CN107432849A - A kind of micromolecule hyaluronic acid skin base solution and preparation method thereof - Google Patents
A kind of micromolecule hyaluronic acid skin base solution and preparation method thereof Download PDFInfo
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- CN107432849A CN107432849A CN201710868456.3A CN201710868456A CN107432849A CN 107432849 A CN107432849 A CN 107432849A CN 201710868456 A CN201710868456 A CN 201710868456A CN 107432849 A CN107432849 A CN 107432849A
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- base solution
- hyaluronic acid
- skin base
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention provides a kind of micromolecule hyaluronic acid skin base solution and preparation method thereof, belong to skin-protection product technical field, the skin base solution includes the raw material of following parts by weight：10 15 parts of deionized water, 25 35 parts of micromolecule hyaluronic acid, 0.8 1.2 parts of Sodium Hyaluronate, 35 parts of yeast extract, 110 15 parts of oligopeptides, 13 parts of glycine betaine, 1.5 2.5 parts of trehalose, 12 parts of levulan, 1.8 2.2 parts of beta glucan, 0.5 2.5 parts of Sodium Polyacrylate, 8 12 parts of Roman chamomile flower extract, 13 parts of parahydroxyacet-ophenone, 12 parts of decoyl hydroximic acid, 10 15 parts of alcohol composition, 6 10 parts of vitamin C, 8 15 parts of squalene；The micromolecule hyaluronic acid skin base solution that invention provides, molecular weight is smaller, it is readily permeable enter skin, have remarkable result to the lifting of the basalis water content of skin, the generation of melanin can be suppressed, Kohakuhi, damaged cell is filled rapidly, also there is preferable improvement to acne, acne etc., the skin base solution uses pure natural raw material, concentration is higher, and practicality is stronger, makes security performance higher.
Description
Technical field
The present invention relates to skin-protection product technical field, more particularly to a kind of micromolecule hyaluronic acid skin base solution and its making side
Method.
Background technology
Hyaluronic acid, it that is to say that sodium hyaluronate is just present in the dermal tissue of human body skin in the form of gluey originally, be responsible for
Moisture, increase skin volume are stored, allows skin to seem full, plentiful, flexible.Young infant skin is comparable to Hard boiled eggs, its glass
Uric acid content is with regard to high!With the growth at people's age, sodium hyaluronate, which is lost in, to be accelerated, and is only left the brephic 65% at 30 years old, at 60 years old
Only it is left 25%.With the loss of sodium hyaluronate, just there is a series of aging phenomenon in skin；Skin problem is that one kind makes us head very much
The problem of pain, such as color spot, blackhead, small pox etc., many people are perplexed by this, with the development of society, people are to liking to be beautiful more
Focus on, many people lift the aesthetic feeling of appearance by various cosmetics, and the requirement more and more higher of people, existing function is more
Single cosmetics can not meet the needs of client.
Therefore, how for present in above-mentioned prior art the shortcomings that, carries out research and development improvement, is actually exerted needed for relevant industry
In view of this target of power research and development, designer of the present invention, are the idea of think of and creation, designed then with experience for many years, pass through
In many ways inquire into and study sampling test, and repeatedly amendment improvement, it is to release the present invention.
Such as Application No.：201610579656.2 Chinese patent disclose and a kind of a kind of be based on extracted form natural plant
The gel of releiving of liquid, it is characterised in that the gel includes the raw material of following composition by weight：Deionized water 25-30 parts, natural plants
Extract solution 21-39 parts, tocopherol acetate 0.25-0.75 parts, EGF 1-3 parts, sodium hyaluronate stoste 25-45 parts,
Cts-b bone collagen 18-22 parts, big particle-transparent matter acid 0.5-1 parts, ceramide 5-8 parts, oligopeptides 15-20 parts, β-Portugal gathers
Sugared 0.5-1 parts, alcohol composition 5-11 parts, adjuvant 3-6 parts, flavouring agent 5-7 parts, preservative 1-2 parts；Relaxed disclosed in this application
Slow setting glue, although tender skin can be played, moisturizing, moisten, repair and go the function of wrinkle, the gel is entered very by injecting
In cortex, in the bridge of the nose, increase augmentation rhinoplasty effect, certain risk be present.
The content of the invention
To overcome function present in prior art single, the problem of security performance is low, and cosmetic result is bad, the present invention carries
A kind of generation for suppressing melanin has been supplied, Kohakuhi, damaged cell is filled rapidly, and has also been had to comedo and acne etc.
