CN106267129A - 用于改善脾肾阳虚证腹泻的中药组合物和制备方法及其应用 - Google Patents

用于改善脾肾阳虚证腹泻的中药组合物和制备方法及其应用 Download PDF

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CN106267129A
CN106267129A CN201610894196.2A CN201610894196A CN106267129A CN 106267129 A CN106267129 A CN 106267129A CN 201610894196 A CN201610894196 A CN 201610894196A CN 106267129 A CN106267129 A CN 106267129A
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Abstract

本发明公开了一种用于改善脾肾阳虚证腹泻的中药组合物及其制备方法和应用，所述中药组合物的有效成分由下述重量份的原料药制备而成：茯苓10‑15份、苍术3‑9份、厚朴3‑9份、白术6‑10份、党参10‑20份、陈皮3‑9份、薏苡仁10‑20份、大枣6‑15份、莲子6‑15份、芡实9‑15份、乌梅6‑12份、干姜3‑9份、桂枝3‑9份、肉豆蔻3‑9份、菟丝子6‑12份、枸杞6‑12份、莱菔子6‑12份、鸡内金5‑10份。本发明所述的中药组合物配伍合理，诸药合用，共奏改善因脾肾阳虚证腹泻之效。

Description

用于改善脾肾阳虚证腹泻的中药组合物和制备方法及其应用
技术领域
本发明涉及中药领域，特别是涉及一种用于改善脾肾阳虚证腹泻的中药组合物和制备方法及其应用。
背景技术
功能性腹泻是临床上常见的一种消化性疾病，以腹泻为主要临床表现，是一种不伴有腹痛或腹部不适，持续性或反复发作排松散便或水样便的功能性肠病，是下消化道最为主要的功能性胃肠病之一。主要表现为胃肠蠕动过快，小肠吸收功能下降。实验室检查及特殊检查皆无器质性病变，此种疾病的发生常与精神因素、温度、食物等相关。随着生活节奏的加快，精神压力的增高，生活习惯及饮食结构的改变，功能性腹泻的发生率达9.7％，其发病率还有逐年增长趋势。
中医认为，功能性腹泻属“泄泻”范畴。影响因素有外感六淫之邪、饮食所伤、情志失调、形体劳倦，涉及脏腑有脾胃、肝、肾及大、小肠，但关系最为密切为脾胃。其中，肾可助脾胃之运化以腐熟水谷。若年老体弱，肾气不足；或久病之后，肾阳受损；或房事无度，名门火衰，致脾失温煦，运化失职，水谷不化，升降失调，清浊不分，而成泄泻。
发明内容
基于此，本发明目的之一在于提供一种用于改善脾肾阳虚证腹泻的中药组合物。
解决上述技术问题的具体技术方案如下：
一种用于改善脾肾阳虚证腹泻的中药组合物，所述中药组合物的有效成分由下述重量份的原料药制备而成：茯苓10-15份、苍术3-9份、厚朴3-9份、白术6-10份、党参10-20份、陈皮3-9份、薏苡仁10-20份、大枣6-15份、莲子6-15份、芡实9-15份、乌梅6-12份、干姜3-9份、桂枝3-9份、肉豆蔻3-9份、菟丝子6-12份、枸杞6-12份、莱菔子6-12份、鸡内金5-10份。
优选的，所述中药组合物的有效成分由下述重量份的原料药制备而成：茯苓11-14份、苍术4-7份、厚朴4-7份、白术7-9份、党参12-18份、陈皮4-7份、薏苡仁12-18份、大枣8-12份、莲子8-12份、芡实10-14份、乌梅7-10份、干姜4-8份、桂枝4-8份、肉豆蔻4-8份、菟丝子7-10份、枸杞7-10份、莱菔子7-10份、鸡内金6-9份。
优选的，所述中药组合物的有效成分由下述重量份的原料药制备而成：茯苓12-13份、苍术5-6份、厚朴5-6份、白术8-9份、党参15-16份、陈皮5-6份、薏苡仁15-16份、大枣9-10份、莲子9-10份、芡实12-13份、乌梅8-9份、干姜5-6份、桂枝5-6份、肉豆蔻5-6份、菟丝子8-9份、枸杞8-9份、莱菔子8-9份、鸡内金8-9份。
本发明的另一目的在于提供一种上述用于改善脾肾阳虚证腹泻的中药组合物的制备方法，包括如下步骤：
(1)先取茯苓、苍术、厚朴、白术、党参、陈皮、薏苡仁、大枣、莲子、芡实、乌梅、干姜、菟丝子、枸杞和莱菔子煎煮；
(2)后下桂枝继续煎煮，过滤，浓缩至清膏；
(3)分别将肉豆蔻、鸡内金粉碎，与步骤(2)所述清膏混匀，即可。
优选的，步骤(1)所述煎煮的时间为10-20min。
优选的，步骤(1)所述煎煮的时间为10-15min。
优选的，步骤(2)所述煎煮的时间为5-10min。
本发明的另一目的在于提供一种上述中药组合物在制备用于改善脾肾阳虚证腹泻的药品或保健品中的应用。
