CN106491897A - 一种用于治疗高血压的中药组合物 - Google Patents
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Abstract
本发明公开了一种用于治疗高血压的中药组合物，按重量份数计算，包括苍术8～24克，紫菀6～18克，桅子6～18克，香附6～18克，罗布麻10～30克，甘草6～18克中的一种以上制成。本发明采用对中药配方进行优化的筛选组合，获得一种能适用于大多数高血压患者的药物，该药物疗效好，见效快，而且副作用小。本发明成本低廉，容易实施，使用效果十分理想。
Description
技术领域
本发明涉及中草药制剂技术领域，特别是一种用于治疗高血压的中药组合物。
背景技术
高血压是最常见的慢性病，也是心脑血管病最主要的危险因素，脑卒中、心肌梗死、心力衰竭及慢性肾脏病是其主要并发症。中国2002 年心血管病报告显示，中国有2 亿高血压患者，高血压病人以1000 万人/ 每年的速度增长，而且全国15 岁以上人群的高血压患病率逐年递增，已经超过20%。
降压治疗的两大目的是：降低血压和减少心脑血管疾病和死亡发生，一般高血压患者，应将血压（收缩压/ 舒张压）降至140/90mmHg 以下；65 岁及以上的老年人的收缩压应控制在150mmHg 以下。
目前市场上治疗高血压的中西药品种繁多。西药治疗高血压，往往能很快使血压下降，甚至恢复正常，但在改善头晕、头痛等症状上效果欠佳。而且多数西药很难控制其对靶器官的破坏。钙通道阻滞剂(CCB) 是我国医生最多处方的降压药物，但其本身副作用也很明显，如反射性的引起心率增快, 心搏出量增加, 也反射性增加血浆肾素活性；直接扩张血管导致交感神经张力增高, 引起心率增快, 头痛, 下肢水肿等。
而中医中药是以辨证为基础的，强调整体治疗，症状改善比较理想，能有效提高患者的生活质量；降压作用缓和，稳定血压效果好，对早期、老年轻度高血压或配合西药治疗较重的高血压病，均可防止或缓和血压较大的波动；中药副作用少，且能减轻或消除西药的副作用；目前一些研究发现，中医中药在对某些受损器官的逆转以及并发症的防治方面也有一定作用。
发明内容
本发明所要解决的技术问题是：提供一种用于治疗高血压的中药组合物，它副作用小，疗效好，适用范围广，以克服现有技术的不足。
本发明的是这样实现的：一种用于治疗高血压的中药组合物，其特征在于：按重量份数计算，由苍术8～24克，紫菀6～18克，桅子6～18克，香附6～18克，罗布麻10～30克，甘草6～18克中的一种以上制成。
优选方案，所述的一种用于治疗高血压的中药组合物，其特征在于：按重量份数计算，由苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克中的一种以上制成。
优选方案，所述的一种用于治疗高血压的中药组合物的制备方法，按重量份数，取苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克混合，将混合物粉碎，取粉碎物料7 ～ 9 克封装，制成中药粉剂。
优选方案，所述的一种用于治疗高血压的中药组合物的制备方法，混合物料粉碎后过100 目筛。
优选方案，所述的一种用于治疗高血压的中药组合物的制备方法，按重量份数，取苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克混合，第一次按重量倍数向混合物中加入10 ～ 15 倍的水进行煎煮1 小时，再分别加入8 ～ 12 重量倍的水煎煮两次，每次煎煮35 分钟，合并煎煮液并滤过，再将滤液浓缩至稠状，制成中药药剂；煎器要求：选择砂锅或搪瓷锅，忌用铁、铜、铝等金属器具。
优选方案，所述的一种用于治疗高血压的中药组合物的制备方法，将滤液浓缩至稠状后，在80℃下进行减压干燥后进行粉碎，过60 目筛，装入胶囊壳，制得硬胶囊剂。
为了验证本发明的效果，对药物成品进行了临床测试，其结果如下：
病例一
患者甲，女，无不良嗜好，生活节律，父母均有高压病史。去年夏天突感头晕、乏力、心悸，医院就诊结果为高血压）（180/80mmHg），血脂1.80mmol/L，服用洛丁新5mg（早服），阿司匹林肠溶片75mg（晚服）4 个月，无明显效果。后改服本发明中药制剂，汤剂，早饭前晚饭后各一次，2 周后血压降至130/76mmHg，后续服1 周巩固疗效，复查血压为124/76mmHg。
病例二
患者乙，男， 13 年前就有高血压， 7 年前检查到了180/120mmHg，用过很多药效果都不好，1 年前开始服用硝苯地平缓释片40 毫克/ 日，倍他乐克50 毫克/ 日，缬沙坦160 毫克/ 日，半年后测得血压为170/110 mmHg，并开始注射血塞通和川芎，后因过敏停药。服用本发明中药制剂，汤剂，早饭前晚饭后各一次，2 周后血压降至145/102mmHg，4 周后血压恢复正常。
