SG11201700810SA - 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides - Google Patents
2'-chloro aminopyrimidinone and pyrimidine dione nucleosidesInfo
- Publication number
- SG11201700810SA SG11201700810SA SG11201700810SA SG11201700810SA SG11201700810SA SG 11201700810S A SG11201700810S A SG 11201700810SA SG 11201700810S A SG11201700810S A SG 11201700810SA SG 11201700810S A SG11201700810S A SG 11201700810SA SG 11201700810S A SG11201700810S A SG 11201700810SA
- Authority
- SG
- Singapore
- Prior art keywords
- nucleosides
- pyrimidine dione
- aminopyrimidinone
- chloro
- chloro aminopyrimidinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462040349P | 2014-08-21 | 2014-08-21 | |
| PCT/US2015/045849 WO2016028866A1 (en) | 2014-08-21 | 2015-08-19 | 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201700810SA true SG11201700810SA (en) | 2017-03-30 |
Family
ID=54066190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201700810SA SG11201700810SA (en) | 2014-08-21 | 2015-08-19 | 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US9617295B2 (en) |
| EP (2) | EP3183261B1 (en) |
| JP (2) | JP6765364B2 (en) |
| KR (1) | KR102528928B1 (en) |
| CN (1) | CN106573954A (en) |
| AR (1) | AR101561A1 (en) |
| AU (1) | AU2015305593C1 (en) |
| BR (1) | BR112017003242A2 (en) |
| CA (1) | CA2958546C (en) |
| EA (1) | EA201790234A1 (en) |
| ES (1) | ES2808868T3 (en) |
| IL (1) | IL250426A0 (en) |
| MX (1) | MX2017002288A (en) |
| NZ (1) | NZ728707A (en) |
| SG (1) | SG11201700810SA (en) |
| TW (1) | TWI673283B (en) |
| WO (1) | WO2016028866A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104114568B (en) | 2011-12-22 | 2017-09-01 | 艾丽奥斯生物制药有限公司 | Substituted nucleosides, nucleotides and the like |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TWI673283B (en) * | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides |
| CR20170157A (en) * | 2014-09-26 | 2017-07-03 | Riboscience Llc | DERIVATIVES OF NUCLEOSIDS REPLACED WITH 4´-VINYL AS INHIBITORS OF THE REPLICATION OF THE RNA OF THE RESPIRATORY RESPIRATORY VIRUS |
| KR20230130175A (en) | 2014-12-26 | 2023-09-11 | 에모리 유니버시티 | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| WO2018009623A1 (en) * | 2016-07-08 | 2018-01-11 | Atea Pharmaceuticals, Inc. | β-D-2'-DEOXY-2'-SUBSTITUTED-4'-SUBSTITUTED-2-SUBSTITUTED-N6-SUBSTITUTED-6-AMINOPURINE NUCLEOTIDES FOR THE TREATMENT OF PARAMYXOVIRUS AND ORTHOMYXOVIRUS INFECTIONS |
| CN118477088A (en) | 2017-12-07 | 2024-08-13 | 埃默里大学 | N4-hydroxycytidine and derivatives and antiviral uses related thereto |
| EP4431100A1 (en) * | 2021-11-12 | 2024-09-18 | National University Corporation Hokkaido University | Antiviral agent |
| WO2024016639A1 (en) * | 2022-07-21 | 2024-01-25 | 华创合成制药股份有限公司 | Anti-viral-infection compound, and preparation method therefor and use thereof |
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| US3361306A (en) | 1966-03-31 | 1968-01-02 | Merck & Co Inc | Aerosol unit dispensing uniform amounts of a medically active ingredient |
| US3565070A (en) | 1969-02-28 | 1971-02-23 | Riker Laboratories Inc | Inhalation actuable aerosol dispenser |
| FR2224175B1 (en) | 1973-04-04 | 1978-04-14 | Isf Spa | |
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| IT1017153B (en) | 1974-07-15 | 1977-07-20 | Isf Spa | APPARATUS FOR INHALATIONS |
| SE438261B (en) | 1981-07-08 | 1985-04-15 | Draco Ab | USE IN A DOSHALATOR OF A PERFORED MEMBRANE |
| US4805811A (en) | 1985-03-29 | 1989-02-21 | Aktiebolaget Draco | Dosage device |
| SE448277B (en) | 1985-04-12 | 1987-02-09 | Draco Ab | INDICATOR DEVICE WITH A DOSAGE DEVICE FOR MEDICINAL PRODUCTS |
| IT1228459B (en) | 1989-02-23 | 1991-06-19 | Phidea S R L | INHALER WITH REGULAR AND COMPLETE EMPTYING OF THE CAPSULE. |
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| US5261538A (en) | 1992-04-21 | 1993-11-16 | Glaxo Inc. | Aerosol testing method |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US5388572A (en) | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
