CN106491382A - A kind of whitening water containing native compound HitorinB - Google Patents
A kind of whitening water containing native compound HitorinB Download PDFInfo
- Publication number
- CN106491382A CN106491382A CN201611056979.XA CN201611056979A CN106491382A CN 106491382 A CN106491382 A CN 106491382A CN 201611056979 A CN201611056979 A CN 201611056979A CN 106491382 A CN106491382 A CN 106491382A
- Authority
- CN
- China
- Prior art keywords
- hitorinb
- whitening
- deoxyshikonin
- water containing
- native compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 150000001875 compounds Chemical class 0.000 title claims abstract description 11
- VOMDIEGPEURZJO-UHFFFAOYSA-N Deoxyshikonin Chemical compound C1=CC(O)=C2C(=O)C(CCC=C(C)C)=CC(=O)C2=C1O VOMDIEGPEURZJO-UHFFFAOYSA-N 0.000 claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 3
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 3
- 239000001540 sodium lactate Substances 0.000 claims description 3
- 229940005581 sodium lactate Drugs 0.000 claims description 3
- 235000011088 sodium lactate Nutrition 0.000 claims description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 5
- 238000002835 absorbance Methods 0.000 description 3
- 238000009499 grossing Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 241000721153 Chloranthus japonicus Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 description 1
- -1 C25 Terpenoids Chemical class 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000208818 Helianthus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 241001071917 Lithospermum Species 0.000 description 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 210000004691 chief cell of stomach Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The present invention discloses a kind of whitening water containing native compound HitorinB, including：Whitening active compositionss, described whitening active compositionss include that HitorinB and deoxyshikonin, HitorinB and deoxyshikonin erection weight ratio are 1 30:1.Whitening active compositionss account for middle weight 0.5 5%.It is found by the applicant that HitorinB is mixed under certain proportion with deoxyshikonin plays good synergy for whitening.
Description
Technical field
The present invention relates to a kind of whitening water containing native compound HitorinB, belongs to cosmetic skin care product field.
Background technology
Astringent is referred to as by cosmetic water, toner/smoothing toner, astringent lotion, is a kind of cosmetics of transparent liquid, is applied to the table of skin
Face, for the health for cleaning skin, keeping skin.The difference of cosmetic water, astringent lotion and toner/smoothing toner is not too big, cosmetic water, convergence
Water is more suitable for that weather is warmmer, compares the fuel-displaced weather of love on the face and uses, and toner/smoothing toner is more suitable for dry season and uses.Astringent exists
Play a part of to take over from the past and set a new course for the future in basic skin protection, with people's quality of the life raising and people to beautiful pursuit, astringent
Kind class is more and more various.HitorinB isolates 25 terpenoid of novel C with six ring skeletons from the aerial partss of India sunflower
Compound.It is published in Hitorins A and B, Hexacyclic C25 Terpenoids from Chloranthus
Japonicus, Org.Lett., 2016,18 (20), 5,420 5423.
It has been found that HitorinB has significant whitening effect under certain proportion with deoxyshikonin.
Content of the invention
For the problem that above-mentioned prior art is present, the present invention provides a kind of whitening containing native compound HitorinB
Water, whitening effect are good.
To achieve these goals, the technical solution used in the present invention is：A kind of containing native compound HitorinB's
Whitening water, including：Whitening active compositionss, described whitening active compositionss include HitorinB and deoxyshikonin,
HitorinB structural formulas are as follows：
Also include glycerol, triethanolamine, sodium lactate (60%), deionized water, hyaluronate sodium and hydroxymethyl cellulose.
HitorinB and deoxyshikonin erection weight ratio are 1-30:1.
Whitening active compositionss account for middle weight 0.5-5%.
It is found by the applicant that HitorinB is mixed under certain proportion with deoxyshikonin plays collaboration well for whitening
Effect, particularly 7：1-10：1 whitening effect is increased substantially, and for skin action temperature and.
Specific embodiment
The invention will be further described below.
Deoxyshikonin, No. CAS：43043-74-9,
The preparation method of HitorinB is referring to document：Hitorins A and B,Hexacyclic C25Terpenoids
From Chloranthus japonicus, Org.Lett., 2016,18 (20), 5,420 5423.
Embodiment 1
HitorinB, deoxyshikonin, deionized water, wherein HitorinB and deoxyshikonin account for 3%, and ratio is 15：
1, remaining is deionized water.
