CN106309912A - Drug for treating oral ulcers and preparation method of drug - Google Patents

Drug for treating oral ulcers and preparation method of drug Download PDF

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Publication number
CN106309912A
CN106309912A CN201610764675.2A CN201610764675A CN106309912A CN 106309912 A CN106309912 A CN 106309912A CN 201610764675 A CN201610764675 A CN 201610764675A CN 106309912 A CN106309912 A CN 106309912A
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gram
radix
grams
dried
drug
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董中芳
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a drug for treating oral ulcers and a preparation method of the drug. The drug is mainly prepared from prepared rehmannia roots, white peony roots, Chinese angelica, common anemarrhena rhizomes, tree peony bark, solomonseal rhizomes, chuanxiong rhizomes and amur corktree bark in a certain weight ratio. The drug has functions of nourishing yin, enriching blood, nourishing blood and the liver, decreasing internal heat, promoting qi circulation and alleviating mental depression; besides, the drug takes effect quickly, is good in curative effect and prevents relapse when used for treating the oral ulcers.

Description

A kind of medicine treating oral ulcer and preparation method thereof
Technical field
The present invention relates to a kind of medicine treating oral ulcer and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Oral ulcer is a kind of common ulcerative damages disease betiding oral mucosa, be more common in inside lip, tongue, The positions such as tongue abdomen, cheek mucosa, vestibule ditch, soft palate, the mucosa at these positions lacks keratinization layer or keratinization is poor.The traditional Chinese medical science is then thought Oral ulcer and retention of heat in the spleen and stomach, hyperactivity of heart-fire, hyperactivity of fire caused by deficiency of YIN, stagnation of QI due to depression of the liver is relevant.Owing to western medicine side effect is big, because of this person Be there is great demand in the Chinese medicine of effectively treatment oral ulcer, up to now, the most do not find about the present invention's Relevant report.
Summary of the invention
The research of the present inventor's foundation theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found and effectively treat oral cavity The medicine of ulcer, thus complete the present invention.
It is an object of the invention to provide the Chinese medicine composition of a kind of effective treatment oral ulcer.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention is to select Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Polygonati, Rhizoma Chuanxiong, Cortex Phellodendri, Radix Glycyrrhizae to carry out Combination preparation, these drug regimens make each efficacy of drugs produce synergism such that it is able to effectively treat oral ulcer. Wherein Radix Rehmanniae Preparata is selected to be because its nature and flavor sweet, tepor, enter liver, kidney channel, have YIN nourishing, the function enriched blood, control deficiency of YIN insufficiency of blood, waist knee joint Flaccidity is weak, chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, and menoxenia is quenched one's thirst, frequency of micturition, deaf, blurred vision.The Radix Paeoniae Alba is selected to be because its nature and flavor bitter Acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, the function of yin fluid astringing receipts antiperspirant, control the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, from Antiperspirant night sweat, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, Having benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea is suffered from abdominal pain, and abdominal mass knot is poly-, metrorrhagia, blood deficiency head Bitterly, dizziness, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.The Rhizoma Anemarrhenae is selected to be because its nature and flavor bitter, Cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, defecates dry Knot, dysuria.Select Cortex Moutan to be because its nature and flavor to work hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, repercussive Function, control the pathogenic heat attacking blood system in febrile diseases, send out speckle, frightened, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea, abdominal mass, carbuncle and ulcer, flutter damage.Select Rhizoma Polygonati It is because its nature and flavor sweet flat, enters spleen, lung, kidney channel, have invigorating the spleen and replenishing QI, moisten cardiopulmonary, the function of bone and muscle strengthening, control deficient cold and heat, pulmonary tuberculosis Hemoptysis, after being ill body void lack of appetite, muscles and bones is weak, rheumatalgia, wind favus disease.Selecting Rhizoma Chuanxiong, to be because its nature and flavor pungent, temperature, enter liver, Gallbladder meridian, has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, controls air-cooled headache rotation dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, warp Close, difficult labour, postpartum stagnation block pain, ulcer sores.Cortex Phellodendri is selected to be because its nature and flavor bitter, cold, enter lung, stomach, kidney channel, have YIN nourishing to drop Fire, moisturizes the function of laxation, controls dysphoria with smothery sensation and quenches one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Radix Glycyrrhizae be because of Sweet flat for its nature and flavor, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, Lack of appetite, loose stool of suffering from abdominal pain, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, Solve poison of drug and alimentary toxicosis.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component is following heavy All there is in weight range preferable curative effect:
Radix Rehmanniae Preparata 15-25 gram, Radix Paeoniae Alba 10-20 gram, Radix Angelicae Sinensis 10-20 gram, Rhizoma Anemarrhenae 10-20 gram, Cortex Moutan 10-20 gram, Rhizoma Polygonati 5-15 Gram, Rhizoma Chuanxiong 4-8 gram, Cortex Phellodendri 4-8 gram, 3-5 gram of Radix Glycyrrhizae.
Preferable amount is:
Radix Rehmanniae Preparata 20 grams, the Radix Paeoniae Alba 15 grams, Radix Angelicae Sinensis 15 grams, the Rhizoma Anemarrhenae 15 grams, Cortex Moutan 15 grams, Rhizoma Polygonati 10 grams, Rhizoma Chuanxiong 6 grams, Cortex Phellodendri 6 Gram, 3 grams of Radix Glycyrrhizae.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Rehmanniae Preparata: take crude drug, steams to surface corvinus, takes out, when solarization to eighty per cant is dry, and section, it is dried；
2, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, and solarization is dried in the air, and profit to inside and outside humidity is uniform, cuts Sheet, is dried；
3, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, slightly dries in the air, and section is dried；
4, the Rhizoma Anemarrhenae: pick clean impurity, hits with water and washes, pull out, soften, and section is dried；
5, Cortex Moutan: pick decontamination, removes core, cleans, runs through, and section is dried；
6, Rhizoma Polygonati: clean earth, slightly moisten, section, dry；
7, Rhizoma Chuanxiong: pick decontamination, is soaked in water by the most large and small, and solarization is dried in the air, and cuts into slices after moistening, is dried；
8, Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, section or shredding, dries；
9, Radix Glycyrrhizae: pick decontamination, cleans, be soaked in water to eighty per cant thoroughly time, pull out, run through, section, dry.
Two, preparation
1, the Radix Rehmanniae Preparata cooked, the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Polygonati, Rhizoma Chuanxiong, Cortex Phellodendri, Radix Glycyrrhizae are put into decocting container In, add water 6 times amount for the first time, and after soaking 100 minutes, intense fire decocts boiling, then with slow fire boiling 20 minutes, filters for the first time Decoction liquor, pours into first time decoction liquor in container；
2, the medicinal residues of filtration being added 4 times amount, intense fire boils, then with slow fire boiling 20 minutes, filters to obtain second time decoction liquor；
3, by twice decoction liquor mixing and stirring, it is divided into 2 doses to take.
In prescription, Radix Rehmanniae Preparata has YIN nourishing, and the function enriched blood is monarch drug；Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing receives antiperspirant；Yellow Cypress has nourishing YIN to lower pathogenic fire, moisturizes the function of laxation, and the two is ministerial drug, and three taste medicines play nourishing YIN and supplementing blood, nourishing blood to suppress the hyperactive liver jointly, and YIN nourishing drops Fire, moisturizes the effect of laxation, and treatment oral ulcer effect is comprehensive, and with nourishing YIN and supplementing blood, nourishing blood to suppress the hyperactive liver, nourishing YIN to lower pathogenic fire is that master can control This, Rhizoma Chuanxiong has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is adjuvant drug, and Radix Glycyrrhizae has and middle emergency, lung moistening, removing toxic substances, is in harmonious proportion The function of all medicines is for making medicine, and medicine all with remainder is to take stopgap measures.
Medicine of the present invention has nourishing YIN and supplementing blood, nourishing blood to suppress the hyperactive liver, nourishing YIN to lower pathogenic fire, the function of activating QI to alleviate the depression, is used for treating oral cavity Ulcer, short treating period, instant effect, non-relapse after healing.
The beneficial effect of of the present invention medicine is expanded on further below by way of test example, these test examples include this The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention:
Taking rabbit 30, male and female dual-purpose, body weight 2.0 2.5kg, divide two groups, often group 15, one of which is overdose test Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is that administration by gavage is given Medicine, twice daily, serve on 7 days, observes every day and is administered reaction, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad Toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept oral ulcer out-patient totally 24 example for medical treatment.
2, diagnostic criteria
Classical symptom is that oral mucosa is congested, and locally causalgia is obvious, and severe patient also can affect diet, speak, and makes daily life The big inconvenience of poling；Can concurrently halitosis, chronic pharyngitis, constipation, headache, dizziness, nauseating, weak, irritated, heating, lymphadenectasis Deng General Symptoms.
3, Therapeutic Method
Selecting above-mentioned medicament, take to patient, take every day 3 times, each 1 dose, 7 days be a course for the treatment of, takes 2 treatments continuously Journey.
4, efficacy assessment standard
Effective: oral ulcer transference cure, recover normal, recovery from illness；
Take a turn for the better: patient's oral mucosa is congested, and locally the phenomenon of causalgia alleviates, and oral ulcer symptom is clearly better, and progressively recovers；
Invalid: not reach improvement standard person.
5, therapeutic outcome (see table)
In above-mentioned treatment, by Drug therapy oral ulcer patient 24 example of the present invention, effective 20 examples of result, obvious effective rate is 83.33%, take a turn for the better 3 examples, and improvement rate is 12.5%, invalid 1 example, and total effective rate is 95.83%.