本发明所述的一种用于改善脾肾阳虚证腹泻的中药组合物及其准备方法和应用具有以下优点和有益效果：
1)本发明所述的中药组合物配伍合理，诸药合用，共奏用于改善脾肾阳虚证腹泻之效，该中药组合物以运脾为主，化湿、脾肾阳双补、消食为辅，相互协同显著改善脾肾阳虚证功能性腹泻。
2)本发明所述制备方法，简单、方便。
具体实施方式
以下将结合具体实施例对本发明做进一步说明，以便本领域技术人员更清楚的了解本发明，但并不因此限制本发明。
实施例1
本实施例涉及一种用于改善脾肾阳虚证腹泻的中药组合物，其有效成分由下述重量的原料药制备而成：茯苓12g、苍术6g、厚朴6g、白术9g、党参16g、陈皮6g、薏苡仁16g、大枣10g、莲子10g、芡实12g、乌梅9g、干姜6g、桂枝6g、肉豆蔻6g、菟丝子9g、枸杞9g、莱菔子9g、鸡内金9g。
上述用于改善脾肾阳虚证腹泻的中药组合物的制备方法，步骤如下：
先取茯苓、苍术、厚朴、白术、党参、陈皮、薏苡仁、大枣、莲子、芡实、乌梅、干姜、菟丝子、枸杞和莱菔子煎煮10-15min，后下桂枝继续煎煮5-10min，过滤，滤渣继续煎煮10min，过滤，合并两次滤液，浓缩至清膏，并与经粉碎的肉豆蔻、鸡内金混匀，即可。
实施例2
本实施例涉及一种用于改善脾肾阳虚证腹泻的中药组合物，其有效成分由下述重量的原料药制备而成：茯苓10g、苍术3g、厚朴3g、白术6g、党参10g、陈皮3g、薏苡仁10g、大枣6g、莲子6g、芡实9g、乌梅6g、干姜3g、桂枝3g、肉豆蔻3g、菟丝子6g、枸杞6g、莱菔子6g、鸡内金5g。
上述用于改善脾肾阳虚证腹泻的中药组合物的制备方法参照实施例1。
实施例3
本实施例涉及一种用于改善脾肾阳虚证腹泻的中药组合物，其有效成分由下述重量的原料药制备而成：茯苓14g、苍术7g、厚朴7g、白术9g、党参18g、陈皮7g、薏苡仁18g、大枣12g、莲子12g、芡实14g、乌梅10g、干姜8g、桂枝8g、肉豆蔻8g、菟丝子10g、枸杞10g、莱菔子10g、鸡内金9g。
上述用于脾肾阳虚证腹泻的中药组合物的制备方法参照实施例1。
以下结合实践中典型病例对本发明的有益效果做进一步说明。
1、病人概况：选择220例，均符合《肠易激综合征中西医结合诊疗方案》中诊断标准。中医诊断为脾肾阳虚证，具体如下：
脾肾阳虚证：主症：①久痢迁延。②脐腹冷痛，喜温喜按。③腰膝酸软，形寒肢冷。④舌质淡胖，苔白润或有齿痕。次症：①腹胀肠鸣。②面色晄白。③少气懒言。④脉细沉或尺脉弱。证型确定：具备主症2项加次症2项，或主症第1项加次症3项。
随机将病人平均分为治疗组1(55例，男性21例，女性34例，年龄43-58岁，病程1～3年)、治疗组2(55例，男性25例，女性30例，年龄40-55岁，病程1～2年)、治疗组3(55例，男性28例，女性27例，年龄45-60岁，病程1～3年)和对照组(55例，男性30例，女性25例，年龄50-60岁，病程1～3年)。四组性别、年龄、病程等比较无显著性差异(P>0.05)，具有可比性。
2、治疗方法
治疗组1-3分别服用实施例1-3所制得的中药组合物，2次/日。对照组服用：茯苓12g、苍术6g、厚朴6g、白术9g、党参16g、陈皮6g、薏苡仁16g、大枣10g、莲子10g、芡实12g、乌梅9g、干姜6g、桂枝6g、肉豆蔻6g、菟丝子9g，制备方法参照实施例1，2次/日。四组疗程为4周，治疗期间停用其他药物，避免辛辣寒凉食物。
3、观测内容
将症状大便泄泻、腹胀腹痛、肠鸣、食欲不振、神疲懒言、腰膝酸痛、畏寒肢冷，根据《中药新药治疗泄泻临床研究指导原则》症状分级量化表，症状程度分为轻度、中度、重度3级，分别积分为1、2、3分。疗程结束后复查血常规、尿常规和生化指标。
采用spss进行数据分析，采用x±s表示，治疗前后采用配对样本t检验，各组间比较采用两组独立样本t检验，计数资料采用X2检验。
4、疗效标准
根据《中药新药治疗泄泻临床研究指导原则》证候疗效判定标准，疗效指数＝[(治疗前症状积分-治疗后症状积分)/治疗前症状积分]×100％。
痊愈：≥95％；显效：70％≤疗效指数＜95％；有效：30％≤疗效指数＜70％；无效：疗效指数＜30％。
5、治疗结果
四组疗效比较结果见表1。从表1可以看出，总有效率治疗组1>治疗组3>治疗组2>对照组。说明实施例所制得的中药组合物可显著改善脾肾阳虚所导致的腹泻。四组治疗前后未见明显不良反应，血、尿常规及生化指标未见异常变化。
表1
组别 例 痊愈 显效 有效 无效 总有效率
对照组 55 24 12 11 8 85.5％
治疗组1 55 36 10 7 2 96.4％
治疗组2 55 30 6 14 5 90.9％
治疗组3 55 33 9 9 4 92.7％

