CN106420596A - Composition containing corn kernel extract and application of composition containing corn kernel extract - Google Patents
Composition containing corn kernel extract and application of composition containing corn kernel extract Download PDFInfo
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- CN106420596A CN106420596A CN201611081729.1A CN201611081729A CN106420596A CN 106420596 A CN106420596 A CN 106420596A CN 201611081729 A CN201611081729 A CN 201611081729A CN 106420596 A CN106420596 A CN 106420596A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a composition containing corn kernel extract and application of the composition containing the corn kernel extract, belongs to the technical field of cosmetics and aims to provide a composition which is capable of effectively reducing pollutant attachment, improving a natural barrier function and anti-irritation ability of the skin, removing free radicals and enhancing an antioxidant defense system while supplementing moisture and energy to the skin and effectively resisting skin allergy, aging and other problems caused by pollutants outside. The composition is mainly prepared from, by weight, 8-30 parts of corn kernel extract, 5-25 parts of moringa pterygosperma seed extract, 5-15 parts of bonamite extract, 5-10 parts of Chondrus crispus extract and 5-15 parts of Boldo leaf extract. The invention further relates to the application of the composition as an additive of anti-pollution skin care products.
Description
Technical field
The present invention relates to a kind of compositionss, specifically, it is a kind of compositionss containing Semen Maydis core extract, the present invention also relates to
And using said composition as the application of antipollution skin-protection product additive, belong to cosmetic technical field.
Background technology
Increase with economic express delivery with producing, the continuous deterioration of environment, air pollution constantly increases, the pollution of the mankind
Source is constantly increasing, such as the polluter of the physical property such as dust, haze, sandstorm, radiation, PM2.5;As second hand smoking, vehicle exhaust,
The polluter of the chemical such as industrial pollution, waste gas.It is easily caused following skin problem:1. lead to skin allergy:In the air is a large amount of
The floating thing allergy of disperse, causes skin pore blocking and allergic symptom, makes one to feel prurituss, play erythema welt, or even triggering
Urticaria and eczema.Additionally, the polluter of physical property leads to, and the particle of in the air is excessive, printing opacity degree reduces, and makes arrival ground
Neighbouring ultraviolet is weakened.So swim in the various virus of near-earth in the air, antibacterial and funguses become to be not easy by ultraviolet
Kill, poor for body constitution, there is skin allergy, for the people of skin injury, this quasi-microorganism reaches with the dust granules of air
To skin, and adhere to skin surface, easily cause the infection of skin, such as folliculitises, tinea versicolor, herpes simplex etc., there is erythra
People can increase.2. lead to the aging of skin:Pollutants in air, such as haze, vehicle exhaust etc. can make skin produce the pole of excess
Unstable free radical, these free radicals pass through to damage the DNA of cell membrane and human body own health, thus accelerating organism aging process,
Aging including skin, such as dull-looking skin, pigmentation, skin easily relaxes, and microgroove or wrinkle, xerosis cutiss, or even
Lead to skin canceration.
Cosmetics on the market are by film forming component or to add ultraviolet attractant, physical property interleaving agent mostly at present,
The pollution of air-isolation and support anti-ultraviolet injury, effect more single it is impossible to comprehensively resist various polluter, antipollution
Effect not notable.
Content of the invention
For the problems referred to above, the first object of the present invention is to provide a kind of adhesion amount that can effectively reduce environmental contaminants,
Murder by poisoning to preventing from heavy metal, strengthens natural cover for defense function and the irritation ability of skin, removes free radical, strengthen antioxygen chemoprevention
Imperial system, keeps the skin wet to skin and energy simultaneously, effectively resist the skin allergy that environmental contaminants cause, aging the problems such as
Compositionss.
The second object of the present invention is the application providing this compositionss as antipollution skin-protection product additive.
For solving first technical problem, first technical scheme that the present invention provides is such:
A kind of compositionss containing Semen Maydis core extract, are mainly grouped into by the group of following weight portion:Semen Maydis core extract 8-
30 parts, wing seed Moringa seed extract 5-25 part, smithsonite extract 5-15 part, Chondrus crispus extract 5-10 part, Bordeaux
Leaf extract 5-15 part.
