CN1066068A - 4-芳基-3-(芳香杂环基脲基)喹啉类衍生物 - Google Patents

4-芳基-3-(芳香杂环基脲基)喹啉类衍生物 Download PDF

Info

Publication number
CN1066068A
CN1066068A CN92103010A CN92103010A CN1066068A CN 1066068 A CN1066068 A CN 1066068A CN 92103010 A CN92103010 A CN 92103010A CN 92103010 A CN92103010 A CN 92103010A CN 1066068 A CN1066068 A CN 1066068A
Authority
CN
China
Prior art keywords
quinoline
chloro
phenyl
group
urea groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN92103010A
Other languages
English (en)
Chinese (zh)
Inventor
E·S·滨中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CN1066068A publication Critical patent/CN1066068A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CN92103010A 1991-04-26 1992-04-25 4-芳基-3-(芳香杂环基脲基)喹啉类衍生物 Pending CN1066068A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69232391A 1991-04-26 1991-04-26
US692,323 1991-04-26

Publications (1)

Publication Number Publication Date
CN1066068A true CN1066068A (zh) 1992-11-11

Family

ID=24780107

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92103010A Pending CN1066068A (zh) 1991-04-26 1992-04-25 4-芳基-3-(芳香杂环基脲基)喹啉类衍生物

Country Status (20)

Country Link
EP (1) EP0590094A1 (pt)
JP (1) JPH0776215B2 (pt)
CN (1) CN1066068A (pt)
AU (1) AU1879792A (pt)
BR (1) BR9205939A (pt)
CA (1) CA2108014A1 (pt)
CZ (1) CZ395592A3 (pt)
DE (1) DE9290049U1 (pt)
FI (1) FI934710A0 (pt)
HU (1) HUT65748A (pt)
IE (1) IE921330A1 (pt)
IL (1) IL101627A0 (pt)
MX (1) MX9201916A (pt)
NO (1) NO933837L (pt)
NZ (1) NZ242493A (pt)
PT (1) PT100426A (pt)
TW (1) TW197436B (pt)
WO (1) WO1992019614A1 (pt)
YU (1) YU44592A (pt)
ZA (1) ZA922976B (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103601677A (zh) * 2013-11-19 2014-02-26 清华大学 制备2-烷硫基喹啉衍生物的方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125325T3 (es) * 1992-01-23 1999-03-01 Pfizer Derivados de 4-fenil-3-(heteroarilureido)-1,2-dihidro-2-oxoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos.
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5843957A (en) * 1995-05-19 1998-12-01 Sumitomo Pharmaceuticals Company, Ltd. Naphthyridine derivatives
EP0842933B1 (en) * 1995-05-31 2004-08-04 Sumitomo Pharmaceuticals Company, Limited Novel naphthyridine derivatives
CN1245500A (zh) * 1996-11-26 2000-02-23 住友制药株式会社 新型萘啶衍生物
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
CA2321237A1 (en) 1998-02-25 1999-09-02 Masami Muraoka Pyridone derivatives and process for producing the same
CA2547518A1 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
TW205037B (pt) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103601677A (zh) * 2013-11-19 2014-02-26 清华大学 制备2-烷硫基喹啉衍生物的方法
CN103601677B (zh) * 2013-11-19 2015-11-18 清华大学 制备2-烷硫基喹啉衍生物的方法

Also Published As

Publication number Publication date
YU44592A (sh) 1994-12-28
MX9201916A (es) 1992-11-01
AU1879792A (en) 1992-12-21
HUT65748A (en) 1994-07-28
WO1992019614A1 (en) 1992-11-12
ZA922976B (en) 1993-10-25
JPH06501025A (ja) 1994-01-27
NZ242493A (en) 1994-08-26
CA2108014A1 (en) 1992-10-27
EP0590094A1 (en) 1994-04-06
FI934710A (fi) 1993-10-25
PT100426A (pt) 1993-08-31
TW197436B (pt) 1993-01-01
NO933837L (no) 1993-10-25
BR9205939A (pt) 1994-09-27
FI934710A0 (fi) 1993-10-25
JPH0776215B2 (ja) 1995-08-16
IL101627A0 (en) 1992-12-30
DE9290049U1 (de) 1994-01-05
CZ395592A3 (en) 1994-02-16
IE921330A1 (en) 1992-11-04
HU9303025D0 (en) 1994-01-28

Similar Documents

Publication Publication Date Title
CN1219764C (zh) 用ω－羧基芳基取代的二苯脲作为raf激酶抑制剂
CN1080919A (zh) 作为酰基辅酶a-胆固醇酰基转移酶抑制剂的、新的n-芳基和n-杂芳基脲类衍生物
CN1188121C (zh) 治疗性取代的胍类
CN1173969C (zh) 新的硫辛酸衍生物、其制备方法、其作为药物的应用和含有这些衍生物的药物组合物
CN1138546C (zh) 用作细胞因子的某些1,4,5-三取代咪唑化合物
CN1031266C (zh) 含氮的六元或十元杂环的制法
CN1036456C (zh) 氨基取代的吡唑
CN1036920C (zh) 含杂环碳酸衍生物
CN1263755C (zh) 作为选择性cox－2抑制剂的吡唑并吡啶衍生物
CN1134420C (zh) 新的取代咪唑化合物
CN1050183A (zh) 作为酰基辅酶a胆固醇酰基转移酶(acat)抑制剂的新的n-芳基和n-杂芳基酰胺及脲衍生物
CN1118464C (zh) 新颖嘧啶衍生物及其制法
CN1213307A (zh) 新的取代的咪唑化合物
CN1073174A (zh) 杂环衍生物
CN1044811A (zh) 杂环化合物
CN87101830A (zh) 二氯苯胺衍生物
CN86106428A (zh) 抗肿瘤方法及其化合物
CN1942449A (zh) 制备哒嗪酮化合物的方法
CN1066068A (zh) 4-芳基-3-(芳香杂环基脲基)喹啉类衍生物
CN1516580A (zh) 磺酰胺类
CN1052478C (zh) 1,4-二取代-5(4h)-四唑啉酮类的制备方法
CN1717388A (zh) 双官能异(硫)氰酸苯酯、其制备方法和中间体
CN1323306A (zh) 萘啶衍生物
CN1033800A (zh) 茚满衍生物和其制备方法
CN1378543A (zh) 具有血管生成抑制活性的取代的哒嗪和稠合的哒嗪

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication