CN106389216A - Persicaria lapathifolia whitening lotion - Google Patents
Persicaria lapathifolia whitening lotion Download PDFInfo
- Publication number
- CN106389216A CN106389216A CN201610955925.0A CN201610955925A CN106389216A CN 106389216 A CN106389216 A CN 106389216A CN 201610955925 A CN201610955925 A CN 201610955925A CN 106389216 A CN106389216 A CN 106389216A
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- CN
- China
- Prior art keywords
- extract
- neohesperidin dihydrochalcone
- persicaria
- pale persicaria
- whitening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a Persicaria lapathifolia whitening lotion. The effective components of the lotion comprise neohesperidin dihydrochalcone, Persicaria lapathifolia extract and matrixes, and the matrixes are magnesium vitamin E phosphate, polyglyceryl-3 diisostearate, glycolic acid, linseed oil and hyaluronic acid respectively. The Persicaria lapathifolia extract is adopted as a main raw material, and neohesperidin dihydrochalcone and some matrixes are added, so the lotion has low price; and a mixture of the Persicaria lapathifolia extract and a small amount of neohesperidin dihydrochalcone has a very good synergistic effect on whitening, and greatly improves the whitening effect especially when a weight ratio of the Persicaria lapathifolia extract to neohesperidin dihydrochalcone is 8:1 to 10:1.
Description
Technical field
The present invention relates to a kind of pale persicaria whitening lotion, belong to cosmetic skin care product field.
Background technology
Astringent is referred to as by cosmetic water, toner/smoothing toner, astringent lotion, is a kind of cosmetics of transparent liquid, is applied to the table of skin
Face, for cleaning skin, keeping the health of skin.Cosmetic water, astringent lotion and toner/smoothing toner difference are not too big, cosmetic water, convergence
Water is more suitable for that weather is warmmer, compares the fuel-displaced weather of love on the face and uses, the season that toner/smoothing toner is more suitable for drying uses.Astringent exists
Acted the effect taken over from the past and set a new course for the future, the raising with people's quality of the life and people are to beautiful pursuit, astringent in basic skin protection
Kind class is more and more various.
Pale persicaria（Scientific name：Eupatorium adenophora Spreng.）：Perennial herb or one-tenth suffruticose are planted
Thing.The sturdy prosperity of rhizome, uprightly, plant height 30-200 centimetre, branch opposite, tiltedly on, stem purple, by white or rust pubescence.
Leaf opposite, blade matter is thin, and avette, triangle or Pedicellus et Pericarpium Trapae shape are avette, outside of belly green, and back side color is shallow, and edge has sparse thick and do not advise
Sawtooth then, is then wavy shallow sawtooth or nearly full edge below inflorescence.Head inflorescence is little, and diameter, up to 6 millimeters, arranges at branch end
Become umbrella room or compound corymb, containing about 40-50 little Hua, tubular flower both sexes, white.Son reality achene, pitchy.Can produce per year for every plant
Achene 10,000 about, mat pappus is propagated with the wind.November at florescence-April in next year, fruiting period March-April.
It is distributed mainly on the ground such as China, the U.S., Australia, New Zealand.It is a kind of important quarantine harmful organisms, be
China suffers from the exemplary of foreign term.Originate in Mexico, each in the world as a kind of ornamental plant from 19th century
Introduce a fine variety after, because its reproductive capacity is strong, it has also become global invasive species.In 2003 by China national Environmental Protection Administration and China
Academy of science issues《First Invasive Alien Species list Chinese》In be at the first place, at present for pale persicaria extract
Be have not been reported using the particularly application in whitening lotion.
Content of the invention
The problem existing for above-mentioned prior art, the present invention provides a kind of pale persicaria whitening lotion, with low cost,
Whitening effect is good.
To achieve these goals, the technical solution used in the present invention is：Effective ingredient includes neohesperidin dihydro Cha Er
Ketone, pale persicaria extract, glycerol, according to weight ratio, described pale persicaria extract and neohesperidin dihydrochalcone
Weight is than 10:1-20:1.
Neohesperidin dihydrochalcone 0.5%, pale persicaria extract 4%, glycerol 5%, propylene glycol 3%, allantoin 2%, hydroxyl second
Base cellulose 0.8%, Pyrusussuriensiss, 2%, hyaluronate sodium 0.8% and water surplus are constituted.
The present invention, with pale persicaria extract as primary raw material, adds neohesperidin dihydrochalcone and some substrate,
It is cheap, and pale persicaria extract mixes to play for whitening with a small amount of neohesperidin dihydrochalcone works in coordination with well
The weight of effect, particularly pale persicaria extract and neohesperidin dihydrochalcone is than 8:1-10:1, whitening effect is significantly
Degree improves.
Specific embodiment
The invention will be further described below.
Neohesperidin dihydrochalcone C28H36O15 CAS 20702-77-6 is purchased from AKSCI company.
Chemical formula is as follows：
Embodiment 1：
The processing technology of described pale persicaria extract is 1) by the pale persicaria after vacuum drying, pulverize in pulverizer
To pale persicaria powder, pale persicaria powder is placed in the extraction kettle of supercritical extraction, 2) supercritical CO 2 is used as molten
Agent, concentration is that 65% ethanol does entrainer；3) adjust extraction kettle and extracting pressure is controlled in 25～30MPa, temperature control exists
45 DEG C, in 9L/h, extraction time controls in 2h for CO2 flow-control, obtains pale persicaria extract.
It is respectively according to weight proportion：Neohesperidin dihydrochalcone 0.5%, pale persicaria extract 4%, glycerol 5%, third
Glycol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Embodiment 2
As embodiment 1 processing technology, difference is：Neohesperidin dihydrochalcone 0.5%, pale persicaria extract
5%th, glycerol 5%, propylene glycol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss 2%, hyaluronate sodium 0.8% and water surplus structure
Become.
Comparative example 1
As embodiment 1 processing technology, difference is that formula is：Pale persicaria extract 5%, glycerol 5%, propylene glycol
3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss 2%, hyaluronate sodium 0.8% and water surplus composition.
Comparative example 2
As embodiment 1 processing technology, difference is：Neohesperidin dihydrochalcone 3%, pale persicaria extract 4%,
Glycerol 5%, propylene glycol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Comparative example 3
As embodiment 1 processing technology, difference is：Pale persicaria extract 4%, glycerol 5%, propylene glycol 3%, allantois
Element 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Embodiment 4
As embodiment 1 processing technology, difference is：Neohesperidin dihydrochalcone 0.5%, Semen Ginkgo extrac 5%, sweet
Oil 5%, propylene glycol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss 2%, hyaluronate sodium 0.8% and water surplus are constituted.
Detection method：
Middle melanin genesis test in suppression mouse melanin cell.
By B16 mouse melanin tumor cell with 1 × 105The density of individual/ml is connected to the culture dish of a diameter of 9cm, at 37 DEG C
5%CO2Under conditions of cultivate 2 days, abandon supernatant, add the sample solution 18-22ml after filtration sterilization, be then incubated for 3 days, abandon
Supernatant, PBS washs, and every hole adds the trypsin solution peptic cell 3min of 0.5ml mass percent 0.2%, and every ware adds 2ml dimension
Hold liquid and terminate digestion. after piping and druming mixes, every kind of concentration is taken out 0.5ml and is made cell counting. remaining cell suspension with 2500r/min from
Heart 5min, abandons supernatant, adds NaoH solution in precipitation, and heating makes melanin dissolve, and selects the enzyme linked immunological of 490nm wavelength
Absorbance is surveyed on detector.
B16 cell suppression ratio=(1- (medicine hole absorbance+medicine hole cell density)+(control wells absorbance+right
According to hole cell density)) × 100%.
Middle melanin genesis test in suppression mouse melanin cell, result is as follows,
A is pale persicaria extract, and B is neohesperidin dihydrochalcone,
Above-mentioned test result indicate that, pale persicaria extract and neohesperidin dihydrochalcone are by a certain percentage（8:1-10:1）Phase
Fusion between mutually has collaborative whitening effect, can effectively suppress melanin to generate, and effect is significant.And between other ratios
Then have no synergism, whitening effect is inconspicuous.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not subject to above-described embodiment
Limit, the change made under other any spirit without departing from the present invention and principle is modified alternative combinations and simplified,
All should be equivalent substitute mode, be included within protection scope of the present invention.
Claims (3)
1. a kind of pale persicaria whitening lotion is it is characterised in that effective ingredient includes neohesperidin dihydrochalcone, Folium rumicis acetosae
Knotweed extract, glycerol, propylene glycol, allantoin, hydroxyethyl cellulose, hyaluronate sodium and water surplus are constituted.
2. a kind of pale persicaria cleawhite pack according to claim 1 is it is characterised in that according to weight ratio, described acid
The weight of mould leaf knotweed extract and neohesperidin dihydrochalcone is than 1:1-20:1.
3. a kind of pale persicaria cleawhite pack according to claim 1 is it is characterised in that described inclusion neohesperidin two
Hydrogen chalcone 0.5%, pale persicaria extract 4%, glycerol 5%, propylene glycol 3%, allantoin 2%, hydroxyethyl cellulose 0.8%, Pyrusussuriensiss,
2%, hyaluronate sodium 0.8% and water surplus are constituted.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610955925.0A CN106389216A (en) | 2016-11-03 | 2016-11-03 | Persicaria lapathifolia whitening lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610955925.0A CN106389216A (en) | 2016-11-03 | 2016-11-03 | Persicaria lapathifolia whitening lotion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106389216A true CN106389216A (en) | 2017-02-15 |
Family
ID=58014368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610955925.0A Pending CN106389216A (en) | 2016-11-03 | 2016-11-03 | Persicaria lapathifolia whitening lotion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106389216A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107822987A (en) * | 2017-12-04 | 2018-03-23 | 刘晓冰 | A kind of valerian whitening lotion |
| WO2020024022A1 (en) * | 2018-07-31 | 2020-02-06 | L'oreal | Sun care composition for whitening the skin, use of the sun care composition, and process of manufacture of the sun care composition |
| CN115778832A (en) * | 2023-02-01 | 2023-03-14 | 北京普世安生物科技有限公司 | Hair growth preparation and preparation method thereof |
-
2016
- 2016-11-03 CN CN201610955925.0A patent/CN106389216A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107822987A (en) * | 2017-12-04 | 2018-03-23 | 刘晓冰 | A kind of valerian whitening lotion |
| WO2020024022A1 (en) * | 2018-07-31 | 2020-02-06 | L'oreal | Sun care composition for whitening the skin, use of the sun care composition, and process of manufacture of the sun care composition |
| US11844855B2 (en) | 2018-07-31 | 2023-12-19 | L'oreal | Sun care composition for whitening the skin, use of the sun care composition, and process of manufacture of the sun care composition |
| CN115778832A (en) * | 2023-02-01 | 2023-03-14 | 北京普世安生物科技有限公司 | Hair growth preparation and preparation method thereof |
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| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170215 |