Embodiment 2
HitorinB, deoxyshikonin, glycerol 5%, triethanolamine 6%, sodium lactate (60%) 4%, hyaluronate sodium 2%
With hydroxymethyl cellulose 3%, remaining deionized water, wherein HitorinB and deoxyshikonin account for 3%, and ratio is 15：1.
Detection method：
Melanin genesis test in suppressing in mouse melanin cell.
By B16 mouse melanin tumor cells with 1 × 105The density of individual/ml is connected to the culture dish of a diameter of 9cm, at 37 DEG C
Cultivate 2 days under conditions of 5%CO2, abandon supernatant, add the sample solution 18-22ml after filtration sterilization, be then incubated for 3 days, abandon
Supernatant, PBS are washed, and add the trypsin solution peptic cell 3min of 0.5ml mass percents 0.2% per hole, add 2ml to tie up per ware
Hold liquid and terminate digestion. after piping and druming is mixed, every kind of concentration is taken out 0.5ml and makees cell counting. remaining cell suspension with 2500r/min from
Heart 5min, abandons supernatant, adds NaoH solution, heating to dissolve melanin, select the enzyme linked immunological of 490nm wavelength in precipitation
Absorbance is surveyed on detector.
B16 cell suppression ratio=(1- (medicine hole absorbance+medicine hole cell density)+(control wells absorbance+right
According to hole cell density)) × 100%.
Melanin genesis test in suppressing in mouse melanin cell, sample solution is HitorinB and deoxidation containing 3%
The mixed liquor of shikonin.
A is HitorinB, and B is deoxyshikonin, as a result as follows,
Above-mentioned test result indicate that, HitorinB and deoxyshikonin by a certain percentage (7：1-10：1) melting each other
Close and there is collaboration whitening effect, can effectively suppress melanin to generate, and effect is significant.And between other ratios, then have no collaboration
Effect, whitening effect be not obvious.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change modification alternative combinations that is made under other any spirit and principle without departing from the present invention simplify,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (4)
1. a kind of whitening water containing native compound HitorinB, it is characterised in that include：Whitening active compositionss, described
Whitening active compositionss include HitorinB and deoxyshikonin, HitorinB structural formulas are as follows：
2. a kind of whitening water containing native compound HitorinB according to claim 1, it is characterised in that also include
Glycerol, triethanolamine, sodium lactate (60%), deionized water, hyaluronate sodium and hydroxymethyl cellulose.
3. a kind of whitening water containing native compound HitorinB according to claim 1, it is characterised in that
HitorinB and deoxyshikonin erection weight ratio are 1-30:1.
4. a kind of whitening water containing native compound HitorinB according to claim 1, it is characterised in that whitening is lived
Property compositionss account for middle weight 0.5-5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056979.XA CN106491382A (en) | 2016-11-25 | 2016-11-25 | A kind of whitening water containing native compound HitorinB |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056979.XA CN106491382A (en) | 2016-11-25 | 2016-11-25 | A kind of whitening water containing native compound HitorinB |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106491382A true CN106491382A (en) | 2017-03-15 |
Family
ID=58329057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611056979.XA Pending CN106491382A (en) | 2016-11-25 | 2016-11-25 | A kind of whitening water containing native compound HitorinB |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106491382A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1220139A (en) * | 1998-10-30 | 1999-06-23 | 新疆穆舒丽曼化妆品有限责任公司 | Alkanna tinctoria haematochrome health-care beautifying cosmetics and its preparing method |
| CN101292946A (en) * | 2008-05-21 | 2008-10-29 | 南方李锦记有限公司 | Cosmetic composition for whitening skin |
| CN102078264A (en) * | 2009-11-30 | 2011-06-01 | 厦门娜其尔日化有限公司 | Whitening skin care product and preparation method thereof |
-
2016
- 2016-11-25 CN CN201611056979.XA patent/CN106491382A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1220139A (en) * | 1998-10-30 | 1999-06-23 | 新疆穆舒丽曼化妆品有限责任公司 | Alkanna tinctoria haematochrome health-care beautifying cosmetics and its preparing method |
| CN101292946A (en) * | 2008-05-21 | 2008-10-29 | 南方李锦记有限公司 | Cosmetic composition for whitening skin |
| CN102078264A (en) * | 2009-11-30 | 2011-06-01 | 厦门娜其尔日化有限公司 | Whitening skin care product and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170315 |
|
| WD01 | Invention patent application deemed withdrawn after publication |