| US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
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| PT2937350T (en) | 2008-04-23 | 2018-04-16 | Gilead Sciences Inc | 1' -substituted carba-nucleoside analogs for antiviral treatment |
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| CN104114568B (en) * | 2011-12-22 | 2017-09-01 | 艾丽奥斯生物制药有限公司 | Substituted nucleosides, nucleotides and the like |
| SG10201804571TA (en) * | 2012-03-21 | 2018-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| GB201220843D0 (en) * | 2012-11-20 | 2013-01-02 | Univ College Cork Nat Univ Ie | Compound |
| US10034893B2 (en) * | 2013-02-01 | 2018-07-31 | Enanta Pharmaceuticals, Inc. | 5, 6-D2 uridine nucleoside/tide derivatives |
| AU2014302711A1 (en) * | 2013-06-26 | 2015-12-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9862743B2 (en) * | 2013-10-11 | 2018-01-09 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TWI673283B (en) * | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides |
-
2015
- 2015-08-07 TW TW104125796A patent/TWI673283B/en active
- 2015-08-14 AR ARP150102625A patent/AR101561A1/en unknown
- 2015-08-19 ES ES15760544T patent/ES2808868T3/en active Active
- 2015-08-19 CN CN201580044979.5A patent/CN106573954A/en active Pending
- 2015-08-19 EP EP15760544.5A patent/EP3183261B1/en active Active
- 2015-08-19 SG SG11201700810SA patent/SG11201700810SA/en unknown
- 2015-08-19 NZ NZ728707A patent/NZ728707A/en unknown
- 2015-08-19 AU AU2015305593A patent/AU2015305593C1/en active Active
- 2015-08-19 JP JP2017508531A patent/JP6765364B2/en active Active
- 2015-08-19 BR BR112017003242A patent/BR112017003242A2/en not_active Application Discontinuation
- 2015-08-19 CA CA2958546A patent/CA2958546C/en active Active
- 2015-08-19 MX MX2017002288A patent/MX2017002288A/en unknown
- 2015-08-19 US US14/830,121 patent/US9617295B2/en active Active
- 2015-08-19 KR KR1020177006312A patent/KR102528928B1/en active IP Right Grant
- 2015-08-19 EA EA201790234A patent/EA201790234A1/en unknown
- 2015-08-19 EP EP20180058.8A patent/EP3738969A1/en active Pending
- 2015-08-19 WO PCT/US2015/045849 patent/WO2016028866A1/en active Application Filing
-
2017
- 2017-02-02 IL IL250426A patent/IL250426A0/en unknown
- 2017-02-24 US US15/441,561 patent/US9982006B2/en active Active
-
2018
- 2018-04-11 US US15/950,442 patent/US20180340004A1/en not_active Abandoned
- 2018-12-06 US US16/212,374 patent/US20190202852A1/en not_active Abandoned
-
2019
- 2019-06-27 US US16/454,536 patent/US20200157137A1/en not_active Abandoned
- 2019-09-10 US US16/565,888 patent/US20200087337A1/en not_active Abandoned
-
2020
- 2020-04-10 JP JP2020070958A patent/JP2020111608A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20200087337A1 (en) | 2020-03-19 |
| AU2015305593C1 (en) | 2018-11-15 |
| CA2958546A1 (en) | 2016-02-25 |
| BR112017003242A2 (en) | 2017-11-28 |
| US20160052953A1 (en) | 2016-02-25 |
| CA2958546C (en) | 2020-06-23 |
| JP2020111608A (en) | 2020-07-27 |
| US20190202852A1 (en) | 2019-07-04 |
| TWI673283B (en) | 2019-10-01 |
| CN106573954A (en) | 2017-04-19 |
| NZ728707A (en) | 2018-06-29 |
| AR101561A1 (en) | 2016-12-28 |
| US20200157137A1 (en) | 2020-05-21 |
| JP2017525699A (en) | 2017-09-07 |
| TW201619178A (en) | 2016-06-01 |
| ES2808868T3 (en) | 2021-03-02 |
| KR20170042643A (en) | 2017-04-19 |
| US9982006B2 (en) | 2018-05-29 |
| US20170327526A1 (en) | 2017-11-16 |
| KR102528928B1 (en) | 2023-05-08 |
| US9617295B2 (en) | 2017-04-11 |
| IL250426A0 (en) | 2017-03-30 |
| WO2016028866A1 (en) | 2016-02-25 |
| AU2015305593B2 (en) | 2018-05-17 |
| EP3183261A1 (en) | 2017-06-28 |
| JP6765364B2 (en) | 2020-10-07 |
| EA201790234A1 (en) | 2017-07-31 |
| US20180340004A1 (en) | 2018-11-29 |
| AU2015305593A1 (en) | 2017-02-23 |
| EP3738969A1 (en) | 2020-11-18 |
| EP3183261B1 (en) | 2020-06-17 |
| MX2017002288A (en) | 2017-05-22 |
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