CN106459003B - 吡唑酰胺衍生物 - Google Patents

吡唑酰胺衍生物 Download PDF

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Publication number
CN106459003B
CN106459003B CN201580010967.0A CN201580010967A CN106459003B CN 106459003 B CN106459003 B CN 106459003B CN 201580010967 A CN201580010967 A CN 201580010967A CN 106459003 B CN106459003 B CN 106459003B
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Expired - Fee Related
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CN106459003A (zh
Inventor
H.P.贝克
S.K.博克
H.布雷格曼
V.J.塞
N.查克卡
T.D.库欣
O.埃普斯泰恩
B.M.福克斯
S.格恩斯-梅耶
X.昊
日比谷健太
平田润
Z.华
J.胡曼
角田真二
P.洛佩兹
中岛良太
冈田和久
S.H.奥森
大野裕之
L.D.彭宁格顿
佐佐木浩介
岛田启子
Y.欣
R.D.怀特
R.P.沃兹
S.伊
X.M.郑
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Teijin Ltd
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Teijin Pharma Ltd
Amgen Inc
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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CN201580010967.0A 2014-02-28 2015-02-27 吡唑酰胺衍生物 Expired - Fee Related CN106459003B (zh)

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JP2014039880 2014-02-28
JP2014-039880 2014-02-28
PCT/JP2015/056584 WO2015129926A1 (en) 2014-02-28 2015-02-27 Pyrazole amide derivative

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TW201803869A (zh) 2016-04-27 2018-02-01 健生藥品公司 作為RORγT調節劑之6-胺基吡啶-3-基噻唑
AU2017317988B2 (en) 2016-08-31 2020-12-24 Jiangsu Hengrui Medicine Co., Ltd. Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
AR110357A1 (es) * 2016-12-15 2019-03-20 Hoffmann La Roche Proceso para preparar inhibidores de btk
WO2018115984A1 (en) 2016-12-19 2018-06-28 Cellix Bio Private Limited Compositions and methods for the treatment of inflammation
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
GB201714745D0 (en) * 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
US10975057B2 (en) 2018-06-18 2021-04-13 Janssen Pharmaceutica Nv 6-aminopyridin-3-yl pyrazoles as modulators of RORgT
JP2021528405A (ja) 2018-06-18 2021-10-21 ヤンセン ファーマシューティカ エヌ.ベー. RORγtのモジュレータとしてのアミド置換チアゾール
EP3807251B1 (en) 2018-06-18 2022-09-07 Janssen Pharmaceutica NV Phenyl and pyridinyl substituted imidazoles as modulators of roryt
JP2021529161A (ja) * 2018-06-18 2021-10-28 ヤンセン ファーマシューティカ エヌ.ベー. RORγtのモジュレーターとしてのピリジニルピラゾール
CN108752185A (zh) * 2018-07-17 2018-11-06 成都道合尔医药技术有限公司 一种1-氟-环戊甲酸的合成方法
WO2020037109A1 (en) * 2018-08-17 2020-02-20 Dow Agrosciences Llc Processes for fluorination
US20230065740A1 (en) 2018-12-28 2023-03-02 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
GB201901559D0 (en) 2019-02-05 2019-03-27 Syngenta Crop Protection Ag Herbicidal compositions
GB201903832D0 (en) * 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
CN112552158B (zh) * 2020-12-09 2023-05-19 南京工业大学 一种含酮羧酸结构的高吸收铬鞣助剂的制备及应用
CN115108980B (zh) * 2022-06-22 2023-06-16 济南大学 一种2-甲基喹啉类化合物的4号位酰基化衍生物的制备方法
AU2024309903A1 (en) 2023-06-28 2026-01-08 Psylo Pty Ltd Compounds
WO2025116652A1 (ko) * 2023-11-30 2025-06-05 주식회사 지엔티파마 자가면역 질환 치료용 조성물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
KR101760164B1 (ko) 2011-07-04 2017-07-20 로타팜 바이오테크 에스.알.엘 Ep4 수용체 길항제로서 사이클릭 아민 유도체
WO2013018695A1 (ja) * 2011-07-29 2013-02-07 武田薬品工業株式会社 複素環化合物
US9815851B2 (en) * 2011-12-02 2017-11-14 Phenex Pharmaceuticals Ag Pyrrolo carboxamides as modulators of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
JO3215B1 (ar) * 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy

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