts 2 hours, and second time adds 90kg water, decocts 2 hours: merge twice decocting liquid, filter, the clear paste that concentrated filtrate extremely weighs with medical material etc.;

C () qinghuo reagent adds ethanol to 70%, place 24 hours, get supernatant in 4 DEG C, reclaims ethanol, obtains alcohol extract;

D (), by periplaneta americana extracting solution, alcohol extract merges, and less than 60 DEG C vacuum concentration are to relative density 1.2 extractum;

E () gets Babu cream substrate 20kg heat fused in water-bath, add extractum and Borneolum Syntheticum, stir, and is applied on cotton, makes 1000 subsides.

Embodiment 4

Get periplaneta americana 9kg, Rhizoma Acori Graminei 9kg, Olibanum 6kg, Flos Caryophylli 3kg, Borneolum Syntheticum 0.5kg;

Standby in order to below legal system:

A periplaneta americana is ground into coarse powder by (), add 9kg water, at 4 DEG C of ultrasonic extraction 1 hour, extracting liquid filtering, centrifugal, obtains periplaneta americana extracting solution;

B Rhizoma Acori Graminei, Olibanum, Flos Caryophylli are decocted with water twice by (), first time adds 120kg water, decocts 1.5 hours, and second time adds 100kg water, decocts 1 hour: merge twice decocting liquid, filter, the clear paste that concentrated filtrate extremely weighs with medical material etc.;

C () qinghuo reagent adds ethanol to 70%, place 24 hours, get supernatant in 4 DEG C, reclaims ethanol, obtains alcohol extract;

D (), by periplaneta americana extracting solution, alcohol extract merges, and less than 60 DEG C vacuum concentration are to relative density 1.2 extractum;

E () gets Babu cream substrate 20kg heat fused in water-bath, add extractum and Borneolum Syntheticum, stir, and is applied on cotton, makes 1000 subsides.

Claims (1)

1. treat a preparation method for angina pectoris nursing plaster, it is characterized in that: the raw material taking off row weight proportion: periplaneta americana 9 parts, Rhizoma Acori Graminei 9 parts, Olibanum 6 parts, Flos Caryophylli 3 parts, Borneolum Syntheticum 0.5 part;

Standby in order to below legal system:

A periplaneta americana is ground into coarse powder by (), add 10 times of water gagings, at 0 ~ 10 DEG C of ultrasonic extraction 1 hour, extracting liquid filtering, centrifugal, obtains periplaneta americana extracting solution;

B Rhizoma Acori Graminei, Olibanum, Flos Caryophylli are decocted with water twice by (), add 6-8 times of water gaging for the first time, decoction 1-2 hour, and second time adds 4-6 times of water gaging, decocts 1-2 hour: merge twice decocting liquid, filters, the clear paste that concentrated filtrate extremely weighs with medical material etc.;

C () qinghuo reagent adds ethanol to 70%, place 24 hours, get supernatant in 4 DEG C, reclaims ethanol, obtains alcohol extract;

D (), by periplaneta americana extracting solution, alcohol extract merges, and less than 60 DEG C vacuum concentration are to relative density 1.2 extractum;

E () gets Babu cream substrate 20 parts of heat fused in water-bath, add extractum and Borneolum Syntheticum, stir, be applied on sark and get final product.