Claims (3)

1. the medicine treating oral ulcer, it is characterised in that: it is made up of the crude drug in following weight range:
Radix Rehmanniae Preparata 15-25 gram, Radix Paeoniae Alba 10-20 gram, Radix Angelicae Sinensis 10-20 gram, Rhizoma Anemarrhenae 10-20 gram, Cortex Moutan 10-20 gram, Rhizoma Polygonati 5-15 Gram, Rhizoma Chuanxiong 4-8 gram, Cortex Phellodendri 4-8 gram, 3-5 gram of Radix Glycyrrhizae.
Medicine the most according to claim 1, the consumption of the most each crude drug is:
Radix Rehmanniae Preparata 20 grams, the Radix Paeoniae Alba 15 grams, Radix Angelicae Sinensis 15 grams, the Rhizoma Anemarrhenae 15 grams, Cortex Moutan 15 grams, Rhizoma Polygonati 10 grams, Rhizoma Chuanxiong 6 grams, Cortex Phellodendri 6 Gram, 3 grams of Radix Glycyrrhizae.
The preparation method of medicine the most according to claim 1 or claim 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Rehmanniae Preparata: take crude drug, steams to surface corvinus, takes out, when solarization to eighty per cant is dry, and section, it is dried；
(2) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, and solarization is dried in the air, and profit to inside and outside humidity is uniform, Section, is dried；
(3) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, slightly dries in the air, and section is dried；
(4) Rhizoma Anemarrhenae: pick clean impurity, hits with water and washes, pull out, soften, and section is dried；
(5) Cortex Moutan: pick decontamination, removes core, cleans, runs through, and section is dried；
(6) Rhizoma Polygonati: clean earth, slightly moisten, section, dry；
(7) Rhizoma Chuanxiong: pick decontamination, is soaked in water by the most large and small, and solarization is dried in the air, and cuts into slices after moistening, is dried；
(8) Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, section or shredding, dries；
(9) Radix Glycyrrhizae: pick decontamination, cleans, be soaked in water to eighty per cant thoroughly time, pull out, run through, section, dry；
(2) prepare
(1) Radix Rehmanniae Preparata cooked, the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Cortex Moutan, Rhizoma Polygonati, Rhizoma Chuanxiong, Cortex Phellodendri, Radix Glycyrrhizae are put into decocting container In, add water 6 times amount, and after soaking 100 minutes, intense fire decocts boiling, then with slow fire boiling 20 minutes, filters to decoct for the first time Liquid, pours into first time decoction liquor in container；
(2) add water 4 times amount by the medicinal residues of filtration, and intense fire boils, then with slow fire boiling 20 minutes, filters to obtain second time decoction liquor；
(3) by twice decoction liquor mixing and stirring, it is divided into 2 doses to take.
CN201610764675.2A 2016-08-31 2016-08-31 Drug for treating oral ulcers and preparation method of drug Withdrawn CN106309912A (en)

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Application Number Priority Date Filing Date Title
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Country Status (1)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105031357A (en) * 2015-08-20 2015-11-11 王莉 Medicine for treating oral ulcer and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105031357A (en) * 2015-08-20 2015-11-11 王莉 Medicine for treating oral ulcer and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
徐俊霞主编: "《中华药浴全书——学用药浴不生病》", 31 October 2013, 金盾出版社 *

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Application publication date: 20170111