Micromolecule hyaluronic acid skin base solution of preferable improvement and preparation method thereof.
A kind of micromolecule hyaluronic acid skin base solution provided by the invention, the skin base solution include the raw material of following parts by weight：Go
Ionized water 10-15 parts, micromolecule hyaluronic acid 25-35 parts, Sodium Hyaluronate 0.8-1.2 parts, yeast extract 3-5 parts, oligopeptides-
110-15 parts, glycine betaine 1-3 parts, trehalose 1.5-2.5 parts, levulan 1-2 parts, beta glucan 1.8-2.2 parts, Sodium Polyacrylate
0.5-2.5 parts, Roman chamomile flower extract 8-12 parts, parahydroxyacet-ophenone 1-3 parts, decoyl hydroximic acid 1-2 parts, alcohols combination
Thing 10-15 parts, vitamin C 6-10 parts, squalene 8-15 parts.
In some embodiments, the alcohol composition includes following components by weight percent：Panthenol 0.8-1.4 parts, butanediol
1-2 parts, 1,2- ethylene glycol 1.5-3 parts, 1,3- propane diols 1-2.2 parts, propane diols 1.2-1.4 parts, glycerine 4.5-5 parts.
In some embodiments, the skin base solution includes the raw material of following parts by weight：10 parts of deionized water, small molecule are transparent
25 parts of matter acid, 1 part of Sodium Hyaluronate, 4 parts of yeast extract, -110 parts of oligopeptides, 1 part of glycine betaine, 2 parts of trehalose, levulan 1
Part, 2 parts of beta glucan, 1 part of Sodium Polyacrylate, 8 parts of Roman chamomile flower extract, 2 parts of parahydroxyacet-ophenone, decoyl hydroximic acid
1 part, 14 parts of alcohol composition, 6 parts of vitamin C, 12 parts of squalene.
In some embodiments, the alcohol composition includes following components by weight percent：1.4 parts of panthenol, 2 parts of butanediol,
2.4 parts of 1,2- ethylene glycol, 2 parts of 1,3- propane diols, 1.2 parts of propane diols, 5 parts of glycerine.
In some embodiments, the micromolecule hyaluronic acid is using restructuring leech hyaluronic acid enzyme hydrolysis hyaluronic acid
It is made.
In some embodiments, the molecular weight of the skin base solution is less than 3000 dalton.
In some embodiments, the skin base solution is made by following steps：
S1：Weigh raw material：Raw material is weighed according to above-mentioned parts by weight, and is individually positioned in standby in the glass container for drying sealing
With；
S2：It is prepared by stoste：The deionized water weighed, micromolecule hyaluronic acid and Sodium Hyaluronate are mixed, and stirred evenly, during stirring
Between be 8-10 minutes；
S3：Add oligopeptides -1 and Roman chamomile flower extract：The oligopeptides -1 weighed and Roman chamomile flower extract are added
It is added in stoste made from step S2, stirs 5-8 minutes, be well mixed mixture；
S4：Further add raw material：Successively by load weighted glycine betaine, trehalose, levulan, beta glucan, Sodium Polyacrylate,
Parahydroxyacet-ophenone, decoyl hydroximic acid, alcohol composition, vitamin C and squalene are added to obtained mixed liquor in step S3
In, it is stirred, mixing time 10-12 minutes；
S5：Load weighted yeast extract is added to obtained mixed liquor in step S4, stirs 5-7 minutes, constant temperature is in 25-28
It is finished product that 12-24 hours are placed under DEG C aerobic conditions.
In some embodiments, manufactured finished product skin base solution in the step 5, it is that the semifluid shape of water white transparency is molten
Liquid.
Compared with prior art, a kind of micromolecule hyaluronic acid skin base solution provided by the invention and preparation method thereof, its is excellent
Point is：
First, micromolecule hyaluronic acid skin base solution provided by the invention, by oligopeptides -1 added in the feed, can repair impaired
Cell surface layer, promote skin newborn.
2nd, micromolecule hyaluronic acid skin base solution provided by the invention, by the micromolecule hyaluronic acid of addition and transparent
Matter acid sodium, by it is mucocutaneous absorb with anti-inflammatory, promote cell growth and differentiation, promote wound reparation, prevent skin senescence,
Keep the physiological effects such as its finish.