苍术：燥湿健脾；祛风湿；明目。主湿困脾胃；倦怠嗜卧；胞痞腹胀；食欲不振；哎吐泄泻；痰饮；湿肿；表证夹湿；头身重痛；痹证温性；肢节酸痛重着；痿襞；夜盲。
紫菀： 温肺，下气，消痰，止咳。治风寒咳嗽气喘，虚劳咳吐脓血，喉痹，小便不利。
桅子：清热，泻火，凉血。治热病虚烦不眠，黄疸，淋病，消渴，目赤，咽痛，吐血，衄血，血痢，尿血，热毒疮疡，扭伤肿痛。
香附：用于肝郁气滞，胸胁胀痛，疝气疼痛，乳房胀痛，脾胃气滞，脘腹痞闷，胀满疼痛，月经不调，经闭痛经。
罗布麻：平肝安神，清热利水。用于肝阳眩晕，心悸失眠，浮肿尿少；高血压病，神经衰弱，肾炎浮肿。
甘草：性味甘平，归心、肺、脾、胃经。具补脾益气、润肺止咳、缓急止痛、缓和药性之功，其有效成分为甘草甜素、甘草次酸、甘草苷元、甘草多糖是临床上常用的中草药之一，调和诸药。
根据典型病例的治疗结果可以看出，；本发明可以正心气，护心阴心阳，补脾健胃，补足精气，平肝阳，益气营血，调理脏腑之功，改善动脉内皮功能，活血化瘀，以降血压，而且疗效快，由于采用的中药组分搭配合理，因此副作用小。
由于采用了上述技术方案，与现有技术相比，本发明采用对中药配方进行优化的筛选组合，获得一种能适用于大多数高血压患者的药物，该药物疗效好，见效快，而且副作用小。本发明成本低廉，容易实施，使用效果十分理想。
具体实施方式
本发明的实施例1 ：一种用于治疗高血压的中药组合物，取按重量份数，取苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克混合，将混合物粉碎，混合物料粉碎后过100 目，取粉碎物料7 ～ 9 克封装，制成中药粉剂。在每天早饭前、晚饭后30 分钟服用。
本发明的实施例2 ：一种用于治疗高血压的中药组合物，按重量份数，取苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克混合，第一次按重量倍数向混合物中加入10 ～ 15 倍的水进行煎煮1 小时，再分别加入8 ～ 12 重量倍的水煎煮两次，每次煎煮35分钟，合并煎煮液并滤过，再将滤液浓缩至稠状，制成中药药剂；煎器要求：选择砂锅或搪瓷锅，忌用铁、铜、铝等金属器具。在每天早饭前、晚饭后30分钟服用。
本发明的实施例3 ：一种用于治疗高血压的中药组合物，取取苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克混合，第一次按重量倍数向混合物中加入10 ～ 15倍的水进行煎煮1 小时，再分别加入8 ～ 12 重量倍的水煎煮两次，每次煎煮35 分钟，合并煎煮液并滤过，再将滤液浓缩至稠状；在80℃下进行减压干燥后进行粉碎，过60 目筛，装入胶囊壳，制得硬胶囊剂。在每天早饭前、晚饭后30分钟服用。
Claims (6)
1.一种用于治疗高血压的中药组合物，其特征在于：按重量份数计算，由苍术8～24克，紫菀6～18克，桅子6～18克，香附6～18克，罗布麻10～30克，甘草6～18克中的一种以上制成。
2.根据权利要求1 所述的一种用于治疗高血压的中药组合物，其特征在于：按重量份数计算，由苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克中的一种以上制成。
3.一种如权利要求1 所述的一种用于治疗高血压的中药组合物的制备方法，其特征在于：按重量份数，取苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克混合，将混合物粉碎，取粉碎物料7 ～ 9 克封装，制成中药粉剂。
4.根据权利要求3 所述的一种用于治疗高血压的中药组合物的制备方法，其特征在于：混合物料粉碎后过100 目筛。
5.一种如权利要求1 所述的一种用于治疗高血压的中药组合物的制备方法，其特征在于：按重量份数，取苍术8克，紫菀6克，桅子6克，香附6克，罗布麻10克，甘草6克混合，第一次按重量倍数向混合物中加入10 ～ 15 倍的水进行煎煮1 小时，再分别加入8 ～ 12 重量倍的水煎煮两次，每次煎煮35 分钟，合并煎煮液并滤过，再将滤液浓缩至稠状，制成中药药剂；煎器要求：选择砂锅或搪瓷锅，忌用铁、铜、铝等金属器具。
6.按照权利要求5 所述的一种用于治疗高血压的中药组合物的制备方法，其特征在于：将滤液浓缩至稠状后，在80℃下进行减压干燥后进行粉碎，过60 目筛，装入胶囊壳，制得硬胶囊剂。
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