CN105342933A - Chinese herbal compound face cleansing effervescent tablet and preparation method thereof - Google Patents
Chinese herbal compound face cleansing effervescent tablet and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses a Chinese herbal compound face cleansing effervescent tablet and a preparation method thereof. The Chinese herbal compound face cleansing effervescent tablet comprises Chinese herbal compound extractive which is prepared from, by mass, 10-90 parts of mung beans, 1-30 parts of florists chrysishhemum, 1-30 parts of poria cocos, 1-30 parts of liquorice, 1-30 parts of moutan bark and 0-5 parts of borneol. According to the Chinese herbal compound face cleansing effervescent tablet and the preparation method, extract obtained by conducting extracting and refining according to the Chinese herbal compound is used as the raw material, the Chinese herbal compound face cleansing effervescent tablet is green, healthy and safe, the stimulation of chemical face cleansing components to skin is eliminated, and the face cleansing effect can be greatly improved; the compound has the effects of cleaning and moistening skin, removing grease, achieving bacteriostasis, conducting whitening, removing freckles and the like, the formula mainly includes affinal drug and diet or traditional Chinese medicinal materials capable of being used for food, and the Chinese herbal compound face cleansing effervescent tablet is simple, safe and effective and is small in toxic and side effect and irritation.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound clean effervescent tablet and preparation method thereof, belong to skin cleaning article technical field.
Background technology
Skin is one of vitals of human body, and under normal physiological condition, sebaceous gland sebum secreted can be covered in skin surface, forms natural protecting film.Skin also can produce the metabolites such as sweat stain, dead cell and crust when carrying out eubolism.When after the Long contact time such as the flue dust dirt in they and external environment, easily form the foreign bodies such as scurf, the oxygen combination that wherein some composition runs in air simultaneously can be become sour, and causes microbial reproduction to produce bad smell.So should note cleaning for being exposed to outer face, to ensure healthy clean skin condition.Going from bad to worse and doings day by day frequently along with environmental pollution, the requirement of current consumer to clean product is more and more higher.
Clean product many employings industrial chemicals is in the market prepared from, and makes it commercially occupy dominant position because it has the advantage such as cheap, formula is simple, dirt-removing power is strong.But the chemical raw material of chemosynthesis inevitably produces stimulation to a certain degree and damage to skin, destructible and remove the double resin layer structure of keratodermatitis, life-time service can reduce skin self-defense power.This kind of clean product mostly is liquid or the heterogeneous system of paste, and volume is comparatively large, carries, transports, the inconvenience such as storage, and easily produces physical stability or Biostatic sex chromosome mosaicism, affects product quality.
Effervescent tablet as a kind of pharmaceutical dosage form of maturation, due to have disintegrate rapidly, store transport and easy to use, the advantage such as preparation technology is simple, be used widely in the field such as medicine and food, but utilization in daily chemical products is rare makes inquiries.
Summary of the invention
The present invention for the deficiency that prior art exists, provides a kind of Chinese medicine compound clean effervescent tablet and preparation method thereof, Chinese medicine compound is combined with effervescent tablet, meet actual operation requirements just.
For solving the problem, the technical solution used in the present invention is as follows:
A kind of Chinese medicine compound clean effervescent tablet and preparation method thereof, comprise Chinese medicinal compound extract, described Chinese medicinal compound extract comprises the component of following mass fraction: 10 ~ 90 parts, Semen phaseoli radiati, Flos Chrysanthemi 1 ~ 30 part, 1 ~ 30 part, Poria, 1 ~ 30 part, Radix Glycyrrhizae, Cortex Moutan 1 ~ 30 part, Borneolum Syntheticum 0 ~ 5 part.
Semen phaseoli radiati: sweet in the mouth, cool in nature, be the good merchantable brand of eliminating toxin and beautifying the skin; Containing abundant Concha Ostreae alkali and different Concha Ostreae alkali in extract, there is remarkable clean and moistening effect, effectively can remove sebum and skin surface foreign body.The effects such as the bioactive substances such as the tannin in Semen phaseoli radiati, flavone compound, protein, vitamin B group, plant sterol also have certain antibacterial, heat-clearing and toxic substances removing, contraction skin, exfoliation, brighten, antiinflammatory anti-acne.