Further, above-mentioned a kind of compositionss containing Semen Maydis core extract, also include Withania kansuensis root extract 2-10 part.
Further, above-mentioned a kind of compositionss containing Semen Maydis core extract, also include olea europaea fruit water 5-20 part.
Further, above-mentioned a kind of compositionss containing Semen Maydis core extract, also include hydrolyzing candida mycoderma extract 1-6
Part.
Further, a kind of above-mentioned compositionss containing Semen Maydis core extract, are mainly grouped into by the group of following weight portion:
Semen Maydis core extract 10-25 part, wing seed Moringa seed extract 10-20 part, smithsonite extract 8-12 part, Chondrus crispus extracts
Thing 6-8 part, boldo tree leaf extract 6-10 part, Withania kansuensis root extract 4-8 part, olea europaea fruit water 10-16 part, the false silk ferment of hydrolysis
Female extract 2-5 part.
Further, in a kind of compositionss containing Semen Maydis core extract described above, the system of wherein Semen Maydis core extract
Standby step is as follows:
1) by Semen Maydis core lyophilization, pulverize, obtain Semen Maydis core coarse powder, by solid-liquid ratio 1:The ratio of 3-5 adds water, then plus
Enter cellulase, the addition of cellulase is 10U/g, digests 2-3h;
2) learnt from else's experience step 1) the Semen Maydis core coarse powder that processes, add the 60-80%'s of Semen Maydis core coarse powder 15-30 times of volume of weight
Ethanol water, in 70-80 DEG C of reflux, extract, 1-3 time, extracts 4-8h, united extraction liquid every time, is subsequently placed in centrifuge and carries out
Centrifugation, centrifuge speed be 5000r/min, centrifugation time be 10-20min after obtain supernatant, by supernatant in 40-60 DEG C,
Rotating speed carries out rotary evaporation under the conditions of 40-70r/min, is concentrated into the 1/3-1/4 of stoste volume, obtains concentrated solution;
3) by step 2) concentrated solution that obtains adds water after dispersion, and upper macroporous resin column, successively with the volume of 3-5 times of column volume
Fraction is the ethanol water eluting of 30-40%, and the volume fraction of 4-6 times of column volume is the ethanol water eluting of 50-60%;
Merge eluent, be concentrated into the 1/4-1/6 of original weight amount, concentrated solution is placed in spray dryer and is spray-dried, obtain Semen Maydis core and carry
Take thing.
Last technical scheme that the present invention provides is that this contains the compositionss of Semen Maydis core extract as antipollution skin protection
The application of product additive.
Compared with prior art, the combination that the present invention provides has following technological merit:
1st, the Semen Maydis core extract in the combination that the present invention provides passes through to promote the tired skin that synthesizes of ATP to inject new energy
Amount, also has simultaneously and resists townie invasion and attack to protect skin, have the effect of antipollution, anti peroxidation of lipid, antibacterial;
Wing seed Moringa seed extract, rich in vitamin, the cationic protein (6000-13000 dalton) of low-molecular-weight and calcium, ferrum, potassium
Deng mineral, contain the active component of fabulous flocculating properties in wing seed moringa seeds, its seed water extract can substantially reduce mixed meanwhile
Bacterial content in water turbidity, hardness and mixed water, has lotus-effect, reduces pollutant attachment skin surface, protects cell,
Murder by poisoning to preventing from heavy metal, plays a protective role to skin;Smithsonite extract is rich in zinc, is closed by inducing metal sulfoprotein
Become, play gene protection effect (protection DNA), improve the protective effect that cell is directed to UVB noci-influence, contribute to isolation dirty
Heavy metal in dye, has long-term protective to alleviation ambient pressure with to antipollution;Chondrus crispus extract, by thickening
Water adipose membrane, to strengthen the natural cover for defense of skin, also assists in other active component and preferably enters skin, allow active function to obtain
More preferably, equably play;Further, it is also possible to supplement mineral, it contains all mineral and trace element in skin composition,
As calcium, zinc, phosphorus, magnesium, copper, ferrum, manganese etc., the fat content in ripe skin can be increased, and promote the metabolism of cell anti-ageing
Always;Boldo tree leaf extract, a kind of synthesis of activation skin beta-alexin (Endogenous antimicrobial polypeptide), strengthen the natural anti-of skin
Fungus strain is united, and reduces bacteria breed, purifies skin, suppresses inflammatory factor, erythema of dispelling, careful pore, improves oily skin.
