CN107737059A - A kind of centella whitening lotion - Google Patents
A kind of centella whitening lotion Download PDFInfo
- Publication number
- CN107737059A CN107737059A CN201711257702.8A CN201711257702A CN107737059A CN 107737059 A CN107737059 A CN 107737059A CN 201711257702 A CN201711257702 A CN 201711257702A CN 107737059 A CN107737059 A CN 107737059A
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- CN
- China
- Prior art keywords
- aurantiamarin
- gotu kola
- centella
- whitening
- weight ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The present invention discloses a kind of centella whitening lotion, and active ingredient includes aurantiamarin, Gotu Kola P.E and matrix, and the weight ratio of described Gotu Kola P.E and aurantiamarin is 1:1‑20:1, matrix is dimension E phosphate esters magnesium, 3 pairs of isostearates of polyglycereol, Glycolic acid, linseed oil and hyaluronic acid.The present invention adds aurantiamarin and some matrix, its is cheap, and Gotu Kola P.E mixes with a small amount of aurantiamarin plays the weight ratio of good synergy, particularly Gotu Kola P.E and aurantiamarin 5 for whitening using Gotu Kola P.E as primary raw material:1‑6:1, whitening effect increases substantially.
Description
Technical field
The present invention relates to a kind of centella whitening lotion, belongs to cosmetic skin care product field.
Background technology
Toner, smoothing toner, astringent lotion are referred to as toner, are a kind of cosmetics of transparent liquid, are applied to the table of skin
Face, for the health for cleaning skin, keeping skin.Toner, astringent lotion and smoothing toner difference are not too big, toner, convergence
Water is more suitable for that weather is warmmer, compares like that fuel-displaced weather uses on the face, and smoothing toner is more suitable for dry season and used.Toner exists
Play a part of to take over from the past and set a new course for the future in basic skin care, with pursuit of the raising and people of people's quality of the life to U.S., toner
Kind class is more and more various.
Gotu Kola P.E main component is Asiaticoside, madecassoside.Principal component is that pinocamphone is applied on a left side
(pinocamphone), left-handed menthones (menthone), pulegone (pulelgone), australene (α-pinene), β-pinane
Alkene (β-pinene), brown lemon alkene (limonene), 1-8- Cineoles (1,8-cineole), cymol (p-cymene),
Isomenthone (isomenthone), isopinocamphone (isopinocamphone), linalool (linalool), menthol
And alpha-terpineol (α-terpineol) etc. (mentholk).Composition is with the place of production, use and other factors and difference has also contained Europe
Sub- blood circulation promoting pill furans (glechomafuran), groundivy lactone (glechomanolide).In addition ursolic acid is still contained
(ursolic acid), cupreol (β-sitosterol), palmitic acid (palmitic acid), butanedioic acid (succinic
Acid), caffeic acid (caffeic acid), forulic acid (ferulic acid), choline (choline), vitamin C and stachyose
(stachyose) etc..
Aurantiamarin CAS：520-26-3 plant origins：Rue family citrus plant sweet orange, lemon, at present for centella
The utilization of extract and aurantiamarin particularly has not been reported in the application of whitening lotion.
The content of the invention
In view of the above-mentioned problems of the prior art, the present invention provides a kind of centella whitening lotion, cost is cheap, beautiful
White effect is good.
To achieve these goals, the technical solution adopted by the present invention is：Active ingredient includes aurantiamarin, centella is extracted
Thing, glycerine, according to weight ratio, the weight ratio of described Gotu Kola P.E and aurantiamarin is 1:1-20:1.Aurantiamarin 0.2%,
Gotu Kola P.E 4%, glycerine 2%, propane diols 1%, allantoin 2%, hydroxyethyl cellulose 0.8%, sorb, 2%, hyalomitome
Sour sodium 0.8% and water surplus are formed.
The present invention adds aurantiamarin and some matrix, its is cheap, accumulated snow using Gotu Kola P.E as primary raw material
Careless extract mixes with a small amount of aurantiamarin and plays good synergy, particularly Gotu Kola P.E and orange peel for whitening
The weight ratio of glycosides is 6:1-5:1, whitening effect increases substantially.