3rd, micromolecule hyaluronic acid skin base solution provided by the invention, by the yeast extract of addition, life can not only be improved
Thing surface-active, improve the antiradical activities of skin.
4th, micromolecule hyaluronic acid skin base solution provided by the invention, by recombinating leech hyaluronic acid enzyme hydrolysis hyalomitome
Acid, reaction condition is gentle, selectivity is strong, and hyaluronic acid, micromolecule hyaluronic acid caused by hydrolysis are not dissolved in cushioning liquid
Without impurity such as inorganic salts, molecular weight distribution concentration and the higher micromolecule hyaluronic acid of purity can be obtained.
5th, micromolecule hyaluronic acid skin base solution provided by the invention, molecular weight is smaller, it is readily permeable enter skin, not only may be used
Suppress the generation of melanin, Kohakuhi, damaged cell is filled rapidly, and also have to acne, acne etc. and preferably change
Kind effect, the skin base solution concentration is higher in addition, has the function that dosage is few and effect is good, practicality is stronger, using pure natural
Raw material, make security performance higher.
6th, the production method of micromolecule hyaluronic acid skin base solution provided by the invention, technique is simple, easy to operate, and raw
The skin base solution concentration of output is higher, and molecular weight is smaller, and skin absorbs preferably, and the basalis water content lifting to skin has significantly
Effect.
Embodiment
With reference to embodiments, the present invention will be described in further detail.It is it should be appreciated that described herein specific real
Example is applied only to explain the present invention, is not intended to limit the present invention.
A kind of micromolecule hyaluronic acid skin base solution is disclosed in the present invention, the skin base solution includes the raw material of following parts by weight：
Deionized water 10-15 parts, micromolecule hyaluronic acid 25-35 parts, Sodium Hyaluronate 0.8-1.2 parts, yeast extract 3-5 parts, widow
Peptide -110-15 parts, glycine betaine 1-3 parts, trehalose 1.5-2.5 parts, levulan 1-2 parts, beta glucan 1.8-2.2 parts, polypropylene
Sour sodium 0.5-2.5 parts, Roman chamomile flower extract 8-12 parts, parahydroxyacet-ophenone 1-3 parts, decoyl hydroximic acid 1-2 parts, alcohols
Composition 10-15 parts, vitamin C 6-10 parts, squalene 8-15 parts；Molecular weight of the present invention is smaller, it is readily permeable enter skin, to skin
The basalis water content lifting of skin has remarkable result, can not only suppress the generation of melanin, Kohakuhi makes damaged cell fast
Speed is full, and also has preferable improvement to comedo and acne etc., and the skin base solution concentration is higher in addition, it is few with dosage and
The good function of effect, practicality is stronger, using pure natural raw material, makes security performance higher.
Each part of the present embodiment is described in detail individually below：
Specifically, in this embodiment of the present invention, the alcohol composition includes following components by weight percent：Panthenol 0.8-1.4
Part, butanediol 1-2 parts, 1,2- ethylene glycol 1.5-3 parts, 1,3- propane diols 1-2.2 parts, propane diols 1.2-1.4 parts, glycerine 4.5-5
Part.
Specifically, the micromolecule hyaluronic acid is made using restructuring leech hyaluronic acid enzyme hydrolysis hyaluronic acid, the branch
Take that method energy reaction condition is gentle, selectivity is strong, and hyaluronic acid is not dissolved in cushioning liquid, small molecule caused by hydrolysis is transparent
Matter acid can obtain molecular weight distribution concentration and the higher micromolecule hyaluronic acid of purity without impurity such as inorganic salts.
Be small molecule skin base solution specifically, the molecular weight of the skin base solution is less than 3000 dalton, it is readily permeable enter skin.
Embodiment one：
A kind of micromolecule hyaluronic acid skin base solution and preparation method thereof disclosed in the present embodiment, the skin base solution include following parts by weight
Raw material：
10 parts of deionized water, 25 parts of micromolecule hyaluronic acid, 1 part of Sodium Hyaluronate, 4 parts of yeast extract, -110 parts of oligopeptides, sweet tea
1 part of dish alkali, 2 parts of trehalose, 1 part of levulan, 2 parts of beta glucan, 1 part of Sodium Polyacrylate, 8 parts of Roman chamomile flower extract,
2 parts of parahydroxyacet-ophenone, 1 part of decoyl hydroximic acid, 14 parts of alcohol composition, 6 parts of vitamin C, 12 parts of squalene.