Withania kansuensis root extract, rich in glucoside, can promote under extreme condition dermal cell growth and strengthen the anti-of skin
Imperial function, has the effect recovering skin function, promoting cell regeneration and rebuild barrier function.
Olea europaea fruit water, rich in multiple polyphenol, especially olive polyphenol, has free radical resisting, defying age, antioxidation, increases
Plus the effects such as skin elasticity, injury skin being caused because of pollution, ultraviolet etc. can be reduced, there is skin lightening effect, test proves it
Also antibacterial, antiinflammatory, irritation effect.
Hydrolysis candida mycoderma extract, can strengthen autophagy system, stimulate the formation of autophagosome, and autophagosome is responsible for dissociation
Cell component, and they be delivered in lysosome decompose, can promote the toxin expelling process of cell, reduce oxidized protein and mistake
The content of lipid oxide;Smooth cheek wrinkle, improve the colour of skin of " poisonous " skin.
2nd, the present composition is to be collocated with each other by wing seed Moringa seed extract and smithsonite extract, to reduce
Pollutant are attached to skin surface, and resist the injury to skin for the heavy metal in pollutant;Chondrus crispus extract and Withania kansuensis
Both root extracts are arranged in pairs or groups, and strengthen natural cover for defense function and the defense function of skin, effectively prevent water loss, isolate outer simultaneously
The pollutant on boundary;Semen Maydis core extract, boldo tree leaf extract, olea europaea fruit water, all can strengthen the natural antibacterial system of skin
System, reduces bacteria breed, purifies skin, suppresses inflammatory factor, strengthens the irritation of skin pollutant to external world.Additionally, with
Upper plant extract all can be kept the skin wet for skin and energy with hydrolysis candida mycoderma extract, the group of Multiple components interworking composition
Compound also has efficient free radical resisting and antioxidative effect, helps skin to reduce because pollution, ultraviolet etc. are to skin further
The injury that skin causes.
3rd, the compositionss of the present invention, by above number of ways, effectively reduce the adhesion amount of environmental contaminants, an antagonism huge sum of money
The murder by poisoning belonging to, strengthens natural cover for defense function and the irritation ability of skin, removes free radical, strengthen Antioxidative Defense System,
Keep the skin wet to skin and energy simultaneously, effectively resist the skin allergy that environmental contaminants cause, aging the problems such as, play anti-soil
The effect of dye.
Specific embodiment
With reference to specific embodiment, the claim of the present invention is described in further detail, but do not constitute right
Any restriction of the present invention, the modification of anyone limited number of time being made in the claims in the present invention protection domain etc, still exist
Within the claims of the present invention.
Wing seed Moringa seed extract is purchased from BASF China, and it is biochemical that smithsonite extract is purchased from Shanghai Pu grace
Science and Technology Ltd., Chondrus crispus extract is purchased from Guangzhou hundred Hao Bo company limited, Withania kansuensis root extract, the false silk ferment of hydrolysis
Female extract is purchased from Guangzhou Bi Sheng trade Co., Ltd, and olea europaea fruit water is purchased from Guangzhou Te Nusi Chemical Co., Ltd., bohr
Many leaf extracts are purchased from Guangzhou Xian Ting trade Co., Ltd.
Embodiment 1
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract 8g,
Wing seed Moringa seed extract 25g, smithsonite extract 5g, Chondrus crispus extract 10g, boldo tree leaf extract 5g.
Embodiment 2
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
30g, wing seed Moringa seed extract 5g, smithsonite extract 15g, Chondrus crispus extract 5g, boldo tree leaf extract
15g.
Embodiment 3
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
20g, wing seed Moringa seed extract 15g, smithsonite extract 10g, Chondrus crispus extract 8g, boldo tree leaf extract
10g.
