CN106619168A - Skin-whitening active component containing natural compounds - Google Patents
Skin-whitening active component containing natural compounds Download PDFInfo
- Publication number
- CN106619168A CN106619168A CN201611056237.7A CN201611056237A CN106619168A CN 106619168 A CN106619168 A CN 106619168A CN 201611056237 A CN201611056237 A CN 201611056237A CN 106619168 A CN106619168 A CN 106619168A
- Authority
- CN
- China
- Prior art keywords
- hypatulina
- skin
- whitening active
- active component
- component containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a skin-whitening active component containing natural compounds. The skin-whitening active composition is prepared from hypatulinA and sinigrin in the weight ratio being (1-30): 1.
Description
Technical field
The present invention relates to a kind of whitening active component containing native compound, belongs to cosmetic skin care product field.
Background technology
Toner, toner/smoothing toner, astringent lotion are referred to as toner, are a kind of cosmetics of transparent liquid, are applied to the table of skin
Face, for the health for cleaning skin, keeping skin.The difference of toner, astringent lotion and toner/smoothing toner is not too big, toner, convergence
Water is more suitable for that weather is warmmer, the fuel-displaced weather of love is compared on the face and is used, and toner/smoothing toner is more suitable for dry season and uses.Toner exists
Play a part of to take over from the past and set a new course for the future in basic skin care, with the pursuit of the raising and people of people's quality of the life to U.S., toner
Kind class is more and more various.HypatulinA is the brand-new framework compound separated from hypericum, with certain anti-
Microbial activity.Hypatulins A and B, Meroterpenes from Hypericum patulum are published in,
Org.Lett, 2016,18 (20), 5360-5363.
It has been found that hypatulinA has significant whitening effect with sinigrin under certain proportion.
The content of the invention
For the problem that above-mentioned prior art is present, the present invention provides a kind of whitening active group containing native compound
Point, whitening effect is good.
To achieve these goals, the technical solution used in the present invention is：One kind contains native compound hypatulinA
Whitening water, including：Whitening active composition, described whitening active composition includes hypatulinA and sinigrin,
HypatulinA is as follows：
Above-mentioned whitening component and glycerine, triethanolamine, sodium lactate (60%), deionized water, Sodium Hyaluronate and methylol
Cellulose forms active whitening water.
HypatulinA and sinigrin erection weight ratio are 1-30:1.
Whitening active composition accounts for middle weight 0.5-5%.
It is found by the applicant that hypatulinA mixes to be played for whitening with sinigrin under certain proportion cooperateing with well
Effect, particularly 10:1-20:1, whitening effect is increased substantially.
Specific embodiment
Below the invention will be further described.
Sinigrin, No. CAS：3952-98-5,
The preparation method of hypatulinA is referring to document：Hypatulins A and B, Meroterpenes from
Hypericum patulum, Org.Lett, 2016,18 (20), 5360-5363.
Embodiment 1
HypatulinA, sinigrin, deionized water, wherein hypatulinA and sinigrin account for 3%, and ratio is 15：
1, remainder is deionized water.
Embodiment 2
HypatulinA, sinigrin, glycerine 5%, triethanolamine 6%, sodium lactate (60%) 4%, Sodium Hyaluronate 2%
With hydroxymethyl cellulose 3%, remaining deionized water, wherein hypatulinA and sinigrin account for 3%, and ratio is 15：1.
Detection method：
Suppress middle melanin genesis test in mouse melanin cell.
B16 mouse melanin tumor cells are connected to into the culture dish of a diameter of 9cm with the density of 1 × 105/ml, in 37 DEG C ﹑
Cultivate 2 days under conditions of 5%CO2, abandon supernatant, add the sample solution 18-22ml after filtration sterilization, be then incubated for 3 days, abandon
Supernatant, PBS washings, the trypsin solution vitellophag 3min of 0.5ml mass percents 0.2% is added per hole, adds 2ml to tie up per ware
Hold liquid and terminate digestion. after piping and druming is mixed, every kind of concentration is taken out 0.5ml and does cell count. remaining cell suspension with 2500r/min from
Heart 5min, abandons supernatant, adds NaoH solution, heating to dissolve melanin in precipitation, selects the enzyme linked immunological of 490nm wavelength
Absorbance is surveyed on detector.