Specifically, the alcohol composition includes following components by weight percent：1.4 parts of panthenol, 2 parts of butanediol, 1,2- ethylene glycol
2.4 parts, 2 parts of 1,3- propane diols, 1.2 parts of propane diols, 5 parts of glycerine.
The skin base solution is made by following steps：
S1：Weigh raw material：Raw material is weighed according to above-mentioned parts by weight, and is individually positioned in standby in the glass container for drying sealing
With；
S2：It is prepared by stoste：By 1 part of 10 parts of the deionized water weighed, 25 parts of micromolecule hyaluronic acid and Sodium Hyaluronate mixing, and
Stir evenly, mixing time is 8 minutes；
S3：Add oligopeptides -1 and Roman chamomile flower extract：- 110 parts of oligopeptides and Roman chamomile the flower extraction that will have been weighed
8 parts of thing is added in stoste made from step S2, stirs 6 minutes, is well mixed mixture；
S4：Further add raw material：Successively by load weighted 1 part of glycine betaine, 2 parts of trehalose, 1 part of levulan, beta glucan 2
Part, 1 part of Sodium Polyacrylate, 2 parts of parahydroxyacet-ophenone, 1 part of decoyl hydroximic acid, 14 parts of alcohol composition, 6 parts of vitamin C, spiny dogfish
12 parts of alkene is added in step S3 in obtained mixed liquor, is stirred, mixing time 11 minutes；
S5：Load weighted 4 parts of yeast extract is added to obtained mixed liquor in step S4, stirred 7 minutes, constant temperature is in 25-
It is finished product that 12-24 hours are placed under 28 DEG C of aerobic conditions；It is further preferred that placed 18 hours under 26 DEG C of constant temperatures,
Make finished product made of the formula materials, it is best in quality.
Manufactured finished product skin base solution in the step 5, it is water white transparency specifically, in this embodiment of the present invention
Semifluid shape solution.
Embodiment two：
A kind of micromolecule hyaluronic acid skin base solution and preparation method thereof disclosed in the present embodiment, the skin base solution include following parts by weight
Raw material：12 parts of deionized water, 30 parts of micromolecule hyaluronic acid, 1 part of Sodium Hyaluronate, 3 parts of yeast extract, oligopeptides -111
Part, 1 part of glycine betaine, 1.5 parts of trehalose, 1 part of levulan, 1.5 parts of beta glucan, 1 part of Sodium Polyacrylate, Roman chamomile flower carry
Take 9 parts of thing, 1 part of parahydroxyacet-ophenone, 1 part of decoyl hydroximic acid, 10 parts of alcohol composition, 7 parts of vitamin C, 9 parts of squalene.
Specifically, the alcohol composition includes following components by weight percent：0.8 part of panthenol, 1 part of butanediol, 1,2- ethylene glycol
1.5 parts, 1 part of 1,3- propane diols, 1.2 parts of propane diols, 4.5 parts of glycerine.
The skin base solution is made by following steps：
S1：Weigh raw material：Raw material is weighed according to above-mentioned parts by weight, and is individually positioned in standby in the glass container for drying sealing
With；
S2：It is prepared by stoste：By 1 part of 12 parts of the deionized water weighed, 30 parts of micromolecule hyaluronic acid and Sodium Hyaluronate mixing, and
Stir evenly, mixing time is 10 minutes；
S3：Add oligopeptides -1 and Roman chamomile flower extract：- 111 parts of oligopeptides and Roman chamomile the flower extraction that will have been weighed
9 parts of thing is added in stoste made from step S2, stirs 8 minutes, is well mixed mixture；
S4：Further add raw material：Successively by load weighted 1 part of glycine betaine, 1.5 parts of trehalose, 1 part of levulan, beta glucan
1.5 parts, 1 part of Sodium Polyacrylate, 1 part of parahydroxyacet-ophenone, 1 part of decoyl hydroximic acid, 10 parts of alcohol composition, 7 parts of vitamin C,
9 parts of squalene is added in step S3 in obtained mixed liquor, is stirred, mixing time 10 minutes
S5：Load weighted 3 parts of yeast extract is added to obtained mixed liquor in step S4, stirred 5 minutes, constant temperature is in 25-
It is finished product that 12-24 hours are placed under 28 DEG C of aerobic conditions；It is further preferred that placed 20 hours under 27 DEG C of constant temperatures,
Make finished product made of the formula materials, it is best in quality.