Embodiment 4
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
10g, the wing seed Moringa seed extract 20g, smithsonite extract 8g, Chondrus crispus extract 9g, boldo tree leaf extract 8g,
Withania kansuensis root extract 6g.
Embodiment 5
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
25g, wing seed Moringa seed extract 10g, smithsonite extract 13g, Chondrus crispus extract 6g, boldo tree leaf extract
12g, olea europaea fruit water 12g.
Embodiment 6
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
12g, the wing seed Moringa seed extract 18g, smithsonite extract 6g, Chondrus crispus extract 8g, boldo tree leaf extract 6g,
Hydrolysis candida mycoderma extract 3g.
Embodiment 7
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
28g, wing seed Moringa seed extract 7g, smithsonite extract 14g, Chondrus crispus extract 7g, boldo tree leaf extract
13g, Withania kansuensis root extract 10g, olea europaea fruit water 5g.
Embodiment 8
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
15g, the wing seed Moringa seed extract 22g, smithsonite extract 9g, Chondrus crispus extract 9g, boldo tree leaf extract 7g,
Withania kansuensis root extract 2g, hydrolyzes candida mycoderma extract 6g.
Embodiment 9
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
20g, wing seed Moringa seed extract 15g, smithsonite extract 10g, Chondrus crispus extract 8g, boldo tree leaf extract
10g, olea europaea fruit water 20g, hydrolyze candida mycoderma extract 1g.
Embodiment 10
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
25g, wing seed Moringa seed extract 10g, smithsonite extract 12g, Chondrus crispus extract 6g, boldo tree leaf extract
10g, Withania kansuensis root extract 4g, olea europaea fruit water 16g, hydrolyze candida mycoderma extract 2g.
Embodiment 11
A kind of compositionss containing Semen Maydis core extract that the present invention provides, are grouped into by following groups:Semen Maydis core extract
10g, the wing seed Moringa seed extract 20g, smithsonite extract 8g, Chondrus crispus extract 8g, boldo tree leaf extract 6g,
Withania kansuensis root extract 8g, olea europaea fruit water 10g, hydrolyze candida mycoderma extract 5g.
The compositionss containing Semen Maydis core extract in embodiment 1 to 11, the preparation method of described Semen Maydis core extract is as follows:
1) by Semen Maydis core lyophilization, pulverize, obtain Semen Maydis core coarse powder, by solid-liquid ratio 1:3-5 (preferably 1:4) ratio adds
Enter water, add cellulase, the addition of cellulase is 10U/g, enzymolysis 2-3h (preferably 2.5h);
2) learnt from else's experience step 1) the Semen Maydis core coarse powder that processes, add Semen Maydis core coarse powder 15-30 times of (preferably 20 times) volume of weight
60-80% (preferably 70%) ethanol water in 70-80 DEG C of (preferably 75 DEG C) reflux, extract, 1-3 time (preferably 2 times), every time
Extract 4-8h (preferably 6h), united extraction liquid, be subsequently placed in centrifuge and be centrifuged, centrifuge speed is 5000r/min, from
The heart time be 10-20min (preferably 15min) after obtain supernatant, by supernatant in 40-60 DEG C (preferably 50 DEG C), rotating speed be 40-
Carry out rotary evaporation under the conditions of 70r/min (preferably 50r/min), be concentrated into the 1/3-1/4 (preferably 1/3) of stoste volume, obtain
Concentrated solution;
3) by step 2) concentrated solution that obtains adds water after dispersion, and upper macroporous resin column, successively with 3-5 times of (preferably 4 times) post
The volume fraction of volume is the ethanol water eluting of 30-40% (preferably 35%), the volume of 4-6 times of (preferably 5 times) column volume
Fraction is the ethanol water eluting of 50-60% (preferably 60%);Merge eluent, be concentrated into the 1/4-1/6 of original weight amount (preferably
1/5), concentrated solution is placed in spray dryer and is spray-dried, obtain Semen Maydis core extract.
The preparation method of above-mentioned composition is to weigh each component according to any one mass number in embodiment 1 to 11, first
After Semen Maydis core extract is dissolved with appropriate amount of deionized water, then mix homogeneously with other compositions.