Claims (8)

1.一种用于改善脾肾阳虚证腹泻的中药组合物，其特征在于，所述中药组合物的有效成分由下述重量份的原料药制备而成：茯苓10-15份、苍术3-9份、厚朴3-9份、白术6-10份、党参10-20份、陈皮3-9份、薏苡仁10-20份、大枣6-15份、莲子6-15份、芡实9-15份、乌梅6-12份、干姜3-9份、桂枝3-9份、肉豆蔻3-9份、菟丝子6-12份、枸杞6-12份、莱菔子6-12份、鸡内金5-10份。
2.根据权利要求1所述的用于改善脾肾阳虚证腹泻的中药组合物，其特征在于，所述中药组合物的有效成分由下述重量份的原料药制备而成：茯苓11-14份、苍术4-7份、厚朴4-7份、白术7-9份、党参12-18份、陈皮4-7份、薏苡仁12-18份、大枣8-12份、莲子8-12份、芡实10-14份、乌梅7-10份、干姜4-8份、桂枝4-8份、肉豆蔻4-8份、菟丝子7-10份、枸杞7-10份、莱菔子7-10份、鸡内金6-9份。
3.根据权利要求2所述的用于改善脾肾阳虚证腹泻的中药组合物，其特征在于，所述中药组合物的有效成分由下述重量份的原料药制备而成：茯苓12-13份、苍术5-6份、厚朴5-6份、白术8-9份、党参15-16份、陈皮5-6份、薏苡仁15-16份、大枣9-10份、莲子9-10份、芡实12-13份、乌梅8-9份、干姜5-6份、桂枝5-6份、肉豆蔻5-6份、菟丝子8-9份、枸杞8-9份、莱菔子8-9份、鸡内金8-9份。
4.一种如上述权利要求1-3任一项所述的用于改善脾肾阳虚证腹泻的中药组合物的制备方法，其特征在于，包括如下步骤：
(1)先取茯苓、苍术、厚朴、白术、党参、陈皮、薏苡仁、大枣、莲子、芡实、乌梅、干姜、菟丝子、枸杞和莱菔子煎煮；
(2)后下桂枝继续煎煮，过滤，浓缩至清膏；
(3)分别将肉豆蔻、鸡内金粉碎，与步骤(2)所述清膏混匀，即可。
5.根据权利要求4所述的用于改善脾肾阳虚证腹泻的中药组合物的制备方法，其特征在于，步骤(1)所述煎煮的时间为10-20min。
6.根据权利要求5所述的用于改善脾肾阳虚证腹泻的中药组合物的制备方法，其特征在于，步骤(1)所述煎煮的时间为10-15min。
7.根据权利要求4所述的用于改善脾肾阳虚证腹泻的中药组合物的制备方法，其特征在于，步骤(2)所述煎煮的时间为5-10min。
8.如权利要求1-3任一项所述的用于改善脾肾阳虚证腹泻的中药组合物在制备用于改善脾肾阳虚证腹泻的药品或保健品中的应用。
CN201610894196.2A 2016-10-12 2016-10-12 用于改善脾肾阳虚证腹泻的中药组合物和制备方法及其应用 Pending CN106267129A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI796023B (zh) * 2021-03-10 2023-03-11 長庚醫療財團法人 藥物組合物及其用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
吴皓萌 等: "21位国医大师治疗慢性泄泻的经验撷菁", 《中华中医药杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI796023B (zh) * 2021-03-10 2023-03-11 長庚醫療財團法人 藥物組合物及其用途

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