Manufactured finished product skin base solution in the step 5, it is colourless specifically, in the above-mentioned embodiment of the present invention
Bright semifluid shape solution.
Specifically, in actual use, the micromolecule hyaluronic acid skin base solution in the application directly can be broken through on skin,
The effect of moisturizing, moisturizing and water lock is preferable, also can be by the way that the micromolecule hyaluronic acid skin base solution is directed into by drainage set
Small molecule is imported in the device for storing liquid of radio-frequency cosmetic instrument, is passed through catheter and is exported to through the fluid hole in massage head on skin,
And massaged and the irradiation of LED reddish yellow light radio-frequency probes, make the effect of conditioning liquid skin permeation more preferable, comfort level more preferably,
Cosmetic result is optimal.
So far, the present embodiment is described in detail.According to above description, those skilled in the art should be to this
Invention has clear understanding.
It should be noted that in specification text, the implementation that does not illustrate or describe is in art
Form known to a person of ordinary skill in the art, is not described in detail.In addition, above-mentioned definition to each element and method and not only limiting
Various concrete structures, shape or the mode mentioned in embodiment.
It should also be noted that, the demonstration of the parameter comprising particular value can be provided herein, but these parameters are without definite etc.
In corresponding value, but analog value can be similar in acceptable error margin or design constraint.The side mentioned in embodiment
To term, such as " on ", " under ", "front", "rear", "left", "right" etc., not it is used for limiting the scope of the invention.In addition,
The step of must occurring unless specifically described or sequentially, the order of above-mentioned steps have no be limited to it is listed above, and can be according to institute
It need to design and change or rearrange.And above-described embodiment can be based on design and reliability consideration, the collocation that is mixed with each other makes
Used with or with other embodiment mix and match, i.e., the technical characteristic in different embodiments can freely form more realities
Apply example.
Particular embodiments described above, the purpose of the present invention, technical scheme and beneficial effect are carried out further in detail
Describe in detail it is bright, should be understood that the foregoing is only the present invention specific embodiment, be not intended to limit the invention, it is all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvements done etc., it should be included in the guarantor of the present invention
Within the scope of shield.
Claims (8)
- A kind of 1. micromolecule hyaluronic acid skin base solution, it is characterised in that：The skin base solution includes the raw material of following parts by weight：Deionization Water 10-15 parts, micromolecule hyaluronic acid 25-35 parts, Sodium Hyaluronate 0.8-1.2 parts, yeast extract 3-5 parts, oligopeptides -110- 15 parts, glycine betaine 1-3 parts, trehalose 1.5-2.5 parts, levulan 1-2 parts, beta glucan 1.8-2.2 parts, Sodium Polyacrylate 0.5- 2.5 parts, Roman chamomile flower extract 8-12 parts, parahydroxyacet-ophenone 1-3 parts, decoyl hydroximic acid 1-2 parts, alcohol composition 10-15 parts, vitamin C 6-10 parts, squalene 8-15 parts.
- 2. micromolecule hyaluronic acid skin base solution according to claim 1, it is characterised in that：The alcohol composition include with Lower components by weight percent：Panthenol 0.8-1.4 parts, butanediol 1-2 parts, 1,2- ethylene glycol 1.5-3 parts, 1,3- propane diols 1-2.2 parts, the third two Alcohol 1.2-1.4 parts, glycerine 4.5-5 parts.
- 3. micromolecule hyaluronic acid skin base solution according to claim 1, it is characterised in that：The skin base solution includes following weight The raw material of part：10 parts of deionized water, 25 parts of micromolecule hyaluronic acid, 1 part of Sodium Hyaluronate, 4 parts of yeast extract, oligopeptides -110 Part, 1 part of glycine betaine, 2 parts of trehalose, 1 part of levulan, 2 parts of beta glucan, 1 part of Sodium Polyacrylate, Roman chamomile flower extract 8 parts, 2 parts of parahydroxyacet-ophenone, 1 part of decoyl hydroximic acid, 14 parts of alcohol composition, 6 parts of vitamin C, 12 parts of squalene.