When specifically used, a kind of compositionss appropriate amount of deionized water containing Semen Maydis core extract prepared by the present invention dissolves
After stirring, it is added directly in skin care item substrate, stirs, addition is the 0.5-10wt% of skin care item gross mass.
A kind of shield containing Semen Maydis core extract of present invention offer, in order to better illustrate advantages of the present invention, is provided
The efficacy test of skin compositionss:
First, with regard to the comparative example of efficacy test
Comparative example 1
Wherein Semen Maydis core extract is the product bought, and remaining is same as in Example 10.
Comparative example 2
Compositionss contain only boldo tree leaf extract 6g, olea europaea fruit water 16g, hydrolyze candida mycoderma extract 2g.
Comparative example 3
Contain only cream substrate.
Comparative example 4
The a certain commercially available antipollution frost bought.
2nd, adsorbing powder dust test
1st, laboratory sample:The compositionss of Example 3-10 preparation, are added in cream substrate, addition is 5%;
2nd, method of testing:Select 45 road association duty personnel, be divided into 9 groups, both hands are cleaned dry by every group of 5 people with handwashing liquid
Only, dried with napkin.Each group of people person all smears the cream substrate of comparative example 3 on about 2 square centimeters of area in left forearm
0.2g, right forearm smear respectively on about 2 square centimeters of area add 5% embodiment 3-10, comparative example 4 commercially available anti-
The white 0.2g of pollution.Allow they on road side 4 hour 3M adhesive tapes on duty will the dust on forearm glue under, weigh, be averaged
Value.Result of the test is shown in Table 1.
Table 1 adsorbing powder dust result of the test
Above-mentioned test data shows, smear the cream adding embodiment of the present invention compositionss in right forearm after, right forearm powder
Dust quantity reduction reaches more than 55% hence it is evident that higher than the cream substrate of comparative example 3 and the Dust Capacity slip of commercially available antipollution frost, saying
The compositionss of the bright present invention can significantly reduce absorption on skin for the dust.
3rd, barrier function test
Normal skin has very strong barrier function, and extraneous harmful substance can be stoped to enter skin.When barrier function damage,
Just there is formation path, moisture scatters and disappears from path between horn cell.Therefore, the moisture percutaneous loss when skin barrier less effective
Increase, otherwise reduce.Protective layer of skin is better, and water content is higher, and the numerical value of skin moisture loss TEWL is lower.This survey
Percutaneous moisture loss (TEWL) on probation evaluates the power of skin barrier function, thus evaluating the antipollution work(of the present composition
Effect.
Laboratory sample:Example 3-10 and the compositionss of comparative example 1-2 preparation, are added in cream substrate, add
Amount is 5%;And the cream substrate of comparative example 3 and the commercially available antipollution cream of comparative example 4.
Test method:Select face skin that 96 female subjects of hydropenia are more dried, age 20-45 year, be divided into 11
Group, every group of 8 people, detect first three sky, face, not using any cosmetics, measures the 1st day not using the facial TEWL value before product
(during detection, with the TEWL probe of CK MPA580, detection is subject to examine skin, tests 5 times, reads meansigma methodss on computers).Every group is subject to
Examination person will take equivalent cream to be applied on skin of face respectively, and wherein left face smears the cream substrate of comparative example 3, and right face smears remaining
Above-mentioned laboratory sample, sooner or later once, continuously uses 28 days, disables within the 29th, 30 days product, the 31st day measurement TEWL.The results are shown in Table
2.
Table 2 barrier function test result
Above-mentioned test data shows, after the cream using interpolation embodiment of the present invention compositionss, its skin moisture runs off
TEWL value is less than cream substrate and the comparative example 4 commercially available antipollution frost of comparative example 3, illustrates that the compositionss of the present invention have enhancing
The effect of skin barrier function.
After cream using the interpolation embodiment of the present invention 10 compositionss, its TEWL value is less than adds embodiment 3 and comparative example 2
The cream of compositionss, illustrates to extract in Semen Maydis core extract, wing seed Moringa seed extract, smithsonite extract, Chondrus crispus
On the basis of thing, boldo tree leaf extract are worked in coordination with, with Withania kansuensis root extract, olea europaea fruit water and hydrolysis candida mycoderma extract
Collaborative, skin barrier function can be effectively increased, reduce scattering and disappearing of moisture of skin.
