CN106456780A - 西罗莫司及其衍生物的络合物、其制备方法以及含有其的药物组合物 - Google Patents

西罗莫司及其衍生物的络合物、其制备方法以及含有其的药物组合物 Download PDF

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Publication number
CN106456780A
CN106456780A CN201580019255.5A CN201580019255A CN106456780A CN 106456780 A CN106456780 A CN 106456780A CN 201580019255 A CN201580019255 A CN 201580019255A CN 106456780 A CN106456780 A CN 106456780A
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China
Prior art keywords
complex
sirolimus
pharmaceutically acceptable
complexes
copolymer
Prior art date
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Pending
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CN201580019255.5A
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English (en)
Chinese (zh)
Inventor
E·R·安吉
T·索里莫斯
R·B·卡帕蒂
Z·芬尼维斯
Z·奥特沃斯
L·摩尔纳
H·格拉维纳斯
G·菲利普西
K·费伦兹
G·海尔托维茨
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Tavanta Therapeutics Hungary Inc
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Druggability Technologies IP Holdco Ltd
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Publication of CN106456780A publication Critical patent/CN106456780A/zh
Pending legal-status Critical Current

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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
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  • Physics & Mathematics (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201580019255.5A 2014-02-14 2015-02-13 西罗莫司及其衍生物的络合物、其制备方法以及含有其的药物组合物 Pending CN106456780A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP1400075 2014-02-14
HU1400075A HUP1400075A2 (hu) 2014-02-14 2014-02-14 Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói
PCT/IB2015/051086 WO2015121836A1 (en) 2014-02-14 2015-02-13 Complexes of sirolimus and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
CN106456780A true CN106456780A (zh) 2017-02-22

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CN201580019255.5A Pending CN106456780A (zh) 2014-02-14 2015-02-13 西罗莫司及其衍生物的络合物、其制备方法以及含有其的药物组合物

Country Status (14)

Country Link
US (1) US20170165237A1 (enExample)
EP (1) EP3104844B1 (enExample)
JP (1) JP6445591B2 (enExample)
CN (1) CN106456780A (enExample)
AU (1) AU2015216631B2 (enExample)
CA (1) CA2939602A1 (enExample)
ES (1) ES2784843T3 (enExample)
HK (1) HK1231416A1 (enExample)
HU (2) HUP1400075A2 (enExample)
IL (1) IL247239A0 (enExample)
PL (1) PL3104844T3 (enExample)
RU (1) RU2016136697A (enExample)
UA (1) UA120508C2 (enExample)
WO (1) WO2015121836A1 (enExample)

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HUP1600271A2 (hu) * 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Ivacaftor és Lumacaftor sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadható készítményei
US10376501B2 (en) 2016-04-25 2019-08-13 Druggability Technologies Ip Holdco Limited Complexes of lumacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HUP1600269A2 (hu) * 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Lumacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyászati készítményei
HUP1600270A2 (hu) * 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Ivacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadott készítményei
US10383865B2 (en) 2016-04-25 2019-08-20 Druggability Technologies Ip Holdco Limited Pharmaceutical combination composition comprising complex formulations of Ivacaftor and Lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them
CA3032473A1 (en) * 2016-08-10 2018-02-15 The Board Of Regents Of The University Of Texas System Topical rapamycin therapy
IL302385B2 (en) * 2017-01-06 2024-06-01 Palvella Therapeutics Inc Non-aqueous preparations of mTOR inhibitors and methods of use
JP2021530463A (ja) * 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物および使用方法
MX2021010058A (es) * 2019-02-20 2021-11-12 Ai Therapeutics Inc Formulaciones de rapamicina tópicas y su uso en el tratamiento de angiofibromas faciales y otros trastornos de la piel.
AU2020277132B1 (en) * 2020-11-24 2021-11-04 Aft Pharmaceuticals Limited A Rapamycin Composition

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