Flos Chrysanthemi: sweet-bitter flavor, cold nature, include that chrysanthemum is sweet, adenine, choline and vitamin isoreactivity composition, have and prolong the effect such as poison beauty treatment, promoting the circulation of QI blood, profit skin, refresh oneself, beneficial color, also can suppress human body tubercule bacillus, staphylococcus, pseudomonas aeruginosa, influenza virus, dermatophytes, comma bacillus, streptococcus activity.
Poria: sweet in the mouth, light, property is put down, mild in medicine property and, not easily produce anaphylaxis, can dissipate the freckle, black dim of give birth to because aqueous vapor is detained face, plays speckle dispelling, brightens, effect of skin of moistening; The main chemical compositions saponin of Poria has foaminess hemolytic, also has emulsification, be conducive to the inflammation removing inflamed sites, and there is the effect of anti-inflammation, have extremely strong bacteriostatic activity and very high bacteriostasis rate to staphylococcus aureus, shigella flexneri, charcoal maggot bacillus.
Cortex Moutan: cold nature, acrid in the mouth, nontoxic, be rich in paeonol, peoniflorin, sterol isoreactivity composition in its extract, the outer used time has effect of excellent anti-inflammation; Simultaneously the activity of extract to tryrosinase has significant inhibition, can also the generation of oxygen-derived free radicals in T suppression cell, by skin deposits pigment reducing decoloration, can make skin whitening.
Borneolum Syntheticum: acrid in the mouth, hardship, cold nature, containing half terpene component and the triterpenoid such as pier fruit acid alphitolic acid, dipterocarpol such as L-Borneol, caryophyllene, has extremely strong transdermal promotion functions, the transdermal penetration effect of other drug can be strengthened, also there is the effects such as antibacterial, antiinflammatory.
Radix Glycyrrhizae: nature and flavor are sweet flat, have the title of " whitening queen ", mainly containing glycyrrhizin, glycyrrhizic acid, enoxolone, liquiritin, flavonoids of Glycyrrhiza isoreactivity composition; Its extract has extremely strong antioxidant activity, energy scavenging free radicals; Tyrosine list phenolase and bis-phenol enzyme can be suppressed well, show reverse competition inhibitory action; Also have certain inhibitory action to dopachrome tautomerase, thus consolidated statement reveals and can effectively generate by check melanin, realizes the object of whitening simultaneously.
As technique scheme further preferably, the mass fraction of described Chinese medicinal compound extract is 10 ~ 100 parts, also comprises the component of following mass fraction:
Filler 1 ~ 90 part, organic acid 1 ~ 50 part, inorganic base 1 ~ 50 part, lubricant 1 ~ 50 part, 0 ~ 10 part, sodium chloride, adhesive are appropriate.
Sodium chloride: there is the concavo-convex pockmark of elimination, dispel black speck, improve rough skin, control is oily, subtract the effect such as double chin, exfoliation.
The preparation method of above-mentioned a kind of Chinese medicine compound clean effervescent tablet, comprise Chinese medicinal compound extract preparation process and clean effervescent tablet preparation process, described Chinese medicinal compound extract preparation process comprises the following steps:
Steps A 1: take Semen phaseoli radiati, Flos Chrysanthemi, Poria, Radix Glycyrrhizae, Cortex Moutan and Borneolum Syntheticum by mass fraction, be ground into coarse powder respectively, for subsequent use;
Steps A 2: get Cortex Moutan coarse powder and add water, with extraction by steam distillation volatile ingredient paeonol, collects distillate after stopping heating, after adding the dissolving of appropriate sodium chloride, and refrigerated overnight, crystallization, filter, cold drying obtains paeonol, for subsequent use;
Steps A 3: the medicinal residues after extraction by steam distillation in steps A 2 and decocting liquid and Semen phaseoli radiati coarse powder, Flos Chrysanthemi coarse powder, Poria coarse powder, Radix Glycyrrhizae coarse powder are merged, decoct with water, filters merge extractive liquid, the refining also filtering and concentrating of precipitate with ethanol is to debita spissitudo, spraying dry, obtains extract extract powder, for subsequent use;
Steps A 4: adopt beta-schardinger dextrin-that Borneolum Syntheticum preparation of inclusion complex is become Borneolum Syntheticum clathrate, for subsequent use;
Steps A 5: adopt beta-schardinger dextrin-that paeonol preparation of inclusion complex obtained for steps A 2 is become paeonol inclusion compound, for subsequent use;
Steps A 6: the paeonol inclusion compound that Borneolum Syntheticum clathrate extract extract powder obtained for steps A 3, steps A 4 obtained, steps A 5 obtain mixes by formula proportion and obtains Chinese medicinal compound extract.