After cream using comparative example 1, TEWL value is also relatively higher than the cream using the preparation of embodiment 10 compositionss, explanation
The Semen Maydis core extract of preparation in this compositions, can effectively supplement skin moisture, reduce moisture loss, preferably increase skin
Barrier function.
4th, remove free radical effect assessment
1st, the preparation of sample
After compositionss elder generation mix homogeneously prepared by the compositionss of embodiment 3-10 preparation and comparative example 2, take mixed in equal amounts
Thing is made into the sample solution that mass fraction is 1% again, carries out testing below.
2nd, ultra-oxygen anion free radical Scavenging activity is evaluated
Take the Tris-HCl buffer 4.5mL of 0.05mol/L pH=8.2, preheat 20min in 25 DEG C of water-baths.Again plus
Enter the pyrogallol solution of 1mL sample and 0.4mL 25mmol/L, after mixing, in 25 DEG C of water-baths, react 5min, add 8mol/
The HCl 1.0mL terminating reaction of L.Reference is made with Tris-HCl buffer, surveys absorbance at 299nm.Blank 1mL
The solvent of sample is substituting sample.Calculate clearance rate (D) according to formula (2).
Ultra-oxygen anion free radical clearance rate (%)=[1- (A2/A1)] × 100% (2)
In formula, A1 is the absorbance of blank;A2 is the absorbance of medicine.
3rd, the Scavenging activity evaluation to hydroxy radical
2mmol/L FeSO is sequentially added in 25mL color comparison tube43mL, 1mmol/L H2O23mL, shakes up, and is subsequently added into
6mmol/L salicylic acid 3mL, shakes up, and takes out, survey its absorbance after 37 DEG C of heating in water bath 15min;It is separately added into certain density
Prepare liquid, shakes up, and continues heating in water bath 15min, takes out and surveys its absorbance.Following formula is that prepare liquid is clear to hydroxy radical (OH)
Except rate:
Scavenging action to hydroxyl free radical (%)=[A1-A2- (A1-A3)]/A1 × 100% (3)
In formula, A1 is the absorbance of reaction system before non-dosing product;A2 removes the absorbance of system after OH for medicine
Value;A3 removes the absorbance of system after OH for blank.
4th, experimental result
Table 3
Laboratory sample | Ultra-oxygen anion free radical clearance rate/% | Scavenging action to hydroxyl free radical/% |
Embodiment 3 | 72.3 | 70.9 |
Embodiment 4 | 76.2 | 74.8 |
Embodiment 5 | 78.9 | 76.3 |
Embodiment 6 | 80.2 | 78.2 |
Embodiment 7 | 83.9 | 80.6 |
Embodiment 8 | 84.8 | 81.6 |
Embodiment 9 | 86.2 | 83.5 |
Embodiment 10 | 90.6 | 88.9 |
Comparative example 2 | 60.5 | 56.8 |
Above-mentioned test data shows, the potent removing free radical of compositionss energy of the present invention, and than comparative example 2 compositionss
Remove free radical effect good, illustrate in Semen Maydis core extract, wing seed Moringa seed extract, smithsonite extract, Chondrus crispus
Extract, boldo tree leaf extract work in coordination with the basis of, then with Withania kansuensis root extract, olea europaea fruit water and hydrolysis candida mycoderma
After extract compounds, serve the effect of Synergistic, improve the left and right of composition removing free radical, increase oxidation resistance.
5th, to propionibacterium acness rejection ability
1st, the preparation of sample
After the compositionss elder generation mix homogeneously of embodiment 1-11 preparation, take equal amount of mixture to be made into sample aqueous solution, carry out
Test below.
2nd, experimental technique
Respectively take sample aqueous solution 1mL to be added separately in sterile glass test tube, topple over 8mL previously prepared improvement GAM respectively
Broth bouillon.Take out divided pure and in 35 DEG C of constant temperature CO2Incubator cultivates the clinical propionibacterium acness of 48h, takes 1mL respectively
Bacteria suspension injection, plus in the human body culture medium test tube of solution of extract, does feminine gender with a teat glass not containing bacteria suspension
Comparison.Every kind of extract culture medium, all from the beginning of low concentration, is inoculated propionibacterium acness successively, is placed in 35 DEG C of perseverances after inoculation as early as possible
Warm CO2Incubator cultivates 48h.After culture, the liquid first extracting in human body culture medium carries out preliminary identification experiment, observes acne third
The Survival of acidfast bacilli.