B16 cell inhibiting rate=(1- (medicine hole absorbance+medicine hole cell density)+(control wells absorbance+right
According to hole cell density)) × 100%.
Suppress middle melanin genesis test in mouse melanin cell, sample solution be containing 3% hypatulinA with it is black
The mixed liquor of Myronate Potassium.
A is hypatulinA, and B is sinigrin, as a result as follows,
It is above-mentioned test result indicate that, hypatulinA and sinigrin by a certain percentage (15：1-20：1) each other
Fusion has collaboration whitening effect, can effectively suppress melanin to generate, and effect is significant.And association is then had no between other ratios
Same-action, whitening effect is not obvious.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention not by above-described embodiment
Limit, the Gai Bian ﹑ Xiu Shi ﹑ Ti Dai ﹑ Zu He ﹑ made under other any Spirit Essences and principle without departing from the present invention simplify,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (2)
1. a kind of whitening active component containing native compound, it is characterised in that include：HypatulinA and sinigrin,
HypatulinA structural formulas are as follows：
2. a kind of whitening active component containing native compound according to claim 1, it is characterised in that
HypatulinA and sinigrin erection weight ratio are 1-30:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056237.7A CN106619168A (en) | 2016-11-25 | 2016-11-25 | Skin-whitening active component containing natural compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056237.7A CN106619168A (en) | 2016-11-25 | 2016-11-25 | Skin-whitening active component containing natural compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106619168A true CN106619168A (en) | 2017-05-10 |
Family
ID=58811289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611056237.7A Pending CN106619168A (en) | 2016-11-25 | 2016-11-25 | Skin-whitening active component containing natural compounds |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106619168A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014118610A1 (en) * | 2013-01-31 | 2014-08-07 | Kgk Synergize Inc. | Methods of skin whitenening by use of canola extracts |
-
2016
- 2016-11-25 CN CN201611056237.7A patent/CN106619168A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014118610A1 (en) * | 2013-01-31 | 2014-08-07 | Kgk Synergize Inc. | Methods of skin whitenening by use of canola extracts |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103393568B (en) | A kind of whitening and spot eliminating cream | |
| CN105232438A (en) | Moisturizing and repairing facial mask and preparation method thereof | |
| CN107374988B (en) | Preparation method of nonionic vesicle with whitening effect | |
| CN105455127A (en) | Process for preparing tea enzyme liquid from fresh tea leaves | |
| CN107157797A (en) | A kind of preparation technology of Application of Collagen from Fish Scales facial mask | |
| CN105476876A (en) | Novel deuterium-depleted lotion and preparation method thereof | |
| CN108524395A (en) | One group of moisturizing whitening mask liquid and preparation method thereof | |
| CN104800096A (en) | Efficient moisturizing composition applied to cosmetics | |
| CN105997740A (en) | Skin-cleaning composition with natural plant extract formula | |
| CN108158913A (en) | A kind of deodorization and sterilization Chinese medicinal toothpaste and preparation method thereof | |
| CN104473841A (en) | Traditional Chinese medicine mask containing dendrobe | |
| CN112494376A (en) | Chinese prescription shampoo and preparation method thereof | |
| CN106619168A (en) | Skin-whitening active component containing natural compounds | |
| Shengkui et al. | The history of China’s food security in the past hundred years | |
| CN101422416A (en) | Use of residual liquid in producing daily chemical product after extracting d-borneol from borneol camphor | |
| CN104814916A (en) | Moisturizing essence and preparing method thereof | |
| CN107536756B (en) | Prickly heat removing skin care cream and preparation method thereof | |
| CN104398416A (en) | Tibetan medicine composition and preparation method and application thereof | |
| CN104840408B (en) | A kind of hand lotion of the hydrolyzate containing quail egg and preparation method thereof | |
| CN107737059A (en) | A kind of centella whitening lotion | |
| CN101167834B (en) | Rosa xanthina dew tasty liquid and preparation method thereof | |
| CN106420508A (en) | Amaranthus retroflexus-containing whitening toning lotion | |
| CN106491382A (en) | A kind of whitening water containing native compound HitorinB | |
| CN108264965A (en) | A kind of preparation method of mud wormwood artemisia enzymatic hydrolyzed extract and its application in cigarette | |
| CN105496852A (en) | Dendrobium nobile mask and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170510 |