CN106349201B - 光学纯的苄基-4-氯苯基的c-糖苷衍生物 - Google Patents
光学纯的苄基-4-氯苯基的c-糖苷衍生物 Download PDFInfo
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- CN106349201B CN106349201B CN201610635305.9A CN201610635305A CN106349201B CN 106349201 B CN106349201 B CN 106349201B CN 201610635305 A CN201610635305 A CN 201610635305A CN 106349201 B CN106349201 B CN 106349201B
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
- 239000000460 chlorine Chemical group 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 4
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 13
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- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
- 229960001254 vildagliptin Drugs 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| CN201610635305.9A CN106349201B (zh) | 2014-01-03 | 2014-01-03 | 光学纯的苄基-4-氯苯基的c-糖苷衍生物 |
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| CN201410004395.2A CN104761522B (zh) | 2014-01-03 | 2014-01-03 | 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物 |
| CN201610635305.9A CN106349201B (zh) | 2014-01-03 | 2014-01-03 | 光学纯的苄基-4-氯苯基的c-糖苷衍生物 |
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| CN106349201B true CN106349201B (zh) | 2018-09-18 |
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| CN201410004395.2A Active CN104761522B (zh) | 2014-01-03 | 2014-01-03 | 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105153137A (zh) * | 2015-09-17 | 2015-12-16 | 上海应用技术学院 | 一种艾格列净的制备方法 |
| CA3010323C (en) * | 2016-01-04 | 2021-08-10 | Je Il Pharmaceutical Co., Ltd. | C-glycoside derivatives having fused phenyl ring or pharmaceutically acceptable salts thereof, method for preparing the same and pharmaceutical composition comprising the same |
| WO2017206827A1 (zh) * | 2016-05-28 | 2017-12-07 | 山东轩竹医药科技有限公司 | 钠-葡萄糖协同转运蛋白2抑制剂的晶型 |
| CN108285439B (zh) * | 2017-01-09 | 2023-05-02 | 江苏天士力帝益药业有限公司 | 一种碳糖苷类钠葡萄糖转运蛋白体2抑制剂 |
| WO2019185026A1 (zh) * | 2018-03-30 | 2019-10-03 | 南京明德新药研发有限公司 | 作为SGLTs抑制剂的葡糖苷类衍生物及其应用 |
| CN110551088B (zh) * | 2018-06-01 | 2022-10-21 | 北京惠之衡生物科技有限公司 | 氘修饰的苄基-4-氯苯基的c-糖苷衍生物 |
| CN112047915B (zh) * | 2019-06-05 | 2023-02-17 | 北京惠之衡生物科技有限公司 | C-糖苷类衍生物新的制备工艺 |
| CN110683998A (zh) * | 2019-11-20 | 2020-01-14 | 杭州华东医药集团浙江华义制药有限公司 | 一种恩格列净中间体的制备方法 |
| CN113248464B (zh) * | 2021-05-31 | 2021-10-26 | 北京惠之衡生物科技有限公司 | 一种c-糖苷类衍生物的合成方法 |
| CN113336733B (zh) * | 2021-05-31 | 2022-02-18 | 北京惠之衡生物科技有限公司 | 一种sglt-2抑制剂的l-脯氨酸共结晶体的制备方法 |
| CN113045525B (zh) * | 2021-05-31 | 2021-09-17 | 北京惠之衡生物科技有限公司 | 一种c-糖苷类衍生物的制备方法及其制剂 |
| CN113248554A (zh) * | 2021-06-25 | 2021-08-13 | 北京惠之衡生物科技有限公司 | 一种c-糖苷类衍生物的杂质的合成方法 |
| CN113372315B (zh) * | 2021-08-12 | 2021-10-29 | 北京惠之衡生物科技有限公司 | 一种c-糖苷类衍生物的杂质的合成方法 |
| CN115073271A (zh) * | 2022-06-08 | 2022-09-20 | 苏州敬业医药化工有限公司 | 一种4’-(5-溴-2-氯苄基)苯酚的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1653075A (zh) * | 2002-05-20 | 2005-08-10 | 百时美施贵宝公司 | C－芳基葡糖苷sglt2抑制剂和方法 |
| CN103030617A (zh) * | 2004-03-16 | 2013-04-10 | 贝林格尔.英格海姆国际有限公司 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
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| CN101260130A (zh) * | 2003-01-03 | 2008-09-10 | 布里斯托尔-迈尔斯斯奎布公司 | 制备c-芳基葡糖苷sglt2抑制剂的方法 |
| US7772191B2 (en) * | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| AU2011228237B2 (en) * | 2010-03-18 | 2016-04-21 | Daiichi Sankyo Company,Limited | Cycloalkyl-substituted imidazole derivative |
| WO2012025857A1 (en) * | 2010-08-23 | 2012-03-01 | Hetero Research Foundation | Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors |
| WO2013000275A1 (zh) * | 2011-06-25 | 2013-01-03 | 山东轩竹医药科技有限公司 | C-糖苷衍生物 |
-
2014
- 2014-01-03 CN CN201610635305.9A patent/CN106349201B/zh active Active
- 2014-01-03 CN CN201410004395.2A patent/CN104761522B/zh active Active
- 2014-03-06 JP JP2014043695A patent/JP6008892B2/ja active Active
- 2014-03-31 KR KR1020140037632A patent/KR101837488B1/ko active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1653075A (zh) * | 2002-05-20 | 2005-08-10 | 百时美施贵宝公司 | C－芳基葡糖苷sglt2抑制剂和方法 |
| CN103030617A (zh) * | 2004-03-16 | 2013-04-10 | 贝林格尔.英格海姆国际有限公司 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104761522B (zh) | 2017-02-15 |
| HK1207626A1 (zh) | 2016-02-05 |
| CN106349201A (zh) | 2017-01-25 |
| KR101837488B1 (ko) | 2018-03-12 |
| KR20150081220A (ko) | 2015-07-13 |
| CN104761522A (zh) | 2015-07-08 |
| JP6008892B2 (ja) | 2016-10-19 |
| JP2015129106A (ja) | 2015-07-16 |
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