3rd, experimental result:
Result shows, adds in the culture medium of embodiment of the present invention 1-11 compositionss, all loses and has propionibacterium acness to give birth to
Long, illustrate that the present composition has obvious inhibition to propionibacterium acness.
6th, stimulus object toleration is tested
Skin is stimulated by xenobiotic pollutants, often can cause redness, prurituss, rise erythema welt situations such as, in the course of time
Cutaneous autoimmune function can be reduced and form sensitivity skin, seriously damage skin health, so repairing impaired and strengthening skin
Immunity is to resist external source pollution mode the most basic, tests antipollution effect of compositionss by skin irritation efficacy assessment.
Experimental technique:Using 3%SLS solution and 5% fruit acid as stimulus, stimulate left and right forearm flexor skin respectively
Until red and swollen, then smear the cream of the compositionss containing 5% embodiment of the present invention 1 in left front arm region, apply in right forearm region
Smear the cream of the compositionss containing 5% embodiment of the present invention 10, test after 2 days is observed red swelling of the skin and disappeared degree.
Test result:3%SLS stimulates left front arm region 1, and skin is substantially red and swollen, smears containing 1 group of 5% embodiment of the present invention
After 2 days, the redness of left front arm region 1 substantially disappears the cream of compound;After 5% fruit acid stimulates right forearm region 2, skin is bright
Aobvious redness, after the cream smeared containing 5% embodiment of the present invention 10 compositionss 2 days, the swollen of right forearm region 2 also substantially disappears.
Illustrate that the compositionss of the present invention have obvious irritation anti-redness effect.
In sum, the present invention passes through Semen Maydis core extract, wing seed Moringa seed extract, smithsonite extract, ripple angle
Fork dish extract, Withania kansuensis root extract, boldo tree leaf extract, hydrolysis candida mycoderma extract and the multiple sky of olea europaea fruit water
So active matter synergism, effectively reduces the attachment of pollutant;Strengthen the natural cover for defense function of skin;Antibacterial anti-inflammatory, increases flesh
The irritation of skin pollutant to external world;Remove free radical, strengthen Antioxidative Defense System, effectively resist environmental contaminants and cause
Skin allergy, aging the problems such as, play resistant to pollution effect.
Claims (7)
1. a kind of compositionss containing Semen Maydis core extract are it is characterised in that mainly include following components in parts by weight:Semen Maydis core carries
Take thing 8-30 part, wing seed Moringa seed extract 5-25 part, smithsonite extract 5-15 part, Chondrus crispus extract 5-10 part,
Boldo tree leaf extract 5-15 part.
2. a kind of compositionss containing Semen Maydis core extract according to claim 1 carry it is characterised in that also including Withania kansuensis root
Take thing 2-10 part.
3. a kind of compositionss containing Semen Maydis core extract according to claim 1 are it is characterised in that also include olea europaea fruit
Water 5-20 part.
4. a kind of compositionss containing Semen Maydis core extract according to claim 1 are it is characterised in that also include hydrolyzing false silk
Yeast extract 1-6 part.
5. a kind of compositionss containing Semen Maydis core extract according to claim 1 it is characterised in that described compositionss by
Following components in parts by weight is constituted:Semen Maydis core extract 10-25 part, wing seed Moringa seed extract 10-20 part, smithsonite extract
8-12 part, Chondrus crispus extract 6-8 part, boldo tree leaf extract 6-10 part, Withania kansuensis root extract 4-8 part, Fructus oleae europaeae
Fruit water 10-16 part, hydrolyzes candida mycoderma extract 2-5 part.
