CN106420508A - Amaranthus retroflexus-containing whitening toning lotion - Google Patents
Amaranthus retroflexus-containing whitening toning lotion Download PDFInfo
- Publication number
- CN106420508A CN106420508A CN201611105042.7A CN201611105042A CN106420508A CN 106420508 A CN106420508 A CN 106420508A CN 201611105042 A CN201611105042 A CN 201611105042A CN 106420508 A CN106420508 A CN 106420508A
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- CN
- China
- Prior art keywords
- amaranthus retroflexus
- extract
- whitening
- oleuropein
- cleupin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an amaranthus retroflexus-containing whitening toning lotion. The effective components of the amaranthus retroflexus-containing whitening toning lotion comprise oleuropein, amaranthus retroflexus extract and matrix, wherein the weight ratio of the amaranthus retroflexus extract to the oleuropein is (10:1)-(20:1), and the matrix is vitamin E magnesium phosphate, polyglycerol-3 diisostearate, glycolic acid, linseed oil and hyaluronic acid. The amaranthus retroflexus-containing whitening toning lotion has the advantages that the amaranthus retroflexus extract is used as the main raw material, the oleuropein and the matrix are added, the amaranthus retroflexus-containing whitening toning lotion is cheap, the amaranthus retroflexus extract is mixed with a small amount of oleuropein to achieve a synergic whitening effect, and the whitening effect is increased greatly especially due to the fact that the weight ratio of the amaranthus retroflexus extract to the oleuropein is (10:1)-(20:1).
Description
Technical field
The present invention relates to a kind of Amaranthus retroflexus whitening lotion, belongs to cosmetic skin care product field.
Background technology
Astringent is referred to as by cosmetic water, toner/smoothing toner, astringent lotion, is a kind of cosmetics of transparent liquid, is applied to the table of skin
Face, for cleaning skin, keeping the health of skin.Cosmetic water, astringent lotion and toner/smoothing toner difference are not too big, cosmetic water, convergence
Water is more suitable for that weather is warmmer, compares the fuel-displaced weather of love on the face and uses, and toner/smoothing toner is more suitable for the season of drying and uses.Astringent exists
Play a part of to take over from the past and set a new course for the future in basic skin protection, as the raising of people's quality of the life and people are to beautiful pursuit, astringent
Kind class is more and more various.
Amaranthus retroflexus, another name：West wind paddy, Latin literary fame：Amaranthus retroflexus. Amaranthaceae, the annual grass of Amaranthus
This, high 20-80 centimetre, sometimes up to more than 1 meter；The month at florescence 7-8, the fruiting period 8-9 month, annual herb, high 20-80 centimetre, sometimes up to 1
Meter Duo；Stem is upright, sturdy, single or branch, light green, sometimes tool band purple fringe, slightly has a wane, close raw pubescence.Blade
Pedicellus et Pericarpium Trapae shape is avette or ellipticity is avette, long 5-12 centimetre, wide 2-5 centimetre, and the sharp point in top or point are recessed, have a little spur, base portion wedge shape, entirely
There is pubescence at edge or wavy edge, two sides and edge, below hair closeer；Petiole is long 1.5-5.5 centimetre, light green, sometimes lavender, has
Pubescence.Panicle basidixed and axil life, uprightly, 2-4 centimetre of diameter, formed by most spikes, basidixed spica is compared with side survivor
Long；Bract and squamella brill shape, long 4-6 millimeter, white, there is 1 keel at the back side, stretches out top and becomes white point awns；Perianth
The circular or square round shape obovate of piece square, long 2-2.5 millimeter, thin film matter, white, there is 1 light green detail arteries and veins, top is suddenly sharp or sharp
Recessed, have spur；Stamen is slightly longer than tapel；Stigma 3, sometimes 2.Utricle is flat avette, is about 1.5 millimeters, ring-type transverse fissure, thin film
Matter, light green, it is wrapped in persitent perianth piece.Seed is subsphaeroidal, 1 millimeter of diameter, brown or black, and edge is blunt.Florescence 7-8
Month, the fruiting period 8-9 month.Produce Heilungkiang, Jilin, Liaoning, the Inner Mongol, Hebei, Shandong, Shanxi, Henan, Shaanxi, Gansu, Ningxia, new
Boundary.On raw meadow in rural area, by farmland, near other, given birth to sometimes on tile-roofed house.At present for the profit of Amaranthus retroflexus extract
Had not been reported in whitening lotion application with being particularly.
Content of the invention
For the problem that above-mentioned prior art is present, the present invention provides a kind of Amaranthus retroflexus whitening lotion, with low cost, beautiful
White effect is good.
To achieve these goals, the technical solution used in the present invention is：Effective ingredient includes that cleupin, Amaranthus retroflexus are carried
Thing, glycerol is taken, according to weight ratio, the weight ratio of described Amaranthus retroflexus extract and cleupin is 10:1-20:1.
Cleupin 0.2%, Amaranthus retroflexus extract 4%, glycerol 5%, Propylene Glycol 3%, allantoin 2%, hydroxyethyl cellulose
0.8%, Pyrusussuriensiss, 2%, hyaluronate sodium 0.8% and water surplus are constituted.
The present invention adds cleupin and some substrate with Amaranthus retroflexus extract as primary raw material, and which is cheap, instead
Branch Herba Amaranthi tricoloriss extract mix with a small amount of cleupin for whitening play good synergy, particularly Amaranthus retroflexus extract and
The weight ratio of cleupin is 10:1-20:1, whitening effect is increased substantially.
Specific embodiment
The invention will be further described below.
Cleupin CAS：32619-42-4
Molecular formula：C25H32O13 is purchased from BIOSYNTH company
Chemical formula is as follows：
Embodiment 1：
The processing technology of described Amaranthus retroflexus extract is 1) by the Amaranthus retroflexus after vacuum drying, crush in pulverizer and obtain instead
Branch Herba Amaranthi tricoloriss powder, Amaranthus retroflexus powder is placed in the extraction kettle of supercritical extraction, 2) use supercritical CO 2 as solvent, concentration is
65% ethanol does entrainer；3) adjust extraction kettle to control extracting pressure in 25～30MPa, temperature control at 45 DEG C, CO2
Flow-control controls in 2h in 9L/h, extraction time, obtains Amaranthus retroflexus extract.
It is respectively according to weight proportion：Cleupin 0.2%, Amaranthus retroflexus extract 4%, glycerol 5%, Propylene Glycol 3%, allantoin
2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss, 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Embodiment 2
As 1 processing technology of embodiment, difference is：Cleupin 0.3%, Amaranthus retroflexus extract 4.5%, glycerol 5%,
Propylene Glycol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss, 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Comparative example 1
It is respectively according to weight proportion：Cleupin 1%, Amaranthus retroflexus extract 4%, glycerol 5%, Propylene Glycol 3%, allantoin 2%, hydroxyl
Ethyl cellulose 0.8%, Pyrusussuriensiss, 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Comparative example 2
As 1 processing technology of embodiment, difference is：Cleupin 3%, Amaranthus retroflexus extract 4%, glycerol 5%, the third two
Alcohol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Comparative example 3
As 1 processing technology of embodiment, difference is：Amaranthus retroflexus extract 4%, glycerol 5%, Propylene Glycol 3%, allantoin
2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss, 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Embodiment 4
As 1 processing technology of embodiment, difference is：Cleupin 0.2%, Semen Ginkgo extrac 4%, glycerol 5%, the third two
Alcohol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Detection method：
Melanin genesis test in suppression mouse melanin cell.
B16 mouse melanin tumor cell is connected to the culture dish of a diameter of 9cm with the density of 1 × 105/ml, at 37 DEG C
Cultivate 2 days under conditions of 5%CO2, supernatant is abandoned, the sample solution 18-22ml after filtration sterilization is added, is then incubated for 3 days, abandons
Supernatant, PBS is washed, and adds the trypsin solution peptic cell 3min of 0.5ml mass percent 0.2% per hole, adds 2ml to tie up per ware
Hold liquid and terminate digestion. after piping and druming is mixed, every kind of concentration is taken out 0.5ml and makees cell counting. remaining cell suspension with 2500r/min from
Heart 5min, abandons supernatant, adds NaoH solution in precipitation, and heating dissolves melanin, selects the enzyme linked immunological of 490nm wavelength
Absorbance is surveyed on detector.
B16 cell suppression ratio=(1- (medicine hole absorbance+medicine hole cell density)+(control wells absorbance+right
According to hole cell density)) × 100%.