Described clean effervescent tablet preparation process comprises the following steps:
Step B1: after lubricant heating and melting, adds inorganic base fine powder, stirs, and leaves standstill cooling, dry, pulverize and sieve, obtain alkali source wrappage after grinding, for subsequent use;
Step B2: Chinese medicinal compound extract, filler, organic acid, sodium chloride be dry, pulverize respectively and sieve, then press formula proportion mix homogeneously, adds adhesive ethanol solution soft material, wet granulation, dry, granulate; Add the alkali source wrappage that step B1 is obtained, after mix homogeneously, tabletting obtains Chinese medicine compound clean effervescent tablet.
Compared with prior art, implementation result of the present invention is as follows in the present invention:
A kind of Chinese medicine compound of the present invention clean effervescent tablet is mainly used in facial cleansing, has antibacterial, auxiliary effect such as jade-like stone profit skin, dispelling speckles and whitening face etc. simultaneously; Chinese medicine compound medication, based on facial cleansing, is equipped with expelling wind and removing dampness, vital energy regualting and blood circulation-promoting, heat-clearing and toxic substances removing medicine simultaneously, to regulate QI and blood, and expelling wind and removing dampness, prevention skin infects, and strengthens skin resistance; Brighten, moisten class medicine, with Glycerin, make the pure white gloss of face skin; In fragrance medicine priming enters.
Water met by a kind of Chinese medicine compound of the present invention clean effervescent tablet can disintegrate rapidly, makes Chinese medicine extract rapid solution formation solution, is then directly used in facial cleansing; Compared with existing clean product form, clean effervescent tablet has the advantage of solid dosage forms, and comprise preparation technology simple, good stability, volume is little, carries, transports, stores and easy to use etc.
The extractum that a kind of Chinese medicine compound of the present invention clean effervescent tablet obtains through Hydrolysis kinetics with Chinese medicine compound is for raw material, and green, healthy, safety, and overcome chemistry clean composition to the stimulation of skin, can improve clean effect greatly; The effects such as this compound recipe has clean moist skin, it is glossy, antibacterial to remove, whitening and speckle dispelling, formula mostly is integration of edible and medicinal herbs kind or can be used for the Chinese crude drug of food, effectively simple and safe, toxic and side effects and zest little.
Accompanying drawing explanation
Fig. 1 is the oil stain removing rate measurement result of Chinese medicine compound clean effervescent tablet group in test example 1;
Fig. 2 is the oil stain removing rate measurement result of matched group in test example 1.
Detailed description of the invention
Below in conjunction with specific embodiments content of the present invention is described.
Specific embodiment 1
Clean the effervescent tablet of a kind of Chinese medicine compound described in the present embodiment, comprise the component of following mass fraction: Chinese medicinal compound extract 50 parts, filler 8 parts, organic acid 8 parts, inorganic base 4 parts, lubricant 8 parts, 4 parts, sodium chloride, and appropriate adhesive ethanol solution;
Described Chinese medicinal compound extract comprises the component of following mass fraction: 10 parts, Semen phaseoli radiati, Flos Chrysanthemi 1 part, 1 part, Poria, 1 part, Radix Glycyrrhizae, Cortex Moutan 1 part;
Described filler is mannitol, and described organic acid is citric acid, and described inorganic base is sodium bicarbonate, and described lubricant is PEG4000; Described adhesive ethanol solution to be PVP-K30 mass concentration be 5% ethanol solution.
The preparation method of a kind of Chinese medicine compound clean effervescent tablet described in the present embodiment, comprise Chinese medicinal compound extract preparation process and clean effervescent tablet preparation process, described Chinese medicinal compound extract preparation process comprises the following steps:
Steps A 1: take Semen phaseoli radiati, Flos Chrysanthemi, Poria, Radix Glycyrrhizae, Cortex Moutan and Borneolum Syntheticum by mass fraction, be ground into coarse powder respectively, for subsequent use;
Steps A 2: get Cortex Moutan coarse powder and add water, with extraction by steam distillation volatile ingredient paeonol, collects distillate after stopping heating, after adding the dissolving of appropriate sodium chloride, and refrigerated overnight, crystallization, filter, cold drying obtains paeonol, for subsequent use;
Steps A 3: by the medicinal residues after extraction by steam distillation in steps A 2 and decocting liquid and Semen phaseoli radiati coarse powder, Flos Chrysanthemi coarse powder, Poria coarse powder, Radix Glycyrrhizae coarse powder merges, decoct with water twice, add the water of 8 times amount for the first time, second time adds the water of 6 times amount, each 2 hours, filter merge extractive liquid, placement is cooled to room temperature, slowly add appropriate 95% ethanol while stirring, place again and be cooled to room temperature, then 4 DEG C of airtight cold preservations 24 hours, filtration obtains precipitate with ethanol solution, it is 1.01 ~ 1.05 that filtrate is evaporated to relative density in 60 DEG C, spraying dry, obtain extract extract powder, for subsequent use,
Steps A 4: adopt beta-schardinger dextrin-that Borneolum Syntheticum preparation of inclusion complex is become Borneolum Syntheticum clathrate, for subsequent use;
Steps A 5: adopt beta-schardinger dextrin-that paeonol preparation of inclusion complex obtained for steps A 2 is become paeonol inclusion compound, for subsequent use;
Steps A 6: the paeonol inclusion compound that Borneolum Syntheticum clathrate extract extract powder obtained for steps A 3, steps A 4 obtained, steps A 5 obtain mixes by formula proportion and obtains Chinese medicinal compound extract.
Described clean effervescent tablet preparation process comprises the following steps:
Step B1: after lubricant heating and melting, adds inorganic base fine powder, stirs, and leaves standstill cooling, dry, pulverize 80 mesh sieves, and obtained alkali source wrappage after grinding, for subsequent use;
Step B2: Chinese medicinal compound extract, filler, organic acid, sodium chloride be dry, pulverize respectively, crosses 80 mesh sieves; After formula proportion mix homogeneously, add the ethanol solution soft material that PVP-K30 mass concentration is 5%, cross 16 mesh sieves and obtain wet granular, 40 ~ 50 DEG C of dryings, cross 14 mesh sieve granulate; Add the alkali source wrappage that step B1 is obtained, add appropriate dehydrated alcohol and obtain soft material, after mix homogeneously, tabletting obtains Chinese medicine compound clean effervescent tablet.
Specific embodiment 2
Clean the effervescent tablet of a kind of Chinese medicine compound described in the present embodiment, comprise the component of following mass fraction: Chinese medicinal compound extract 70 parts, filler 12 parts, organic acid 12 parts, inorganic base 6 parts, lubricant 12 parts, 6 parts, sodium chloride, and appropriate adhesive ethanol solution;
Described Chinese medicinal compound extract comprises the component of following mass fraction: 90 parts, Semen phaseoli radiati, Flos Chrysanthemi 30 parts, 30 parts, Poria, 30 parts, Radix Glycyrrhizae, Cortex Moutan 30 parts, Borneolum Syntheticum 5 parts;
Described filler is mannitol, and described organic acid is citric acid, and described inorganic base is sodium bicarbonate, and described lubricant is PEG4000; Described adhesive ethanol solution to be PVP-K30 mass concentration be 5% ethanol solution.
Described in the present embodiment, the preparation method of a kind of Chinese medicine compound clean effervescent tablet is with specific embodiment 1.