6. a kind of compositionss containing Semen Maydis core extract according to claim 1 are it is characterised in that described Semen Maydis core extracts
Thing by following step be obtained:
1) by Semen Maydis core lyophilization, pulverize, obtain Semen Maydis core coarse powder, by solid-liquid ratio 1:The ratio of 3-5 adds water, adds fibre
The plain enzyme of dimension, the addition of cellulase is 10U/g, digests 2-3h;
2) learnt from else's experience step 1) the Semen Maydis core coarse powder that processes, add the ethanol of the 60-80% of Semen Maydis core coarse powder 15-30 times of volume of weight
Aqueous solution, in 70-80 DEG C of reflux, extract, 1-3 time, extracts 4-8h, united extraction liquid every time, be subsequently placed in centrifuge carry out from
The heart, centrifuge speed be 5000r/min, centrifugation time be 10-20min after obtain supernatant, by supernatant in 40-60 DEG C, turn
Speed carries out rotary evaporation under the conditions of 40-70r/min, is concentrated into the 1/3-1/4 of stoste volume, obtains concentrated solution;
3) by step 2) concentrated solution that obtains adds water after dispersion, and upper macroporous resin column, successively with the volume fraction of 3-5 times of column volume
Ethanol water eluting for 30-40%, the volume fraction of 4-6 times of column volume is the ethanol water eluting of 50-60%;Merge
Eluent, is concentrated into the 1/4-1/6 of original weight amount, concentrated solution is placed in spray dryer and is spray-dried, obtain Semen Maydis core extract.
7. the answering as antipollution skin-protection product additive of a kind of compositionss containing Semen Maydis core extract described in claim 1
With.
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107550815A (en) * | 2017-09-18 | 2018-01-09 | 上海家化联合股份有限公司 | A kind of maize seed extract and its application in skin preparations for extenal use |
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CN108888575A (en) * | 2018-08-09 | 2018-11-27 | 福建樱幼佳科技有限公司 | A kind of baby skin protection product and preparation method thereof |
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CN109276513A (en) * | 2018-10-12 | 2019-01-29 | 诺斯贝尔化妆品股份有限公司 | A kind of composite plant oil-control bilayer surfactant at Han You le bamboo powder end |
CN114867464A (en) * | 2019-08-06 | 2022-08-05 | 大自然化妆品股份有限公司 | Topical cosmetic composition, said composition and use for the facial administration of a tonic |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120164121A1 (en) * | 2009-09-04 | 2012-06-28 | Societe Industrielle Limousine D'application Biologique, Dite Silab | Active ingredient that is obtained from candida saitoana and cosmetic use for detoxifying skin cells |
CN103976906A (en) * | 2014-05-29 | 2014-08-13 | 上海清轩生物科技有限公司 | Plant extract mixture having moisturizing and inflammation-diminishing effects |
CN104490715A (en) * | 2015-01-08 | 2015-04-08 | 上海圣婕化妆品有限公司 | Anti-allergy stress relief face mask essence containing saccharide isomerate and preparation method thereof |
CN105055261A (en) * | 2015-09-15 | 2015-11-18 | 广州智媛生物科技有限公司 | Anti-pollution skincare product and preparation method thereof |
-
2016
- 2016-11-30 CN CN201611081729.1A patent/CN106420596B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120164121A1 (en) * | 2009-09-04 | 2012-06-28 | Societe Industrielle Limousine D'application Biologique, Dite Silab | Active ingredient that is obtained from candida saitoana and cosmetic use for detoxifying skin cells |
CN103976906A (en) * | 2014-05-29 | 2014-08-13 | 上海清轩生物科技有限公司 | Plant extract mixture having moisturizing and inflammation-diminishing effects |
CN104490715A (en) * | 2015-01-08 | 2015-04-08 | 上海圣婕化妆品有限公司 | Anti-allergy stress relief face mask essence containing saccharide isomerate and preparation method thereof |
CN105055261A (en) * | 2015-09-15 | 2015-11-18 | 广州智媛生物科技有限公司 | Anti-pollution skincare product and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
温辉梁: "《生物化工产品生产技术》", 31 December 2004, 江西科学技术出版社 * |
王建新主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
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CN108888575A (en) * | 2018-08-09 | 2018-11-27 | 福建樱幼佳科技有限公司 | A kind of baby skin protection product and preparation method thereof |
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