Melanin genesis test in suppression mouse melanin cell,
Sample solution is the mixed liquor of the Amaranthus retroflexus extract containing 3% and cleupin.
A is Amaranthus retroflexus extract, and B is cleupin, as a result as follows,
| Effective ingredient | Suppression ratio（%） |
| A:B( 30：1) | 48.4 |
| A:B( 25：1) | 48.3 |
| A:B( 20：1) | 67.1 |
| A:B( 15：1) | 69.3 |
| A:B( 10：1) | 48.1 |
| A:B( 5：1) | 46.5 |
| A:B( 3：1) | 45.3 |
| A:B( 1：1) | 36.1 |
| A:B( 1：5) | 34.8 |
| A:B( 1：10) | 35.7 |
| A | 37.6 |
| B | 30.3 |
Above-mentioned test result indicate that, Amaranthus retroflexus extract and cleupin by a certain percentage (15：1-20：1) melting each other
Close with collaboration whitening effect, can effectively suppress melanin to generate, and effect is significant.And between other ratios, then have no collaboration
Effect, whitening effect is not obvious.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change modification alternative combinations simplification that is made under other any spirit without departing from the present invention and principle,
Equivalent substitute mode is all should be, is included within protection scope of the present invention.
Claims (4)
1. a kind of Amaranthus retroflexus whitening lotion, it is characterised in that effective ingredient includes cleupin, Amaranthus retroflexus extract.
2. a kind of Amaranthus retroflexus whitening lotion, it is characterised in that also include glycerol, Propylene Glycol, allantoin, hydroxyethyl cellulose,
Hyaluronate sodium and water surplus are constituted.
3. a kind of plant whitening facial film according to claim 1, it is characterised in that according to weight ratio, described Amaranthus retroflexus
The weight ratio of extract and cleupin is 10:1-20:1.
4. a kind of plant whitening facial film according to claim 2, it is characterised in that described including cleupin 0.2%,
Amaranthus retroflexus extract 4%, glycerol 5%, Propylene Glycol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss, 2%, hyaluronate sodium
0.8% and water surplus constitute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611105042.7A CN106420508A (en) | 2016-12-05 | 2016-12-05 | Amaranthus retroflexus-containing whitening toning lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611105042.7A CN106420508A (en) | 2016-12-05 | 2016-12-05 | Amaranthus retroflexus-containing whitening toning lotion |
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| Publication Number | Publication Date |
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| CN106420508A true CN106420508A (en) | 2017-02-22 |
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| CN201611105042.7A Pending CN106420508A (en) | 2016-12-05 | 2016-12-05 | Amaranthus retroflexus-containing whitening toning lotion |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107822987A (en) * | 2017-12-04 | 2018-03-23 | 刘晓冰 | A kind of valerian whitening lotion |
| CN114469820A (en) * | 2022-03-17 | 2022-05-13 | 中国科学院兰州化学物理研究所 | Olive leaf extract and application thereof in preparation of skin whitening cosmetics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011026216A (en) * | 2009-07-22 | 2011-02-10 | Shodoshima Healty Land Kk | Cosmetic |
| CN103110527A (en) * | 2013-02-22 | 2013-05-22 | 苏州天南星生物科技有限公司 | External preparation for spot treatment |
-
2016
- 2016-12-05 CN CN201611105042.7A patent/CN106420508A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011026216A (en) * | 2009-07-22 | 2011-02-10 | Shodoshima Healty Land Kk | Cosmetic |
| CN103110527A (en) * | 2013-02-22 | 2013-05-22 | 苏州天南星生物科技有限公司 | External preparation for spot treatment |
Non-Patent Citations (4)
| Title |
|---|
| 朱亚民: "《内蒙古植物药志 第1卷》", 31 December 2000, 内蒙古出版社 * |
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
| 郭雪峰等: "黄酮类化合物的提取.分离纯化和含量测定方法的研究进展", 《安徽农业科学》 * |
| 齐向东等: "《微创美容外科学》", 28 February 2013, 浙江科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107822987A (en) * | 2017-12-04 | 2018-03-23 | 刘晓冰 | A kind of valerian whitening lotion |
| CN114469820A (en) * | 2022-03-17 | 2022-05-13 | 中国科学院兰州化学物理研究所 | Olive leaf extract and application thereof in preparation of skin whitening cosmetics |
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Application publication date: 20170222 |