Specific embodiment 3
Clean the effervescent tablet of a kind of Chinese medicine compound described in the present embodiment, comprise the component of following mass fraction: Chinese medicinal compound extract 60 parts, filler 10 parts, organic acid 10 parts, inorganic base 5 parts, lubricant 10 parts, 7 parts, sodium chloride, and appropriate adhesive ethanol solution;
Described Chinese medicinal compound extract comprises the component of following mass fraction: 20 parts, Semen phaseoli radiati, Flos Chrysanthemi 10 parts, 20 parts, Poria, 10 parts, Radix Glycyrrhizae, Cortex Moutan 20 parts, Borneolum Syntheticum 1 part;
Described filler is mannitol, and described organic acid is tartaric acid, and described inorganic base is sodium carbonate, and described lubricant is PEG4000; Described adhesive ethanol solution to be PVP-K30 mass concentration be 5% ethanol solution.
Described in the present embodiment, the preparation method of a kind of Chinese medicine compound clean effervescent tablet is with specific embodiment 1.
Specific embodiment 4
Clean the effervescent tablet of a kind of Chinese medicine compound described in the present embodiment, comprise the component of following mass fraction: Chinese medicinal compound extract 55 parts, filler 11 parts, organic acid 9 parts, inorganic base 5 parts, lubricant 11 parts, 3 parts, sodium chloride, and appropriate adhesive ethanol solution;
Described Chinese medicinal compound extract comprises the component of following mass fraction: 50 parts, Semen phaseoli radiati, Flos Chrysanthemi 20 parts, 10 parts, Poria, 20 parts, Radix Glycyrrhizae, Cortex Moutan 10 parts, Borneolum Syntheticum 3 parts;
Described filler is mannitol, and described organic acid is tartaric acid, and described inorganic base is sodium carbonate, and described lubricant is PEG4000; Described adhesive ethanol solution to be PVP-K30 mass concentration be 5% ethanol solution.
Described in the present embodiment, the preparation method of a kind of Chinese medicine compound clean effervescent tablet is with specific embodiment 1.
Test example 1: oil stain removing rate measures
German CK company (Courage+khazakaElectronicGmbh) MPA10 type Multi-functional skin tester is adopted to measure oil stain removing rate.Choose 20 experimenters, age bracket is between 20 ~ 45 years old, men and women half and half, be divided into 2 groups at random, often organize and use Chinese medicine compound clean effervescent tablet in embodiment 1 to 4 and commercially available cleansing milk respectively, using the fixed position of forehead, buccal as test zone, measure the skin oil and fat content of above-mentioned selection area before and after washing one's face respectively.Oil stain removing rate is calculated, to evaluate the effect of deoiling of product by following formula 1.
Formula 1:
Shown in measurement result accompanying drawing 1, from accompanying drawing 1, Chinese medicine compound provided by the invention clean effervescent tablet all has obvious degrease effect to different experimenter, due to individual variation, the oil stain removing rate difference to some extent at different experimenter and different test position, but all higher than 75%, and carry out paired sample with the measurement result of matched group shown in accompanying drawing 2
tinspection, there was no significant difference between the two.Result shows: Chinese medicine compound provided by the invention clean effervescent tablet has excellent facial degrease effect.
Test example 2: tyrosinase activity inhibition test
Tryrosinase is the biosynthetic key enzyme of dermal melanin, and restraint of tyrosinase is active, can improve the metabolism of chromatophorous tryrosinase in skin, stop Pigmented formation.
l-tyrosine in pH value 6.8 buffer solution, under the catalysis of tryrosinase, can be by
l-oxidizing tyrosine produces the colors of DOPA quinones brown, and DOPA quinones has absorption, after adding tyrosinase inhibitor at wavelength 475nm place, its absorbance reduces, and linear, therefore can according to the changing value of absorbance, for evaluating the suppression efficiency of product to tryrosinase.
The configuration of 2.1 solution:
The preparation of buffer solution: secure ph is the phosphate buffered solution 1000ml of 6.8.
