CN106573954A - 2’‑氯氨基嘧啶酮和嘧啶二酮核苷 - Google Patents

2’‑氯氨基嘧啶酮和嘧啶二酮核苷 Download PDF

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Publication number
CN106573954A
CN106573954A CN201580044979.5A CN201580044979A CN106573954A CN 106573954 A CN106573954 A CN 106573954A CN 201580044979 A CN201580044979 A CN 201580044979A CN 106573954 A CN106573954 A CN 106573954A
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China
Prior art keywords
compound
alkyl
pharmaceutically acceptable
acceptable salt
formula
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Pending
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CN201580044979.5A
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English (en)
Chinese (zh)
Inventor
M.O.H.克拉克
R.L.马克曼
D.西格尔
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Gilead Sciences Inc
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Gilead Sciences Inc
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Publication of CN106573954A publication Critical patent/CN106573954A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580044979.5A 2014-08-21 2015-08-19 2’‑氯氨基嘧啶酮和嘧啶二酮核苷 Pending CN106573954A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462040349P 2014-08-21 2014-08-21
US62/040,349 2014-08-21
PCT/US2015/045849 WO2016028866A1 (en) 2014-08-21 2015-08-19 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides

Publications (1)

Publication Number Publication Date
CN106573954A true CN106573954A (zh) 2017-04-19

Family

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CN201580044979.5A Pending CN106573954A (zh) 2014-08-21 2015-08-19 2’‑氯氨基嘧啶酮和嘧啶二酮核苷

Country Status (17)

Country Link
US (6) US9617295B2 (cg-RX-API-DMAC10.html)
EP (2) EP3738969A1 (cg-RX-API-DMAC10.html)
JP (2) JP6765364B2 (cg-RX-API-DMAC10.html)
KR (1) KR102528928B1 (cg-RX-API-DMAC10.html)
CN (1) CN106573954A (cg-RX-API-DMAC10.html)
AR (1) AR101561A1 (cg-RX-API-DMAC10.html)
AU (1) AU2015305593C1 (cg-RX-API-DMAC10.html)
BR (1) BR112017003242A2 (cg-RX-API-DMAC10.html)
CA (1) CA2958546C (cg-RX-API-DMAC10.html)
EA (1) EA201790234A1 (cg-RX-API-DMAC10.html)
ES (1) ES2808868T3 (cg-RX-API-DMAC10.html)
IL (1) IL250426A0 (cg-RX-API-DMAC10.html)
MX (1) MX2017002288A (cg-RX-API-DMAC10.html)
NZ (1) NZ728707A (cg-RX-API-DMAC10.html)
SG (1) SG11201700810SA (cg-RX-API-DMAC10.html)
TW (1) TWI673283B (cg-RX-API-DMAC10.html)
WO (1) WO2016028866A1 (cg-RX-API-DMAC10.html)

Cited By (1)

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WO2024016639A1 (zh) * 2022-07-21 2024-01-25 华创合成制药股份有限公司 一种抗病毒感染的化合物及其制备方法和用途

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USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
TWI673283B (zh) * 2014-08-21 2019-10-01 美商基利科學股份有限公司 ２’－氯胺基嘧啶酮及嘧啶二酮核苷類
CR20170157A (es) * 2014-09-26 2017-07-03 Riboscience Llc Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial
EP3939985B1 (en) 2014-12-26 2024-05-08 Emory University Pharmaceutical compositions comprising n4-hydroxycytidine derivatives for the treatment or prevention of influenza or coronavirus infections
WO2018009623A1 (en) * 2016-07-08 2018-01-11 Atea Pharmaceuticals, Inc. β-D-2'-DEOXY-2'-SUBSTITUTED-4'-SUBSTITUTED-2-SUBSTITUTED-N6-SUBSTITUTED-6-AMINOPURINE NUCLEOTIDES FOR THE TREATMENT OF PARAMYXOVIRUS AND ORTHOMYXOVIRUS INFECTIONS
ES2995458T3 (en) 2017-12-07 2025-02-10 Univ Emory N4-hydroxycytidine derivative and anti-viral uses related thereto
WO2023085242A1 (ja) * 2021-11-12 2023-05-19 国立大学法人北海道大学 抗ウイルス剤
PE20250684A1 (es) 2022-03-15 2025-03-04 Rome Therapeutics Inc Compuestos y metodos para el tratamiento de enfermedades

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WO2013096679A1 (en) * 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
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WO2014079903A1 (en) * 2012-11-20 2014-05-30 University College Cork Phosphonucleosides useful in the treatment of viral disorders
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WO2013096679A1 (en) * 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013142525A1 (en) * 2012-03-21 2013-09-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
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US20140219958A1 (en) * 2013-02-01 2014-08-07 Enanta Pharmaceuticals, Inc. 5, 6-d2 uridine nucleoside/tide derivatives

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024016639A1 (zh) * 2022-07-21 2024-01-25 华创合成制药股份有限公司 一种抗病毒感染的化合物及其制备方法和用途

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BR112017003242A2 (pt) 2017-11-28
EA201790234A1 (ru) 2017-07-31
CA2958546C (en) 2020-06-23
KR20170042643A (ko) 2017-04-19
EP3183261A1 (en) 2017-06-28
WO2016028866A1 (en) 2016-02-25
US9617295B2 (en) 2017-04-11
AR101561A1 (es) 2016-12-28
EP3183261B1 (en) 2020-06-17
US20160052953A1 (en) 2016-02-25
US20180340004A1 (en) 2018-11-29
US20190202852A1 (en) 2019-07-04
AU2015305593A1 (en) 2017-02-23
AU2015305593B2 (en) 2018-05-17
JP2017525699A (ja) 2017-09-07
US9982006B2 (en) 2018-05-29
TW201619178A (zh) 2016-06-01
NZ728707A (en) 2018-06-29
US20200087337A1 (en) 2020-03-19
TWI673283B (zh) 2019-10-01
MX2017002288A (es) 2017-05-22
JP2020111608A (ja) 2020-07-27
JP6765364B2 (ja) 2020-10-07
SG11201700810SA (en) 2017-03-30
CA2958546A1 (en) 2016-02-25
AU2015305593C1 (en) 2018-11-15
EP3738969A1 (en) 2020-11-18
KR102528928B1 (ko) 2023-05-08
ES2808868T3 (es) 2021-03-02
IL250426A0 (en) 2017-03-30
US20200157137A1 (en) 2020-05-21
US20170327526A1 (en) 2017-11-16

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