CN106471004A - 作为用于免疫疗法的apc活化剂的tc‑ptp抑制剂 - Google Patents

作为用于免疫疗法的apc活化剂的tc‑ptp抑制剂 Download PDF

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Publication number
CN106471004A
CN106471004A CN201580023358.9A CN201580023358A CN106471004A CN 106471004 A CN106471004 A CN 106471004A CN 201580023358 A CN201580023358 A CN 201580023358A CN 106471004 A CN106471004 A CN 106471004A
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infection
optionally substituted
alkyl
cancer
halogen
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米歇尔·L·特朗布莱
克劳迪娅·佩纳福特
马修·菲尔德哈默
乔治·佐格普洛斯
卡梅伦·布莱克
谢尔顿·克兰
伍-林赫·特鲁恩
布莱恩·肯尼迪
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Mcgill University Royal Academy Of Academic Development
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
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CN201580023358.9A 2014-02-28 2015-02-27 作为用于免疫疗法的apc活化剂的tc‑ptp抑制剂 Pending CN106471004A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461945922P 2014-02-28 2014-02-28
US61/945,922 2014-02-28
PCT/CA2015/000131 WO2015127548A1 (en) 2014-02-28 2015-02-27 Tc-ptp inhibitors as apc activators for immunotherapy

Publications (1)

Publication Number Publication Date
CN106471004A true CN106471004A (zh) 2017-03-01

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US (3) US9828399B2 (enExample)
EP (1) EP3110824A4 (enExample)
JP (1) JP2017513812A (enExample)
CN (1) CN106471004A (enExample)
CA (1) CA2977839C (enExample)
WO (1) WO2015127548A1 (enExample)

Cited By (4)

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CN107652277A (zh) * 2017-08-09 2018-02-02 江苏工程职业技术学院 一种依帕列净的制备方法
WO2019149279A1 (zh) * 2018-02-02 2019-08-08 科济生物医药（上海）有限公司 细胞免疫治疗的组合
CN113166130A (zh) * 2018-11-19 2021-07-23 11949098加拿大股份有限公司 视黄酸受体相关（rar）孤儿核受体（ror）的4,5,6,7-四氢-l-苯并噻吩调节剂
CN114269763A (zh) * 2019-03-26 2022-04-01 美国密歇根州立大学试剂中心 Stat3的小分子降解剂

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EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
JP2017524348A (ja) * 2014-06-10 2017-08-31 モナッシュ ユニバーシティ 養子細胞移入のためのｐｔｐｎ２阻害を用いた白血球の産生方法
JP7653759B2 (ja) 2016-01-20 2025-03-31 フェイト セラピューティクス，インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
AU2017210031C1 (en) * 2016-01-20 2020-11-26 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
CA3019835A1 (en) 2016-04-08 2017-10-12 Purdue Research Foundation Methods and compositions for car t cell therapy
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
AU2018219226B2 (en) 2017-02-07 2024-12-19 Seattle Children's Hospital (dba Seattle Children's Research Institute) Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
CN110582288B (zh) 2017-02-28 2024-09-20 恩多塞特公司 用于car t细胞疗法的组合物和方法
JP2020517259A (ja) 2017-04-19 2020-06-18 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 操作された抗原受容体を発現する免疫細胞
WO2019036815A1 (en) * 2017-08-24 2019-02-28 The Royal Institution For The Advancement Of Learning/Mcgill University ENHANCEMENT OF CD8 + T LYMPHOCYTES FOR ADOPTIVE CELL THERAPY BY INHIBITING PTPN1 (PTP1B) AND PTPN2 (TC-PTP))
WO2019144095A1 (en) 2018-01-22 2019-07-25 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of use for car t cells
AU2019218729B2 (en) 2018-02-06 2025-12-04 Seattle Children's Hospital (dba Seattle Children's Research Institute) Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors
WO2019165121A1 (en) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses therof
JP7568224B2 (ja) 2018-02-23 2024-10-16 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞療法のための配列決定法
EP3765094A4 (en) 2018-03-15 2021-12-22 KSQ Therapeutics, Inc. GENE REGULATORY COMPOSITIONS AND PROCEDURES FOR IMPROVED IMMUNOTHERAPY
TWI888352B (zh) 2018-06-21 2025-07-01 美商嘉來克生命科學有限責任公司 蛋白質酪胺酸磷酸酯酶抑制劑及其使用方法
WO2019243537A1 (en) * 2018-06-21 2019-12-26 Universiteit Gent Method for the in vitro differentiation and maturation of dendritic cells for therapeutic use
US20220081691A1 (en) * 2018-08-07 2022-03-17 Dana-Farber Cancer Institute, Inc Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages
KR102983496B1 (ko) 2019-03-14 2026-06-29 칼리코 라이프 사이언시스 엘엘씨 단백질 티로신 포스파타제 억제제 및 이의 사용 방법
WO2020205467A1 (en) 2019-03-29 2020-10-08 The Regents Of The University Of Michigan Stat3 protein degraders
AU2020401376A1 (en) * 2019-12-12 2022-06-30 Kumquat Biosciences Inc. Compositions and methods for potentiating immune activity
IL295063A (en) 2020-02-04 2022-09-01 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Chimeric antigen receptors (car) against dinitrophenol
WO2024243441A1 (en) 2023-05-24 2024-11-28 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107652277A (zh) * 2017-08-09 2018-02-02 江苏工程职业技术学院 一种依帕列净的制备方法
WO2019149279A1 (zh) * 2018-02-02 2019-08-08 科济生物医药（上海）有限公司 细胞免疫治疗的组合
CN110123837A (zh) * 2018-02-02 2019-08-16 科济生物医药（上海）有限公司 细胞免疫治疗的组合
US12178786B2 (en) 2018-02-02 2024-12-31 Crage Medical Co., Limited Combination of cellular immunotherapy
CN113166130A (zh) * 2018-11-19 2021-07-23 11949098加拿大股份有限公司 视黄酸受体相关（rar）孤儿核受体（ror）的4,5,6,7-四氢-l-苯并噻吩调节剂
CN114269763A (zh) * 2019-03-26 2022-04-01 美国密歇根州立大学试剂中心 Stat3的小分子降解剂

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WO2015127548A1 (en) 2015-09-03
CA2977839A1 (en) 2015-09-03
EP3110824A4 (en) 2017-11-29
CA2977839C (en) 2022-07-26
US20180072763A1 (en) 2018-03-15
US10150787B2 (en) 2018-12-11
US20170015690A1 (en) 2017-01-19
JP2017513812A (ja) 2017-06-01
US9828399B2 (en) 2017-11-28
US10005804B2 (en) 2018-06-26
US20180265531A1 (en) 2018-09-20
EP3110824A1 (en) 2017-01-04

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Application publication date: 20170301