Embodiment：
The invention will be further described below.
Embodiment 1：
According to weight proportion, Gotu Kola P.E is 20 with aurantiamarin:1, Gotu Kola P.E accounts for total amount altogether with aurantiamarin
2%, glycerine 2%, propane diols 1%, allantoin 2%, hydroxyethyl cellulose 0.8%, sorb 2%, the He of Sodium Hyaluronate 0.8%
Water surplus are formed.
Embodiment 2：
According to weight proportion, Gotu Kola P.E is 15 with aurantiamarin:1, Gotu Kola P.E accounts for total amount altogether with aurantiamarin
2%, glycerine 2%, propane diols 1%, allantoin 2%, hydroxyethyl cellulose 0.8%, sorb 2%, the He of Sodium Hyaluronate 0.8%
Water surplus are formed.
Embodiment 3：
According to weight proportion, Gotu Kola P.E is 6 with aurantiamarin:1, Gotu Kola P.E accounts for total amount altogether with aurantiamarin
2%, glycerine 2%, propane diols 1%, allantoin 2%, hydroxyethyl cellulose 0.8%, sorb 2%, Sodium Hyaluronate 0.8% and water
Surplus is formed.
Embodiment 4：
According to weight proportion, Gotu Kola P.E is 5 with aurantiamarin:1, Gotu Kola P.E accounts for total amount altogether with aurantiamarin
2%, glycerine 2%, propane diols 1%, allantoin 2%, hydroxyethyl cellulose 0.8%, sorb 2%, Sodium Hyaluronate 0.8% and water
Surplus is formed.
Embodiment 5：
According to weight proportion, Gotu Kola P.E is 3 with aurantiamarin:1, Gotu Kola P.E accounts for total amount altogether with aurantiamarin
2%, glycerine 2%, propane diols 1%, allantoin 2%, hydroxyethyl cellulose 0.8%, sorb 2%, Sodium Hyaluronate 0.8% and water
Surplus is formed.
Embodiment 6：
According to weight proportion, Gotu Kola P.E is 2 with aurantiamarin:1, Gotu Kola P.E accounts for total amount altogether with aurantiamarin
2%, glycerine 2%, propane diols 1%, allantoin 2%, hydroxyethyl cellulose 0.8%, sorb 2%, Sodium Hyaluronate 0.8% and water
Surplus forms
Embodiment 7：
According to weight proportion, Gotu Kola P.E is 1 with aurantiamarin:1, Gotu Kola P.E accounts for total amount altogether with aurantiamarin
2%, glycerine 2%, propane diols 1%, allantoin 2%, hydroxyethyl cellulose 0.8%, sorb 2%, Sodium Hyaluronate 0.8% and water
Surplus is formed.
Detection method：
Suppress middle melanin genesis experiment in mouse melanin cell.
B16 mouse melanin tumor cells are connected to a diameter of 9cm culture dish with 1 × 105/ml density, in 37 DEG C ﹑
Cultivated 2 days under conditions of 2%CO2, abandon supernatant, the sample solution 18-22ml added after filtration sterilization, be then incubated for 3 days, abandon
Supernatant, PBS washings, the trypsin solution vitellophag 3min of 0.5ml mass percents 0.2% is added per hole, adds 2ml to tie up per ware
Liquid is held to terminate after digestion piping and druming mixes, every kind of concentration take out 0.5ml do remaining cell suspension of cell count with 2500r/min from
Heart 5min, abandons supernatant, and NaoH solution is added in precipitation, and heating dissolves melanin, selects the enzyme linked immunological of 490nm wavelength
Absorbance is surveyed on detector.
B16 cell inhibiting rate=(1- (medicine hole absorbance+medicine hole cell density)+(control wells absorbance+right
According to hole cell density)) × 100%.
