CN106458976B - 用于治疗疾病诸如糖尿病的吡咯烷gpr40调节剂 - Google Patents

用于治疗疾病诸如糖尿病的吡咯烷gpr40调节剂 Download PDF

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CN106458976B
CN106458976B CN201580022579.4A CN201580022579A CN106458976B CN 106458976 B CN106458976 B CN 106458976B CN 201580022579 A CN201580022579 A CN 201580022579A CN 106458976 B CN106458976 B CN 106458976B
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alkyl
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substituted
alkoxy
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CN106458976A (zh
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E·A·朱里卡
洪振球
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Bristol Myers Squibb Co
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CN201580022579.4A 2014-05-07 2015-05-06 用于治疗疾病诸如糖尿病的吡咯烷gpr40调节剂 Active CN106458976B (zh)

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US201461989651P 2014-05-07 2014-05-07
US61/989,651 2014-05-07
PCT/US2015/029409 WO2015171722A1 (en) 2014-05-07 2015-05-06 Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes

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CN106458976A CN106458976A (zh) 2017-02-22
CN106458976B true CN106458976B (zh) 2020-05-22

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TR201809633T4 (tr) * 2014-05-07 2018-07-23 Bristol Myers Squibb Co Diyabet gibi hastalıkların tedavisine yönelik pirolidin GPR40 modülatörleri.
EP3509588B1 (en) 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
WO2018049324A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Monocyclic compounds useful as gpr120 modulators
JPWO2018181847A1 (ja) * 2017-03-31 2020-03-05 武田薬品工業株式会社 芳香環化合物
CN110947003B (zh) * 2017-08-21 2021-04-02 武汉大学 Gpr31抑制剂在制备治疗肾脏缺血再灌注损伤及相关疾病药物中的应用
CN111712494A (zh) 2018-02-13 2020-09-25 吉利德科学公司 Pd-1/pd-l1抑制剂
EP4600247A3 (en) 2018-04-19 2025-11-19 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR20230159715A (ko) 2018-07-13 2023-11-21 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
AU2019366355B2 (en) 2018-10-24 2022-10-13 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
JP2024522718A (ja) 2021-06-16 2024-06-21 セルジーン コーポレーション 神経変性疾患の治療のための、カルボン酸基を含むアゼチジニル化合物
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WO2014078609A1 (en) * 2012-11-16 2014-05-22 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators
CN105121426A (zh) * 2012-11-16 2015-12-02 百时美施贵宝公司 吡咯烷gpr40调节剂

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CA2948161C (en) 2020-10-27
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PH12016502034B1 (en) 2022-03-23
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EP3140296B1 (en) 2018-04-11
EA201692037A1 (ru) 2017-06-30
EP3140296A1 (en) 2017-03-15
SMT201800342T1 (it) 2018-09-13
US9873679B2 (en) 2018-01-23
KR20160147049A (ko) 2016-12-21
US20150322044A1 (en) 2015-11-12
BR112016024936A2 (pt) 2017-08-15
MY181959A (en) 2021-01-15
PL3140296T3 (pl) 2018-08-31
SG11201609170UA (en) 2016-12-29
CA2948161A1 (en) 2015-11-12
MA39427B1 (fr) 2018-09-28
PH12016502034A1 (en) 2017-01-09
JP2017514856A (ja) 2017-06-08
MX378160B (es) 2025-03-10
TW201625585A (zh) 2016-07-16
PE20161363A1 (es) 2016-12-17
TWI659951B (zh) 2019-05-21
US20180099949A1 (en) 2018-04-12
HRP20180641T1 (hr) 2018-06-01

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