The preparation of compound recipe clean effervescent tablet solution: accurately take a certain amount of compound recipe clean effervescent tablet (embodiment 1 to 4 obtains, and is equivalent to traditional Chinese medicinal extract powder 100mg), be settled to 100ml with the phosphate buffer of pH value 6.8, be mixed with compound recipe clean effervescent tablet solution.
The preparation of tyrosinase solution: accurately take tryrosinase 5mg, is settled to 10ml by the phosphate buffered solution of pH6.8, is mixed with tyrosinase solution.
lthe preparation of-tyrosine solution: accurately take
l-tyrosine 25mg, is settled to 50ml by the phosphate buffered solution of pH value 6.8, is mixed with
l-tyrosine solution.
2.2 tyrosinase activities suppress to measure:
Get four test tubes being numbered 1,2,3,4, respectively according to as shown in table 1 four groups of experimental programs, preparation reaction system, liquor capacity is 5ml, then four test tubes is placed in 37 DEG C of water-baths and hatches 30min, measure respectively in 475nm place its absorbance (
a), as shown in table 1 below.Calculating under experimental concentration compound recipe clean effervescent tablet solution to the suppression ratio of tyrosinase activity according to following formula 2 is 93.2%, and as can be seen here, compound recipe clean effervescent tablet has the ability of good restraint of tyrosinase activity.
Formula 2:
Table 1, compound recipe clean effervescent tablet solution to the inhibitory action of tyrosinase activity (
± s, n=3)
Above content is detailed description made for the present invention in conjunction with specific embodiments, can not assert that the present invention specifically implements to be only limitted to these explanations.For those skilled in the art, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to the scope of protection of the invention.
Claims (9)
1. a Chinese medicine compound clean effervescent tablet, it is characterized in that, comprise Chinese medicinal compound extract, described Chinese medicinal compound extract comprises the component of following mass fraction: 10 ~ 90 parts, Semen phaseoli radiati, Flos Chrysanthemi 1 ~ 30 part, 1 ~ 30 part, Poria, 1 ~ 30 part, Radix Glycyrrhizae, Cortex Moutan 1 ~ 30 part, Borneolum Syntheticum 0 ~ 5 part.
2. a kind of Chinese medicine compound as claimed in claim 1 clean effervescent tablet, is characterized in that, the mass fraction of described Chinese medicinal compound extract is 10 ~ 100 parts, also comprises the component of following mass fraction:
Filler 1 ~ 90 part, organic acid 1 ~ 50 part, inorganic base 1 ~ 50 part, lubricant 1 ~ 50 part, 0 ~ 10 part, sodium chloride, adhesive are appropriate.
3. a kind of Chinese medicine compound as claimed in claim 1 clean effervescent tablet, it is characterized in that, comprise the component of following mass fraction: Chinese medicinal compound extract 50 ~ 70 parts, filler 8 ~ 12 parts, organic acid 8 ~ 12 parts, inorganic base 4 ~ 6 parts, lubricant 8 ~ 12 parts, 4 ~ 6 parts, sodium chloride, and appropriate adhesive ethanol solution;
Described filler is mannitol, and described organic acid is citric acid or tartaric acid, and described inorganic base is sodium bicarbonate or sodium carbonate, and described lubricant is PEG4000.
4. a kind of Chinese medicine compound as claimed in claim 3 clean effervescent tablet, is characterized in that, described adhesive ethanol solution to be PVP-K30 mass concentration be 5% ethanol solution.