Suppress middle melanin genesis experiment in mouse melanin cell, it is as a result as follows,
A is Gotu Kola P.E, and B is aurantiamarin
It is above-mentioned test result indicates that, Gotu Kola P.E and aurantiamarin by a certain percentage (5：1-6：1) it is mutual to melt
Closing has collaboration whitening effect, can effectively suppress melanin generation, and significant effect.And collaboration is then had no between other ratios
Effect, whitening effect unobvious.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, others are any to be simplified without departing from the Gai Bian ﹑ Xiu Shi ﹑ Ti Dai ﹑ Zu He ﹑ made under Spirit Essences and principle of the invention,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (2)
- A kind of 1. centella whitening lotion, it is characterised in that active ingredient include aurantiamarin, Gotu Kola P.E, glycerine, third Glycol, allantoin, hydroxyethyl cellulose, Sodium Hyaluronate and water surplus are formed.
- 2. a kind of centella whitening lotion according to claim 1, it is characterised in that according to weight ratio, described product The weight ratio of careless extract and aurantiamarin is avenged 1:1-20:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711257702.8A CN107737059A (en) | 2017-12-04 | 2017-12-04 | A kind of centella whitening lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711257702.8A CN107737059A (en) | 2017-12-04 | 2017-12-04 | A kind of centella whitening lotion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107737059A true CN107737059A (en) | 2018-02-27 |
Family
ID=61239952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711257702.8A Withdrawn CN107737059A (en) | 2017-12-04 | 2017-12-04 | A kind of centella whitening lotion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107737059A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330931A (en) * | 2018-10-11 | 2019-02-15 | 浙江大学自贡创新中心 | A kind of Gotu Kola P.E and preparation method thereof applied to cosmetics |
| CN109908046A (en) * | 2019-02-25 | 2019-06-21 | 重庆西南果品营养研究院 | A kind of surfactant and preparation method of the ingredient containing natural citrus |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569640A (en) * | 2008-04-30 | 2009-11-04 | 浙江康恩贝健康产品有限公司 | Application of total asiaticoside to preparation of medicaments or cosmetics for preventing and curing striae gravidarum |
| CN104434622A (en) * | 2014-11-05 | 2015-03-25 | 航天神舟生物科技集团有限公司 | Novel function and application of seville orange flower extract |
| CN106389215A (en) * | 2016-11-03 | 2017-02-15 | 徐州得铸生物科技有限公司 | Whitening lotion prepared from puncturevine caltrop fruit |
| CN106562894A (en) * | 2016-10-12 | 2017-04-19 | 广东药科大学 | Skin-whitening, anti-aging and anti-allergic hesperidin composition, application and preparation |
-
2017
- 2017-12-04 CN CN201711257702.8A patent/CN107737059A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569640A (en) * | 2008-04-30 | 2009-11-04 | 浙江康恩贝健康产品有限公司 | Application of total asiaticoside to preparation of medicaments or cosmetics for preventing and curing striae gravidarum |
| CN104434622A (en) * | 2014-11-05 | 2015-03-25 | 航天神舟生物科技集团有限公司 | Novel function and application of seville orange flower extract |
| CN106562894A (en) * | 2016-10-12 | 2017-04-19 | 广东药科大学 | Skin-whitening, anti-aging and anti-allergic hesperidin composition, application and preparation |
| CN106389215A (en) * | 2016-11-03 | 2017-02-15 | 徐州得铸生物科技有限公司 | Whitening lotion prepared from puncturevine caltrop fruit |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330931A (en) * | 2018-10-11 | 2019-02-15 | 浙江大学自贡创新中心 | A kind of Gotu Kola P.E and preparation method thereof applied to cosmetics |
| CN109330931B (en) * | 2018-10-11 | 2021-11-02 | 浙江大学自贡创新中心 | Centella asiatica extract applied to cosmetics and preparation method thereof |
| CN109908046A (en) * | 2019-02-25 | 2019-06-21 | 重庆西南果品营养研究院 | A kind of surfactant and preparation method of the ingredient containing natural citrus |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180227 |