- 4. micromolecule hyaluronic acid skin base solution according to claim 3, it is characterised in that：The alcohol composition include with Lower components by weight percent：1.4 parts of panthenol, 2 parts of butanediol, 2.4 parts of 1,2- ethylene glycol, 2 parts of 1,3- propane diols, 1.2 parts of propane diols, glycerine 5 parts.
- 5. the micromolecule hyaluronic acid skin base solution according to claim 1 or 3, it is characterised in that：The small molecule hyalomitome Acid is made using restructuring leech hyaluronic acid enzyme hydrolysis hyaluronic acid.
- 6. micromolecule hyaluronic acid skin base solution according to claim 1, it is characterised in that：The molecular weight of the skin base solution is less than 3000 dalton.
- A kind of 7. preparation method of micromolecule hyaluronic acid skin base solution, it is characterised in that：The skin base solution is made by following steps：S1：Weigh raw material：Raw material is weighed according to above-mentioned parts by weight, and is individually positioned in standby in the glass container for drying sealing With；S2：It is prepared by stoste：The deionized water weighed, micromolecule hyaluronic acid and Sodium Hyaluronate are mixed, and stirred evenly, during stirring Between be 8-10 minutes；S3：Add oligopeptides -1 and Roman chamomile flower extract：The oligopeptides -1 weighed and Roman chamomile flower extract are added It is added in stoste made from step S2, stirs 5-8 minutes, be well mixed mixture；S4：Further add raw material：Successively by load weighted glycine betaine, trehalose, levulan, beta glucan, Sodium Polyacrylate, Parahydroxyacet-ophenone, decoyl hydroximic acid, alcohol composition, vitamin C and squalene are added to obtained mixed liquor in step S3 In, it is stirred, mixing time 10-12 minutes；S5：Load weighted yeast extract is added to obtained mixed liquor in step S4, stirs 5-7 minutes, constant temperature is in 25-28 It is finished product that 12-24 hours are placed under DEG C aerobic conditions.
- 8. the preparation method of micromolecule hyaluronic acid skin base solution according to claim 7, it is characterised in that：The step 5 In manufactured finished product skin base solution, be water white transparency semifluid shape solution.
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| CN109303745A (en) * | 2018-11-29 | 2019-02-05 | 广州暨创医美生物科技有限公司 | A kind of application of facial mask liquid, preparation method and facial mask and its facial mask comprising the facial mask liquid |
| CN109528527A (en) * | 2019-01-07 | 2019-03-29 | 江苏怡欣健康管理有限公司 | Small molecule sodium hyaluronate stoste and preparation method thereof |
| CN110613638A (en) * | 2019-10-19 | 2019-12-27 | 浙江英树生物科技有限公司 | Hyaluronic acid moisturizing and repairing foundation liquid and preparation method thereof |
| CN110897916A (en) * | 2019-12-20 | 2020-03-24 | 鹂诺生物医药科技(上海)有限公司 | Formula of multi-effect muscle base solution |
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| 佚名: ""ZOZ玻尿酸酵母原液"，获取网址：http://ftba.nmpa.gov.cn:8181/ftban/itownet/hzp_ba/fw/pz.jsp?processid=201705261617047stb2&nid=201705261617047stb2", 《国产非特殊用途化妆品备案服务平台》 * |
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| CN108210436A (en) * | 2018-03-14 | 2018-06-29 | 佛山市迭蓓生物科技有限公司 | A kind of microcapsules eye compacts skin base solution and preparation method |
| CN109303745A (en) * | 2018-11-29 | 2019-02-05 | 广州暨创医美生物科技有限公司 | A kind of application of facial mask liquid, preparation method and facial mask and its facial mask comprising the facial mask liquid |
| CN109528527A (en) * | 2019-01-07 | 2019-03-29 | 江苏怡欣健康管理有限公司 | Small molecule sodium hyaluronate stoste and preparation method thereof |
| CN110613638A (en) * | 2019-10-19 | 2019-12-27 | 浙江英树生物科技有限公司 | Hyaluronic acid moisturizing and repairing foundation liquid and preparation method thereof |
| CN110897916A (en) * | 2019-12-20 | 2020-03-24 | 鹂诺生物医药科技(上海)有限公司 | Formula of multi-effect muscle base solution |
| CN110897916B (en) * | 2019-12-20 | 2023-02-03 | 鹂诺生物医药科技(上海)有限公司 | Formula of multi-effect muscle base solution |
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Application publication date: 20171205 |