5. the preparation method of a kind of Chinese medicine compound as claimed in claim 2 or claim 3 clean effervescent tablet, is characterized in that, comprise Chinese medicinal compound extract preparation process and clean effervescent tablet preparation process, described Chinese medicinal compound extract preparation process comprises the following steps:
Steps A 1: take Semen phaseoli radiati, Flos Chrysanthemi, Poria, Radix Glycyrrhizae, Cortex Moutan and Borneolum Syntheticum by mass fraction, be ground into coarse powder respectively, for subsequent use;
Steps A 2: get Cortex Moutan coarse powder and add water, with extraction by steam distillation volatile ingredient paeonol, collects distillate after stopping heating, after adding the dissolving of appropriate sodium chloride, and refrigerated overnight, crystallization, filter, cold drying obtains paeonol, for subsequent use;
Steps A 3: the medicinal residues after extraction by steam distillation in steps A 2 and decocting liquid and Semen phaseoli radiati coarse powder, Flos Chrysanthemi coarse powder, Poria coarse powder, Radix Glycyrrhizae coarse powder are merged, decoct with water, filters merge extractive liquid, the refining also filtering and concentrating of precipitate with ethanol is to debita spissitudo, spraying dry, obtains extract extract powder, for subsequent use;
Steps A 4: adopt beta-schardinger dextrin-that Borneolum Syntheticum preparation of inclusion complex is become Borneolum Syntheticum clathrate, for subsequent use;
Steps A 5: adopt beta-schardinger dextrin-that paeonol preparation of inclusion complex obtained for steps A 2 is become paeonol inclusion compound, for subsequent use;
Steps A 6: the paeonol inclusion compound that Borneolum Syntheticum clathrate extract extract powder obtained for steps A 3, steps A 4 obtained, steps A 5 obtain mixes by formula proportion and obtains Chinese medicinal compound extract.
6. a kind of Chinese medicine compound as claimed in claim 5 clean effervescent tablet and preparation method thereof, it is characterized in that, the method decocted with water described in steps A 3 is: decoct with water twice, adds the water of 8 times amount for the first time, and second time adds the water of 6 times amount, each 2 hours.
7. a kind of Chinese medicine compound as claimed in claim 5 clean effervescent tablet and preparation method thereof, it is characterized in that, precipitate with ethanol described in steps A 3 is refined and filtering and concentrating to the method for debita spissitudo is: place and be cooled to room temperature, slowly add appropriate 95% ethanol while stirring, place again and be cooled to room temperature, then 4 DEG C of airtight cold preservations 24 hours, filter and obtain precipitate with ethanol solution, it is 1.01 ~ 1.05 that filtrate is evaporated to relative density in 60 DEG C.
8. a kind of Chinese medicine compound as claimed in claim 5 clean effervescent tablet and preparation method thereof, is characterized in that, described clean effervescent tablet preparation process comprises the following steps:
Step B1: after lubricant heating and melting, adds inorganic base fine powder, stirs, and leaves standstill cooling, dry, pulverize and sieve, obtain alkali source wrappage after grinding, for subsequent use;
Step B2: Chinese medicinal compound extract, filler, organic acid, sodium chloride be dry, pulverize respectively and sieve, then press formula proportion mix homogeneously, adds adhesive ethanol solution soft material, wet granulation, dry, granulate; Add the alkali source wrappage that step B1 is obtained, after mix homogeneously, tabletting obtains Chinese medicine compound clean effervescent tablet.
9. a kind of Chinese medicine compound as claimed in claim 5 clean effervescent tablet and preparation method thereof, is characterized in that, described clean effervescent tablet preparation process comprises the following steps:
Step B1: after lubricant heating and melting, adds inorganic base fine powder, stirs, and leaves standstill cooling, dry, pulverize 80 mesh sieves, and obtained alkali source wrappage after grinding, for subsequent use;
Step B2: Chinese medicinal compound extract, filler, organic acid, sodium chloride be dry, pulverize respectively, crosses 80 mesh sieves; After formula proportion mix homogeneously, add the ethanol solution soft material that PVP-K30 mass concentration is 5%, cross 16 mesh sieves and obtain wet granular, 40 ~ 50 DEG C of dryings, cross 14 mesh sieve granulate; Add the alkali source wrappage that step B1 is obtained, add appropriate dehydrated alcohol and obtain soft material, after mix homogeneously, tabletting obtains Chinese medicine compound clean effervescent tablet.
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| CN109568232A (en) * | 2019-01-22 | 2019-04-05 | 广州博科健康科技集团有限公司 | A kind of clean face powder of whitening and preparation method thereof |
| CN116808100A (en) * | 2023-06-21 | 2023-09-29 | 安康市郑远元生物科技有限公司 | Effervescent tablet lotion containing traditional Chinese medicine extract and preparation method thereof |
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| CN105342933B (en) | 2018-03-13 |
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